{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:14:28Z","timestamp":1791832468918,"version":"4.3.4"},"reference-count":165,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1053\/j.gastro.2016.12.052","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:17:56Z","timestamp":1486732676000},"page":"1656-1670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":230,"title":["Gastrointestinal Complications of Obesity"],"prefix":"10.1053","volume":"152","author":[{"given":"Michael","family":"Camilleri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmeet","family":"Malhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.12.052_bib1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0002-9610(85)80029-5","article-title":"Effect of obesity on esophageal transit","volume":"149","author":"Mercer","year":"1985","journal-title":"Am J Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib2","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/BF01296818","article-title":"Effect of obesity on gastroesophageal resistance to flow in man","volume":"36","author":"Zacchi","year":"1991","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.orcp.2015.05.018","article-title":"Prevalence and relationship between gastrointestinal symptoms among individuals of different body mass index: a population-based study","volume":"10","author":"Eslick","year":"2016","journal-title":"Obes Res Clin Pract"},{"key":"10.1053\/j.gastro.2016.12.052_bib4","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1155\/2014\/960520","article-title":"High prevalence of esophageal dysmotility in asymptomatic obese patients","volume":"28","author":"C\u00f4t\u00e9-Daigneault","year":"2014","journal-title":"Can J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib5","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00464-006-9102-y","article-title":"Esophageal motility disorders in the morbidly obese population","volume":"21","author":"Koppman","year":"2007","journal-title":"Surg Endosc"},{"key":"10.1053\/j.gastro.2016.12.052_bib6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1381\/096089299765552990","article-title":"High prevalence of asymptomatic esophageal motility disorders among morbidly obese patients","volume":"9","author":"Jaffin","year":"1999","journal-title":"Obes Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nrgastro.2011.73","article-title":"Influence of obesity on the risk of esophageal disorders","volume":"8","author":"Lagergren","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib8","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/apt.12208","article-title":"The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease","volume":"37","author":"Anggiansah","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.12.052_bib9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/ajg.2009.5","article-title":"Obesity is associated with increased 48-h esophageal acid exposure in patients with symptomatic gastroesophageal reflux","volume":"104","author":"Crowell","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1080\/00365520212502","article-title":"Body mass and reflux oesophagitis: an oestrogen-dependent association?","volume":"37","author":"Nilsson","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/jama.290.1.66","article-title":"Obesity and estrogen as risk factors for gastroesophageal reflux symptoms","volume":"290","author":"Nilsson","year":"2003","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2016.12.052_bib12","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1053\/j.gastro.2008.01.009","article-title":"Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins","volume":"134","author":"Nordenstedt","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib13","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1111\/j.1572-0241.2006.00849.x","article-title":"Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis","volume":"101","author":"Corley","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib15","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.cgh.2013.05.009","article-title":"Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis","volume":"11","author":"Singh","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib16","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1136\/gut.2006.109413","article-title":"Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms","volume":"56","author":"Corley","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib17","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1111\/j.1365-2036.2009.04146.x","article-title":"Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease","volume":"30","author":"De Groot","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.12.052_bib18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/oby.20279","article-title":"Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial","volume":"21","author":"Singh","year":"2013","journal-title":"Obesity"},{"key":"10.1053\/j.gastro.2016.12.052_bib19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/01.mcg.0000225631.07039.6d","article-title":"Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics","volume":"41","author":"Fass","year":"2007","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib20","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3748\/wjg.v18.i20.2545","article-title":"Association between body mass index and erosive esophagitis: a meta-analysis","volume":"18","author":"Cai","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib21","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1136\/gutjnl-2012-304103","article-title":"Protective role of gluteofemoral obesity in erosive oesophagitis and Barrett's oesophagus","volume":"63","author":"Rubenstein","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib22","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1056\/NEJMra1314530","article-title":"Esophageal carcinoma","volume":"371","author":"Rustgi","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib23","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1111\/j.1572-0241.2005.00251.x","article-title":"Abdominal