{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:02:21Z","timestamp":1794013341414,"version":"4.8.0"},"reference-count":181,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1053\/j.gastro.2017.11.279","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T01:39:35Z","timestamp":1513906775000},"page":"1140-1171.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":424,"title":["Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut\u2212Brain Interaction): A Rome Foundation Working Team Report"],"prefix":"10.1053","volume":"154","author":[{"given":"Douglas A.","family":"Drossman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Szigethy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"T\u00f6rnblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Van Oudenhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2017.11.279_bib1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/j.gastro.2005.04.020","article-title":"Functional GI disorders: what's in a name?","volume":"128","author":"Drossman","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV","volume":"148","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib3","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM197306142882405","article-title":"Medical assessment by a delphi group opinion technic","volume":"298","author":"Milholland","year":"1973","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib4","first-page":"44","article-title":"The WTR's, the Delphic Oracle\u00a0and the Roman Conclaves","volume":"4","author":"Torsoli","year":"1991","journal-title":"Gastroenterol Int"},{"key":"10.1053\/j.gastro.2017.11.279_bib5","series-title":"Essential Psychopharmacology: Neuroscientific Basis and Practical Applications","author":"Stahl","year":"2008"},{"key":"10.1053\/j.gastro.2017.11.279_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/nmo.12509","article-title":"Centrally targeted pharmacotherapy for chronic abdominal pain","volume":"27","author":"T\u00f6rnblom","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2017.11.279_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-med-012309-103958","article-title":"The brain\u2013gut axis in abdominal pain syndromes","volume":"62","author":"Mayer","year":"2011","journal-title":"Annu Rev Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrgastro.2015.121","article-title":"Towards a systems view of IBS","volume":"12","author":"Mayer","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib9","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2017.11.279_bib10","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1053\/j.gastro.2016.02.027","article-title":"Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders","volume":"150","author":"Van Oudenhove","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1431","article-title":"State\u2013dependent opioid control of pain","volume":"5","author":"Fields","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2017.11.279_bib12","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/1073858408317242","article-title":"Cognitive role of neurogenesis in depression and antidepressant treatment","volume":"14","author":"Perera","year":"2008","journal-title":"Neuroscientist"},{"key":"10.1053\/j.gastro.2017.11.279_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0006-3223(99)00009-8","article-title":"Does stress damage the brain?","volume":"45","author":"Bremner","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/PSY.0b013e31818d1e02","article-title":"Patients with pain disorder show gray-matter loss in pain-processing structures: a voxel-based morphometric study","volume":"71","author":"Valet","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-5618.2008.00435.x","article-title":"Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder","volume":"10","author":"Konarski","year":"2008","journal-title":"Bipolar Disord"},{"key":"10.1053\/j.gastro.2017.11.279_bib16","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1053\/j.gastro.2009.12.043","article-title":"Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors","volume":"138","author":"Blankstein","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cgh.2011.11.024","article-title":"Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis","volume":"10","author":"Frokjaer","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1017\/S1461145708009309","article-title":"A\u00a0systematic review and meta-analysis of clinical studies on major depression and BDNF levels: Implications for the role of neuroplasticity in depression","volume":"11","author":"Brunoni","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib19","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1176\/ps.2008.59.10.1121","article-title":"Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants","volume":"59","author":"Hansen","year":"2008","journal-title":"Psychiatr Serv"},{"key":"10.1053\/j.gastro.2017.11.279_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0140-6736(03)12599-8","article-title":"Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review","volume":"361","author":"Geddes","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2017.11.279_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00296-016-3468-5","article-title":"Comparative efficacy and tolerability of duloxetine, pregabalin, and milnacipran for the treatment of fibromyalgia: a Bayesian network meta-analysis of randomized controlled trials","volume":"36","author":"Lee","year":"2016","journal-title":"Rheumatol Int"},{"key":"10.1053\/j.gastro.2017.11.279_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007115.pub3","article-title":"Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia","author":"Lunn","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010292","article-title":"Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome","author":"Hauser","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib24","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","author":"Moore","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphar.2011.00028","article-title":"Alpha 2 delta (alpha(2)delta) ligands, gabapentin and pregabalin: what is the