{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:01:56Z","timestamp":1790373716176,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013856","name":"Debbie's Dream Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1053\/j.gastro.2019.09.037","type":"journal-article","created":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T01:35:58Z","timestamp":1570239358000},"page":"598-609.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"title":["Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia"],"prefix":"10.1053","volume":"158","author":[{"given":"Joseph","family":"Burclaff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer G.","family":"Willet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 B.","family":"S\u00e1enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-4662","authenticated-orcid":false,"given":"Jason C.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2019.09.037_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ar.1092360202","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2019.09.037_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ar.1092360204","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2019.09.037_bib3","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1053\/j.gastro.2010.08.003","article-title":"TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa","volume":"139","author":"Quante","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib4","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.yexcr.2011.08.017","article-title":"The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist","volume":"317","author":"Goldenring","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2019.09.037_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00212218","article-title":"Cells intermediate between mucous neck cells and chief cells in rat stomach","volume":"233","author":"Suzuki","year":"1983","journal-title":"Cell Tissue Res"},{"key":"10.1053\/j.gastro.2019.09.037_bib6","doi-asserted-by":"crossref","first-page":"G368","DOI":"10.1152\/ajpgi.00021.2010","article-title":"Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of \u201cfloxed\u201d alleles","volume":"299","author":"Huh","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2019.09.037_bib7","first-page":"639","article-title":"Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma","volume":"79","author":"Schmidt","year":"1999","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2019.09.037_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jcmgh.2016.11.001","article-title":"Murine models of gastric corpus preneoplasia","volume":"3","author":"Petersen","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.09.037_bib9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jcmgh.2016.05.006","article-title":"Stomach organ and cell lineage differentiation: from embryogenesis to adult homeostasis","volume":"2","author":"Willet","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2019.09.037_bib10","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798311","article-title":"Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis","volume":"37","author":"Willet","year":"2018","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2019.09.037_bib11","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1053\/j.gastro.2010.09.005","article-title":"Mature chief cells are cryptic progenitors for metaplasia in the stomach","volume":"139","author":"Nam","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2013.09.008","article-title":"Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium","volume":"155","author":"Stange","year":"2013","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2019.09.037_bib13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/ncb3541","article-title":"Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach","volume":"19","author":"Leushacke","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.gastro.2019.09.037_bib14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/j.gastro.2016.09.018","article-title":"Identification of stem cells in the epithelium of the stomach corpus and antrum of mice","volume":"152","author":"Matsuo","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ccell.2015.10.003","article-title":"Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche","volume":"28","author":"Hayakawa","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2019.09.037_bib16","doi-asserted-by":"crossref","first-page":"G583","DOI":"10.1152\/ajpgi.00351.2017","article-title":"Mature gastric chief cells are not required for the development of metaplasia","volume":"314","author":"Kinoshita","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2019.09.037_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ncb3567","article-title":"Lgr5 joins the club of gastric stem cell markers in the corpus","volume":"19","author":"Phesse","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.gastro.2019.09.037_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.gastro.2011.09.050","article-title":"Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach","volume":"142","author":"Huh","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-1-4939-3603-8_28","article-title":"Modeling murine gastric metaplasia through tamoxifen-induced acute parietal cell loss","volume":"1422","author":"Saenz","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1053\/j.gastro.2019.09.037_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devcel.2015.02.013","article-title":"Salivary gland homeostasis is maintained through acinar cell self-duplication","volume":"33","author":"Aure","year":"2015","journal-title":"Dev Cell"},{"key":"10.1053\/j.gastro.2019.09.037_bib21","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1073\/pnas.0902508106","article-title":"Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis","volume":"106","author":"Sangiorgi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2019.09.037_bib22","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI29988","article-title":"Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration","volume":"117","author":"Desai","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2019.09.037_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.gastro.2018.09.050","article-title":"Tropism for spasmolytic polypeptide-expressing metaplasia allows Helicobacter pylori to expand its intragastric niche","volume":"156","author":"Saenz","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/j.gastro.2017.11.278","article-title":"Metaplastic cells in the stomach arise, independently of stem cells, via dedifferentiation or transdifferentiation of chief cells","volume":"154","author":"Radyk","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/ar.1092360203","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2019.09.037_bib26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1242\/dev.02700","article-title":"The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1","volume":"134","author":"Ramsey","year":"2007","journal-title":"Development"},{"key":"10.1053\/j.gastro.2019.09.037_bib27","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1136\/gutjnl-2012-302401","article-title":"Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression","volume":"62","author":"Weis","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.09.037_bib28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/cas.12236","article-title":"Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia","volume":"104","author":"Wada","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1053\/j.gastro.2019.09.037_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ar.1092360205","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2019.09.037_bib30","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1053\/j.gastro.2010.08.050","article-title":"XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum","volume":"139","author":"Huh","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib31","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1074\/jbc.M115.685750","article-title":"Transcriptional regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4alpha (HNF4Alpha) is vital to beta-cell function","volume":"291","author":"Moore","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2019.09.037_bib32","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2353\/ajpath.2010.100328","article-title":"The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma","volume":"177","author":"Lennerz","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2019.09.037_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/(SICI)1096-9896(199902)187:3<331::AID-PATH241>3.0.CO;2-S","article-title":"The mucous neck cell in the human gastric corpus: a distinctive, functional cell lineage","volume":"187","author":"Hanby","year":"1999","journal-title":"J\u00a0Pathol"},{"key":"10.1053\/j.gastro.2019.09.037_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/gut.20.8.693","article-title":"Cell differentiation in human gastric gland as revealed by nuclear binding of tritiated actinomycin","volume":"20","author":"Stoffels","year":"1979","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2019.09.037_bib35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF00307670","article-title":"Cell population kinetics of zymogen and parietal cells in the stomach of mice","volume":"134","author":"Willems","year":"1972","journal-title":"Z\u00a0Zellforsch Mikrosk Anat"},{"key":"10.1053\/j.gastro.2019.09.037_bib36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0016-5085(19)32584-3","article-title":"Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. A selective effect of gastrin on parietal cell proliferation","volume":"69","author":"Willems","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2019.09.037_bib37","doi-asserted-by":"crossref","first-page":"G767","DOI":"10.1152\/ajpgi.00415.2001","article-title":"Multipotential stem cells in adult mouse gastric epithelium","volume":"283","author":"Bjerknes","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"9","key":"10.1053\/j.gastro.2019.09.037_bib38","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.035071","article-title":"Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas","volume":"11","author":"Burclaff","year":"2018","journal-title":"Dis Model Mech"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519414091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508519414091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:23:39Z","timestamp":1758036219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508519414091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0016508519414091"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2019.09.037","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2019.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the AGA Institute","name":"copyright","label":"Copyright"}]}}