{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:02:15Z","timestamp":1771660935975,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1053\/j.gastro.2018.10.025","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T19:31:41Z","timestamp":1539804701000},"page":"582-591.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Synthetic Neoepitopes of the Transglutaminase\u2013Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease"],"prefix":"10.1053","volume":"156","author":[{"given":"Rok Seon","family":"Choung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahryar","family":"Khaleghi Rostamkolaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine M.","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric V.","family":"Marietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol T.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasanth","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Bei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karenah E.","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari Krishnan","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.10.025_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"ACG clinical guidelines: diagnosis and management of celiac disease","volume":"108","author":"Rubio-Tapia","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.10.025_bib2","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.4049\/jimmunol.1601693","article-title":"T\u00a0Cells in celiac disease","volume":"198","author":"Jabri","year":"2017","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib3","doi-asserted-by":"crossref","first-page":"e0147777","DOI":"10.1371\/journal.pone.0147777","article-title":"Determination of B-Cell epitopes in patients with celiac disease: peptide microarrays","volume":"11","author":"Choung","year":"2016","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2018.10.025_bib4","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/S0016-5085(98)70008-3","article-title":"Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease","volume":"115","author":"Sulkanen","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.gastro.2010.04.007","article-title":"Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study","volume":"139","author":"Walker","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1651-2227.1992.tb12306.x","article-title":"Increasing incidence of childhood coeliac disease in Sweden. Results of a national study","volume":"81","author":"Cavell","year":"1992","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.gastro.2018.10.025_bib7","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cgh.2015.11.016","article-title":"Amount may beat timing: gluten intake and risk of childhood celiac disease","volume":"14","author":"Ludvigsson","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.10.025_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MPG.0b013e31818c52cc","article-title":"Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic","volume":"49","author":"Myleus","year":"2009","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2018.10.025_bib9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I","article-title":"T\u00a0cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase","volume":"31","author":"Molberg","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib10","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/clinchem\/47.11.2023","article-title":"Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides","volume":"47","author":"Aleanzi","year":"2001","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2018.10.025_bib11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/gut.41.6.851","article-title":"Autoantibodies in coeliac disease: tissue transglutaminase\u2014guilt by association?","volume":"41","author":"Sollid","year":"1997","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.10.025_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/cmi.2010.68","article-title":"Novel trends in celiac disease","volume":"8","author":"Matthias","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12016-010-8223-1","article-title":"Cutting-edge issues in celiac disease and in gluten intolerance","volume":"42","author":"Bizzaro","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/apt.12621","article-title":"Predictors of persistent villous atrophy in coeliac disease: a population-based study","volume":"39","author":"Lebwohl","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.10.025_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Machine Learning"},{"key":"10.1053\/j.gastro.2018.10.025_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/1471-2105-12-324","article-title":"rapmad: robust analysis of peptide microarray data","volume":"12","author":"Renard","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1053\/j.gastro.2018.10.025_bib17","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J\u00a0Mach Learn Res"},{"key":"10.1053\/j.gastro.2018.10.025_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/jnci\/91.5.453","article-title":"Statistical analysis of array expression data as applied to the problem of tamoxifen resistance","volume":"91","author":"Hilsenbeck","year":"1999","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2018.10.025_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2249.2003.02326.x","article-title":"Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa","volume":"134","author":"Ciccocioppo","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib20","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1001\/jama.2010.549","article-title":"Diagnostic testing for celiac disease among patients with abdominal\u00a0symptoms: a systematic review","volume":"303","author":"van der Windt","year":"2010","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2018.10.025_bib21","first-page":"1","article-title":"Clinical utility of serologic testing for celiac disease in Ontario: an evidence-based analysis","volume":"10","year":"2010","journal-title":"Ont Health Technol Assess Ser"},{"key":"10.1053\/j.gastro.2018.10.025_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1365-2036.2008.03797.x","article-title":"Combination testing for antibodies in the diagnosis of coeliac disease: comparison of multiplex immunoassay and ELISA methods","volume":"28","author":"Rashtak","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.10.025_bib23","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/j.1572-0241.2000.02259.x","article-title":"Tissue transglutaminase antibodies in celiac disease: assessment of\u00a0a commercial kit","volume":"95","author":"Sugai","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.10.025_bib24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cgh.2007.12.008","article-title":"What is the role of serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysis","volume":"6","author":"Hopper","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.10.025_bib25","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1053\/j.gastro.2016.11.043","article-title":"Prevalence and morbidity of undiagnosed celiac disease from a community-based study","volume":"152","author":"Choung","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2018.10.025_bib27","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.10.025_bib28","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/gutjnl-2016-311574","article-title":"Transition