{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:52:12Z","timestamp":1792039932518,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T00:00:00Z","timestamp":1564185600000},"content-version":"am","delay-in-days":360,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1053\/j.gastro.2018.04.019","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T22:22:12Z","timestamp":1524608532000},"page":"355-373.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":189,"title":["Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas"],"prefix":"10.1053","volume":"155","author":[{"given":"Xiaosheng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-0316","authenticated-orcid":false,"given":"Mingyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.04.019_bib1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A\u00a0genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.04.019_bib2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1053\/gast.2002.32997","article-title":"CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability","volume":"122","author":"Hawkins","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib3","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1053\/j.gastro.2006.08.038","article-title":"High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy","volume":"131","author":"Spring","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/PAS.0000000000000103","article-title":"Critical appraisal of the diagnosis of the sessile serrated adenoma","volume":"38","author":"Bettington","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2018.04.019_bib5","series-title":"WHO classification of tumours of the digestive system","article-title":"Serrated polyps of the colon and rectum and serrated polyposis","author":"Snover","year":"2010"},{"key":"10.1053\/j.gastro.2018.04.019_bib6","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1053\/j.gastro.2009.12.066","article-title":"Role of the serrated pathway in colorectal cancer pathogenesis","volume":"138","author":"Leggett","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/gutjnl-2014-307793","article-title":"Long-term risk of colorectal cancer in individuals with serrated polyps","volume":"64","author":"Holme","year":"2015","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.019_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrgastro.2015.73","article-title":"Serrated neoplasia-role in colorectal carcinogenesis and clinical implications","volume":"12","author":"JE","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.019_bib9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/carcin\/bgp127","article-title":"Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability","volume":"30","author":"Colotta","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1053\/j.gastro.2018.04.019_bib10","first-page":"1207","article-title":"Meta-analyses of colorectal cancer risk factors","volume":"24","author":"Johnson","year":"2013","journal-title":"Cancer Causes Control"},{"key":"10.1053\/j.gastro.2018.04.019_bib11","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1053\/j.gastro.2010.01.057","article-title":"Primary prevention of colorectal cancer","volume":"138","author":"Chan","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib12","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/j.gastro.2014.12.035","article-title":"Nutrients, foods, and colorectal cancer prevention","volume":"148","author":"Song","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/gutjnl-2016-312893","article-title":"Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps","volume":"67","author":"Davenport","year":"2018","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.019_bib14","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/aje\/kwm400","article-title":"Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps","volume":"167","author":"Shrubsole","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2018.04.019_bib15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/aje\/kws282","article-title":"Differences in epidemiologic risk factors for colorectal adenomas and serrated polyps by lesion severity and anatomical site","volume":"177","author":"Burnett-Hartman","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2018.04.019_bib16","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1001\/jama.290.22.2959","article-title":"Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals","volume":"290","author":"Lieberman","year":"2003","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2018.04.019_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.7326\/0003-4819-122-5-199503010-00002","article-title":"Physical activity, obesity, and risk for colon cancer and adenoma in men","volume":"122","author":"Giovannucci","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-128-9-199805010-00001","article-title":"Postmenopausal hormone use and risk for colorectal cancer and adenoma","volume":"128","author":"Grodstein","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib19","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1002\/ijc.28578","article-title":"Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women","volume":"134","author":"Nimptsch","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2018.04.019_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1249\/00005768-199301000-00011","article-title":"Compendium of physical activities: classification of energy costs of human physical activities","volume":"25","author":"Ainsworth","year":"1993","journal-title":"Med Sci Sports Exerc"},{"key":"10.1053\/j.gastro.2018.04.019_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.7326\/0003-4819-140-3-200402030-00006","article-title":"A\u00a0prospective study of aspirin use and the risk for colorectal adenoma","volume":"140","author":"Chan","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.294.8.914","article-title":"Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer","volume":"294","author":"Chan","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2018.04.019_bib23","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1056\/NEJMoa067208","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of