obesity and the risk of Barrett's esophagus","volume":"100","author":"El-Serag","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1053\/j.gastro.2007.04.046","article-title":"Abdominal obesity and body mass index as risk factors for Barrett's esophagus","volume":"133","author":"Corley","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1572-0241.2007.01621.x","article-title":"A\u00a0systematic review and meta-analysis of the risk of increasing adiposity on Barrett's esophagus","volume":"103","author":"Cook","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib26","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/gut.2007.131243","article-title":"Leptin and the risk of Barrett's oesophagus","volume":"57","author":"Kendall","year":"2008","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib27","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1136\/gut.2008.171553","article-title":"Association of adiponectin multimers with Barrett's oesophagus","volume":"58","author":"Rubenstein","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.canep.2011.03.001","article-title":"Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets","volume":"35","author":"Ryan","year":"2011","journal-title":"Cancer Epidemiol"},{"key":"10.1053\/j.gastro.2016.12.052_bib29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s10620-015-3867-6","article-title":"Ghrelin and leptin have a complex relationship with risk of Barrett's esophagus","volume":"61","author":"Thomas","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib30","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.cgh.2013.02.017","article-title":"Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma","volume":"11","author":"Duggan","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib31","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1158\/1055-9965.EPI-05-0860","article-title":"Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis","volume":"15","author":"Kubo","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib32","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1053\/j.gastro.2010.04.014","article-title":"A\u00a0population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence","volume":"139","author":"McElholm","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib33","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/ajg.2011.417","article-title":"IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity","volume":"107","author":"Doyle","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1080\/09674845.2008.11732814","article-title":"Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor","volume":"65","author":"Ogunwobi","year":"2008","journal-title":"Br J Biomed Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib35","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/bjs.7072","article-title":"Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma","volume":"97","author":"Howard","year":"2010","journal-title":"Br J Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib36","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1053\/j.gastro.2014.09.016","article-title":"Peripheral mechanisms in appetite regulation","volume":"148","author":"Camilleri","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib37","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1467-789X.2011.00969.x","article-title":"Gastrointestinal symptoms and obesity: a meta-analysis","volume":"13","author":"Eslick","year":"2012","journal-title":"Obes Rev"},{"key":"10.1053\/j.gastro.2016.12.052_bib38","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1111\/j.1572-0241.2004.30887.x","article-title":"Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study","volume":"99","author":"Delgado-Aros","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib39","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1053\/j.gastro.2003.11.007","article-title":"Independent influences of body mass and gastric volumes on satiation in humans","volume":"126","author":"Delgado-Aros","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib40","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S1542-3565(05)00285-5","article-title":"Effect of gastric volume or emptying on meal-related symptoms after liquid nutrients in obesity: a pharmacologic study","volume":"3","author":"Delgado-Aros","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib41","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1053\/j.gastro.2014.11.020","article-title":"Quantitative gastrointestinal and psychological traits associated with obesity and response to weight-loss therapy","volume":"148","author":"Acosta","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib42","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000334680","article-title":"Is obesity a new risk factor for gastritis?","volume":"85","author":"Yamamoto","year":"2012","journal-title":"Digestion"},{"key":"10.1053\/j.gastro.2016.12.052_bib43","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1440-1746.2006.04494.x","article-title":"Influence of overweight and obesity on upper endoscopic findings","volume":"22","author":"Kim","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib44","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1007\/s10620-011-1681-3","article-title":"Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis","volume":"56","author":"Yamamoto","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib45","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1016\/j.ejca.2009.04.019","article-title":"Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies","volume":"45","author":"Yang","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.gastro.2016.12.052_bib46","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1158\/1055-9965.EPI-13-0042","article-title":"Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies","volume":"22","author":"Chen","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib47","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ejim.2009.07.013","article-title":"The