evidence for potential use of these ligands in irritable bowel syndrome","volume":"2","author":"Gale","year":"2011","journal-title":"Front Pharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib26","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1097\/ALN.0000000000000017","article-title":"Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients","volume":"119","author":"Harris","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1053\/j.gastro.2017.11.279_bib27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ajg.2017.57","article-title":"Central neuromodulators for treating functional GI disorders: a primer","volume":"112","author":"Sobin","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib29","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1572-0241.2008.02021.x","article-title":"Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial","volume":"103","author":"Bouras","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib30","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3748\/wjg.v19.i26.4214","article-title":"Effect of amitriptyline on gastrointestinal function and brain\u2013gut peptides: a double-blind trial","volume":"19","author":"Huang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2982.2007.01029.x","article-title":"The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: a double-blind, randomized, placebo-controlled trial","volume":"20","author":"Choung","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2017.11.279_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2036.1994.tb00273.x","article-title":"Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome","volume":"8","author":"Gorard","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF02063948","article-title":"Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome","volume":"40","author":"Gorard","year":"1995","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2017.11.279_bib34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2036.2004.02151.x","article-title":"Differential effects of two types of antidepressants, amitriptyline and fluoxetine, on anorectal motility and visceral perception","volume":"20","author":"Siproudhis","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3959(98)00031-1","article-title":"Effects of tricyclic antidepressants on mechanosensitive pelvic nerve afferent fibers innervating the rat colon","volume":"76","author":"Su","year":"1998","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2017.11.279_bib36","first-page":"G460","article-title":"Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans","volume":"275","author":"Gorelick","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2017.11.279_bib37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/gut.42.6.807","article-title":"Imipramine decreases oesophageal pain perception in human male volunteers","volume":"42","author":"Peghini","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.11.279_bib38","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJM199405193302003","article-title":"Imipramine in patients with chest pain despite normal coronary angiograms","volume":"330","author":"Cannon","year":"1994","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib39","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1572-0241.1998.00160.x","article-title":"Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia","volume":"93","author":"Mertz","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib40","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gut.2004.047423","article-title":"Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome","volume":"54","author":"Morgan","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.11.279_bib41","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2036.2008.03918.x","article-title":"Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome","volume":"29","author":"Thoua","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2036.2006.02772.x","article-title":"Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: a double-blind, placebo-controlled study","volume":"23","author":"Broekaert","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2036.2003.01469.x","article-title":"Influence of the selective serotonin re\u2013uptake inhibitor, paroxetine, on gastric sensorimotor function in humans","volume":"17","author":"Tack","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib44","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2036.2010.04522.x","article-title":"The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers","volume":"33","author":"Janssen","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib45","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2036.1994.tb00315.x","article-title":"Inhibition of 5-hydroxytryptamine re-uptake impairs human gall-bladder emptying","volume":"8","author":"Gorard","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib46","doi-asserted-by":"crossref","first-page":"G130","DOI":"10.1152\/ajpgi.00266.2002","article-title":"Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health","volume":"284","author":"Chial","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2017.11.279_bib47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2036.2006.02724.x","article-title":"Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man","volume":"23","author":"Tack","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib48","article-title":"Effects of serotonin agonists buspirone and citalopram on multimodal esophageal stimulation in healthy volunteers","author":"Boeckxstaens","year":"2013","journal-title":"Acta Gastroenterol Belg"},{"key":"10.1053\/j.gastro.2017.11.279_bib49","first-page":"1259","article-title":"The effect of acute serotonergic modulation on rectal motor function in diarrhea-predominant irritable bowel syndrome and healthy controls","volume":"24","author":"van Nieuwenhoven","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1542-3565(03)70039-1","article-title":"The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable\u00a0bowel syndrome: a double blind, randomized, placebo-controlled