COX-2","volume":"356","author":"Chan","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/aje\/kww104","article-title":"Validity of a dietary questionnaire assessed by comparison with multiple weighed dietary records or 24-hour recalls","volume":"185","author":"Yuan","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2018.04.019_bib25","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/aje\/kwx328","article-title":"Relative validity of nutrient intakes assessed by questionnaire, 24-hour recalls, and diet records compared with urinary recovery and plasma concentration biomarkers: findings for women","volume":"187","author":"Yuan","year":"2018","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2018.04.019_bib26","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Diet, nutrition, physical activity, and\u00a0the prevention of colorectal cancer. Available at http:\/\/www.aicr.org\/continuous-update-project\/reports\/colorectal-cancer-2017-report.pdf."},{"key":"10.1053\/j.gastro.2018.04.019_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamainternmed.2015.0533","article-title":"Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship","volume":"175","author":"Arem","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib28","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(16)30370-1","article-title":"Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women","volume":"388","author":"Ekelund","year":"2016","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2018.04.019_bib29","series-title":"Dietary Guidelines for Americans, 2010","year":"2010"},{"key":"10.1053\/j.gastro.2018.04.019_bib30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer","volume":"143","author":"Lieberman","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1158\/1940-6207.CAPR-15-0307","article-title":"Plasma inflammatory markers and risk of advanced colorectal adenoma in women","volume":"9","author":"Song","year":"2016","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1053\/j.gastro.2018.04.019_bib32","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1053\/j.gastro.2015.11.046","article-title":"Increased risk of colorectal cancer development among patients with serrated polyps","volume":"150","author":"Erichsen","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1309\/V8Q9KDD5AJ9LNBAG","article-title":"Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases","volume":"125","author":"Goldstein","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/j.gastro.2018.04.019_bib34","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/MCG.0000000000000840","article-title":"Factors associated with classification of hyperplastic polyps as sessile serrated adenomas\/polyps on morphologic review","volume":"52","author":"Anderson","year":"2018","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.019_bib35","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/ijc.30168","article-title":"Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of proximal colon cancer through the serrated neoplasia pathway","volume":"139","author":"Yu","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2018.04.019_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1158\/2159-8290.CD-14-0863","article-title":"The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints","volume":"5","author":"Llosa","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2018.04.019_bib37","first-page":"509347","article-title":"The influence of smoking, gender, and family history on colorectal adenomas","volume":"2010","author":"Onega","year":"2010","journal-title":"J\u00a0Cancer Epidemiol"},{"key":"10.1053\/j.gastro.2018.04.019_bib38","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/jnci\/djj468","article-title":"Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer","volume":"98","author":"Samowitz","year":"2006","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2018.04.019_bib39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/ajg.2016.589","article-title":"A\u00a0prospective study of smoking and risk of synchronous colorectal cancers","volume":"112","author":"Drew","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.019_bib40","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1158\/1055-9965.EPI-09-0211","article-title":"The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum","volume":"18","author":"Wallace","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2018.04.019_bib41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/j.gastro.2016.09.003","article-title":"Lifestyle risk factors for serrated colorectal polyps: a systematic review and meta-analysis","volume":"152","author":"Bailie","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib42","first-page":"25","article-title":"Alcohol, DNA methylation, and cancer","volume":"35","author":"Varela-Rey","year":"2013","journal-title":"Alcohol Res"},{"key":"10.1053\/j.gastro.2018.04.019_bib43","first-page":"253","article-title":"Physical activity, obesity, and risk of colorectal adenoma in women (United States)","volume":"7","author":"Giovannucci","year":"1996","journal-title":"Cancer Causes Control"},{"key":"10.1053\/j.gastro.2018.04.019_bib44","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1200\/JCO.2012.48.4691","article-title":"Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial","volume":"31","author":"Kitahara","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2018.04.019_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2169\/internalmedicine.48.1562","article-title":"Modifiable risk factors for colorectal neoplasms and hyperplastic