{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:22:50Z","timestamp":1790396570643,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011838","name":"REACH Healthcare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011838","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2-OD023859"],"award-info":[{"award-number":["OT2-OD023859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK063922-16"],"award-info":[{"award-number":["T32 DK063922-16"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 DK120115"],"award-info":[{"award-number":["F32 DK120115"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1053\/j.gastro.2019.04.034","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:03:03Z","timestamp":1557266583000},"page":"522-536.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice"],"prefix":"10.1053","volume":"157","author":[{"given":"Kristen M.","family":"Smith-Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthe J.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Albers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2019.04.034_bib1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(88)90064-4","article-title":"Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides","volume":"24","author":"Holzer","year":"1988","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2019.04.034_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(94)E0017-B","article-title":"Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves","volume":"45","author":"Maggi","year":"1995","journal-title":"Prog Neurobiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroscience.2006.02.015","article-title":"Transient receptor potential vanilloid 1-immunopositive neurons in the mouse are more prevalent within colon afferents compared to skin and muscle afferents","volume":"140","author":"Christianson","year":"2006","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2019.04.034_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.20816","article-title":"Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat","volume":"494","author":"Christianson","year":"2006","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2019.04.034_bib5","doi-asserted-by":"crossref","first-page":"G348","DOI":"10.1152\/ajpgi.90578.2008","article-title":"Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon","volume":"297","author":"Matsumoto","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.surg.2009.11.019","article-title":"Intracolonic capsaicin stimulates colonic motility and defecation in conscious dogs","volume":"147","author":"Hayashi","year":"2010","journal-title":"Surgery"},{"key":"10.1053\/j.gastro.2019.04.034_bib7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0306-4522(90)90266-7","article-title":"Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide","volume":"39","author":"Maggi","year":"1990","journal-title":"Neuroscience"},{"issue":"11","key":"10.1053\/j.gastro.2019.04.034_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112466","article-title":"Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique","volume":"9","author":"Spencer","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2019.04.034_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(02)02653-5","article-title":"Cellular distribution of vanilloid VR1 receptor immunoreactivity in the guinea-pig myenteric plexus","volume":"458","author":"Anavi-Goffer","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2019.04.034_bib10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuroscience.2010.10.024","article-title":"Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons","volume":"172","author":"Matsumoto","year":"2011","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2019.04.034_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cne.10801","article-title":"Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract","volume":"465","author":"Ward","year":"2003","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2019.04.034_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fnins.2013.00179","article-title":"Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon","volume":"7","author":"Travis","year":"2013","journal-title":"Front Neurosci"},{"issue":"5","key":"10.1053\/j.gastro.2019.04.034_bib13","doi-asserted-by":"crossref","first-page":"G880","DOI":"10.1152\/ajpgi.00250.2016","article-title":"Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRP\u03b1-mCherry reporter mice","volume":"311","author":"Spencer","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0197-0186(87)90085-4","article-title":"Biosynthesis of tachykinins (substance P, neurokinin A and neuropeptide K) in neurons of the guinea pig myenteric plexus","volume":"10","author":"Deacon","year":"1987","journal-title":"Neurochem Int"},{"key":"10.1053\/j.gastro.2019.04.034_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-009-0798-6","article-title":"Characterisation of calcitonin gene-related peptide-immunoreactive neurons in the myenteric plexus of rat colon","volume":"337","author":"Mitsui","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1053\/j.gastro.2019.04.034_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(01)02480-6","article-title":"Vanilloid receptor type 1-immunoreactivity is expressed by intrinsic afferent neurones in the guinea-pig myenteric plexus","volume":"319","author":"Anavi-Goffer","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1053\/j.gastro.2019.04.034_bib17","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1172\/JCI72340","article-title":"Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis","volume":"124","author":"de Jong","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2019.04.034_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1369\/0022155413513589","article-title":"Vanilloid receptor-1 (TRPV1) expression and function in the vasculature of the rat","volume":"62","author":"Toth","year":"2014","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1053\/j.gastro.2019.04.034_bib19","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.3009","article-title":"The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells","volume":"15","author":"Bertin","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2019.04.034_bib20","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1111\/febs.13306","article-title":"Functional expression of TRPV channels in T cells and their implications in immune regulation","volume":"282","author":"Majhi","year":"2015","journal-title":"FEBS J"},{"key":"10.1053\/j.gastro.2019.04.034_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fncel.2013.00183","article-title":"Imaging neuron-glia interactions in the enteric nervous system","volume":"7","author":"Boesmans","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3389\/fncel.2015.00436","article-title":"Use of genetically encoded calcium indicators (GECIs) combined with advanced motion tracking techniques to examine the behavior of neurons and glia in the enteric nervous system of the intact murine colon","volume":"9","author":"Hennig","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib23","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1523\/JNEUROSCI.4175-14.2015","article-title":"Changes in nicotinic neurotransmission during enteric nervous system development","volume":"35","author":"Foong","year":"2015","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib24","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1073\/pnas.93.12.5860","article-title":"Efficient in\u00a0vivo manipulation of mouse genomic sequences at the zygote stage","volume":"93","author":"Lakso","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.04.034_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2004.04.008","article-title":"Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice","volume":"127","author":"Brierley","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.04.034_bib26","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1523\/JNEUROSCI.0837-18.2018","article-title":"Optogenetic activation