study","volume":"1","author":"Kuiken","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1542-3565(03)70038-X","article-title":"Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans","volume":"1","author":"Chial","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/15563650701517731","article-title":"Gastric bezoar following venlafaxine overdose","volume":"45","author":"Djogovic","year":"2007","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1053\/j.gastro.2017.11.279_bib53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.apha.2015.11.002","article-title":"The pharmacology of visceral pain","volume":"75","author":"Johnson","year":"2016","journal-title":"Adv Pharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2982.2011.01671.x","article-title":"Effect of mianserin on gastric sensorimotor function and gastric emptying: a randomized, placebo-controlled, double-blind, crossover study in healthy volunteers","volume":"23","author":"Janssen","year":"2011","journal-title":"Neurogastroenterol Motil"},{"issue":"12","key":"10.1053\/j.gastro.2017.11.279_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13146","article-title":"The effect of mirtazapine on gastric accommodation, gastric sensitiity to distention and nutrient tolerance in healthy subjects","volume":"29","author":"Carbone","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2017.11.279_bib56","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cgh.2015.09.043","article-title":"Mirtazapine in patients with functional dyspepsia patients and weight loss","volume":"14","author":"Tack","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib57","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1442-2050.2011.01275.x","article-title":"Effect of buspirone, a 5-HT1A receptor agonist, on esophageal motility in healthy volunteers","volume":"25","author":"Di Stefano","year":"2012","journal-title":"Dis Esophagus"},{"key":"10.1053\/j.gastro.2017.11.279_bib58","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1365-2036.2008.03849.x","article-title":"Influence of buspirone on gastric sensorimotor function in man","volume":"28","author":"Van Oudenhove","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib59","unstructured":"Corsetti M, Meleine M, Vos R, et\u00a0al. Effect of the 5-HT1A agonist buspirone on rectal and colonic sensorimotor function during pressure- and volume-controlled distentions in man. 2016."},{"key":"10.1053\/j.gastro.2017.11.279_bib60","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2036.2000.00742.x","article-title":"Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis","volume":"14","author":"Mansi","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1046\/j.1365-2036.2002.01180.x","article-title":"Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia","volume":"16","author":"Distrutti","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib62","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1365-2036.2005.02685.x","article-title":"Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel\u00a0syndrome","volume":"22","author":"Lee","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib63","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1136\/gut.2006.110858","article-title":"Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome","volume":"56","author":"Houghton","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.11.279_bib64","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1176\/appi.ajp.2009.09030312","article-title":"Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials","volume":"166","author":"Nelson","year":"2009","journal-title":"Am J Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/0706743715620411","article-title":"Combining antidepressants in acute treatment of depression: a meta-analysis of 38 studies including 4511 patients","volume":"61","author":"Henssler","year":"2016","journal-title":"Can J Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib66","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s10620-009-0723-6","article-title":"Atypical antipsychotic Quetiapine in the management of severe, refractory functional gastrointestinal disorders","volume":"54","author":"Grover","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2017.11.279_bib67","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2016.1464","article-title":"CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016","volume":"315","author":"Dowell","year":"2016","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2017.11.279_bib68","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrgastro.2014.53","article-title":"Diagnosis and treatment of narcotic bowel syndrome","volume":"11","author":"Kurlander","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib69","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1053\/j.gastro.2016.02.034","article-title":"Centrally mediated disorders of gastrointestinal pain","volume":"148","author":"Keefer","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2017.141","article-title":"Opioid misuse in gastroenterology and nonopioid management of abdominal pain","author":"Szigethy","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib71","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11894-014-0410-4","article-title":"Narcotic bowel syndrome and opiod induced constipation","volume":"16","author":"Szigethy","year":"2014","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1053\/j.gastro.2017.11.279_bib72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0016-5085(03)00669-3","article-title":"Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders","volume":"125","author":"Drossman","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib73","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1365-2036.2008.03633.x","article-title":"Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome","volume":"27","author":"Vahedi","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib74","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.cgh.2008.11.014","article-title":"Not all side effects associated with tricyclic antidepressant therapy are true side