{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:50:44Z","timestamp":1793346644106,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1053\/j.gastro.2017.09.006","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T05:32:04Z","timestamp":1505194324000},"page":"154-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":219,"title":["Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants"],"prefix":"10.1053","volume":"154","author":[{"given":"Huey-Huey","family":"Chua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chieh","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ling","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Luen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chia","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Hsing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2017.09.006_bib1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2017.09.006_bib2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.chom.2015.04.007","article-title":"Microbiota in allergy and asthma and the emerging relationship with the gut microbiome","volume":"17","author":"Fujimura","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1053\/j.gastro.2017.09.006_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1939-4551-7-12","article-title":"Allergic diseases and asthma: a global public health concern and a call to action","volume":"7","author":"Pawankar","year":"2014","journal-title":"World Allergy Organ J"},{"key":"10.1053\/j.gastro.2017.09.006_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/gut.2006.100164","article-title":"Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study","volume":"56","author":"Penders","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.09.006_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2180-12-95","article-title":"Unbalance of intestinal microbiota in atopic children","volume":"12","author":"Candela","year":"2012","journal-title":"BMC Microbiol"},{"key":"10.1053\/j.gastro.2017.09.006_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaci.2007.07.061","article-title":"Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants","volume":"121","author":"Gore","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2466-8-19","article-title":"Early intestinal Bacteroides fragilis colonisation and development of asthma","volume":"8","author":"Vael","year":"2008","journal-title":"BMC Pulm Med"},{"key":"10.1053\/j.gastro.2017.09.006_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1399-3038.2005.00371.x","article-title":"Comparison of fecal microflora in children with atopic eczema\/dermatitis syndrome according to IgE sensitization to food","volume":"17","author":"Kendler","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jaci.2007.09.011","article-title":"Reduced diversity in the early fecal microbiota of infants with atopic eczema","volume":"121","author":"Wang","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaci.2007.05.018","article-title":"Gut microbiota and development of atopic eczema in 3 European birth cohorts","volume":"120","author":"Adlerberth","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib11","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1365-2222.2011.03817.x","article-title":"Temporal variations in early gut microbial colonization are associated with allergen-specific immunoglobulin E but not atopic eczema at 2 years of age","volume":"41","author":"Storro","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/j.gastro.2017.09.006_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1574-695X.2011.00872.x","article-title":"Aberrant structures of fecal bacterial community in allergic infants profiled by 16S rRNA gene pyrosequencing","volume":"63","author":"Nakayama","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1053\/j.gastro.2017.09.006_bib13","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jaci.2016.01.010","article-title":"Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis","volume":"137","author":"Jones","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib14","first-page":"187","article-title":"Lysed enterococcus faecalis FK-23 oral administration reveals inverse association between tuberculin responses and clinical manifestations in perennial allergic rhinitis: a pilot study","volume":"14","author":"Shimada","year":"2004","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000323893","article-title":"Faecal microbiota and short-chain fatty acid levels in faeces from infants with cow's milk protein allergy","volume":"156","author":"Thompson-Chagoyan","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib16","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/AEM.00003-14","article-title":"Altered fecal microbiota composition associated with food allergy in infants","volume":"80","author":"Ling","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1053\/j.gastro.2017.09.006_bib17","doi-asserted-by":"crossref","first-page":"e23031","DOI":"10.1371\/journal.pone.0023031","article-title":"Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity","volume":"6","author":"Johansson","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2017.09.006_bib18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2222.2007.02676.x","article-title":"Differences in the composition of intestinal Bifidobacterium species and the development of allergic diseases in infants in rural Japan","volume":"37","author":"Suzuki","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/j.gastro.2017.09.006_bib19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/pai.12522","article-title":"Alterations in the gut microbiotas of children with food sensitization in early life","volume":"27","author":"Chen","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib20","first-page":"69","article-title":"Phylogenetic analysis by 16S ribosomal DNA sequence comparison reveals two unrelated groups of species within the genus Ruminococcus","volume":"129","author":"Rainey","year":"1995","journal-title":"FEMS Microbiol Lett"},{"key":"10.1053\/j.gastro.2017.09.006_bib21","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1099\/ijs.0.65208-0","volume":"58","author":"Liu","year":"2008","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1053\/j.gastro.2017.09.006_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.intimp.2014.05.034","article-title":"Key mediators in the immunopathogenesis of allergic asthma","volume":"23","author":"Hall","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1053\/j.gastro.2017.09.006_bib23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2017.09.006_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib25","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/intimm\/dxn060","article-title":"IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells","volume":"20","author":"Smithgall","year":"2008","journal-title":"Int Immunol"},{"key":"10.1053\/j.gastro.2017.09.006_bib26","series-title":"The Prokaryotes\u2014A Handbook on the Biology of Bacteria. Archea and bacteria: Firmicutes, Acitomycetes","author":"Dworkin","year":"2006"},{"key":"10.1053\/j.gastro.2017.09.006_bib27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/gbe\/evu050","article-title":"A\u00a0phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria","volume":"6","author":"Meehan","year":"2014","journal-title":"Genome Biol Evol"},{"key":"10.1053\/j.gastro.2017.09.006_bib28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2017.09.006_bib29","doi-asserted-by":"crossref","first-page":"307ra152","DOI":"10.1126\/scitranslmed.aab2271","article-title":"Early infancy microbial and metabolic alterations affect risk of childhood asthma","volume":"7","author":"Arrieta","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.gastro.2017.09.006_bib30","doi-asserted-by":"crossref","first-page":"e104114","DOI":"10.1371\/journal.pone.0104114","article-title":"Toll-like receptor ligands LPS and poly (I: C) exacerbate airway hyperresponsiveness in a model of airway allergy in mice, independently of inflammation","volume":"9","author":"Starkhammar","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2017.09.006_bib31","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/gut.2003.026252","article-title":"Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport","volume":"53","author":"Menard","year":"2004","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.09.006_bib32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.2010.223263","article-title":"Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives","volume":"60","author":"Joossens","year":"2011","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.09.006_bib33","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1053\/j.gastro.2010.08.049","article-title":"A\u00a0pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes","volume":"139","author":"Willing","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.09.006_bib34","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/ajg.2010.281","article-title":"Mucolytic bacteria with increased prevalence in IBD mucosa augment in\u00a0vitro utilization of mucin by other bacteria","volume":"105","author":"Png","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.09.006_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/gutjnl-2015-309398","article-title":"Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC","volume":"66","author":"Machiels","year":"2017","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.09.006_bib36","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1128\/JCM.03382-12","article-title":"Two cases of Ruminococcus gnavus bacteremia associated with diverticulitis","volume":"51","author":"Hansen","year":"2013","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1053\/j.gastro.2017.09.006_bib37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1091\/mbc.e15-10-0724","article-title":"Epithelial Sel1L is required for the maintenance of intestinal homeostasis","volume":"27","author":"Sun","year":"2016","journal-title":"Mol Biol Cell"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2017.09.006_bib38","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.1006451107","article-title":"The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions","volume":"108","author":"Johansson","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2017.09.006_bib39","doi-asserted-by":"crossref","first-page":"e76341","DOI":"10.1371\/journal.pone.0076341","article-title":"Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent","volume":"8","author":"Crost","year":"2013","journal-title":"PLoS One"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517361437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517361437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:17:52Z","timestamp":1758035872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517361437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0016508517361437"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2017.09.006","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2017.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}