prevalence of Helicobacter pylori in obese subjects","volume":"20","author":"Arslan","year":"2009","journal-title":"Eur J Intern Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib48","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1136\/gutjnl-2013-305092","article-title":"Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response","volume":"63","author":"Ericksen","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib49","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/annonc\/mds244","article-title":"A\u00a0meta-analysis\u00a0of body mass index and esophageal and gastric cardia adenocarcinoma","volume":"24","author":"Turati","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2016.12.052_bib50","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1158\/1055-9965.EPI-11-0834","article-title":"Sex hormones, hormonal interventions, and gastric cancer risk: a meta-analysis","volume":"21","author":"Camargo","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib51","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1093\/jnci\/djq289","article-title":"Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium","volume":"102","author":"Cook","year":"2010","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2016.12.052_bib52","doi-asserted-by":"publisher","first-page":"R85","DOI":"10.1530\/JOE-15-0469","article-title":"The role of bile acids in metabolic regulation","volume":"228","author":"V\u00edtek","year":"2016","journal-title":"J\u00a0Endocrinol"},{"key":"10.1053\/j.gastro.2016.12.052_bib53","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.molmed.2015.09.001","article-title":"Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders","volume":"21","author":"Fiorucci","year":"2015","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib54","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.biochi.2013.08.011","article-title":"From fatty-acid sensing to chylomicron synthesis: role of intestinal lipid-binding proteins","volume":"96","author":"Buttet","year":"2014","journal-title":"Biochimie"},{"key":"10.1053\/j.gastro.2016.12.052_bib55","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3945\/ajcn.115.114538","article-title":"Comparative effects of intra-duodenal whey protein hydrolysate on antropyloroduodenal motility, gut hormones, glycemia, appetite, and energy intake in lean and obese men","volume":"102","author":"Hutchison","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib56","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1210\/jc.2014-3144","article-title":"Accelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycemia","volume":"100","author":"Nguyen","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.052_bib57","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1007\/s10620-008-0410-z","article-title":"The epidemiology of obesity and gastrointestinal and other diseases: an overview","volume":"53","author":"Moayyedi","year":"2008","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib58","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1365-2982.2004.00530.x","article-title":"Association of upper and lower gastrointestinal tract symptoms with body mass index in an Australian cohort","volume":"16","author":"Talley","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.12.052_bib59","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1111\/j.1572-0241.2004.30388.x","article-title":"Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study","volume":"99","author":"Talley","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib60","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/apt.13143","article-title":"Functional gastrointestinal disorders in 35,447 adults and their association with body mass index","volume":"41","author":"Le Pluart","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.12.052_bib61","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1136\/gut.2004.057497","article-title":"Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study","volume":"54","author":"Aro","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib62","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/j.1572-0241.2004.04139.x","article-title":"Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption","volume":"99","author":"Sadik","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib63","doi-asserted-by":"publisher","first-page":"G382","DOI":"10.1152\/ajpgi.90286.2008","article-title":"High body mass alters colonic sensory-motor function and transit in humans","volume":"295","author":"Delgado-Aros","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.12.052_bib64","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.clnu.2012.02.009","article-title":"Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors","volume":"31","author":"Teixeira","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib65","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.nutres.2012.07.003","article-title":"Potential mechanisms for the emerging link between obesity and\u00a0increased intestinal permeability","volume":"32","author":"Teixeira","year":"2012","journal-title":"Nutr Res"},{"key":"10.1053\/j.gastro.2016.12.052_bib66","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1158\/1055-9965.EPI-03-0160","article-title":"Bowel inflammation as measured by fecal calprotectin: a link between lifestyle factors and colorectal cancer risk","volume":"13","author":"Poullis","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib67","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.diabet.2010.11.002","article-title":"Metformin and digestive disorders","volume":"37","author":"Bouchoucha","year":"2011","journal-title":"Diab Metab"},{"key":"10.1053\/j.gastro.2016.12.052_bib68","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1111\/j.1572-0241.2006.00750.x","article-title":"Overweight in celiac disease: prevalence, clinical characteristics, and effect of a gluten-free diet","volume":"101","author":"Dickey","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib69","first-page":"11","article-title":"Patients