effects","volume":"7","author":"Thiwan","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011790","article-title":"Milnacipran for pain in fibromyalgia in adults","author":"Cording","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib76","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1468-1331.2009.02648.x","article-title":"A\u00a0double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain","volume":"16","author":"Skljarevski","year":"2009","journal-title":"Eur J Neurol"},{"key":"10.1053\/j.gastro.2017.11.279_bib77","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1097\/BRS.0000000000001707","article-title":"Randomized, double-blind, placebo-controlled phase III trial of duloxetine monotherapy in Japanese patients with chronic low back pain","volume":"41","author":"Konno","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1053\/j.gastro.2017.11.279_bib78","first-page":"1282","article-title":"Duloxetine versus placebo in patients with chronic low back pain: a 12-week, fixed-dose, randomized, double-blind trial","volume":"11","author":"Skljarevski","year":"2010","journal-title":"J\u00a0Pain"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2017.11.279_bib79","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1002\/hup.622","article-title":"A\u00a0double-blind placebo-controlled trial of milnacipran in the treatment of fibromyalgia","volume":"19","author":"Vitton","year":"2004","journal-title":"Hum Psychopharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib80","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1468-2982.2007.01300.x","article-title":"A\u00a0randomized, double-blind, placebo-controlled study of venlafaxine XR in out-patients with tension-type headache","volume":"27","author":"Zissis","year":"2007","journal-title":"Cephalalgia"},{"key":"10.1053\/j.gastro.2017.11.279_bib81","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cgh.2008.02.051","article-title":"Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial","volume":"6","author":"van Kerkhoven","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib82","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/hup.1038","article-title":"Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study","volume":"24","author":"Brennan","year":"2009","journal-title":"Hum Psychopharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib83","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4088\/JCP.v59n1002","article-title":"Effects of venlafaxine on blood pressure: a meta-analysis of original data from 3744 depressed patients","volume":"59","author":"Thase","year":"1998","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib84","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1124\/jpet.302.3.1013","article-title":"Pregabalin (CI-1008) inhibits the trinitrobenzene sulfonic acid-induced chronic colonic allodynia in the rat","volume":"302","author":"Diop","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib85","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-3565(24)38882-2","article-title":"Antinociceptive effect of pregabalin in septic shock-induced rectal hypersensitivity in rats","volume":"295","author":"Eutamene","year":"2000","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib86","first-page":"631","article-title":"Use of preoperative gabapentin significantly reduces postoperative opioid consumption: a meta-analysis","volume":"9","author":"Arumugam","year":"2016","journal-title":"J\u00a0Pain Res"},{"key":"10.1053\/j.gastro.2017.11.279_bib87","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.biopsych.2006.06.015","article-title":"Resolution of sleepiness and fatigue in major depressive disorder: a comparison of bupropion and the selective serotonin reuptake inhibitors","volume":"60","author":"Papakostas","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib88","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4088\/JCP.v62n0608","article-title":"Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study","volume":"62","author":"Appelberg","year":"2001","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib89","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1586\/ecp.11.17","article-title":"Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain","volume":"4","author":"Zhou","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib90","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.pain.2014.09.004","article-title":"Efficacy of memantine in the treatment of fibromyalgia: a double-blind, randomised, controlled trial with 6-month follow-up","volume":"155","author":"Olivan-Blazquez","year":"2014","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2017.11.279_bib91","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/15360288.2016.1241334","article-title":"Memantine for the Treatment of phantom limb pain: a systematic review","volume":"30","author":"Loy","year":"2016","journal-title":"J\u00a0Pain Palliat Care Pharmacother"},{"key":"10.1053\/j.gastro.2017.11.279_bib92","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1177\/1060028014548872","article-title":"Memantine for the prevention of primary headache disorders","volume":"48","author":"Huang","year":"2014","journal-title":"Ann Pharmacother"},{"key":"10.1053\/j.gastro.2017.11.279_bib93","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0140-6736(00)02033-X","article-title":"Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial","volume":"355","author":"Camilleri","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2017.11.279_bib94","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1572-0241.2005.40365.x","article-title":"A\u00a0dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS","volume":"100","author":"Chang","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib95","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJMoa1505180","article-title":"Eluxadoline for irritable bowel syndrome with