{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:33:13Z","timestamp":1790285593343,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01DK62277"],"award-info":[{"award-number":["1R01DK62277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01DK100287"],"award-info":[{"award-number":["1R01DK100287"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01CA204586"],"award-info":[{"award-number":["R01CA204586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH-NHLBI","award":["1R01HL128297-01"],"award-info":[{"award-number":["1R01HL128297-01"]}]},{"name":"NIH, NIDDK","award":["5T32DK639-22"],"award-info":[{"award-number":["5T32DK639-22"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1053\/j.gastro.2018.06.048","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T03:31:42Z","timestamp":1530329502000},"page":"1218-1232.e24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice"],"prefix":"10.1053","volume":"155","author":[{"given":"Tirthadipa","family":"Pradhan-Sundd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Vats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn O.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola Adebayo","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Kakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Cornuet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minakshi","family":"Poddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari N.","family":"Nejak-Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan P.","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithu","family":"Sundd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.06.048_bib1","first-page":"1","article-title":"Deaths: final data for 2013","volume":"64","author":"Xu","year":"2016","journal-title":"Natl Vital Stat Rep"},{"key":"10.1053\/j.gastro.2018.06.048_bib2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cgh.2011.03.020","article-title":"Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988\u00a0to\u00a02008","volume":"9","author":"Younossi","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.06.048_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound\u00a0healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Na. Rev Immunol"},{"key":"10.1053\/j.gastro.2018.06.048_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","article-title":"The burden of liver disease in Europe: a review of available epidemiological data","volume":"58","author":"Blachier","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2018.06.048_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2018.06.048_bib6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell\u00a0death responses in liver disease: Mechanisms and\u00a0clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.06.048_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jgh.12212","article-title":"Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches","volume":"28","author":"Schuppan","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.06.048_bib8","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1002\/hep.29585","article-title":"Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis","volume":"67","author":"Pradhan-Sundd","year":"2017","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2018.06.048_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm1055","article-title":"Signalling to and from tight junctions","volume":"4","author":"Matter","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1053\/j.gastro.2018.06.048_bib10","doi-asserted-by":"crossref","first-page":"e25718","DOI":"10.4161\/tisb.25718","article-title":"Bile duct epithelial tight junctions and barrier function","volume":"1","author":"Rao","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1053\/j.gastro.2018.06.048_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00795-003-0220-5","article-title":"Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes","volume":"36","author":"Kojima","year":"2003","journal-title":"Med Electron Microsc"},{"key":"10.1053\/j.gastro.2018.06.048_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1203\/00006450-199808000-00001","article-title":"Hepatobiliary transport: molecular mechanisms of development and cholestasis","volume":"44","author":"Arrese","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2018.06.048_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/jhep.2001.26751","article-title":"A\u00a0modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver","volume":"34","author":"Akhurst","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2018.06.048_bib14","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/carcin\/23.10.1685","article-title":"Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations\u00a0in rat liver","volume":"23","author":"Croager","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1053\/j.gastro.2018.06.048_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-5926-9-8","article-title":"Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet","volume":"9","author":"Ueberham","year":"2010","journal-title":"Comp Hepatol"},{"key":"10.1053\/j.gastro.2018.06.048_bib16","first-page":"103","article-title":"Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease","volume":"79","author":"Preisegger","year":"1999","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2018.06.048_bib17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0002-9440(10)64480-X","article-title":"Bile acid-induced Mallory body formation in drug-primed mouse liver","volume":"161","author":"Fickert","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2018.06.048_bib18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2353\/ajpath.2007.061133","article-title":"A\u00a0new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis","volume":"171","author":"Fickert","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2018.06.048_bib19","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.24506","article-title":"Spontaneous repopulation of \u03b2-catenin null livers with \u03b2-catenin-positive hepatocytes after chronic murine liver injury","volume":"54","author":"Thompson","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2018.06.048_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nmeth.1543","article-title":"Stabilized imaging of immune surveillance in the mouse