with coeliac disease are increasingly overweight or obese on presentation","volume":"21","author":"Tucker","year":"2012","journal-title":"J\u00a0Gastrointest Liver Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib70","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1365-2036.2012.05001.x","article-title":"Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet","volume":"35","author":"Kabbani","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.12.052_bib71","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/ejcn.2010.161","article-title":"Celiac disease and obesity: need for nutritional follow-up after diagnosis","volume":"64","author":"Valletta","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib72","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s10620-010-1541-6","article-title":"Is obesity a risk factor for Crohn's disease?","volume":"56","author":"Mendall","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib73","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/ajg.2012.453","article-title":"Body mass index and the risk for Crohn's disease and ulcerative colitis: data from a European Prospective Cohort Study (The IBD in EPIC Study)","volume":"108","author":"Chan","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib74","doi-asserted-by":"publisher","first-page":"e0144872","DOI":"10.1371\/journal.pone.0144872","article-title":"Body mass index is associated with inflammatory bowel disease: a systematic review and meta-analysis","volume":"10","author":"Dong","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.12.052_bib75","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1002\/ibd.21585","article-title":"Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease","volume":"17","author":"Long","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib76","doi-asserted-by":"publisher","first-page":"6912","DOI":"10.3748\/wjg.v20.i22.6912","article-title":"Serum adipokines in inflammatory bowel disease","volume":"20","author":"Waluga","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib77","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2249.2012.04660.x","article-title":"Serum levels and mesenteric fat tissue expression of adiponectin and leptin in patients with Crohn's disease","volume":"170","author":"Rodrigues","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2016.12.052_bib78","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fimmu.2016.00154","article-title":"Inflammation meets metabolic disease: gut feeling mediated by GLP-1","volume":"7","author":"Zietek","year":"2016","journal-title":"Front Immunol"},{"key":"10.1053\/j.gastro.2016.12.052_bib79","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/eci.12542","article-title":"Gastric emptying and disease activity in inflammatory bowel disease","volume":"45","author":"Keller","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.052_bib80","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/DCR.0000000000000550","article-title":"Increased incidence of surgical site infection in IBD patients","volume":"59","author":"Bhakta","year":"2016","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.gastro.2016.12.052_bib81","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1007\/s10620-015-3629-5","article-title":"Obesity in inflammatory bowel disease: a marker of less severe disease","volume":"60","author":"Flores","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib82","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1097\/MIB.0000000000000560","article-title":"Impact of obesity on the management and clinical course of patients with inflammatory bowel disease","volume":"21","author":"Seminerio","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib83","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1097\/MIB.0b013e31829cf401","article-title":"Increased body mass index is associated with earlier time to loss of response to infliximab in patients with inflammatory bowel disease","volume":"19","author":"Harper","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib84","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/MEG.0b013e32835d1f15","article-title":"Does weight-adjusted anti-tumour necrosis factor treatment favour obese patients with Crohn's disease?","volume":"25","author":"Bhalme","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib85","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s11605-015-3060-4","article-title":"Obesity does not impact perioperative or postoperative outcomes in patients with inflammatory bowel disease","volume":"20","author":"Guardado","year":"2016","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib86","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jpeds.2008.09.053","article-title":"Obesity is related to multiple functional abdominal diseases","volume":"154","author":"Teitelbaum","year":"2009","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2016.12.052_bib87","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/MPG.0b013e3181ef8e3c","article-title":"Constipation and colonic transit times in children with morbid obesity","volume":"52","author":"vd Baan-Slootweg","year":"2011","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib88","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000339881","article-title":"Obesity, metabolic syndrome and the risk of development of colonic diverticulosis","volume":"86","author":"Kopylov","year":"2012","journal-title":"Digestion"},{"key":"10.1053\/j.gastro.2016.12.052_bib89","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.cgh.2016.01.020","article-title":"Distribution and characteristics of colonic diverticula in a United States screening population","volume":"14","author":"Peery","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib90","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1053\/j.gastro.2008.09.025","article-title":"Obesity increases the risks of diverticulitis and diverticular