diarrhea","volume":"374","author":"Lembo","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib96","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1053\/j.gastro.2010.08.041","article-title":"Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation","volume":"139","author":"Johnston","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib97","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/ajg.2012.255","article-title":"A\u00a012-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation","volume":"107","author":"Rao","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib98","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1572-0241.2004.04127.x","article-title":"Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet: a double-blind, placebo-controlled trial","volume":"99","author":"Tabas","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib99","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2036.2005.02566.x","article-title":"The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study","volume":"22","author":"Vahedi","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib100","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.3748\/wjg.v19.i30.4958","article-title":"Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain","volume":"19","author":"Park","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib101","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1067\/mhj.2000.108514","article-title":"Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin","volume":"140","author":"Varia","year":"2000","journal-title":"Am Heart J"},{"key":"10.1053\/j.gastro.2017.11.279_bib102","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/ajg.2010.82","article-title":"Efficacy of venlafaxine for symptomatic relief in young adult patients with functional chest pain: a randomized, double-blind, placebo-controlled, crossover trial","volume":"105","author":"Lee","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib103","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4088\/JCP.v64n1013","article-title":"Comparative effects of mirtazapine and fluoxetine on sleep physiology measures in patients with major depression and insomnia","volume":"64","author":"Winokur","year":"2003","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib104","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2013.08.048","article-title":"Olanzapine for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting","volume":"722","author":"Navari","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib105","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-2036.2011.04775.x","article-title":"Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study","volume":"34","author":"Braak","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib106","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","article-title":"Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study","volume":"149","author":"Talley","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib107","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/ajg.2017.154","article-title":"ACG and CAG Clinical Guideline: management of dyspepsia","volume":"112","author":"Moayyedi","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib108","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib109","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/MEG.0b013e328355638f","article-title":"The management of cyclic vomiting syndrome: a systematic review","volume":"24","author":"Lee","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cgh.2006.10.004","article-title":"Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: a case series","volume":"5","author":"Clouse","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib111","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1056\/NEJMoa052964","article-title":"Medication augmentation after the failure of SSRIs for depression","volume":"354","author":"Trivedi","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib112","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1001\/jama.285.17.2208","article-title":"Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination","volume":"285","author":"Holroyd","year":"2001","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1053\/j.gastro.2017.11.279_bib113","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/01674820209074672","article-title":"A\u00a0randomized comparison of psychological (cognitive behavior therapy), medical (fluoxetine) and combined treatment for women with premenstrual dysphoric disorder","volume":"23","author":"Hunter","year":"2002","journal-title":"J\u00a0Psychosom Obstet Gynaecol"},{"key":"10.1053\/j.gastro.2017.11.279_bib114","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/art.38228","article-title":"Quetiapine fumarate extended-release for the treatment of major depression with comorbid fibromyalgia syndrome: a double-blind, randomized, placebo\u2013controlled study","volume":"66","author":"McIntyre","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib115","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1007\/s00213-013-3422-0","article-title":"Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial","volume":"231","author":"Calandre","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1053\/j.gastro.2017.11.279_bib116","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0006-8993(02)03570-9","article-title":"Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism","volume":"956","author":"Ichikawa","year":"2002","journal-title":"Brain Res"},{"key":"10.1053\/j.gastro.2017.11.279_bib117","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2165\/11597130-000000000-00000","article-title":"The role of antipsychotics in the management of fibromyalgia","volume":"26","author":"Calandre","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1053\/j.gastro.2017.11.279_bib118","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1038\/sj.npp.1301646","article-title":"N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity","volume":"33","author":"Jensen","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2017.11.279_bib119","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib120","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ajg.2014.148","article-title":"Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis","volume":"109","author":"Ford","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib121","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.3748\/wjg.v19.i46.8605","article-title":"Cognitive-behavioral