{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:12:51Z","timestamp":1793373171808,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Agency for Research","award":["10-IAHU-03"],"award-info":[{"award-number":["10-IAHU-03"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1053\/j.gastro.2018.07.034","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T12:20:47Z","timestamp":1533126047000},"page":"1553-1563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication"],"prefix":"10.1053","volume":"155","author":[{"given":"Eya","family":"Ben Azzouz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Boumaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Mezouar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Bardou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Carlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"M\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-4294","authenticated-orcid":false,"given":"Benoit","family":"Desnues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.07.034_bib1","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/S1473-3099(15)00537-X","article-title":"Tropheryma whipplei infection and Whipple\u2019s disease","volume":"16","author":"Marth","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib2","first-page":"79","article-title":"[From Whipple\u2019s disease to Tropheryma whipplei infections]","volume":"60","author":"Lagier","year":"2010","journal-title":"Med Mal Infect"},{"key":"10.1053\/j.gastro.2018.07.034_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MD.0b013e3181f204a8","article-title":"Systemic Tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center","volume":"89","author":"Lagier","year":"2010","journal-title":"Medicine (Baltimore)"},{"key":"10.1053\/j.gastro.2018.07.034_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00002281-200101000-00012","article-title":"Whipple disease and arthritis","volume":"13","author":"Puechal","year":"2001","journal-title":"Curr Opin Rheumatol"},{"key":"10.1053\/j.gastro.2018.07.034_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra062477","article-title":"Whipple\u2019s disease","volume":"356","author":"Fenollar","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2018.07.034_bib6","first-page":"103","article-title":"Tropheryma whipplei and Whipple\u2019s disease","volume":"69","author":"Fenollar","year":"2014","journal-title":"J\u00a0Infect"},{"key":"10.1053\/j.gastro.2018.07.034_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3201\/eid1602.090610","article-title":"Tropheryma whipplei in patients with pneumonia","volume":"16","author":"Bousbia","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1086\/655677","article-title":"Tropheryma whipplei Bacteremia during Fever in Rural West Africa","volume":"51","author":"Fenollar","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"10.1053\/j.gastro.2018.07.034_bib9","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3201\/eid1605.091801","article-title":"Tropheryma whipplei in children with gastroenteritis","volume":"16","author":"Raoult","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/CVI.13.2.170-178.2006","article-title":"Whipple\u2019s disease: a macrophage disease","volume":"13","author":"Desnues","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib11","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.4049\/jimmunol.175.7.4575","article-title":"IL-16 is critical for Tropheryma whipplei replication in Whipple\u2019s disease","volume":"175","author":"Desnues","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000722","article-title":"Type I interferon induction is detrimental during infection with the Whipple\u2019s disease bacterium, Tropheryma whipplei","volume":"6","author":"Al Moussawi","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1053\/j.gastro.2018.07.034_bib13","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1038\/cddis.2010.11","article-title":"Tropheryma whipplei, the Whipple\u2019s disease bacillus, induces macrophage apoptosis through the extrinsic pathway","volume":"1","author":"Gorvel","year":"2010","journal-title":"Cell Death Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib14","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1086\/491745","article-title":"Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2\/alternatively activated macrophages","volume":"192","author":"Desnues","year":"2005","journal-title":"J\u00a0Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1053\/gast.2002.36583","article-title":"Dysregulated peripheral and mucosal Th1\/Th2 response in Whipple's disease","volume":"123","author":"Marth","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.07.034_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1053\/j.gastro.2009.07.066","article-title":"Impaired immune\u00a0functions of monocytes and macrophages in\u00a0Whipple\u2019s disease","volume":"138","author":"Moos","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.07.034_bib17","first-page":"4326495","article-title":"Recent advances in our understanding of HLA-G biology: lessons from a wide spectrum of human diseases","volume":"2016","author":"Morandi","year":"2016","journal-title":"J\u00a0Immunol Res"},{"key":"10.1053\/j.gastro.2018.07.034_bib18","first-page":"298569","article-title":"Immunomodulatory properties of HLA-G in infectious diseases","volume":"2014","author":"Amiot","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1053\/j.gastro.2018.07.034_bib19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00018-010-0580-7","article-title":"Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association","volume":"68","author":"Donadi","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"10.1053\/j.gastro.2018.07.034_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.humimm.2009.07.015","article-title":"Human leukocyte antigen-G polymorphism in relation to expression, function, and disease","volume":"70","author":"Larsen","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082517","article-title":"HLA-G UTR haplotype conservation in the Malian population: association with soluble HLA-G","volume":"8","author":"Carlini","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2018.07.034_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.humimm.2012.10.027","article-title":"HLA-G haplotype structure shows good conservation between different populations and good correlation with high, normal and low soluble HLA-G expression","volume":"74","author":"Di Cristofaro","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib23","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/annonc\/mdm356","article-title":"HLA-G expression in human ovarian carcinoma counteracts NK cell function","volume":"18","author":"Lin","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2018.07.034_bib24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(03)14071-8","article-title":"Genome-based design of a cell-free culture medium for Tropheryma whipplei","volume":"362","author":"Renesto","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2018.07.034_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.ai.2015.04.001","article-title":"HLA-G: an immune checkpoint molecule","volume":"127","author":"Carosella","year":"2015","journal-title":"Adv Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00002030-200402200-00008","article-title":"Functionally active HLA-G polymorphisms are associated with the risk of heterosexual HIV-1 infection in African women","volume":"18","author":"Matte","year":"2004","journal-title":"AIDS"},{"key":"10.1053\/j.gastro.2018.07.034_bib27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/039463200601900213","article-title":"Hierarchy of baby-linked immunogenetic risk factors in the vertical transmission of hepatitis C