bleeding","volume":"136","author":"Strate","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib91","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/oxfordjournals.aje.a009508","article-title":"Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum","volume":"147","author":"Bird","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2016.12.052_bib92","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1158\/1055-9965.EPI-06-0229","article-title":"Change in body size and the risk of colorectal adenomas","volume":"16","author":"Sedjo","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib93","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-230X-9-4","article-title":"An association between colonic adenoma and abdominal obesity: a cross-sectional study","volume":"9","author":"Kim","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib94","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/oby.2008.216","article-title":"Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men","volume":"16","author":"Lee","year":"2008","journal-title":"Obesity"},{"key":"10.1053\/j.gastro.2016.12.052_bib95","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1007\/s10620-009-0811-7","article-title":"Obesity is associated with an increased prevalence of advanced adenomatous colon polyps in a male veteran population","volume":"54","author":"Siddiqui","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib96","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1053\/j.gastro.2011.12.050","article-title":"Body mass index increases risk for colorectal adenomas based on meta-analysis","volume":"142","author":"Ben","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib97","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3109\/00365521.2012.737364","article-title":"The association between obesity and colorectal adenoma: systematic review and meta-analysis","volume":"48","author":"Omata","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib98","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1055\/s-0032-1309837","article-title":"Obesity, weight change, and risk of adenoma recurrence: a prospective trial","volume":"44","author":"Laiyemo","year":"2012","journal-title":"Endoscopy"},{"key":"10.1053\/j.gastro.2016.12.052_bib99","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/MCG.0b013e318207f3cf","article-title":"Risk factors for sessile serrated adenomas","volume":"45","author":"Anderson","year":"2011","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib100","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1463-1318.2009.01766.x","article-title":"Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index","volume":"11","author":"Harriss","year":"2009","journal-title":"Colorectal Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib101","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1467-789X.2009.00613.x","article-title":"A\u00a0quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies","volume":"11","author":"Ning","year":"2010","journal-title":"Obes Rev"},{"key":"10.1053\/j.gastro.2016.12.052_bib102","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1158\/1055-9965.EPI-07-0708","article-title":"Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events","volume":"16","author":"Moghaddam","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2016.12.052_bib103","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/ajcn\/86.3.556","article-title":"Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies","volume":"86","author":"Larsson","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib104","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/gutjnl-2013-304701","article-title":"Obesity and colorectal cancer","volume":"62","author":"Bardou","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib105","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/cid\/cit280","article-title":"Obesity as a risk factor for Clostridium difficile infection","volume":"57","author":"Bishara","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib106","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/gutjnl-2011-301181","article-title":"Regional colon transit in patients with dys-synergic defaecation or slow transit in patients with constipation","volume":"61","author":"Nullens","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib107","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1572-0241.1999.00782.x","article-title":"Descending perineum syndrome: audit of clinical and laboratory features and outcome of pelvic floor retraining","volume":"94","author":"Harewood","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib108","doi-asserted-by":"publisher","first-page":"E92","DOI":"10.1111\/j.1463-1318.2011.02584.x","article-title":"Obesity and bariatric surgery: a systematic review of associations with defecatory dysfunction","volume":"13","author":"Poylin","year":"2011","journal-title":"Colorectal Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib109","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/ajg.2014.396","article-title":"Epidemiology, pathophysiology, and classification of fecal incontinence: state of the science summary for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) workshop","volume":"110","author":"Bharucha","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib110","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ajog.2014.10.015","article-title":"Functional disability among older women with fecal incontinence","volume":"212","author":"Erekson","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/j.gastro.2016.12.052_bib111","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1001\/jama.2015.5370","article-title":"Nonalcoholic fatty liver disease: a systematic