therapy for the management of irritable bowel syndrome","volume":"19","author":"Tang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib122","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cpr.2016.11.001","article-title":"Comparative efficacy of psychological therapies for improving mental health and daily functioning in irritable bowel syndrome: a systematic review and meta-analysis","volume":"51","author":"Laird","year":"2017","journal-title":"Clin Psychol Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib123","doi-asserted-by":"crossref","first-page":"549308","DOI":"10.1155\/2015\/549308","article-title":"Psychological therapies in patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"2015","author":"Altayar","year":"2015","journal-title":"Gastroenterol Res Pract"},{"key":"10.1053\/j.gastro.2017.11.279_bib124","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cgh.2012.10.031","article-title":"Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist","volume":"11","author":"Palsson","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib125","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/nrdp.2016.14","article-title":"Irritable bowel syndrome","volume":"2","author":"Enck","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1053\/j.gastro.2017.11.279_bib126","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5056\/jnm.2014.20.2.152","article-title":"The efficacy of hypnotherapy in the treatment of irritable bowel syndrome: a systematic review and meta-analysis","volume":"20","author":"Lee","year":"2014","journal-title":"J\u00a0Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2017.11.279_bib127","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005110.pub2","article-title":"Hypnotherapy for treatment of irritable bowel syndrome","author":"Webb","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2017.11.279_bib128","doi-asserted-by":"crossref","first-page":"140724","DOI":"10.1155\/2014\/140724","article-title":"Mindfulness-based therapies in the treatment of functional gastrointestinal disorders: a meta-analysis","volume":"2014","author":"Aucoin","year":"2014","journal-title":"Evid Based Complement\u00a0Alternat Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib129","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3999(03)00076-X","article-title":"Cognitive change in patients undergoing hypnotherapy for irritable bowel syndrome","volume":"56","author":"Gonsalkorale","year":"2004","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1053\/j.gastro.2017.11.279_bib130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/nmo.12474","article-title":"The potential role of behavioral therapies in the management of centrally mediated abdominal pain","volume":"27","author":"Keefer","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2017.11.279_bib131","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123861","article-title":"Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease","volume":"10","author":"Kuo","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2017.11.279_bib132","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/apt.13145","article-title":"Hypnotherapy for irritable bowel syndrome: an audit of one thousand adult patients","volume":"41","author":"Miller","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib133","doi-asserted-by":"crossref","first-page":"359","DOI":"10.15403\/jgld.2014.1121.253.ibs","article-title":"Psychological interventions for irritable bowel syndrome","volume":"25","author":"Surdea-Blaga","year":"2016","journal-title":"J\u00a0Gastrointestin Liver Dis"},{"key":"10.1053\/j.gastro.2017.11.279_bib134","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/00029157.2015.1039114","article-title":"Hypnosis treatment of gastrointestinal disorders: a comprehensive review of the empirical evidence","volume":"58","author":"Palsson","year":"2015","journal-title":"Am J Clin Hypn"},{"key":"10.1053\/j.gastro.2017.11.279_bib135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3109\/00365521.2012.658858","article-title":"Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome","volume":"47","author":"Lindfors","year":"2012","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib136","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jpsychores.2010.10.004","article-title":"Pathways connecting cognitive behavioral therapy and change in bowel symptoms of IBS","volume":"70","author":"Jones","year":"2011","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1053\/j.gastro.2017.11.279_bib137","first-page":"115","article-title":"Gut-directed hypnotherapy for irritable bowel syndrome: piloting a primary care-based randomised controlled trial","volume":"56","author":"Roberts","year":"2006","journal-title":"Br J Gen Pract"},{"key":"10.1053\/j.gastro.2017.11.279_bib138","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cgh.2015.09.027","article-title":"A\u00a0comprehensive self-management irritable bowel syndrome program produces sustainable changes in behavior after 1 year","volume":"14","author":"Zia","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib139","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.brat.2009.05.002","article-title":"Brief cognitive-behavioral internet therapy for irritable bowel syndrome","volume":"47","author":"Hunt","year":"2009","journal-title":"Behav Res Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib140","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/ajg.2011.139","article-title":"Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: a randomized trial","volume":"106","author":"Ljotsson","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib141","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ajg.2016.503","article-title":"Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome: a randomized controlled trial","volume":"112","author":"Bonnert","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib142","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ctcp.2013.01.001","article-title":"Nurse-led