{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:52Z","timestamp":1789500652115,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["2-P30ES010126-15A1"],"award-info":[{"award-number":["2-P30ES010126-15A1"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","award":["2015-IDG-1007"],"award-info":[{"award-number":["2015-IDG-1007"]}],"id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007810","name":"University of North Carolina Wilmington","doi-asserted-by":"publisher","award":["P30 DK034987"],"award-info":[{"award-number":["P30 DK034987"]}],"id":[{"id":"10.13039\/100007810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2-P30-CA016086-40"],"award-info":[{"award-number":["2-P30-CA016086-40"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK034987"],"award-info":[{"award-number":["P30 DK034987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK101856"],"award-info":[{"award-number":["R01 DK101856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1053\/j.gastro.2019.03.014","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T02:44:40Z","timestamp":1552272280000},"page":"65-73.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"title":["Efficacy of Budesonide vs Fluticasone for Initial Treatment of Eosinophilic Esophagitis in a Randomized Controlled Trial"],"prefix":"10.1053","volume":"157","author":[{"given":"Evan S.","family":"Dellon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Woosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Arrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"McGee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn","family":"Covington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Moist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica H.","family":"Gebhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Tylicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan O.","family":"Shoyoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Galanko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2019.03.014_bib1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1056\/NEJMra1502863","article-title":"Eosinophilic esophagitis","volume":"373","author":"Furuta","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2019.03.014_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of eosinophilic esophagitis","volume":"154","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ajg.2014.316","article-title":"Health-care utilization, costs, and the burden of disease related to eosinophilic esophagitis in the United States","volume":"110","author":"Jensen","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2019.03.014_bib4","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1053\/j.gastro.2014.07.055","article-title":"Advances in clinical management of eosinophilic esophagitis","volume":"147","author":"Dellon","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1053\/gast.2002.32998","article-title":"Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate","volume":"122","author":"Teitelbaum","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib6","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1053\/j.gastro.2006.08.033","article-title":"A\u00a0randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis","volume":"131","author":"Konikoff","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cgh.2012.03.018","article-title":"Swallowed fluticasone improves histologic but not symptomatic responses of adults with eosinophilic esophagitis","volume":"10","author":"Alexander","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.03.014_bib8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1053\/j.gastro.2014.04.019","article-title":"Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis","volume":"147","author":"Butz","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib9","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/j.1572-0241.2007.01379.x","article-title":"Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children","volume":"102","author":"Aceves","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2019.03.014_bib10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2010.05.001","article-title":"Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial","volume":"139","author":"Dohil","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib11","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2010.07.048","article-title":"Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis","volume":"139","author":"Straumann","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1053\/j.gastro.2012.04.049","article-title":"Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis","volume":"143","author":"Dellon","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cgh.2014.05.021","article-title":"Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis","volume":"13","author":"Gupta","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.03.014_bib14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/gutjnl-2014-308815","article-title":"A\u00a0randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis","volume":"65","author":"Miehlke","year":"2016","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.03.014_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/j.gastro.2016.11.021","article-title":"Budesonide oral suspension improves symptomatic, endoscopic, and histologic parameters compared with placebo in patients with eosinophilic esophagitis","volume":"152","author":"Dellon","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib16","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1007\/s10620-017-4642-7","article-title":"Six-food elimination diet and topical steroids are effective for eosinophilic esophagitis: a meta-regression","volume":"62","author":"Cotton","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2019.03.014_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/MPG.0000000000001626","article-title":"Retrospective comparison of fluticasone propionate and oral viscous budesonide in children with eosinophilic esophagitis","volume":"66","author":"Fable","year":"2018","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2019.03.014_bib18","first-page":"55","article-title":"Treatment of eosinophilic esophagitis: is oral viscous budesonide superior to swallowed fluticasone spray?","volume":"7","author":"Krishna","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"10.1053\/j.gastro.2019.03.014_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2019.03.014_bib20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ajg.2013.71","article-title":"ACG Clinical Guideline: Evidence based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis","volume":"108","author":"Dellon","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2019.03.014_bib21","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1007\/s10620-009-1005-z","article-title":"Inter- and intraobserver reliability and validation of a new method for determination of eosinophil counts in patients with esophageal eosinophilia","volume":"55","author":"Dellon","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2019.03.014_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.humpath.2016.12.017","article-title":"Determination of esophageal eosinophil counts and other histologic features of eosinophilic esophagitis by pathology trainees is highly accurate","volume":"62","author":"Rusin","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1053\/j.gastro.2019.03.014_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.gie.2006.04.037","article-title":"Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis","volume":"64","author":"Gonsalves","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2019.03.014_bib24","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/apt.12413","article-title":"Development and field testing of a novel patient-reported outcome measure of dysphagia in patients with eosinophilic esophagitis","volume":"38","author":"Dellon","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2019.03.014_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/gutjnl-2011-301817","article-title":"Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system","volume":"62","author":"Hirano","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.03.014_bib26","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.17554\/j.issn.2224-3992.2015.04.562","article-title":"Evaluation of histologic cutpoints for treatment response in eosinophilic esophagitis","volume":"4","author":"Wolf","year":"2015","journal-title":"J\u00a0Gastroenterol Hepatol Res"},{"key":"10.1053\/j.gastro.2019.03.014_bib27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cgh.2017.09.046","article-title":"Optimal histologic cutpoints for treatment response in patients with eosinophilic esophagitis: analysis of data from a prospective cohort study","volume":"16","author":"Reed","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.03.014_bib28","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1053\/j.gastro.2014.08.028","article-title":"Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis","volume":"147","author":"Schoepfer","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib29","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s10620-009-0859-4","article-title":"Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis","volume":"55","author":"Peterson","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2019.03.014_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cgh.2007.11.008","article-title":"Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children","volume":"6","author":"Schaefer","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.03.014_bib31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ajg.2012.443","article-title":"Randomized controlled trial comparing aerosolized swallowed fluticasone to esomeprazole for esophageal eosinophilia","volume":"108","author":"Moawad","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2019.03.014_bib32","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1016\/S0016-5085(17)30960-5","article-title":"A\u00a0randomized, double-blind, placebo-controlled trial of a fluticasone propionate orally disintegrating tablet in adult and adolescent patients with eosinophilic esophagitis: a phase 1\/2A safety and tolerability study","volume":"152","author":"Hirano","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.03.014_bib33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1365-2036.2010.04476.x","article-title":"Practice patterns for the evaluation and treatment of eosinophilic oesophagitis","volume":"32","author":"Peery","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2019.03.014_bib34","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1164\/ajrccm.162.6.9912072","article-title":"Therapeutic ratio of inhaled corticosteroids in adult asthma. A dose-range comparison between fluticasone propionate and budesonide, measuring their effect on bronchial hyperresponsiveness and adrenal cortex function","volume":"162","author":"Nielsen","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/j.gastro.2019.03.014_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.iac.2005.05.004","article-title":"Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids","volume":"25","author":"Hubner","year":"2005","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1053\/j.gastro.2019.03.014_bib36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cgh.2014.07.034","article-title":"Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patients","volume":"13","author":"Wolf","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.03.014_bib37","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/j.gastro.2018.07.009","article-title":"Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE conference","volume":"155","author":"Dellon","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519335553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519335553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:47Z","timestamp":1777405487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508519335553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0016508519335553"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2019.03.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735330266.793563892","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735330266.793563759","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Budesonide vs Fluticasone for Initial Treatment of Eosinophilic Esophagitis in a Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2019.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}