of colon epithelium of the mouse produces high-frequency bursting in extrinsic colon afferents and engages visceromotor responses","volume":"38","author":"Makadia","year":"2018","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib27","first-page":"628","article-title":"Artemin immunotherapy is effective in preventing and reversing cystitis-induced bladder hyperalgesia via TRPA1 regulation","volume":"16","author":"DeBerry","year":"2015","journal-title":"J\u00a0Pain"},{"key":"10.1053\/j.gastro.2019.04.034_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20527","article-title":"Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators","volume":"5","author":"Smith-Edwards","year":"2016","journal-title":"Elife"},{"key":"10.1053\/j.gastro.2019.04.034_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1097-0185(199806)251:2<185::AID-AR6>3.0.CO;2-Y","article-title":"The identification and chemical coding of cholinergic neurons in the small and large intestine of the mouse","volume":"251","author":"Sang","year":"1998","journal-title":"Anat Rec"},{"issue":"Suppl 4","key":"10.1053\/j.gastro.2019.04.034_bib30","doi-asserted-by":"crossref","first-page":"iv15","DOI":"10.1136\/gut.47.suppl_4.iv15","article-title":"Anatomy and physiology of the enteric nervous system","volume":"47","author":"Costa","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.04.034_bib31","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1113\/JP271919","article-title":"Insights into the mechanisms underlying colonic motor patterns","volume":"594","author":"Spencer","year":"2016","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnins.2014.00075","article-title":"Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis","volume":"8","author":"Dinning","year":"2014","journal-title":"Front Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.1978.sp012248","article-title":"The sacral parasympathetic reflex pathway regulating colonic motility and defaecation in the cat","volume":"276","author":"De Groat","year":"1978","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(88)91555-7","article-title":"Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat","volume":"450","author":"Ness","year":"1988","journal-title":"Brain Res"},{"key":"10.1053\/j.gastro.2019.04.034_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0166-4328(97)00185-X","article-title":"Developmental and injury induced plasticity in the micturition reflex pathway","volume":"92","author":"de Groat","year":"1998","journal-title":"Behav Brain Res"},{"key":"10.1053\/j.gastro.2019.04.034_bib36","doi-asserted-by":"crossref","first-page":"11800","DOI":"10.1038\/ncomms11800","article-title":"Simultaneous optical and electrical in\u00a0vivo analysis of the enteric nervous system","volume":"7","author":"Rakhilin","year":"2016","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2019.04.034_bib37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrgastro.2012.168","article-title":"Regulation of gastrointestinal motility\u2014insights from smooth muscle biology","volume":"9","author":"Sanders","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.04.034_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4939-0897-4_3","article-title":"The enteric nervous system and gastrointestinal innervation: integrated local and central control","volume":"817","author":"Furness","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"10.1053\/j.gastro.2019.04.034_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-1838(00)00127-2","article-title":"Types of neurons in the enteric nervous system","volume":"81","author":"Furness","year":"2000","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1053\/j.gastro.2019.04.034_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2982.2003.00384.x","article-title":"Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach","volume":"15","author":"Schicho","year":"2003","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2019.04.034_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.autneu.2006.01.004","article-title":"Efferent-like roles of afferent neurons in the gut: blood flow regulation and tissue protection","volume":"125","author":"Holzer","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib42","first-page":"G657","article-title":"Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin","volume":"261","author":"Li","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2019.04.034_bib43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1440-1746.2004.03764.x","article-title":"Calcitonin gene-related peptide released by capsaicin suppresses myoelectrical activity of gastric smooth muscle","volume":"20","author":"Mizuguchi","year":"2005","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.04.034_bib44","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/ejp.1189","article-title":"Physiological and pathological characterization of capsaicin-induced reversible nerve degeneration and hyperalgesia","volume":"22","author":"Chiang","year":"2018","journal-title":"Eur J Pain"},{"key":"10.1053\/j.gastro.2019.04.034_bib45","first-page":"CD007393","article-title":"Topical capsaicin (high concentration) for chronic neuropathic pain in adults","volume":"1","author":"Derry","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2019.04.034_bib46","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ana.22126","article-title":"Capsaicin induces degeneration of cutaneous autonomic nerve fibers","volume":"68","author":"Gibbons","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1053\/j.gastro.2019.04.034_bib47","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.1523\/JNEUROSCI.18-21-08947.1998","article-title":"Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function","volume":"18","author":"Simone","year":"1998","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2019.04.034_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-1838(82)90087-X","article-title":"Parasympathetic preganglionic neurons in the sacral spinal cord","volume":"5","author":"De Groat","year":"1982","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1053\/j.gastro.2019.04.034_bib49","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/cne.21535","article-title":"Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers","volume":"506","author":"Forrest","year":"2008","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2019.04.034_bib50","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI76306","article-title":"Colitis-induced neuroplasticity disrupts motility in the inflamed and post-inflamed colon","volume":"125","author":"Mawe","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2019.04.034_bib51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrgastro.2011.83","article-title":"New insights into visceral hypersensitivity\u2014clinical implications in IBS","volume":"8","author":"Zhou","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.04.034_bib53","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2004.04.008","article-title":"Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice","volume":"127","author":"Brierley","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.04.034_bib54","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1523\/JNEUROSCI.0837-18.2018","article-title":"Optogenetic activation of colon epithelium of the mouse produces high-frequency bursting in extrinsic colon afferents and engages visceromotor responses","volume":"38","author":"Makadia","year":"2018","journal-title":"J\u00a0Neurosci"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519367277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519367277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:33:01Z","timestamp":1777383181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508519367277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0016508519367277"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2019.04.034","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2019.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}