virus","volume":"19","author":"Martinetti","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1053\/j.gastro.2018.07.034_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/jvh.12395","article-title":"Association of an HLA-G 14-bp insertion\/deletion polymorphism with high HBV replication in chronic hepatitis","volume":"22","author":"Laaribi","year":"2015","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1053\/j.gastro.2018.07.034_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2217\/fmb.15.143","article-title":"HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients","volume":"11","author":"Rizzo","year":"2016","journal-title":"Future Microbiol"},{"key":"10.1053\/j.gastro.2018.07.034_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/sji.12385","article-title":"Upregulation of soluble HLA-G5 and HLA-G6 isoforms in the milder histopathological stages of Helicobacter pylori infection: a role for subverting immune responses?","volume":"83","author":"Souza","year":"2016","journal-title":"Scand J Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.humimm.2016.01.004","article-title":"Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: localized versus disseminated disease","volume":"77","author":"Saurabh","year":"2016","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib32","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1007\/s00018-012-1069-3","article-title":"Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors","volume":"69","author":"HoWangYin","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"10.1053\/j.gastro.2018.07.034_bib33","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.humimm.2016.01.010","article-title":"The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice","volume":"77","author":"Takahashi","year":"2016","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/CMR.00033-16","article-title":"Clinical manifestations, treatment, and diagnosis of Tropheryma whipplei infections","volume":"30","author":"Dolmans","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1053\/j.gastro.2018.07.034_bib35","doi-asserted-by":"crossref","first-page":"e32340","DOI":"10.7554\/eLife.32340","article-title":"IRF4 haploinsufficiency in a family with Whipple\u2019s disease","volume":"7","author":"Guerin","year":"2018","journal-title":"Elife"},{"key":"10.1053\/j.gastro.2018.07.034_bib36","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1053\/j.gastro.2009.01.051","article-title":"The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple\u2019s disease","volume":"136","author":"Martinetti","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.07.034_bib37","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s10096-015-2433-7","article-title":"-295 T-to-C promoter region IL-16 gene polymorphism is associated with Whipple\u2019s disease","volume":"34","author":"Biagi","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib38","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1007\/s10096-012-1677-8","article-title":"Cytokine genetic profile in Whipple\u2019s disease","volume":"31","author":"Biagi","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib39","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1128\/IAI.00803-15","article-title":"Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine-lactone induces HLA-G expression in human immune cells","volume":"83","author":"Bortolotti","year":"2015","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2018.07.034_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.1300368","article-title":"The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-l-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages","volume":"191","author":"Glucksam-Galnoy","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib41","doi-asserted-by":"crossref","first-page":"15226","DOI":"10.1128\/JVI.79.24.15226-15237.2005","article-title":"Modulation of HLA-G expression in human neural cells after neurotropic viral infections","volume":"79","author":"Lafon","year":"2005","journal-title":"J\u00a0Virol"},{"key":"10.1053\/j.gastro.2018.07.034_bib42","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.4049\/jimmunol.164.12.6426","article-title":"Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection","volume":"164","author":"Onno","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib43","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1084\/jem.185.10.1743","article-title":"A\u00a0novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing","volume":"185","author":"Cella","year":"1997","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2018.07.034_bib44","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.186.11.1809","article-title":"A\u00a0common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells","volume":"186","author":"Colonna","year":"1997","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2018.07.034_bib45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jlb.66.5.718","article-title":"Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells","volume":"66","author":"Colonna","year":"1999","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1053\/j.gastro.2018.07.034_bib46","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4049\/jimmunol.166.2.781","article-title":"Uterine macrophages express the gp49B inhibitory receptor in midgestation","volume":"166","author":"Matsumoto","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2018.07.034_bib47","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1182\/blood-2004-03-0885","article-title":"Are interleukin-16 and thrombopoietin new tools for the in\u00a0vitro generation of dendritic cells?","volume":"104","author":"Della Bella","year":"2004","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2018.07.034_bib48","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/art.11151","article-title":"Salmonella septicemia in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: association with decreased interferon-gamma production and Toll-like receptor 4 expression","volume":"48","author":"Netea","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2018.07.034_bib49","first-page":"386","article-title":"Listeria endocarditis in a patient with psoriatic arthritis on infliximab: are biologic agents as treatment for inflammatory arthritis increasing the incidence of Listeria infections?","volume":"60","author":"Kelesidis","year":"2010","journal-title":"J\u00a0Infect"},{"key":"10.1053\/j.gastro.2018.07.034_bib50","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/MMBR.00010-14","article-title":"Latent tuberculosis infection: myths, models, and molecular mechanisms","volume":"78","author":"Dutta","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1053\/j.gastro.2018.07.034_bib51","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1086\/593174","article-title":"Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis","volume":"198","author":"Harris","year":"2008","journal-title":"J\u00a0Infect Dis"},{"key":"10.1053\/j.gastro.2018.07.034_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13256-015-0632-6","article-title":"Whipple\u2019s disease diagnosed during anti-tumor necrosis factor alpha treatment: two case reports and review of the literature","volume":"9","author":"Ramos","year":"2015","journal-title":"J\u00a0Med Case Rep"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518348224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518348224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T02:45:36Z","timestamp":1541213136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518348224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0016508518348224"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.07.034","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the AGA Institute","name":"copyright","label":"Copyright"}]}}