{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:42:14Z","timestamp":1792460534692,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1053\/j.gastro.2016.12.051","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:32:49Z","timestamp":1486733569000},"page":"1638-1646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation"],"prefix":"10.1053","volume":"152","author":[{"given":"Sonia","family":"Caprio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Kursawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.12.051_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jamapediatrics.2014.21","article-title":"Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012","volume":"168","author":"Skinner","year":"2014","journal-title":"JAMA Pediatr"},{"key":"10.1053\/j.gastro.2016.12.051_bib2","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1001\/jama.2016.6361","article-title":"Trends in obesity prevalence among children and adolescents in the United States, 1988\u20131994 through 2013\u20132014","volume":"315","author":"Ogden","year":"2016","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2016.12.051_bib3","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/jama.288.14.1728","article-title":"Prevalence and trends in overweight among U.S. children and adolescents, 1999-2000","volume":"288","author":"Ogden","year":"2002","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2016.12.051_bib4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1067\/mpd.2001.114476","article-title":"Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study","volume":"138","author":"Biro","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2016.12.051_bib5","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1210\/jc.2002-021267","article-title":"Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors","volume":"88","author":"Bacha","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"suppl 4","key":"10.1053\/j.gastro.2016.12.051_bib6","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1542\/peds.2007-2329C","article-title":"Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report","volume":"120","author":"Barlow","year":"2007","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2016.12.051_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpeds.2006.08.042","article-title":"Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study","volume":"150","author":"Freedman","year":"2007","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2016.12.051_bib8","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1542\/peds.2005-0242","article-title":"Screening and interventions for childhood overweight: a summary of evidence for the US Preventive Services Task Force","volume":"116","author":"Whitlock","year":"2005","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2016.12.051_bib9","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1502821","article-title":"Cardiometabolic risks and severity of obesity in children and young adults","volume":"373","author":"Skinner","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib10","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1056\/NEJMoa031049","article-title":"Obesity and the metabolic syndrome in children and adolescents","volume":"350","author":"Weiss","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib11","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.2337\/dc08-9024","article-title":"Influence of race, ethnicity, and culture on childhood obesity: implications for prevention and treatment: a consensus statement of Shaping America's Health and the Obesity Society","volume":"31","author":"Caprio","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2016.12.051_bib12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJMoa012578","article-title":"Prevalence of impaired glucose tolerance among children and adolescents with marked obesity","volume":"346","author":"Sinha","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1067\/mpd.2001.112658","article-title":"Adiposity in childhood predicts obesity and insulin resistance in young adulthood","volume":"138","author":"Steinberger","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2016.12.051_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0026-0495(96)90060-8","article-title":"Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study","volume":"45","author":"Srinivasan","year":"1996","journal-title":"Metabolism"},{"key":"10.1053\/j.gastro.2016.12.051_bib15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.108.3.712","article-title":"Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study","volume":"108","author":"Freedman","year":"2001","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2016.12.051_bib16","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.jacc.2014.07.962","article-title":"Childhood obesity and adult cardiovascular disease","volume":"64","author":"Litwin","year":"2014","journal-title":"J AM Coll Cardio"},{"key":"10.1053\/j.gastro.2016.12.051_bib17","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2337\/diab.46.8.1341","article-title":"Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children","volume":"46","author":"Odeleye","year":"1997","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib18","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMra1011035","article-title":"Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease","volume":"371","author":"Shulman","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(03)14364-4","article-title":"Pre-type 2 diabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance and altered myocellular and abdominal fat partitioning","volume":"362","author":"Weiss","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2016.12.051_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/07853890500383895","article-title":"Is visceral obesity the cause of the metabolic syndrome?","volume":"38","author":"Despres","year":"2006","journal-title":"Ann Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.051_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.12.051_bib23","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2337\/diacare.25.9.1631","article-title":"Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes","volume":"25","author":"Cruz","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2016.12.051_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2337\/db07-0932","article-title":"High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic syndrome","volume":"57","author":"Taksali","year":"2008","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib25","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.22858","article-title":"Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link?","volume":"49","author":"Cali","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.051_bib26","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/dc10-0284","article-title":"Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents","volume":"33","author":"D\u2019Adamo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2016.12.051_bib27","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.1073\/pnas.0904944106","article-title":"Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity","volume":"106","author":"Fabbrini","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.12.051_bib28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.051_bib29","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jc.2006-1010","article-title":"Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat","volume":"91","author":"Burgert","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.051_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/01.MPG.0000164698.03164.E5","article-title":"Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase","volume":"41","author":"Nadeau","year":"2005","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2016.12.051_bib31","doi-asserted-by":"crossref","first-page":"e161971","DOI":"10.1001\/jamapediatrics.2016.1971","article-title":"Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease","volume":"170","author":"Newton","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1053\/j.gastro.2016.12.051_bib32","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1161\/01.CIR.96.9.3248","article-title":"Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association","volume":"96","author":"Eckel","year":"1997","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2016.12.051_bib33","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.12.051_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","article-title":"Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms","volume":"4","author":"Calle","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2016.12.051_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7326\/0003-4819-138-1-200301070-00008","article-title":"Obesity in adulthood and its consequences for life expectancy: a life-table analysis","volume":"138","author":"Peeters","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/79111","article-title":"Failure of adipocyte differentiation causes type II diabetes mellitus?","volume":"26","author":"Danforth","year":"2000","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.12.051_bib37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1749-6632.2002.tb04292.x","article-title":"Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus","volume":"967","author":"Ravussin","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.gastro.2016.12.051_bib38","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1301\/nr.2007.jun.S7-S12","article-title":"Adipose tissue expandability in the maintenance of metabolic homeostasis","volume":"65","author":"Gray","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1053\/j.gastro.2016.12.051_bib39","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","article-title":"Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2013an allostatic perspective","volume":"1801","author":"Virtue","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2016.12.051_bib40","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.2337\/db10-0113","article-title":"Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis","volume":"59","author":"Kursawe","year":"2010","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib41","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2337\/db12-0889","article-title":"Decreased transcription of ChREBP-alpha\/beta isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia","volume":"62","author":"Kursawe","year":"2013","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib42","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.2337\/db11-0616","article-title":"SirT1 regulates adipose tissue inflammation","volume":"60","author":"Gillum","year":"2011","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib43","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.12.051_bib44","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.051_bib45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncpendmet0976","article-title":"Mechanisms of macrophage activation in obesity-induced insulin resistance","volume":"4","author":"Odegaard","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.051_bib46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1053\/j.gastro.2016.12.051_bib47","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.051_bib48","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1542\/peds.2004-2854","article-title":"Obesity and inflammation: evidence for an elementary lesion","volume":"117","author":"Sbarbati","year":"2006","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2016.12.051_bib49","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1210\/jc.2011-2806","article-title":"Adipose tissue remodeling in children: the link between collagen deposition and age-related adipocyte growth","volume":"97","author":"Tam","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.051_bib50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/ajcn\/59.5.955","article-title":"Critical periods in childhood for the development of obesity","volume":"59","author":"Dietz","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.051_bib51","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.12.051_bib52","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0026-0495(74)90076-6","article-title":"Effects of age, sex, and clinical conditions on adipose tissue cellularity in man","volume":"23","author":"Bjorntorp","year":"1974","journal-title":"Metabolism"},{"key":"10.1053\/j.gastro.2016.12.051_bib53","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0300-595X(76)80023-0","article-title":"Adipose tissue cellularity in human obesity","volume":"5","author":"Hirsch","year":"1976","journal-title":"Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.051_bib54","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.12.051_bib55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2016.12.051_bib56","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1210\/en.2011-1326","article-title":"Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage","volume":"152","author":"Youm","year":"2011","journal-title":"Endocrinology"},{"key":"10.1053\/j.gastro.2016.12.051_bib57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2016.12.051_bib58","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2016.12.051_bib59","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.12.051_bib60","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2337\/db15-1478","article-title":"A\u00a0role of the inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents","volume":"65","author":"Kursawe","year":"2016","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.12.051_bib61","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/oby.2001.35","article-title":"Growth of visceral fat, subcutaneous abdominal fat, and total body fat in children","volume":"9","author":"Huang","year":"2001","journal-title":"Obes Res"},{"key":"10.1053\/j.gastro.2016.12.051_bib62","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/oby.2011.264","article-title":"Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children","volume":"20","author":"Bennett","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1053\/j.gastro.2016.12.051_bib63","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1172\/JCI118846","article-title":"Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs","volume":"98","author":"Rebrin","year":"1996","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.051_bib64","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2015.01.012","article-title":"Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes","volume":"160","author":"Perry","year":"2015","journal-title":"Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T16:51:46Z","timestamp":1583859106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517301440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0016508517301440"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.12.051","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727301573.793542200","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the AGA Institute","name":"copyright","label":"Copyright"}]}}