{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:14:58Z","timestamp":1789848898461,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 DK 68055"],"award-info":[{"award-number":["P01 DK 68055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1053\/j.gastro.2018.02.027","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T22:34:36Z","timestamp":1520289276000},"page":"2122-2136.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice"],"prefix":"10.1053","volume":"154","author":[{"given":"Gianluca","family":"Cipriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Terhaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth T.","family":"Eisenman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"\u00d6rd\u00f6g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela B.","family":"Gajdos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-5235","authenticated-orcid":false,"given":"Gianrico","family":"Farrugia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.02.027_bib1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of\u00a0macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2018.02.027_bib2","first-page":"291","article-title":"Diabetic gastroparesis","volume":"13","author":"Farrell","year":"1995","journal-title":"Dig Dis"},{"key":"10.1053\/j.gastro.2018.02.027_bib3","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/j.1572-0241.2001.03683.x","article-title":"Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?","volume":"96","author":"Talley","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.02.027_bib4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ncpgasthep0838","article-title":"Mechanisms of disease: the pathological basis of gastroparesis\u2014a review of experimental and clinical studies","volume":"4","author":"Vittal","year":"2007","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.02.027_bib5","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/nmo.12389","article-title":"Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis","volume":"26","author":"Bernard","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.02.027_bib6","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2337\/diabetes.49.10.1731","article-title":"Remodeling of\u00a0networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis","volume":"49","author":"Ordog","year":"2000","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2018.02.027_bib7","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1053\/j.gastro.2011.01.046","article-title":"Cellular changes in diabetic and idiopathic gastroparesis","volume":"140","author":"Grover","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib8","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1053\/j.gastro.2008.09.003","article-title":"Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis","volume":"135","author":"Choi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib9","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1053\/j.gastro.2010.02.014","article-title":"CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice","volume":"138","author":"Choi","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.02.027_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jcmgh.2015.09.001","article-title":"Diabetic mice\u00a0lacking macrophages are protected against the development of delayed gastric emptying","volume":"2","author":"Cipriani","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.02.027_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jcmgh.2016.01.003","article-title":"Intrinsic gastrointestinal macrophages: their phenotype and role\u00a0in gastrointestinal motility","volume":"2","author":"Cipriani","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.02.027_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.02.027_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cell.2015.12.023","article-title":"Neuro-immune interactions drive tissue programming in intestinal macrophages","volume":"164","author":"Gabanyi","year":"2016","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.02.027_bib15","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1242\/dev.120.6.1357","article-title":"Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse","volume":"120","author":"Cecchini","year":"1994","journal-title":"Development"},{"key":"10.1053\/j.gastro.2018.02.027_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V","article-title":"Biology and action of colony-stimulating factor-1","volume":"46","author":"Stanley","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"10.1053\/j.gastro.2018.02.027_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/156802609789007327","article-title":"Colony-stimulating factor-1 receptor\u00a0inhibitors for the treatment of cancer and inflammatory disease","volume":"9","author":"Patel","year":"2009","journal-title":"Curr Top Med Chem"},{"key":"10.1053\/j.gastro.2018.02.027_bib18","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2018.02.027_bib19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2018.02.027_bib20","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1053\/gast.2002.37056","article-title":"Plasticity of electrical pacemaking by interstitial cells of Cajal and gastric dysrhythmias in W\/W mutant mice","volume":"123","author":"Ordog","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib21","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1053\/j.gastro.2010.05.083","article-title":"Kitlow stem cells cause resistance to Kit\/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors","volume":"139","author":"Bardsley","year":"2010","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1053\/j.gastro.2018.02.027_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12984","article-title":"Tumor necrosis factor alpha derived from classically activated \u201cM1\u201d macrophages reduces interstitial cell of Cajal numbers","volume":"29","author":"Eisenman","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.02.027_bib23","doi-asserted-by":"crossref","first-page":"E3709","DOI":"10.1073\/pnas.1619406114","article-title":"Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis","volume":"114","author":"Kulkarni","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2018.02.027_bib24","doi-asserted-by":"crossref","first-page":"e0115563","DOI":"10.1371\/journal.pone.0115563","article-title":"Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice","volume":"10","author":"Yamaji","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2018.02.027_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI8273C1","article-title":"Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy","volume":"106","author":"Watkins","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2018.02.027_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/gutjnl-2016-312940","article-title":"Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system","volume":"67","author":"Becker","year":"2018","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.02.027_bib27","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.lfs.2013.04.009","article-title":"Oxidative\u00a0damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca(2)(+) ions in oxidative processes","volume":"92","author":"Zavodnik","year":"2013","journal-title":"Life Sci"},{"key":"10.1053\/j.gastro.2018.02.027_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-2982.2003.00461.x","article-title":"Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine","volume":"16","author":"Ozaki","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.02.027_bib29","first-page":"719","article-title":"Macrophages in the external muscle layers of mammalian intestines","volume":"10","author":"Mikkelsen","year":"1995","journal-title":"Histol Histopathol"},{"key":"10.1053\/j.gastro.2018.02.027_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.autneu.2012.02.004","article-title":"Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract","volume":"169","author":"Phillips","year":"2012","journal-title":"Auton Neurosci"},{"key":"10.1053\/j.gastro.2018.02.027_bib31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"Varol","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.gastro.2018.02.027_bib32","doi-asserted-by":"crossref","first-page":"19396","DOI":"10.1038\/srep19396","article-title":"DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2018.02.027_bib33","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1046\/j.1523-1755.2000.07705.x","article-title":"The missing link: a single unifying mechanism for diabetic complications","volume":"77","author":"Nishikawa","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.gastro.2018.02.027_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2017.04.020","article-title":"Hyperglycemia\u00a0increases interstitial cells of Cajal via MAPK1 and MAPK3 signaling to ETV1 and KIT, leading to rapid gastric emptying","volume":"153","author":"Hayashi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jcmgh.2016.04.006","article-title":"Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice","volume":"2","author":"Choi","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.02.027_bib36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the\u00a0macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.02.027_bib37","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1053\/j.gastro.2008.09.003","article-title":"Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis","volume":"135","author":"Choi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib38","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1053\/j.gastro.2010.02.014","article-title":"CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice","volume":"138","author":"Choi","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.02.027_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jcmgh.2015.09.001","article-title":"Diabetic mice lacking macrophages are protected against the development of delayed gastric emptying","volume":"2","author":"Cipriani","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.02.027_bib40","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/diabetes.54.5.1528","article-title":"Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach","volume":"54","author":"Horvath","year":"2005","journal-title":"Diabetes"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518302440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518302440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:00:07Z","timestamp":1787850007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518302440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0016508518302440"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.02.027","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}