{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:10:18Z","timestamp":1792087818165,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15fk0210018h0003"],"award-info":[{"award-number":["15fk0210018h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16fk0210101h0001"],"award-info":[{"award-number":["16fk0210101h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1053\/j.gastro.2017.01.041","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T15:16:37Z","timestamp":1486134997000},"page":"1383-1394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection"],"prefix":"10.1053","volume":"152","author":[{"given":"Kentaro","family":"Matsuura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuho","family":"Ikeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Iio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Isogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritomo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Namisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yoshiji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Asahina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Kusakabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohji","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Suetsugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Hiasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Genda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Sakaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Nishiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2017.01.041_bib1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2017.01.041_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.gastro.2009.09.067","article-title":"Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression","volume":"138","author":"Davis","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.01.041_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/hep.27826","article-title":"Ledipasvir and sofosbuvir in patients with genotype 1 hepatitis C virus infection and compensated cirrhosis: an integrated safety and efficacy analysis","volume":"62","author":"Reddy","year":"2015","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/hepr.12393","article-title":"Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon-based antiviral therapy","volume":"45","author":"Hiramatsu","year":"2014","journal-title":"Hepatol Res"},{"key":"10.1053\/j.gastro.2017.01.041_bib5","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/cncr.20537","article-title":"Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy","volume":"101","author":"Makiyama","year":"2004","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2017.01.041_bib6","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1093\/jac\/dks269","article-title":"A\u00a0novel predictive score for hepatocellular carcinoma development in patients with chronic hepatitis C after sustained response to pegylated interferon and ribavirin combination therapy","volume":"67","author":"Chang","year":"2012","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1053\/j.gastro.2017.01.041_bib7","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.2169\/internalmedicine.52.1180","article-title":"Clinical characteristics of\u00a0patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy:\u00a0current status in Japan","volume":"52","author":"Sato","year":"2013","journal-title":"Intern Med"},{"key":"10.1053\/j.gastro.2017.01.041_bib8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/hep.26087","article-title":"Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C","volume":"57","author":"Arase","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.28535","article-title":"Risk of hepatocellular carcinoma after sustained virologic response in veterans with HCV-infection","volume":"64","author":"El-Serag","year":"2016","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jhep.2012.10.017","article-title":"Efficacy of pegylated interferon alpha-2b and ribavirin treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis C: a prospective, multicenter study","volume":"58","author":"Ogawa","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2017.01.041_bib11","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/hep.26442","article-title":"alpha-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C","volume":"58","author":"Asahina","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib12","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.cgh.2013.11.033","article-title":"Post-treatment levels of alpha-fetoprotein predict incidence of hepatocellular carcinoma after interferon therapy","volume":"12","author":"Oze","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.01.041_bib13","doi-asserted-by":"crossref","first-page":"e4157","DOI":"10.1097\/MD.0000000000004157","article-title":"Pretreatment glucose status determines HCC development in HCV patients with mild liver disease after curative antiviral therapy","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1053\/j.gastro.2017.01.041_bib14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/hep.21363","article-title":"A\u00a0simple noninvasive index for predicting long-term outcome of chronic hepatitis C after interferon-based therapy","volume":"44","author":"Yu","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jhep.2014.02.022","article-title":"Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus eradication","volume":"61","author":"Huang","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2017.01.041_bib16","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/jmv.22094","article-title":"Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy","volume":"83","author":"Akuta","year":"2011","journal-title":"J\u00a0Med Virol"},{"key":"10.1053\/j.gastro.2017.01.041_bib17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C","volume":"41","author":"Tanaka","year":"2009","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance","volume":"461","author":"Ge","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2017.01.041_bib19","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","article-title":"IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy","volume":"41","author":"Suppiah","year":"2009","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib20","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.097","article-title":"Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection","volume":"143","author":"Patin","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.01.041_bib21","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jhep.2012.12.024","article-title":"A\u00a0genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region","volume":"58","author":"Urabe","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2017.01.041_bib22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.809","article-title":"Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma","volume":"43","author":"Kumar","year":"2011","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ng.876","article-title":"Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers","volume":"43","author":"Miki","year":"2011","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ng.638","article-title":"Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers","volume":"42","author":"Zhang","year":"2010","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib25","doi-asserted-by":"crossref","first-page":"e28798","DOI":"10.1371\/journal.pone.0028798","article-title":"Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection","volume":"6","author":"Chan","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2017.01.041_bib26","doi-asserted-by":"crossref","first-page":"e1002791","DOI":"10.1371\/journal.pgen.1002791","article-title":"GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers","volume":"8","author":"Li","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng.2483","article-title":"Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma","volume":"45","author":"Jiang","year":"2013","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2017.01.041_bib28","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/hep.26506","article-title":"Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: a longitudinal analysis","volume":"58","author":"Noureddin","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hep.24350","article-title":"Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C","volume":"54","author":"Trepo","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib30","doi-asserted-by":"crossref","first-page":"26372","DOI":"10.1074\/jbc.M203247200","article-title":"Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen","volume":"277","author":"Rattenholl","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib31","doi-asserted-by":"crossref","first-page":"15661","DOI":"10.1074\/jbc.M210588200","article-title":"Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin","volume":"278","author":"Veitch","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib32","doi-asserted-by":"crossref","first-page":"41626","DOI":"10.1074\/jbc.M406630200","article-title":"Bone morphogenetic protein-1\/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis","volume":"279","author":"Ge","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib33","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1074\/jbc.M409841200","article-title":"BMP-1\/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan","volume":"280","author":"Gonzalez","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib34","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1126\/science.271.5247.360","article-title":"Bone morphogenetic protein-1: the type I procollagen C-proteinase","volume":"271","author":"Kessler","year":"1996","journal-title":"Science"},{"key":"10.1053\/j.gastro.2017.01.041_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200606058","article-title":"BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein","volume":"175","author":"Ge","year":"2006","journal-title":"J\u00a0Cell Biol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2017.01.041_bib36","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1038\/sj.cdd.4401163","article-title":"Hepatitis C and\u00a0liver fibrosis","volume":"10","author":"Schuppan","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1053\/j.gastro.2017.01.041_bib37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.46.4.443","article-title":"Is liver fibrosis reversible?","volume":"46","author":"Benyon","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.01.041_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/dbio.1999.9383","article-title":"Mammalian BMP-1\/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis","volume":"213","author":"Scott","year":"1999","journal-title":"Dev Biol"},{"key":"10.1053\/j.gastro.2017.01.041_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/geno.1996.0260","article-title":"Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid\/bone morphogenetic protein-1","volume":"34","author":"Takahara","year":"1996","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2017.01.041_bib40","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/0016-5085(94)90824-9","article-title":"Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis","volume":"107","author":"Aihara","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.01.041_bib41","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/hep.510280512","article-title":"Fibrosis accelerates the development of enzyme-altered lesions in the rat liver","volume":"28","author":"Sakaida","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massague","year":"2008","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2017.01.041_bib43","doi-asserted-by":"crossref","first-page":"19059","DOI":"10.1074\/jbc.272.30.19059","article-title":"Transforming growth factor-beta regulation of bone morphogenetic protein-1\/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes","volume":"272","author":"Lee","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib44","doi-asserted-by":"crossref","first-page":"29014","DOI":"10.1074\/jbc.M111.252585","article-title":"Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3","volume":"286","author":"Kim","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2017.01.041_bib45","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2741\/s348","article-title":"Growth factor pathways in development and progression of hepatocellular carcinoma","volume":"4","author":"Nalesnik","year":"2012","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1053\/j.gastro.2017.01.041_bib46","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1349-7006.2009.01087.x","article-title":"Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma","volume":"100","author":"Amann","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1053\/j.gastro.2017.01.041_bib47","doi-asserted-by":"crossref","first-page":"ra7","DOI":"10.1126\/scisignal.2004612","article-title":"The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin alpha5beta1, p38 MAPK, and matrix metalloproteinases","volume":"7","author":"Odagiri","year":"2014","journal-title":"Sci Signal"},{"key":"10.1053\/j.gastro.2017.01.041_bib48","first-page":"5042","article-title":"High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats","volume":"52","author":"Nakae","year":"1992","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2017.01.041_bib49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hep.1840030118","article-title":"Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis?","volume":"3","author":"Perez Tamayo","year":"1983","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3350\/cmh.2015.21.2.105","article-title":"Hepatitis C virus-induced hepatocellular carcinoma","volume":"21","author":"Goossens","year":"2015","journal-title":"Clin Mol Hepatol"},{"key":"10.1053\/j.gastro.2017.01.041_bib51","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.febslet.2009.12.050","article-title":"Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase","volume":"584","author":"Berry","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2017.01.041_bib52","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/hep.510290439","article-title":"Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysis","volume":"29","author":"Ikeda","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib53","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.510270529","article-title":"Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group","volume":"27","author":"Kasahara","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2017.01.041_bib54","doi-asserted-by":"crossref","first-page":"174","DOI":"10.7326\/0003-4819-131-3-199908030-00003","article-title":"Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy","volume":"131","author":"Yoshida","year":"1999","journal-title":"Ann Intern Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517301300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:15:42Z","timestamp":1758035742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517301300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0016508517301300"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2017.01.041","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2017.01.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}