hypnotherapy: an innovative approach to irritable bowel syndrome","volume":"19","author":"Bremner","year":"2013","journal-title":"Complement Ther Clin Pract"},{"key":"10.1053\/j.gastro.2017.11.279_bib143","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/00029157.2015.1030492","article-title":"Nurse-administered, gut-directed hypnotherapy in IBS: efficacy and factors predicting a positive response","volume":"58","author":"Lovdahl","year":"2015","journal-title":"Am J Clin Hypn"},{"key":"10.1053\/j.gastro.2017.11.279_bib144","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/JCP.0000000000000263","article-title":"Duration of initial antidepressant treatment and subsequent relapse of major depression","volume":"35","author":"Baldessarini","year":"2015","journal-title":"J\u00a0Clin Psychopharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib145","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1136\/gut.52.11.1623","article-title":"Long term benefits of hypnotherapy for irritable bowel syndrome","volume":"52","author":"Gonsalkorale","year":"2003","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2017.11.279_bib146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychores.2014.03.006","article-title":"Cognitive-behavioral therapy for irritable bowel syndrome: a meta-analysis","volume":"77","author":"Li","year":"2014","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1053\/j.gastro.2017.11.279_bib147","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1038\/ctg.2016.69","article-title":"Psychological interventions for irritable bowel syndrome and inflammatory bowel diseases","volume":"8","author":"Ballou","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib148","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(16)00161-6","article-title":"Use of and barriers to access to opioid analgesics: a worldwide, regional, and national study","volume":"387","author":"Berterame","year":"2016","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2017.11.279_bib149","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/j.1532-2149.2014.496.x","article-title":"Changes in trends and pattern of strong opioid prescribing in primary care","volume":"18","author":"Zin","year":"2014","journal-title":"Eur J Pain"},{"key":"10.1053\/j.gastro.2017.11.279_bib150","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4088\/JCP.10com06560","article-title":"A\u00a0national epidemic of unintentional prescription opioid overdose deaths: how physicians can help control it","volume":"72","author":"Paulozzi","year":"2011","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib151","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.15585\/mmwr.mm655051e1","article-title":"Increases in drug and\u00a0opioid-involved overdose deaths\u2014United States, 2010\u20132015","volume":"65","author":"Rudd","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1053\/j.gastro.2017.11.279_bib152","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMra1508490","article-title":"Nonmedical prescription-opioid use and heroin use","volume":"374","author":"Compton","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib153","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1111\/add.13491","article-title":"Non-medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study","volume":"111","author":"Banerjee","year":"2016","journal-title":"Addiction"},{"key":"10.1053\/j.gastro.2017.11.279_bib154","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1056\/NEJMsa1406143","article-title":"Trends in opioid analgesic abuse and mortality in the United States","volume":"372","author":"Dart","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib155","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.cgh.2007.06.013","article-title":"The narcotic bowel syndrome: clinical features, pathophysiology, and management","volume":"5","author":"Grunkemeier","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib156","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4088\/JCP.15m10386","article-title":"Nonmedical prescription opioid use and DSM-5 nonmedical prescription opioid use disorder in the United States","volume":"77","author":"Saha","year":"2016","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib157","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1526-4637.2011.01260.x","article-title":"A\u00a0history of being prescribed controlled substances and risk of drug overdose death","volume":"13","author":"Paulozzi","year":"2012","journal-title":"Pain Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib158","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/pds.3980","article-title":"Changes in the medical management of patients on opioid analgesics following a diagnosis of substance abuse","volume":"25","author":"Paulozzi","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1053\/j.gastro.2017.11.279_bib159","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1056\/NEJMp1612578","article-title":"Ending the opioid epidemic\u2014a call to action","volume":"375","author":"Murthy","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(10)63269-6","article-title":"Patients with IBS\u00a0commonly use narcotics","volume":"138","author":"Dorn","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib161","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/MCG.0b013e318189a7f9","article-title":"International survey of patients with IBS: Symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit","volume":"43","author":"Drossman","year":"2009","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib162","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1365-2036.2008.03689.x","article-title":"Gastrointestinal side effects in chronic opioid users: results from a population-based survey","volume":"27","author":"Cook","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2017.11.279_bib163","first-page":"1077","article-title":"Prescribing patterns for outpatient treatment of constipation, irritable bowel syndrome-related constipation, and opioid-induced constipation: a retrospective cross-sectional