from childhood to adulthood in coeliac disease: the Prague consensus report","volume":"65","author":"Ludvigsson","year":"2016","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.10.025_bib29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbadis.2004.06.009","article-title":"Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease","volume":"1690","author":"Skovbjerg","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2018.10.025_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12016-009-8160-z","article-title":"Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope","volume":"38","author":"Matthias","year":"2010","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib31","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1021\/jm5017126","article-title":"Synthetic peptides reproducing tissue transglutaminase-gliadin complex neo-epitopes as probes for antibody detection in celiac disease patients' sera","volume":"58","author":"Di Pisa","year":"2015","journal-title":"J\u00a0Med Chem"},{"key":"10.1053\/j.gastro.2018.10.025_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jcla.21816","article-title":"Assessment of a test for the screening and diagnosis of celiac disease","volume":"30","author":"Porcelli","year":"2016","journal-title":"J\u00a0Clin Lab Anal"},{"key":"10.1053\/j.gastro.2018.10.025_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-159-3-201308060-00006","article-title":"Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study","volume":"159","author":"Lebwohl","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2018.10.025_bib34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1210\/jc.2013-3164","article-title":"Persistent mucosal damage and risk of fracture in celiac disease","volume":"99","author":"Lebwohl","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2018.10.025_bib35","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/ajg.2010.10","article-title":"Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet","volume":"105","author":"Rubio-Tapia","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.10.025_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apt.12164","article-title":"Mucosal healing and mortality in coeliac disease","volume":"37","author":"Lebwohl","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.10.025_bib37","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1053\/j.gastro.2006.10.004","article-title":"American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease","volume":"131","author":"Rostom","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib38","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1053\/j.gastro.2006.10.003","article-title":"AGA Institute medical position statement on the diagnosis and management of celiac disease","volume":"131","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib39","series-title":"World Gastroenterology Organisation practice guidelines: celiac disease","first-page":"1","author":"Bai","year":"2016"},{"key":"10.1053\/j.gastro.2018.10.025_bib40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/MPG.0000000000001460","article-title":"Value of IgA tTG in predicting mucosal recovery in children with celiac disease on a gluten-free diet","volume":"64","author":"Leonard","year":"2017","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2018.10.025_bib41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.05.015","article-title":"Tests for serum transglutaminase and endomysial antibodies do not detect most patients with celiac disease and persistent villous atrophy on gluten-free diets: a meta-analysis","volume":"153","author":"Silvester","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.025_bib42","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1365-2036.2009.03992.x","article-title":"Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet","volume":"29","author":"Lanzini","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.10.025_bib43","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/00365520701452217","article-title":"Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit","volume":"42","author":"Kaukinen","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.10.025_bib44","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1007\/s10620-007-0058-0","article-title":"Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up","volume":"53","author":"Volta","year":"2008","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2018.10.025_bib45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/apt.12603","article-title":"Persistence of elevated deamidated gliadin peptide antibodies on a gluten-free diet indicates nonresponsive coeliac disease","volume":"39","author":"Spatola","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.10.025_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MPG.0b013e3182145511","article-title":"Use of deamidated gliadin peptide antibodies to monitor diet compliance in childhood celiac disease","volume":"53","author":"Monzani","year":"2011","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2018.10.025_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.182.1.75","article-title":"Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis","volume":"182","author":"McRae","year":"1995","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2018.10.025_bib48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/358155a0","article-title":"Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen","volume":"358","author":"Lehmann","year":"1992","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.025_bib49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s001250050031","article-title":"Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group","volume":"43","author":"Sohnlein","year":"2000","journal-title":"Diabetologia"},{"key":"10.1053\/j.gastro.2018.10.025_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-065X.1998.tb01217.x","article-title":"Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis","volume":"164","author":"Vincent","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1053\/j.gastro.2018.10.025_bib51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri724","article-title":"Epitope spreading in immune-mediated diseases: implications for immunotherapy","volume":"2","author":"Vanderlugt","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molimm.2012.03.030","article-title":"An analysis of B-cell\u00a0epitope discontinuity","volume":"51","author":"Sivalingam","year":"2012","journal-title":"Mol Immunol"},{"key":"10.1053\/j.gastro.2018.10.025_bib53","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1074\/mcp.M113.033308","article-title":"Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays","volume":"13","author":"Forsstrom","year":"2014","journal-title":"Mol Cell Proteomics"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518351564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518351564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T09:41:10Z","timestamp":1605260470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518351564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0016508518351564"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.10.025","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthetic Neoepitopes of the Transglutaminase\u2013Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}