{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:38:25Z","timestamp":1777531105410,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["BMH4-CT96-0233"],"award-info":[{"award-number":["BMH4-CT96-0233"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["250114"],"award-info":[{"award-number":["250114"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003510","name":"Haridus- ja Teadusministeerium","doi-asserted-by":"publisher","award":["IUT20-43"],"award-info":[{"award-number":["IUT20-43"]}],"id":[{"id":"10.13039\/501100003510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1053\/j.gastro.2017.06.049","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T21:31:42Z","timestamp":1499203902000},"page":"961-970.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Avoidance of Cow's Milk\u2013Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial"],"prefix":"10.1053","volume":"153","author":[{"given":"Mila","family":"Hyytinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkki","family":"Savilahti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvi M.","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"H\u00e4rk\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Ilonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Luopaj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raivo","family":"Uibo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"Vaarala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans K.","family":"\u00c5kerblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K.","family":"\u00c5kerblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Eskola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Haavisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-M.","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Holm C","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-L.","family":"J\u00e4rvenp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Jokisalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-L.","family":"K\u00e4\u00e4r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Kaski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Komulainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Korpela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lautala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Niemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nuuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rantanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Renko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Renlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Salo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Talvitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Uotila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wetterstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hy\u00f6ty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ilonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Klemetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Knip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Kulmala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Paronen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Reunanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Saukkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Savilahti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Savola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Teramo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Vaarala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2017.06.049_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1056\/NEJMoa1313977","article-title":"Risk of pediatric celiac disease according to HLA haplotype and country","volume":"371","author":"Liu","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2017.06.049_bib2","first-page":"7","article-title":"The new epidemiology of celiac disease","volume":"59","author":"Catassi","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2017.06.049_bib3","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1001\/jama.293.19.2343","article-title":"Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease","volume":"293","author":"Norris","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2017.06.049_bib4","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jama.290.13.1721","article-title":"Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies","volume":"290","author":"Ziegler","year":"2003","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2017.06.049_bib5","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1400697","article-title":"Introduction of gluten, HLA status, and the risk of celiac disease in children","volume":"371","author":"Lionetti","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.06.049_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1542\/peds.2014-1787","article-title":"Age at gluten introduction and risk of celiac disease","volume":"135","author":"Aronsson","year":"2015","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2017.06.049_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cgh.2015.09.030","article-title":"Effects of gluten intake on risk of celiac disease: a case-control study on a Swedish birth cohort","volume":"14","author":"Aronsson","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.06.049_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/adc.2005.082016","article-title":"Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies","volume":"91","author":"Akobeng","year":"2006","journal-title":"Arch Dis Child"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2017.06.049_bib9","first-page":"18","article-title":"Early nutrition: prevention of celiac disease?","volume":"59","author":"Schaart","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2017.06.049_bib10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1056\/NEJMoa1404172","article-title":"Randomized feeding intervention in infants at high risk for celiac disease","volume":"371","author":"Vriezinga","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.06.049_bib11","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.1542\/peds.2013-1752","article-title":"Early feeding and risk of celiac disease in a prospective birth cohort","volume":"132","author":"St\u00f8rdal","year":"2013","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2017.06.049_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10620-005-2574-0","article-title":"Intestinal permeability in long-term follow-up of patients with celiac disease on a gluten-free diet","volume":"50","author":"Duerksen","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2017.06.049_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1398-9995.1981.tb04101.x","article-title":"Cow\u2019s milk allergy","volume":"36","author":"Savilahti","year":"1981","journal-title":"Allergy"},{"key":"10.1053\/j.gastro.2017.06.049_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1399-5448.2008.00413.x","article-title":"Enchanced levels of cow\u2019s milk antibodies in infancy in children who develop type 1 diabetes later in childhood","volume":"9","author":"Luopaj\u00e4rvi","year":"2008","journal-title":"Pediatr Diabetes"},{"key":"10.1053\/j.gastro.2017.06.049_bib15","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2337\/diacare.16.7.984","article-title":"Increased levels of cow\u2019s milk and beta-lactoglobulin antibodies in young children with newly diagnosed IDDM","volume":"16","author":"Savilahti","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2017.06.049_bib16","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1056\/NEJMoa1004809","article-title":"Dietary intervention in infancy and later signs of beta-cell autoimmunity","volume":"363","author":"Knip","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.06.049_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1651-2227.2010.02107.x","article-title":"Feasibility and compliance in a nutritional primary prevention pilot trial in infants at increased risk for type 1 diabetes","volume":"100","author":"Virtanen","year":"2011","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.gastro.2017.06.049_bib18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2337\/diacare.19.8.795","article-title":"Rapid HLA-DQB1 genotyping for four alleles in the assessment of the risk for IDDM in the Finnish population","volume":"19","author":"Ilonen","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2017.06.049_bib19","article-title":"Triple-label hybridization assay for type 1 diabetes related HLA alleles","volume":"18","author":"Sj\u00f6roos","year":"1995","journal-title":"Biotechniques"},{"key":"10.1053\/j.gastro.2017.06.049_bib20","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s001250051067","article-title":"Autoantibodies associated with type I diabetes mellitus persist after diagnosis in children","volume":"41","author":"Savola","year":"1998","journal-title":"Diabetologia"},{"key":"10.1053\/j.gastro.2017.06.049_bib21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1203\/01.PDR.0000100905.41131.3F","article-title":"Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of type 1 diabetes","volume":"55","author":"Hoppu","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2017.06.049_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ajg.2008.8","article-title":"A\u00a0report on the International Transglutaminase Autoantibody Workshop for celiac disease","volume":"104","author":"Li","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.06.049_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2249.2007.03487.x","article-title":"Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing celiac disease","volume":"150","author":"Ankelo","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2017.06.049_bib24","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3748\/wjg.v12.i9.1430","article-title":"Screening for celiac disease in Down\u2019s syndrome patients revealed cases of subtotal villous atrophy without typical for celiac disease HLA-DQ and tissue transglutaminase antibodies","volume":"12","author":"Uibo","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.06.049_bib25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MPG.0000000000001105","article-title":"Gluten introduction and the risk of coeliac disease: a position paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition","volume":"62","author":"Szajewska","year":"2016","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2017.06.049_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/adc.46.249.665","article-title":"IgA deficiency in children. A clinical study with special reference to intestinal findings","volume":"46","author":"Savilahti","year":"1971","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.gastro.2017.06.049_bib27","first-page":"299","article-title":"Autoimmunity in selective IgA deficiency: relationship to anti-bovine protein antibodies, circulating immune complexes and clinical disease","volume":"45","author":"Cunningham-Rundles","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2017.06.049_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2249.2007.03298.x","article-title":"Mucosal reactivity to cow\u2019s milk protein in coeliac diasese","volume":"147","author":"Kristj\u00e1nsson","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2017.06.049_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.32.7.749","article-title":"Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs","volume":"32","author":"Hall","year":"1991","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.06.049_bib30","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gutjnl-2011-300327","article-title":"Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis","volume":"61","author":"Heyman","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.06.049_bib31","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1111\/j.1572-0241.2007.01360.x","article-title":"Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study","volume":"102","author":"Simell","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.06.049_bib32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/MPG.0b013e31821c974f","article-title":"Spontaneous negative seroconversion of endomysial antibodies does not exclude subsequent celiac disease","volume":"53","author":"Kurppa","year":"2011","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517358626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517358626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:42:57Z","timestamp":1762162977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517358626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0016508517358626"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2017.06.049","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Avoidance of Cow's Milk\u2013Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2017.06.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the AGA Institute","name":"copyright","label":"Copyright"}]}}