{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:26:25Z","timestamp":1787851585727,"version":"build-2784847793"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["PPSP.6171192"],"award-info":[{"award-number":["PPSP.6171192"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1053\/j.gastro.2018.04.030","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T16:47:21Z","timestamp":1525366041000},"page":"2018-2021.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Management of Patients With Functional Heartburn"],"prefix":"10.1053","volume":"154","author":[{"given":"Yeong Yeh","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.04.030_bib1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1572-0241.2006.00525.x","article-title":"Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid","volume":"101","author":"Shapiro","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib2","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","article-title":"Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury","volume":"137","author":"Souza","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.04.030_bib3","doi-asserted-by":"crossref","unstructured":"Naliboff BD, Mayer M, Fass R, et\u00a0al. The effect of life stress on symptoms of heartburn. Psychosom Med 66:426\u2013434.","DOI":"10.1097\/01.psy.0000124756.37520.84"},{"key":"10.1053\/j.gastro.2018.04.030_bib4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2982.2006.00761.x","article-title":"Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional\u00a0heartburn","volume":"18","author":"Yang","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.04.030_bib5","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/gutjnl-2016-311715","article-title":"Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux\u00a0disease and Barrett\u2019s oesophagus","volume":"65","author":"Fock","year":"2016","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.030_bib6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s10620-017-4815-4","article-title":"Fragments of e-cadherin as biomarkers of non-erosive reflux disease","volume":"63","author":"Jovov","year":"2018","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2018.04.030_bib7","first-page":"e13067","article-title":"Ambulatory reflux monitoring for diagnosis of gastro-esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group","author":"Roman","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.04.030_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2017-314722","article-title":"Modern diagnosis of GERD: the Lyon Consensus","author":"Gyawali","year":"2018","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.030_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cgh.2015.06.026","article-title":"Analyses of the Post-reflux Swallow-induced Peristaltic Wave Index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance-pH monitoring of patients with reflux disease","volume":"14","author":"Frazzoni","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.030_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ctg.2017.22","article-title":"Endoscopic-guided measurement of mucosal admittance can discriminate gastroesophageal reflux disease from functional heartburn","volume":"8","author":"Matsumura","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11605-008-0653-1","article-title":"Recurrent symptoms after fundoplication with a negative pH study\u2013recurrent reflux or functional heartburn?","volume":"13","author":"Thompson","year":"2009","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2018.04.030_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.436","article-title":"Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease","volume":"8","author":"Ranaldo","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1053\/j.gastro.2018.04.030_bib13","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/apt.14064","article-title":"Randomised clinical trial: addition of alginate-antacid (Gaviscon Double Action) to proton pump inhibitor therapy in patients with breakthrough symptoms","volume":"45","author":"Coyle","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.04.030_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1365-2036.2004.02217.x","article-title":"A\u00a0single dose of ranitidine 150 mg modulates oesophageal\u00a0acid sensitivity in patients with functional\u00a0heartburn","volume":"20","author":"Rodriguez-Stanley","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.04.030_bib15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/nmo.12313","article-title":"Comparing omeprazole with fluoxetine for treatment of patients with heartburn and normal endoscopy who failed once daily proton pump inhibitors: double-blind placebo-controlled trial","volume":"26","author":"Ostovaneh","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.04.030_bib16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cgh.2006.01.014","article-title":"Effect of tegaserod on esophageal pain threshold, regurgitation, and symptom relief in patients with functional heartburn and mechanical sensitivity","volume":"4","author":"Rodriguez-Stanley","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.030_bib17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/dote.12353","article-title":"Feasibility and acceptability of esophageal-directed hypnotherapy for functional heartburn","volume":"29","author":"Riehl","year":"2016","journal-title":"Dis Esophagus"},{"key":"10.1053\/j.gastro.2018.04.030_bib18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/MEG.0b013e3283525a0c","article-title":"Functional chest\u00a0pain responds to biofeedback treatment but functional heartburn does not: what is the difference?","volume":"24","author":"Shapiro","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.030_bib19","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1365-2036.2003.01423.x","article-title":"Non-erosive reflux disease (NERD)\u2013acid reflux and symptom patterns","volume":"17","author":"Martinez","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.04.030_bib20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/gut.2005.087668","article-title":"Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring","volume":"55","author":"Mainie","year":"2006","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.030_bib21","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1111\/j.1572-0241.2008.02119.x","article-title":"The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy","volume":"103","author":"Savarino","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/gut.2008.175810","article-title":"Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease","volume":"58","author":"Savarino","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.04.030_bib23","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.dld.2011.01.016","article-title":"The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease","volume":"43","author":"Savarino","year":"2011","journal-title":"Dig Liver Dis"},{"key":"10.1053\/j.gastro.2018.04.030_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00535-011-0480-0","article-title":"Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients","volume":"47","author":"Savarino","year":"2012","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib25","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1097\/MEG.0b013e328365d2a8","article-title":"Refractory GERD: increased body mass index is associated with persisting acid exposure but not hypersensitive esophagus or functional heartburn","volume":"25","author":"Viazis","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.030_bib26","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/nmo.12666","article-title":"Majority of symptoms in esophageal reflux PPI non-responders are not related to reflux","volume":"27","author":"Roman","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.04.030_bib27","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/ajg.2016.432","article-title":"Functional heartburn overlaps with irritable bowel syndrome more often than GERD","volume":"111","author":"Bortoli N de","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5056\/jnm14038","article-title":"Diagnostic utility of impedance-pH monitoring in refractory non-erosive reflux disease","volume":"20","author":"Khan","year":"2014","journal-title":"J\u00a0Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2018.04.030_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000368766","article-title":"Evaluation of proton pump inhibitor-resistant nonerosive reflux disease by esophageal manometry and 24-hour esophageal impedance and pH monitoring","volume":"91","author":"Kawamura","year":"2015","journal-title":"Digestion"},{"key":"10.1053\/j.gastro.2018.04.030_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/jgh.12743","article-title":"Usefulness of baseline impedance in patients with proton pump inhibitor-refractory nonerosive reflux disease","volume":"30","author":"Kohata","year":"2015","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.04.030_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-016-0525-1","article-title":"Motility characteristics in the transition zone in gastroesophageal reflux disease (GORD) patients","volume":"16","author":"Li","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"10.1053\/j.gastro.2018.04.030_bib32","first-page":"1","article-title":"Role of altered esophageal intraluminal baseline impedance levels in patients with gastroesophageal reflux disease refractory to proton pump inhibitors","volume":"95","author":"Jiang","year":"2016","journal-title":"Med (United States)"},{"key":"10.1053\/j.gastro.2018.04.030_bib33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0175263","article-title":"Ambulatory 24-hour multichannel intraluminal impedance-pH monitoring and high resolution endoscopy distinguish patients with non-erosive reflux disease from those with functional heartburn","volume":"12","author":"Chu","year":"2017","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2018.04.030_bib34","article-title":"An analysis of 342 patients with refractory gastroesophageal reflux disease symptoms using questionnaires, high-resolution manometry, and impedance-pH monitoring","volume":"96","author":"Wang","year":"2017","journal-title":"Med (United States)"},{"key":"10.1053\/j.gastro.2018.04.030_bib35","doi-asserted-by":"crossref","first-page":"e3040","DOI":"10.1038\/cddis.2017.436","article-title":"Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease","volume":"8","author":"Ranaldo","year":"2017","journal-title":"Cell Death Dis"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518344809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518344809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:00:44Z","timestamp":1787850044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518344809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0016508518344809"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.04.030","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Patients With Functional Heartburn","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}