{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:21:22Z","timestamp":1793215282302,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1053\/j.gastro.2019.02.005","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T11:52:23Z","timestamp":1550145143000},"page":"2208-2216.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"title":["Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn\u2019s Disease"],"prefix":"10.1053","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-0329","authenticated-orcid":false,"given":"Anders","family":"Dige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Tarri","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Agnholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil Ginnerup","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-425X","authenticated-orcid":false,"given":"Michaela","family":"Tencerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-0869","authenticated-orcid":false,"given":"Moustapha","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Krogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-3319","authenticated-orcid":false,"given":"Lilli","family":"Lundby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2019.02.005_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/gast.2002.32362","article-title":"The natural history of fistulizing Crohn\u2019s disease in Olmsted County, Minnesota","volume":"122","author":"Schwartz","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.02.005_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/MEG.0000000000000840","article-title":"Time trends in the epidemiology and outcome of perianal fistulizing Crohn\u2019s disease in a population-based cohort","volume":"29","author":"Gottgens","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.02.005_bib3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1136\/gutjnl-2017-314918","article-title":"Modern management of perianal fistulas in Crohn\u2019s disease: future directions","volume":"67","author":"Kotze","year":"2018","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.02.005_bib4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/apt.12906","article-title":"Systematic review: the combined surgical and medical treatment of fistulising perianal Crohn\u2019s disease","volume":"40","author":"Yassin","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2019.02.005_bib5","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","article-title":"Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn\u2019s disease: a phase 3 randomised, double-blind controlled trial","volume":"388","author":"Panes","year":"2016","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2019.02.005_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.gastro.2017.04.001","article-title":"Autologous mesenchymal stem cells, applied in a bioabsorbable matrix, for treatment of perianal fistulas in patients with Crohn\u2019s disease","volume":"153","author":"Dietz","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.02.005_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00384-012-1581-9","article-title":"Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn\u2019s disease: results from a multicenter phase I\/IIa clinical trial","volume":"28","author":"de la Portilla","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"10.1053\/j.gastro.2019.02.005_bib8","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/stem.1357","article-title":"Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn\u2019s fistula","volume":"31","author":"Lee","year":"2013","journal-title":"Stem Cells"},{"key":"10.1053\/j.gastro.2019.02.005_bib9","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","article-title":"A\u00a0phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation","volume":"48","author":"Garcia-Olmo","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.gastro.2019.02.005_bib10","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2015.06.014","article-title":"Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn\u2019s disease","volume":"149","author":"Molendijk","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.02.005_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/DCR.0b013e3181973487","article-title":"Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial","volume":"52","author":"Garcia-Olmo","year":"2009","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.gastro.2019.02.005_bib12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/DCR.0b013e318255364a","article-title":"Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: Fistula Advanced Therapy Trial 1) and long-term evaluation","volume":"55","author":"Herreros","year":"2012","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.gastro.2019.02.005_bib13","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2017.12.020","article-title":"Long-term efficacy and safety of stem cell therapy (cx601) for complex perianal fistulas in patients with Crohn\u2019s disease","volume":"154","author":"Panes","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.02.005_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cyto.a.20813","article-title":"Stromal vascular progenitors in adult human adipose tissue","volume":"77","author":"Zimmerlin","year":"2010","journal-title":"Cytometry A"},{"key":"10.1053\/j.gastro.2019.02.005_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1479-5876-5-55","article-title":"\u201cIn\u00a0vitro\u201d and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells","volume":"5","author":"Astori","year":"2007","journal-title":"J\u00a0Transl Med"},{"key":"10.1053\/j.gastro.2019.02.005_bib16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/asj\/sjw022","article-title":"Content of soluble factors and characteristics of stromal vascular fraction cells in lipoaspirates from different subcutaneous adipose tissue depots","volume":"36","author":"Grasys","year":"2016","journal-title":"Aesthet Surg J"},{"key":"10.1053\/j.gastro.2019.02.005_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10151-017-1739-0","article-title":"Efficacy of autologous fat graft injection in the treatment of anovaginal fistulas","volume":"22","author":"Norderval","year":"2018","journal-title":"Tech Coloproctol"},{"key":"10.1053\/j.gastro.2019.02.005_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10151-018-1755-8","article-title":"Micro-fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and feasibility","volume":"22","author":"Naldini","year":"2018","journal-title":"Tech Coloproctol"},{"key":"10.1053\/j.gastro.2019.02.005_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 1: diagnosis and medical management","volume":"11","author":"Gomollon","year":"2017","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2019.02.005_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1053\/j.gastro.2019.02.005_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-61737-960-4_2","article-title":"Isolation of human adipose-derived stem cells from lipoaspirates","volume":"702","author":"Yu","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1053\/j.gastro.2019.02.005_bib22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4252\/wjsc.v7.i2.470","article-title":"CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture","volume":"7","author":"Alvarez-Viejo","year":"2015","journal-title":"World J Stem Cells"},{"key":"10.1053\/j.gastro.2019.02.005_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/asj\/sjv135","article-title":"Adipose Derived Stromal Cell (ADSC) Injections for Pain Management of Osteoarthritis in the Human Knee Joint","volume":"36","author":"Fodor","year":"2016","journal-title":"Aesthet Surg J"},{"key":"10.1053\/j.gastro.2019.02.005_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-016-0918-5","article-title":"Effects of the intramyocardial implantation of stromal vascular fraction in patients with chronic ischemic cardiomyopathy","volume":"14","author":"Comella","year":"2016","journal-title":"J\u00a0Transl Med"},{"key":"10.1053\/j.gastro.2019.02.005_bib25","doi-asserted-by":"crossref","first-page":"e11667","DOI":"10.1097\/MD.0000000000011667","article-title":"Treatment of human chronic wounds with autologous extracellular matrix\/stromal vascular fraction gel: a STROBE-compliant study","volume":"97","author":"Deng","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1053\/j.gastro.2019.02.005_bib26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/rheumatology\/kev323","article-title":"Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up","volume":"55","author":"Guillaume-Jugnot","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1053\/j.gastro.2019.02.005_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jcp.20636","article-title":"Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates","volume":"208","author":"Yoshimura","year":"2006","journal-title":"J\u00a0Cell Physiol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519303750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519303750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:21:35Z","timestamp":1758036095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508519303750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0016508519303750"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2019.02.005","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2019.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}