{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:06:26Z","timestamp":1790629586091,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91740205"],"award-info":[{"award-number":["91740205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771540"],"award-info":[{"award-number":["31771540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31620103911"],"award-info":[{"award-number":["31620103911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571446"],"award-info":[{"award-number":["31571446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1053\/j.gastro.2018.10.054","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T11:56:41Z","timestamp":1542110201000},"page":"676-691.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":211,"title":["Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS"],"prefix":"10.1053","volume":"156","author":[{"given":"Wei","family":"Zhuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiman","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisong","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.10.054_bib1","first-page":"87","article-title":"Global Cancer Statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2018.10.054_bib2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nrc.2016.24","article-title":"Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?","volume":"16","author":"Hayakawa","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2018.10.054_bib3","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1093\/annonc\/mdt401","article-title":"No improvement in median survival for patients with metastatic gastric cancer despite increased use of chemotherapy","volume":"24","author":"Bernards","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2018.10.054_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nsmb.2942","article-title":"Discovery and annotation of long noncoding RNAs","volume":"22","author":"Mattick","year":"2015","journal-title":"Nat Struct Mol Biol"},{"key":"10.1053\/j.gastro.2018.10.054_bib5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ccr.2014.03.010","article-title":"A\u00a0long noncoding RNA ACTIVATED by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma","volume":"25","author":"Yuan","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ncb3464","article-title":"A\u00a0ROR1 HER3 IncRNA signalling axis modulates the Hippo YAP pathway to regulate bone metastasis","volume":"19","author":"Li","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.gastro.2018.10.054_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/j.gastro.2017.04.046","article-title":"Long noncoding RNAs in the pathogenesis of Barrett\u2019s esophagus and esophageal carcinoma","volume":"153","author":"Abraham","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.10.054_bib8","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1158\/2159-8290.CD-15-0921","article-title":"LncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern","volume":"6","author":"Sun","year":"2016","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2018.10.054_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41467-017-00304-1","article-title":"Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion","volume":"8","author":"Song","year":"2017","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2018.10.054_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrg3722","article-title":"The rise of regulatory RNA","volume":"15","author":"Morris","year":"2014","journal-title":"Nat Rev Genet"},{"key":"10.1053\/j.gastro.2018.10.054_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature13906","article-title":"Rapid modelling of cooperating genetic events in cancer through somatic genome editing","volume":"516","author":"Sanchez-Rivera","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.054_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2015.12.017","article-title":"Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins","volume":"164","author":"Lee","year":"2016","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.054_bib14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tibs.2016.07.003","article-title":"Linking long noncoding RNA localization and function","volume":"41","author":"Chen","year":"2016","journal-title":"Trend Biochem Sci"},{"key":"10.1053\/j.gastro.2018.10.054_bib15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ccell.2015.02.004","article-title":"A\u00a0cytoplasmic NF-kappa B interacting long noncoding RNA blocks I kappa B phosphorylation and suppresses breast cancer metastasis","volume":"27","author":"Liu","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.molcel.2012.06.027","article-title":"LincRNA-p21 suppresses target mRNA translation","volume":"47","author":"Yoon","year":"2012","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib17","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1038\/emboj.2013.188","article-title":"Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step","volume":"32","author":"Gumireddy","year":"2013","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2018.10.054_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature11508","article-title":"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat","volume":"491","author":"Carrieri","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.054_bib19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/368558a0","article-title":"B61 is a ligand for the Eck receptor protein-tyrosine kinase","volume":"368","author":"Bartley","year":"1994","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.054_bib20","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1158\/0008-5472.CAN-06-1560","article-title":"Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice","volume":"66","author":"Brantley-Sieders","year":"2006","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2018.10.054_bib21","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1038\/onc.2013.180","article-title":"ADAM12-cleaved ephrin-A1 contributes to lung metastasis","volume":"33","author":"Ieguchi","year":"2014","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2018.10.054_bib22","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1158\/0008-5472.CAN-15-0847","article-title":"The EPHRIN-A1\/EPHA2 signaling axis regulates glutamine metabolism in HER2-positive breast cancer","volume":"76","author":"Youngblood","year":"2016","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2018.10.054_bib23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ccr.2014.01.010","article-title":"A\u00a0peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer","volume":"25","author":"Jiao","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.2010.230623","article-title":"Gastrokine 1 induces senescence through p16\/Rb pathway activation in gastric cancer cells","volume":"61","author":"Xing","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.10.054_bib25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.stem.2008.03.013","article-title":"A\u00a0hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation","volume":"2","author":"Sampath","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib26","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1038\/sj.onc.1210992","article-title":"Ephrin-A1 promotes the malignant progression of intestinal tumors in Apc(min\/+) mice","volume":"27","author":"Shi","year":"2008","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2018.10.054_bib27","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2015.04.034","article-title":"RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity","volume":"161","author":"Pefanis","year":"2015","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.cell.2015.02.038","article-title":"Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis","volume":"160","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrd.2016.238","article-title":"Cornerstones of CRISPR-Cas in drug discovery and therapy","volume":"16","author":"Fellmann","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1053\/j.gastro.2018.10.054_bib30","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2012.09.024","article-title":"MicroRNAs mediate gene silencing via multiple different pathways in Drosophila","volume":"48","author":"Fukaya","year":"2012","journal-title":"Molecular Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","author":"Sonenberg","year":"2009","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature25757","article-title":"Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells","volume":"555","author":"Lubelsky","year":"2018","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.10.054_bib33","first-page":"9462","article-title":"Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function","volume":"44","author":"Chillon","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2018.10.054_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molcel.2013.11.004","article-title":"Reciprocal regulation of HIF-1 alpha and LincRNA-p21 modulates the Warburg effect","volume":"53","author":"Yang","year":"2014","journal-title":"Molecular Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/gb-2011-12-12-236","article-title":"Alu elements: know the SINEs","volume":"12","author":"Deininger","year":"2011","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2018.10.054_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd3625","article-title":"RNA therapeutics: beyond RNA interference and antisense oligonucleotides","volume":"11","author":"Kole","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1053\/j.gastro.2018.10.054_bib37","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ymthe.2017.03.023","article-title":"FDA-approved oligonucleotide therapies in 2017","volume":"25","author":"Stein","year":"2017","journal-title":"Mol Ther"},{"key":"10.1053\/j.gastro.2018.10.054_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chembiol.2011.12.008","article-title":"RNA-based therapeutics: current progress and future prospects","volume":"19","author":"Burnett","year":"2012","journal-title":"Chem Biol"},{"key":"10.1053\/j.gastro.2018.10.054_bib39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ccr.2014.01.010","article-title":"A\u00a0peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer","volume":"25","author":"Jiao","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2018.10.054_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.2010.230623","article-title":"Gastrokine 1 induces senescence through p16\/Rb pathway activation in gastric cancer cells","volume":"61","author":"Xing","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.10.054_bib41","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518352685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518352685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:19:43Z","timestamp":1758035983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518352685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0016508518352685"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.10.054","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.10.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}