{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:15:43Z","timestamp":1793650543306,"version":"4.5.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1053\/j.gastro.2018.05.035","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T13:17:11Z","timestamp":1527167831000},"page":"740-751.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":389,"title":["Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance"],"prefix":"10.1053","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-3032","authenticated-orcid":false,"given":"Marcia Irene","family":"Canto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alejandro","family":"Almario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Schulick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Blackford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0624-8149","authenticated-orcid":false,"given":"Eun Ji","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-3617","authenticated-orcid":false,"given":"Abanti","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayane","family":"Yenokyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab R.","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot K.","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.05.035_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2018.05.035_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10689-016-9915-3","article-title":"Dilemmas in the management of screen-detected lesions in patients at high risk for pancreatic cancer","volume":"16","author":"Ibrahim","year":"2017","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2018.05.035_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gutjnl-2012-303108","article-title":"International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer","volume":"62","author":"Canto","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.05.035_bib6","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds","volume":"64","author":"Klein","year":"2004","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2018.05.035_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/gepi.1102","article-title":"Evidence for a major gene influencing risk of pancreatic cancer","volume":"23","author":"Klein","year":"2002","journal-title":"Genet Epidemiol"},{"key":"10.1053\/j.gastro.2018.05.035_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1171202","article-title":"Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene","volume":"324","author":"Jones","year":"2009","journal-title":"Science"},{"key":"10.1053\/j.gastro.2018.05.035_bib9","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ajg.2009.725","article-title":"High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations","volume":"105","author":"van Lier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.05.035_bib10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/gim.2014.153","article-title":"BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study","volume":"17","author":"Zhen","year":"2015","journal-title":"Genet Med"},{"key":"10.1053\/j.gastro.2018.05.035_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1572-0241.2007.01597.x","article-title":"Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series","volume":"103","author":"Rebours","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.05.035_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00439-008-0554-0","article-title":"Germline BRCA1 mutations predispose to pancreatic adenocarcinoma","volume":"124","author":"Al-Sukhni","year":"2008","journal-title":"Hum Genet"},{"key":"10.1053\/j.gastro.2018.05.035_bib13","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1001\/jama.2009.1529","article-title":"Risk of pancreatic cancer in families with Lynch syndrome","volume":"302","author":"Kastrinos","year":"2009","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2018.05.035_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/2159-8290.CD-11-0194","article-title":"ATM mutations in patients with hereditary pancreatic cancer","volume":"2","author":"Roberts","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2018.05.035_bib15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11605-011-1781-6","article-title":"Screening for pancreatic cancer in a high-risk cohort: an eight-year experience","volume":"16","author":"Al-Sukhni","year":"2012","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2018.05.035_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10689-012-9582-y","article-title":"Multiple small \u201cimaging\u201d branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?","volume":"12","author":"Bartsch","year":"2013","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2018.05.035_bib17","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cgh.2006.02.005","article-title":"Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study","volume":"4","author":"Canto","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1542-3565(04)00244-7","article-title":"Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach","volume":"2","author":"Canto","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1053\/j.gastro.2012.01.005","article-title":"Frequent detection of pancreatic lesions in asymptomatic high-risk individuals","volume":"142","author":"Canto","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.05.035_bib20","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/S0016-5107(02)70092-8","article-title":"Screening and surveillance for hereditary pancreatic cancer","volume":"56","author":"Kimmey","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2018.05.035_bib21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1136\/gut.2008.171611","article-title":"Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer","volume":"58","author":"Langer","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.05.035_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ajg.2011.65","article-title":"Feasibility and yield of screening in relatives from familial pancreatic cancer families","volume":"106","author":"Ludwig","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.05.035_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10689-010-9414-x","article-title":"German national case collection for familial pancreatic cancer (FaPaCa): ten years experience","volume":"10","author":"Schneider","year":"2011","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2018.05.035_bib24","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/j.gastro.2010.11.048","article-title":"Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation","volume":"140","author":"Vasen","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.05.035_bib25","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/ajg.2009.276","article-title":"The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer","volume":"104","author":"Poley","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.05.035_bib26","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1200\/JCO.2015.64.0730","article-title":"Benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers","volume":"34","author":"Vasen","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2018.05.035_bib27","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/gutjnl-2014-308008","article-title":"A\u00a0multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals","volume":"65","author":"Harinck","year":"2016","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.05.035_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000090023","article-title":"International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas","volume":"6","author":"Tanaka","year":"2006","journal-title":"Pancreatology"},{"key":"10.1053\/j.gastro.2018.05.035_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"10.1053\/j.gastro.2018.05.035_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cgh.2010.09.008","article-title":"Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms","volume":"9","author":"Kang","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib31","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s10620-015-3679-8","article-title":"Rapid growth rates of suspected pancreatic cyst branch duct intraductal papillary mucinous neoplasms predict malignancy","volume":"60","author":"Kwong","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2018.05.035_bib32","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1053\/j.gastro.2015.01.015","article-title":"American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts","volume":"148","author":"Vege","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.05.035_bib33","series-title":"WHO Classification of Tumours of the Digestive System","year":"2010"},{"key":"10.1053\/j.gastro.2018.05.035_bib34","series-title":"WHO Classification of Tumors of the Endocrine Organs","year":"2017"},{"key":"10.1053\/j.gastro.2018.05.035_bib35","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.gie.2008.07.043","article-title":"EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification","volume":"69","author":"Catalano","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2018.05.035_bib36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MPA.0b013e31820a5975","article-title":"Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: a multicenter study in Japan","volume":"40","author":"Maguchi","year":"2011","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2018.05.035_bib37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cgh.2006.07.013","article-title":"Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients","volume":"4","author":"Tada","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib38","first-page":"645","article-title":"Natural history of intraductal papillary mucinous neoplasm and non-neoplastic cyst: long-term imaging follow-up study","volume":"12","author":"Hisada","year":"2017","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1053\/j.gastro.2018.05.035_bib39","first-page":"22","article-title":"Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms","volume":"46","author":"Kamata","year":"2014","journal-title":"Endoscopy"},{"key":"10.1053\/j.gastro.2018.05.035_bib40","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cgh.2014.11.028","article-title":"KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound","volume":"13","author":"Eshleman","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib41","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2012-302823","article-title":"Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts","volume":"62","author":"Kanda","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.05.035_bib42","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cgh.2012.11.016","article-title":"Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia","volume":"11","author":"Kanda","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.05.035_bib43","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1136\/gutjnl-2015-311166","article-title":"Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms","volume":"66","author":"Yu","year":"2017","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.05.035_bib44","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1073\/pnas.1704961114","article-title":"Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers","volume":"114","author":"Cohen","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2018.05.035_bib45","doi-asserted-by":"crossref","unstructured":"Suenega M, Yu J, Shindo K, et\u00a0al. Pancreatic juice mutation concentrations can help predict the grade of dysplasia in patients undergoing pancreatic surveillance [published online ahead of print May 25, 2018]. Clin Cancer Res https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-2463.","DOI":"10.1158\/1078-0432.CCR-17-2463"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518345682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518345682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T14:40:14Z","timestamp":1539614414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518345682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0016508518345682"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.05.035","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}