{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:12:19Z","timestamp":1793938339286,"version":"4.8.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK083952"],"award-info":[{"award-number":["DK083952"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES023438"],"award-info":[{"award-number":["ES023438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES030429"],"award-info":[{"award-number":["ES030429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1053\/j.gastro.2019.05.066","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T01:58:45Z","timestamp":1559527125000},"page":"793-806.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice"],"prefix":"10.1053","volume":"157","author":[{"given":"Jiong","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chun","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-3736","authenticated-orcid":false,"given":"Yongdong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech G.","family":"Garbacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meishu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songrong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan P.","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-9457","authenticated-orcid":false,"given":"Da","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-155X","authenticated-orcid":false,"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2019.05.066_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2019.05.066_bib2","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2019.05.066_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.05.066_bib4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2019.05.066_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20","article-title":"The aryl hydrocarbon receptor complex and the control of gene expression","volume":"18","author":"Beischlag","year":"2008","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1053\/j.gastro.2019.05.066_bib6","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1039\/C4TX00236A","article-title":"Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs","volume":"4","author":"Jackson","year":"2015","journal-title":"Toxicol Res"},{"key":"10.1053\/j.gastro.2019.05.066_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfs253","article-title":"High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq","volume":"130","author":"Lo","year":"2012","journal-title":"Toxicol Sci"},{"issue":"5211","key":"10.1053\/j.gastro.2019.05.066_bib8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.7732381","article-title":"Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor","volume":"268","author":"Fernandez-Salguero","year":"1995","journal-title":"Science"},{"key":"10.1053\/j.gastro.2019.05.066_bib9","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.93.13.6731","article-title":"Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development","volume":"93","author":"Schmidt","year":"1996","journal-title":"Proc Natl Acad Sci U\u00a0S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.plipres.2017.06.001","article-title":"Aryl hydrocarbon receptor (AHR): \u201cpioneer member\u201d of the basic-helix\/loop\/helix per-Arnt-sim (bHLH\/PAS) family of \u201csensors\u201d of foreign and endogenous signals","volume":"67","author":"Nebert","year":"2017","journal-title":"Prog Lipid Res"},{"issue":"7135","key":"10.1053\/j.gastro.2019.05.066_bib11","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature05683","article-title":"Dioxin receptor is a ligand-dependent E3 ubiquitin ligase","volume":"446","author":"Ohtake","year":"2007","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2019.05.066_bib12","doi-asserted-by":"crossref","first-page":"13481","DOI":"10.1073\/pnas.0902132106","article-title":"Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin\/+ mice with natural ligands","volume":"106","author":"Kawajiri","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib13","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1128\/MCB.01658-12","article-title":"Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3","volume":"33","author":"He","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2019.05.066_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kft236","article-title":"Aryl hydrocarbon receptor\u2013dependent induction of liver fibrosis by dioxin","volume":"137","author":"Pierre","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2019.05.066_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1289\/EHP316","article-title":"Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL\/6J diet-induced obesity mouse model","volume":"125","author":"Duval","year":"2017","journal-title":"Environ Health Perspect"},{"key":"10.1053\/j.gastro.2019.05.066_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2019.05.066_bib17","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib18","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/me.2015-1145","article-title":"CAR suppresses hepatic gluconeogenesis by facilitating the ubiquitination and degradation of PGC1\u03b1","volume":"29","author":"Gao","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1053\/j.gastro.2019.05.066_bib19","doi-asserted-by":"crossref","first-page":"14694","DOI":"10.1073\/pnas.232562899","article-title":"A\u00a0ligand for the aryl hydrocarbon receptor isolated from lung","volume":"99","author":"Song","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib20","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1073\/pnas.0504757102","article-title":"Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types","volume":"102","author":"Walisser","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cmet.2014.11.002","article-title":"Cell-type-resolved quantitative proteomics of murine liver","volume":"20","author":"Azimifar","year":"2014","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2019.05.066_bib22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1021\/tx100328r","article-title":"Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes","volume":"24","author":"Dere","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"10.1053\/j.gastro.2019.05.066_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1471-2164-12-365","article-title":"Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver","volume":"12","author":"Dere","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1053\/j.gastro.2019.05.066_bib24","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1101\/gad.1388806","article-title":"Smad3-dependent nuclear translocation of \u03b2-catenin is required for TGF-\u03b21-induced proliferation of bone marrow-derived adult human mesenchymal stem cells","volume":"20","author":"Jian","year":"2006","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2019.05.066_bib25","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/bbrc.2001.6110","article-title":"Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-\/-) knockout mice having increased hepatic BaP-DNA adduct