{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:27:41Z","timestamp":1791325661284,"version":"4.3.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA009676"],"award-info":[{"award-number":["CA009676"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA046592"],"award-info":[{"award-number":["CA046592"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA158319"],"award-info":[{"award-number":["CA158319"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA967622"],"award-info":[{"award-number":["CA967622"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA200113"],"award-info":[{"award-number":["CA200113"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA163059"],"award-info":[{"award-number":["CA163059"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1053\/j.gastro.2018.12.004","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T09:40:38Z","timestamp":1545212438000},"page":"1404-1415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage"],"prefix":"10.1053","volume":"156","author":[{"given":"Daysha","family":"Ferrer-Torres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Nancarrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-5192","authenticated-orcid":false,"given":"Rork","family":"Kuick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Weh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramita","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-0659","authenticated-orcid":false,"given":"Jules","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishindra M.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Orringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia I.","family":"Canto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Kresty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Chak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2018.12.004_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrc2773","article-title":"Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis","volume":"10","author":"Reid","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2018.12.004_bib2","doi-asserted-by":"crossref","first-page":"S1367","DOI":"10.1016\/S0003-4975(03)01202-5","article-title":"Geographical distribution and racial disparity in esophageal cancer","volume":"76","author":"Pickens","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.gastro.2018.12.004_bib3","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1093\/annonc\/mds181","article-title":"The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends","volume":"23","author":"Thrift","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2018.12.004_bib4","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3748\/wjg.v21.i26.7933","article-title":"Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries","volume":"21","author":"Domper Arnal","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2018.12.004_bib5","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1053\/j.gastro.2004.03.077","article-title":"Gastroesophageal reflux among different racial groups in the United States","volume":"126","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.12.004_bib6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/gut.41.5.594","article-title":"Associations between different forms of gastro-oesophageal reflux disease","volume":"41","author":"El-Serag","year":"1997","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.12.004_bib7","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1046\/j.1365-2036.2002.01351.x","article-title":"Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease","volume":"16","author":"Spechler","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2018.12.004_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cgh.2015.10.028","article-title":"Sex and racial disparity in incidence of esophageal adenocarcinoma: observations and\u00a0explanations","volume":"14","author":"Thrift","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.12.004_bib9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/mnfr.200900110","article-title":"GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage","volume":"53","author":"Petermann","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1053\/j.gastro.2018.12.004_bib10","doi-asserted-by":"crossref","first-page":"54867","DOI":"10.18632\/oncotarget.10253","article-title":"Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas","volume":"7","author":"Ferrer-Torres","year":"2016","journal-title":"Oncotarget"},{"key":"10.1053\/j.gastro.2018.12.004_bib11","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2018.12.004_bib12","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2018.12.004_bib13","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/nar\/3.9.2303","article-title":"General method for isolation of high molecular-weight DNA from eukaryotes","volume":"3","author":"Blin","year":"1976","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2018.12.004_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000472","article-title":"Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes","volume":"5","author":"Zhao","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2018.12.004_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038958","article-title":"Molecular trajectories leading to the alternative fates of duplicate genes","volume":"7","author":"Marotta","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2018.12.004_bib16","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature12531","article-title":"Transcriptome and genome sequencing uncovers functional variation in humans","volume":"501","author":"Lappalainen","year":"2013","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.12.004_bib17","doi-asserted-by":"crossref","first-page":"33438","DOI":"10.18632\/oncotarget.5586","article-title":"Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in\u00a0vitro and in\u00a0vivo through pleiotropic cell death induction and PI3K\/AKT\/mTOR inactivation","volume":"6","author":"Kresty","year":"2015","journal-title":"Oncotarget"},{"key":"10.1053\/j.gastro.2018.12.004_bib18","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/mc.22432","article-title":"Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma","volume":"55","author":"Weh","year":"2016","journal-title":"Mol Carcinog"},{"key":"10.1053\/j.gastro.2018.12.004_bib19","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/carcin\/20.9.1801","article-title":"An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload","volume":"20","author":"Chen","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1053\/j.gastro.2018.12.004_bib20","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1158\/1055-9965.EPI-05-0014","article-title":"The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma","volume":"14","author":"Brabender","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2018.12.004_bib21","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1073\/pnas.0909797107","article-title":"Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers","volume":"107","author":"Saadi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2018.12.004_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/modpathol.2014.81","article-title":"Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression","volume":"28","author":"Lochhead","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1053\/j.gastro.2018.12.004_bib23","doi-asserted-by":"crossref","first-page":"35815","DOI":"10.1038\/srep35815","article-title":"Racial differences in microRNA and gene expression in hypertensive women","volume":"6","author":"Dluzen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2018.12.004_bib24","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1086\/512017","article-title":"Gene-expression variation within and among human populations","volume":"80","author":"Storey","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2018.12.004_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ajhg.2007.12.015","article-title":"Evaluation of genetic variation contributing to differences in gene expression between populations","volume":"82","author":"Zhang","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2018.12.004_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1383-5742(00)00050-8","article-title":"Mammalian class theta GST and differential susceptibility to carcinogens: a review","volume":"463","author":"Landi","year":"2000","journal-title":"Mutat Res"},{"key":"10.1053\/j.gastro.2018.12.004_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A\u00a0global reference\u00a0for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2018.12.004_bib28","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/mnfr.200800444","article-title":"Impact of apple polyphenols on GSTT2 gene expression, subsequent protection of DNA and modulation of proliferation using LT97 human colon adenoma cells","volume":"53","author":"Miene","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1053\/j.gastro.2018.12.004_bib29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1126\/science.1188021","article-title":"A\u00a0draft sequence of the Neandertal genome","volume":"328","author":"Green","year":"2010","journal-title":"Science"},{"key":"10.1053\/j.gastro.2018.12.004_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.1224344","article-title":"A\u00a0high-coverage genome sequence from an archaic Denisovan individual","volume":"338","author":"Meyer","year":"2012","journal-title":"Science"},{"key":"10.1053\/j.gastro.2018.12.004_bib31","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1073\/pnas.1709235114","article-title":"Direct dating of Neanderthal remains from the site of Vindija Cave and implications for the Middle to Upper Paleolithic transition","volume":"114","author":"Deviese","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2018.12.004_bib32","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.7314\/APJCP.2012.13.10.4967","article-title":"Null genotype of GSTT1 contributes to esophageal cancer risk in Asian populations: evidence from a meta-analysis","volume":"13","author":"Yi","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1053\/j.gastro.2018.12.004_bib33","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/jgh.13289","article-title":"Trends in esophageal cancer survival in United States adults from 1973 to 2009: a SEER database analysis","volume":"31","author":"Njei","year":"2016","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2018.12.004_bib34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"63","author":"El-Serag","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2018.12.004_bib35","series-title":"Global status report on noncommunicable diseases 2014","first-page":"176","year":"2014"},{"key":"10.1053\/j.gastro.2018.12.004_bib36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1053\/j.gastro.2011.11.019","article-title":"Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis","volume":"142","author":"Liao","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2018.12.004_bib37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0304-4165(98)00042-7","article-title":"Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon","volume":"1381","author":"Van Lieshout","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2018.12.004_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/antiox5030027","article-title":"Cranberries and cancer: an update of preclinical studies evaluating the cancer inhibitory potential of cranberry and cranberry derived constituents","volume":"5","author":"Weh","year":"2016","journal-title":"Antioxidants (Basel)"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518354015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508518354015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:44:18Z","timestamp":1762163058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508518354015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0016508518354015"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2018.12.004","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2018.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}