review","volume":"313","author":"Rinella","year":"2015","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2016.12.052_bib112","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","article-title":"Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib113","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib114","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bjc.6603932","article-title":"Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies","volume":"97","author":"Larsson","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2016.12.052_bib115","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.12.052_bib116","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib117","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1053\/j.gastro.2007.11.038","article-title":"Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease","volume":"134","author":"Fabbrini","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib118","doi-asserted-by":"publisher","first-page":"E584","DOI":"10.1152\/ajpendo.00272.2010","article-title":"Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?","volume":"299","author":"Hodson","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1053\/j.gastro.2016.12.052_bib119","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jhep.2009.03.019","article-title":"Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis","volume":"51","author":"Argo","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib120","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.cgh.2014.04.014","article-title":"Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib121","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.12.052_bib122","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib123","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s11605-014-2678-y","article-title":"Bariatric surgery improves histological features of nonalcoholic fatty liver disease and liver fibrosis","volume":"19","author":"Taitano","year":"2015","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib124","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4254\/wjh.v4.i12.382","article-title":"Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients","volume":"4","author":"Vargas","year":"2012","journal-title":"World J Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib125","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/oby.2005.140","article-title":"Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease","volume":"13","author":"Clark","year":"2005","journal-title":"Obes Res"},{"key":"10.1053\/j.gastro.2016.12.052_bib126","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fphys.2016.00344","article-title":"Roux-en Y gastric bypass results in long-term remission of hepatocyte apoptosis and hepatic histological features of non-alcoholic steatohepatitis","volume":"7","author":"Schneck","year":"2016","journal-title":"Front Physiol"},{"key":"10.1053\/j.gastro.2016.12.052_bib127","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib128","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib129","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2016.12.052_bib130","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib131","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/hep.27016","article-title":"Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer","volume":"60","author":"Aleksandrova","year":"2014","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib132","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1002\/hep.28123","article-title":"Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009","volume":"62","author":"Younossi","year":"2015","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib133","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/liv.13031","article-title":"The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment","volume":"36","author":"Margini","year":"2016","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2016.12.052_bib134","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.cgh.2012.10.001","article-title":"Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review","volume":"10","author":"White","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"Suppl","key":"10.1053\/j.gastro.2016.12.052_bib135","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1097\/MCG.0b013e3182872f29","article-title":"Epidemiology of hepatocellular carcinoma: consider the population","volume":"47","author":"Mittal","year":"2013","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib136","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.diii.2016.06.002","article-title":"Obesity conveys poor outcome in patients with hepatocellular carcinoma treated by transarterial chemoembolization","volume":"98","author":"Wu","year":"2017","journal-title":"Diagn Interv Imaging"},{"key":"10.1053\/j.gastro.2016.12.052_bib137","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3748\/wjg.14.1553","article-title":"Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma","volume":"14","author":"Utsunomiya","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib138","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1002\/hep.28785","article-title":"The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib139","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/hep.26231","article-title":"Health care costs associated with hepatocellular carcinoma: a population-based study","volume":"58","author":"Thein","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.12.052_bib140","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.12.052_bib141","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2016.12.052_bib142","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ccell.2016.05.020","article-title":"Metabolic inflammation-associated IL-17A causes non-alcoholic steatohepatitis and hepatocellular carcinoma","volume":"30","author":"Gomes","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2016.12.052_bib143","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12885-015-2007-1","article-title":"MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL\/6J mice","volume":"16","author":"Tessitore","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1053\/j.gastro.2016.12.052_bib144","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jhep.2014.02.030","article-title":"Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"61","author":"Liu","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib145","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s10620-008-0578-2","article-title":"Steatocholecystitis