levels","volume":"289","author":"Uno","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2019.05.066_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.taap.2004.01.014","article-title":"Cyp1a1(-\/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria","volume":"196","author":"Uno","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1053\/j.gastro.2019.05.066_bib27","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2012.10.006","article-title":"Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis","volume":"16","author":"Matsubara","year":"2012","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2019.05.066_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2010.11.003","article-title":"Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice","volume":"280","author":"Ozeki","year":"2011","journal-title":"Toxicology"},{"key":"10.1053\/j.gastro.2019.05.066_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2016.09.025","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increases necroinflammation and hepatic stellate cell activation but does not exacerbate experimental liver fibrosis in mice","volume":"311","author":"Lamb","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1053\/j.gastro.2019.05.066_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15287398909531288","article-title":"Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand","volume":"27","author":"Pirkle","year":"1989","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1053\/j.gastro.2019.05.066_bib31","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1073\/pnas.1118467109","article-title":"Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor","volume":"109","author":"Wincent","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.05.066_bib32","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1074\/jbc.M109.093526","article-title":"Smad3 prevents \u03b2-catenin degradation and facilitates \u03b2-catenin nuclear translocation in chondrocytes","volume":"285","author":"Zhang","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2019.05.066_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2009.09.043","article-title":"Ubiquitin ligase Nedd4L targets activated Smad2\/3 to limit TGF-\u03b2 signaling","volume":"36","author":"Gao","year":"2009","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.0959-9673.2004.00397.x","article-title":"Liver portal fibrosis in dioxin receptor-null mice that\u00a0overexpress the latent transforming growth factor-\u03b2-binding protein-1","volume":"85","author":"Corchero","year":"2004","journal-title":"Int J Exp Pathol"},{"key":"10.1053\/j.gastro.2019.05.066_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/hep.20004","article-title":"Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion","volume":"39","author":"Andreola","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2019.05.066_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2019.05.066_bib37","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/me.2015-1145","article-title":"CAR suppresses hepatic gluconeogenesis by facilitating the ubiquitination and degradation of PGC1\u03b1","volume":"29","author":"Gao","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1053\/j.gastro.2019.05.066_bib38","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in\u00a0vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.05.066_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tiv.2014.11.011","article-title":"In\u00a0vitro re-expression of the aryl hydrocarbon receptor (Ahr) in cultured Ahr-deficient mouse antral follicles partially restores the phenotype to that of cultured wild-type mouse follicles","volume":"29","author":"Ziv-Gal","year":"2015","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1053\/j.gastro.2019.05.066_bib40","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1111\/j.1582-4934.2008.00569.x","article-title":"BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt\/\u03b2-catenin signalling","volume":"13","author":"Tang","year":"2009","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1053\/j.gastro.2019.05.066_bib41","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2007.135","article-title":"A\u00a0protocol for rapid generation of recombinant adenoviruses using the AdEasy system","volume":"2","author":"Luo","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2019.05.066_bib42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nprot.2006.27","article-title":"Protocol for the fast chromatin immunoprecipitation (ChIP) method","volume":"1","author":"Nelson","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2019.05.066_bib43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2010.10.029","article-title":"PARP-1 attenuates Smad-mediated transcription","volume":"40","author":"L\u00f6nn","year":"2010","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A\u00a0vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ccell.2016.09.004","article-title":"p62\/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer","volume":"30","author":"Duran","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib46","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1038\/s41467-018-05495-9","article-title":"Systematic identification of non-coding pharmacogenomic landscape in cancer","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2019.05.066_bib47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ccell.2018.03.006","article-title":"lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer","volume":"33","author":"Wang","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib48","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1021\/tx100328r","article-title":"Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes","volume":"24","author":"Dere","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"10.1053\/j.gastro.2019.05.066_bib49","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2011.08.050","article-title":"Master transcription factors determine cell- type-specific responses to TGF-\u03b2 signaling","volume":"147","author":"Mullen","year":"2011","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2019.05.066_bib50","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1002\/stem.1371","article-title":"Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells","volume":"31","author":"Zhang","year":"2013","journal-title":"Stem Cells"},{"key":"10.1053\/j.gastro.2019.05.066_bib51","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Affo","year":"2013","journal-title":"Gut"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519409840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519409840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:21:30Z","timestamp":1758036090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508519409840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0016508519409840"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2019.05.066","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2019.05.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the AGA Institute","name":"copyright","label":"Copyright"}]}}