polyps","volume":"48","author":"Omata","year":"2009","journal-title":"Intern Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib46","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.gastro.2005.05.051","article-title":"Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps","volume":"129","author":"Schoen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib47","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1158\/1055-9965.EPI-13-1285","article-title":"Body size, physical activity, early-life energy restriction, and associations with methylated insulin-like growth factor-binding protein genes in colorectal cancer","volume":"23","author":"Simons","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2018.04.019_bib48","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/gut.2007.125955","article-title":"Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people","volume":"56","author":"John","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.019_bib49","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5114\/aoms.2016.57594","article-title":"Expression of COX-2, IL-1beta, TNF-alpha and IL-4 in epithelium of serrated adenoma, adenoma and hyperplastic polyp","volume":"12","author":"Szylberg","year":"2016","journal-title":"Arch Med Sci"},{"key":"10.1053\/j.gastro.2018.04.019_bib50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.smim.2017.09.006","article-title":"Microbiome, inflammation and colorectal cancer","volume":"32","author":"Chen","year":"2017","journal-title":"Semin Immunol"},{"key":"10.1053\/j.gastro.2018.04.019_bib51","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/jcpe.12634","article-title":"Does obesity influence the subgingival microbiota composition in periodontal health and disease?","volume":"43","author":"Maciel","year":"2016","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1053\/j.gastro.2018.04.019_bib52","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/ijc.29488","article-title":"Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway","volume":"137","author":"Ito","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2018.04.019_bib53","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1056\/NEJMoa021735","article-title":"A\u00a0randomized trial of aspirin to prevent colorectal adenomas","volume":"348","author":"Baron","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2018.04.019_bib54","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0016-5085(03)00887-4","article-title":"Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial","volume":"125","author":"Benamouzig","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/j.gastro.2007.10.014","article-title":"Aspirin and folic acid for the prevention of recurrent colorectal adenomas","volume":"134","author":"Logan","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.019_bib56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrc.2016.4","article-title":"Aspirin and colorectal cancer: the promise of precision chemoprevention","volume":"16","author":"Drew","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2018.04.019_bib57","doi-asserted-by":"crossref","first-page":"d6617","DOI":"10.1136\/bmj.d6617","article-title":"Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies","volume":"343","author":"Aune","year":"2011","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2018.04.019_bib58","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1158\/1055-9965.EPI-08-0402","article-title":"Vitamin D and prevention of colorectal adenoma: a meta-analysis","volume":"17","author":"Wei","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2018.04.019_bib59","first-page":"CD003548","article-title":"Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps","author":"Weingarten","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2018.04.019_bib60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4162\/nrp.2017.11.5.419","article-title":"Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis","volume":"11","author":"Park","year":"2017","journal-title":"Nutr Res Pract"},{"key":"10.1053\/j.gastro.2018.04.019_bib61","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1158\/1940-6207.CAPR-12-0292","article-title":"A\u00a0randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC\/beta-catenin pathway in the normal mucosa of colorectal adenoma patients","volume":"5","author":"Ahearn","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1053\/j.gastro.2018.04.019_bib62","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1038\/onc.2008.88","article-title":"DICKKOPF-4 is induced by TCF\/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3","volume":"27","author":"Pendas-Franco","year":"2008","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2018.04.019_bib63","first-page":"4305","article-title":"K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency","volume":"51","author":"Llor","year":"1991","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2018.04.019_bib64","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1309\/603UQKM7C2KELGJU","article-title":"Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential","volume":"129","author":"Wu","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/j.gastro.2018.04.019_bib65","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/PAS.0b013e3181b6da19","article-title":"Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation","volume":"33","author":"Yachida","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2018.04.019_bib66","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ijc.20775","article-title":"Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study","volume":"114","author":"Brink","year":"2005","journal-title":"Int J Cancer"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518304803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518304803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:18:00Z","timestamp":1758035880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518304803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0016508518304803"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.04.019","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}