{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:30:11Z","timestamp":1784770211555,"version":"3.55.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1053\/j.gastro.2020.03.027","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T12:07:08Z","timestamp":1584706028000},"page":"1538-1540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Channelopathy of the Pancreas Causes Chronic Pancreatitis"],"prefix":"10.1053","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-9922","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"Sahin-T\u00f3th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2020.03.027_bib1","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1053\/j.gastro.2018.11.081","article-title":"Genetics, cell biology, and pathophysiology of pancreatitis","volume":"156","author":"Mayerle","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.03.027_bib2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1053\/j.gastro.2020.01.005","article-title":"Variants that affect function of calcium channel TRPV6 are associated with early-onset chronic pancreatitis","volume":"158","author":"Masamune","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.03.027_bib3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceca.2017.04.006","article-title":"TRPV6: from identification to function","volume":"67","author":"Fecher-Trost","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1053\/j.gastro.2020.03.027_bib4","article-title":"Structure and function of the calcium-selective TRP channel TRPV6","author":"Yelshanskaya","year":"2020","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2020.03.027_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3109\/01677063.2010.514369","article-title":"The history of the Drosophila TRP channel: the birth of a new channel superfamily","volume":"24","author":"Minke","year":"2010","journal-title":"J\u00a0Neurogenet"},{"key":"10.1053\/j.gastro.2020.03.027_bib6","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2020.03.027_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1359\/jbmr.061110","article-title":"Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene","volume":"22","author":"Bianco","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1053\/j.gastro.2020.03.027_bib8","doi-asserted-by":"crossref","first-page":"ra27","DOI":"10.1126\/scisignal.2001791","article-title":"Male fertility depends on Ca2+ absorption by TRPV6 in epididymal epithelia","volume":"4","author":"Weissgerber","year":"2011","journal-title":"Sci Signal"},{"key":"10.1053\/j.gastro.2020.03.027_bib9","doi-asserted-by":"crossref","first-page":"17930","DOI":"10.1074\/jbc.M111.328286","article-title":"Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation","volume":"287","author":"Weissgerber","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2020.03.027_bib10","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/ajmg.a.40484","article-title":"TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton","volume":"176A","author":"Burren","year":"2018","journal-title":"Am J Med Genet"},{"key":"10.1053\/j.gastro.2020.03.027_bib11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.ajhg.2018.04.006","article-title":"TRPV6 variants interfere with maternal-fetal calcium transport through the placenta and cause transient neonatal hyperparathyroidism","volume":"102","author":"Suzuki","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2020.03.027_bib12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1210\/js.2018-00374","article-title":"TRPV6 gene mutation in a dizygous twin with transient neonatal hyperparathyroidism","volume":"3","author":"Yamashita","year":"2019","journal-title":"J\u00a0Endocr Soc"},{"key":"10.1053\/j.gastro.2020.03.027_bib13","first-page":"374","article-title":"TRPV6 as a target for cancer therapy","volume":"11","author":"Stewart","year":"2020","journal-title":"J\u00a0Cancer"},{"key":"10.1053\/j.gastro.2020.03.027_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2020.03.027_bib15","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1007\/s10620-017-4601-3","article-title":"Genetic risk in chronic pancreatitis: the trypsin-dependent pathway","volume":"62","author":"Hegyi","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2020.03.027_bib16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/MOG.0000000000000380","article-title":"Genetic risk in chronic pancreatitis: the misfolding-dependent pathway","volume":"33","author":"Sahin-T\u00f3th","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1053\/j.gastro.2020.03.027_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jsbmb.2004.03.029","article-title":"Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1\u03b1,25-dihydroxy Vitamin D3 and dietary Ca2+","volume":"89-90","author":"van de Graaf","year":"2004","journal-title":"J\u00a0Steroid Biochem Mol Biol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520303760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520303760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:25:16Z","timestamp":1758036316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508520303760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0016508520303760"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2020.03.027","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Channelopathy of the Pancreas Causes Chronic Pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.01.029","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the AGA Institute","name":"copyright","label":"Copyright"}]}}