study","volume":"21","author":"Trinkley","year":"2015","journal-title":"J\u00a0Manag Care Spec Pharm"},{"key":"10.1053\/j.gastro.2017.11.279_bib164","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ajgsup.2014.6","article-title":"The narcotic bowel syndrome: a recent update","volume":"2","author":"Drossman","year":"2014","journal-title":"Am J Gastroenterol Suppl"},{"key":"10.1053\/j.gastro.2017.11.279_bib165","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.cgh.2007.06.013","article-title":"The narcotic bowel syndrome: clinical features, pathophysiology, and management","volume":"5","author":"Grunkemeier","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib166","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1526-4637.2001.01026.x","article-title":"Opioid drugs: a comparative survey of therapeutic and \"street\" use","volume":"2","author":"Cowan","year":"2001","journal-title":"Pain Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib167","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1017\/S0033291711002145","article-title":"Mood and anxiety disorders and their association with non-medical prescription opioid use and prescription opioid-use disorder: longitudinal evidence from the National Epidemiologic Study on Alcohol and Related Conditions","volume":"42","author":"Martins","year":"2012","journal-title":"Psychol Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib168","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/ajg.2012.142","article-title":"Diagnosis, characterization, and 3-month outcome after detoxification of 39 patients with narcotic bowel syndrome","volume":"107","author":"Drossman","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib169","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2017.141","article-title":"Opioid misuse in gastroenterology","author":"Szigethy","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib170","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1001\/archpsyc.62.10.1157","article-title":"Comparison of pharmacological treatments for opioid-dependent adolescents: a randomized controlled trial","volume":"62","author":"Marsch","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1053\/j.gastro.2017.11.279_bib171","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.2008.574","article-title":"Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: a randomized trial","volume":"300","author":"Woody","year":"2008","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2017.11.279_bib172","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/17474124.2016.1207524","article-title":"Implementing psychological therapies for functional GI disorders in children and adults","volume":"10","author":"Reed-Knight","year":"2016","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2017.11.279_bib173","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ajg.2013.56","article-title":"2012 David Sun lecture: helping your patient by helping yourself\u2013how to improve the patient-physician relationship by optimizing communication skills","volume":"108","author":"Drossman","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2017.11.279_bib174","doi-asserted-by":"crossref","first-page":"688","DOI":"10.7326\/0003-4819-123-9-199511010-00008","article-title":"Diagnosing and treating patients with refractory functional gastrointestinal disorders","volume":"123","author":"Drossman","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib175","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/0003-4819-122-2-199501150-00005","article-title":"The irritable bowel syndrome: long-term prognosis and the physician-patient interaction","volume":"122","author":"Owens","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2017.11.279_bib176","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1053\/j.gastro.2016.02.029","article-title":"Pharmacological, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders","volume":"150","author":"Camilleri","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2017.11.279_bib177","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1001\/jama.2016.12103","article-title":"Getting pharmacogenomics into the clinic","volume":"316","author":"Abbasi","year":"2016","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2017.11.279_bib178","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2217\/pgs-2016-0173","article-title":"What is the future of pharmacogenomics in pain management?","volume":"18","author":"Peiro","year":"2017","journal-title":"Pharmacogenomics"},{"key":"10.1053\/j.gastro.2017.11.279_bib179","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00228-011-1094-4","article-title":"The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine","volume":"68","author":"Azuma","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1053\/j.gastro.2017.11.279_bib180","doi-asserted-by":"crossref","first-page":"150","DOI":"10.9758\/cpn.2015.13.2.150","article-title":"Improved antidepressant remission in major depression via a pharmacokinetic pathway polygene pharmacogenetic report","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"10.1053\/j.gastro.2017.11.279_bib181","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000430915","article-title":"Clinical utility of combinatorial pharmacogenomics-guided antidepressant therapy: evidence from three clinical studies","volume":"1","author":"Altar","year":"2015","journal-title":"Mol Neuropsychiatry"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517367185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508517367185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T03:58:21Z","timestamp":1751169501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508517367185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":181,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0016508517367185"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2017.11.279","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut\u2212Brain Interaction): A Rome Foundation Working Team Report","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2017.11.279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}