and fatty gallbladder disease","volume":"54","author":"Tsai","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib146","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.7326\/0003-4819-119-10-199311150-00010","article-title":"Contributions of obesity and weight loss to\u00a0gallstone disease","volume":"119","author":"Everhart","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib147","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1381\/0960892053268273","article-title":"Gallbladder pathology in morbid obesity","volume":"15","author":"Dittrick","year":"2005","journal-title":"Obes Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib148","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2458-9-88","article-title":"The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis","volume":"9","author":"Guh","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1053\/j.gastro.2016.12.052_bib149","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ajcn\/80.1.38","article-title":"Prospective study of abdominal adiposity and gallstone disease in US men","volume":"80","author":"Tsai","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2016.12.052_bib150","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1136\/gut.2005.076133","article-title":"Central adiposity, regional fat distribution, and the risk of cholecystectomy in women","volume":"55","author":"Tsai","year":"2006","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.12.052_bib151","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1023\/B:DDAS.0000011595.39555.c0","article-title":"Determinants of gallbladder kinetics in obesity","volume":"49","author":"Mathus-Vliegen","year":"2004","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.12.052_bib152","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.gassur.2006.04.005","article-title":"Insulin resistance causes human gallbladder dysmotility","volume":"10","author":"Nakeeb","year":"2006","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib153","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s11605-003-0030-z","article-title":"Diabetes and hyperlipidemia correlate with gallbladder contractility in leptin-related murine obesity","volume":"7","author":"Tran","year":"2003","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2016.12.052_bib154","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3748\/wjg.15.1869","article-title":"Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome","volume":"15","author":"Lee","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib155","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/ajg.2008.77","article-title":"Low mortality and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include \u201cmoderately severe acute pancreatitis\u201d","volume":"104","author":"Vege","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.12.052_bib156","first-page":"244","article-title":"Is obesity an indicator of complications and mortality in acute pancreatitis? An updated meta-analysis","volume":"13","author":"Chen","year":"2012","journal-title":"J\u00a0Dig Dis"},{"key":"10.1053\/j.gastro.2016.12.052_bib157","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1111\/j.1365-2036.2006.02915.x","article-title":"Systematic review: adipose tissue, obesity and gastrointestinal diseases","volume":"23","author":"John","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.12.052_bib158","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1097\/MPA.0b013e3181b65bbe","article-title":"Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis","volume":"38","author":"Sharma","year":"2009","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2016.12.052_bib159","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1210\/en.2003-1336","article-title":"Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans","volume":"145","author":"Fain","year":"2004","journal-title":"Endocrinology"},{"key":"10.1053\/j.gastro.2016.12.052_bib160","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2016.12.052_bib161","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1093\/annonc\/mdr398","article-title":"Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies","volume":"23","author":"Aune","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2016.12.052_bib162","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"International Agency for Research on Cancer Handbook Working Group. Body fatness and cancer\u2013viewpoint of\u00a0the IARC Working Group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.12.052_bib163","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s10552-012-9942-9","article-title":"Association of colorectal adenoma with components of metabolic syndrome","volume":"23","author":"Kim","year":"2012","journal-title":"Cancer Causes Control"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.12.052_bib164","first-page":"8","article-title":"Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)","volume":"8","author":"Bellentani","year":"2009","journal-title":"Ann Hepatol"},{"key":"10.1053\/j.gastro.2016.12.052_bib165","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/S0016-5085(03)01200-9","article-title":"Is obesity a risk factor for cirrhosis-related death or hospitalization? A\u00a0population-based cohort study","volume":"125","author":"Ioannou","year":"2003","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:07:14Z","timestamp":1568804834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517301452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":165,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0016508517301452"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.12.052","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrointestinal Complications of Obesity","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.12.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the AGA Institute","name":"copyright","label":"Copyright"}]}}