lung","volume":"8","author":"Looney","year":"2011","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2018.06.048_bib21","doi-asserted-by":"crossref","DOI":"10.4161\/intv.29748","article-title":"Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged sickle cell disease mice","volume":"3","author":"Bennewitz","year":"2014","journal-title":"Intravital"},{"key":"10.1053\/j.gastro.2018.06.048_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89761","article-title":"Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli","volume":"2","author":"Bennewitz","year":"2017","journal-title":"JCI Insight"},{"key":"10.1053\/j.gastro.2018.06.048_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0307-4412(00)00002-9","article-title":"Carboxyfluorescein fluorescence experiments","volume":"28","author":"Massou","year":"2000","journal-title":"Biochem Educ"},{"key":"10.1053\/j.gastro.2018.06.048_bib24","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1117\/1.2710237","article-title":"Visualization of hepatobiliary excretory function by intravital multiphoton microscopy","volume":"12","author":"Liu","year":"2011","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1053\/j.gastro.2018.06.048_bib25","doi-asserted-by":"crossref","first-page":"G1091","DOI":"10.1152\/ajpgi.90681.2008","article-title":"In\u00a0vivo dynamic metabolic imaging of obstructive cholestasis in mice","volume":"296","author":"Li","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2018.06.048_bib26","doi-asserted-by":"crossref","first-page":"F867","DOI":"10.1152\/ajprenal.90264.2008","article-title":"Biology of claudins","volume":"295","author":"Angelow","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1053\/j.gastro.2018.06.048_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15419060600726209","article-title":"Claudins\u2014key pieces in the tight junction puzzle","volume":"13","author":"Koval","year":"2006","journal-title":"Cell Commun Adhes"},{"key":"10.1053\/j.gastro.2018.06.048_bib28","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/ng.2918","article-title":"Mutations in TJP2 cause progressive cholestatic liver disease","volume":"46","author":"Sambrotta","year":"2014","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2018.06.048_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2015.1026537","article-title":"Mutations in TJP2, encoding zona occludens 2, and liver disease","volume":"3","author":"Sambrotta","year":"2015","journal-title":"Tissue Barriers"},{"key":"10.1053\/j.gastro.2018.06.048_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ng1147","article-title":"Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT","volume":"34","author":"Carlton","year":"2003","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2018.06.048_bib31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00418-007-0374-7","article-title":"Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin","volume":"129","author":"Maly","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1053\/j.gastro.2018.06.048_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12876-016-0416-5","article-title":"Altered expression levels of occludin, claudin-1 and myosin light chain kinase in the common bile duct of pediatric patients with pancreaticobiliary maljunction","volume":"16","author":"Huang","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"10.1053\/j.gastro.2018.06.048_bib33","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1053\/j.gastro.2018.06.048_bib34","first-page":"89","article-title":"Molecular mechanisms in bile formation","volume":"15","author":"Meier","year":"2000","journal-title":"News Physiol Sci"},{"key":"10.1053\/j.gastro.2018.06.048_bib35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0016-5085(03)01068-0","article-title":"Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice","volume":"125","author":"Wagner","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.06.048_bib36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/hep.20049","article-title":"Chronic liver disease mortality in the United States, 1990-1998","volume":"39","author":"Vong","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2018.06.048_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/MOG.0b013e3283521d6a","article-title":"Stem cell therapy in chronic liver disease","volume":"28","author":"Takami","year":"2012","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1053\/j.gastro.2018.06.048_bib38","first-page":"189","article-title":"Cell therapy in chronic liver disease","volume":"32","author":"Nicolas","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1053\/j.gastro.2018.06.048_bib39","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.mcna.2008.03.006","article-title":"Management of chronic liver failure until liver transplantation","volume":"92","author":"Arora","year":"2008","journal-title":"Med Clin North Am"},{"key":"10.1053\/j.gastro.2018.06.048_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mcna.2013.09.007","article-title":"When to consider liver transplant during the management of chronic liver disease","volume":"98","author":"Fox","year":"2014","journal-title":"Med Clin North Am"},{"key":"10.1053\/j.gastro.2018.06.048_bib41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jhep.2014.05.011","article-title":"Chronic kidney disease: a major concern in liver transplantation in the XXI century","volume":"61","author":"Sol\u00e0","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2018.06.048_bib42","doi-asserted-by":"crossref","first-page":"40331","DOI":"10.1038\/srep40331","article-title":"Blood occludin level as a potential biomarker for early blood brain barrier damage following ischemic stroke","volume":"7","author":"Pan","year":"2017","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2018.06.048_bib43","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/labinvest.2011.115","article-title":"Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver","volume":"91","author":"Yamazaki","year":"2011","journal-title":"Lab Invest"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518346900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518346900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:19:40Z","timestamp":1758035980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518346900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0016508518346900"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.06.048","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}