{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:23:13Z","timestamp":1758079393307,"version":"3.44.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1053\/j.gastro.2020.08.006","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T02:39:24Z","timestamp":1596767964000},"page":"1233-1235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting Alternative Brush Border Trafficking Routes to Treat Microvillous Inclusion Disease"],"prefix":"10.1053","volume":"159","author":[{"given":"Shabnam","family":"Abtahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-9455","authenticated-orcid":false,"given":"Jerrold R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2020.08.006_bib1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1053\/j.gastro.2018.03.067","article-title":"Advances in evaluation of chronic diarrhea in infants","volume":"154","author":"Thiagarajah","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.08.006_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0016-5085(78)90458-4","article-title":"Familial enteropathy: a syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villus atrophy","volume":"75","author":"Davidson","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.08.006_bib3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000478-200207000-00008","article-title":"CD10: a valuable tool for the light microscopic diagnosis of microvillous inclusion disease (familial microvillous atrophy)","volume":"26","author":"Groisman","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2020.08.006_bib4","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1053\/j.gastro.2018.08.025","article-title":"Loss of MYO5B leads to reductions in Na(+) absorption with maintenance of CFTR-dependent Cl(-) secretion in enterocytes","volume":"155","author":"Engevik","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.08.006_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 Na+\/H+ exchanger","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2020.08.006_bib6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/350354a0","article-title":"Glucose\/galactose malabsorption caused by a defect in the Na+\/glucose cotransporter","volume":"350","author":"Turk","year":"1991","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2020.08.006_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7524148","article-title":"Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model","volume":"266","author":"Gabriel","year":"1994","journal-title":"Science"},{"key":"10.1053\/j.gastro.2020.08.006_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jcmgh.2015.11.009","article-title":"Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum","volume":"2","author":"Weis","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2020.08.006_bib9","doi-asserted-by":"crossref","first-page":"16494","DOI":"10.1074\/jbc.M300580200","article-title":"Lysophosphatidic acid stimulates brush border Na+\/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism","volume":"278","author":"Lee-Kwon","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2020.08.006_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbalip.2004.04.005","article-title":"Lysophosphatidic acid induces exocytic trafficking of Na(+)\/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C","volume":"1683","author":"Choi","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2020.08.006_bib11","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1091\/mbc.e16-12-0862","article-title":"Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes","volume":"28","author":"Sarker","year":"2017","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2020.08.006_bib12","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1074\/jbc.M409471200","article-title":"Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation","volume":"280","author":"Shiue","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2020.08.006_bib13","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1242\/jcs.056713","article-title":"NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid","volume":"123","author":"Cha","year":"2010","journal-title":"J\u00a0Cell Sci"},{"key":"10.1053\/j.gastro.2020.08.006_bib14","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/j.gastro.2010.10.042","article-title":"D-glucose acts via sodium\/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+\/H+ exchange regulatory factor 2-dependent process","volume":"140","author":"Lin","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.08.006_bib15","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/j.gastro.2020.06.008","article-title":"Lysophosphatidic acid\u00a0increases maturation of brush borders and SGLT1 activity in MYO5B-deficient Mice, a model of microvillus inclusion disease","volume":"159","author":"Kaji","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.08.006_bib16","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1053\/j.gastro.2020.02.034","article-title":"Editing myosin VB gene to create porcine model of microvillus inclusion disease, with microvillus-lined inclusions and alterations in sodium transporters","volume":"158","author":"Engevik","year":"2020","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520350228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520350228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:28:11Z","timestamp":1758036491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508520350228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0016508520350228"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2020.08.006","relation":{},"ISSN":["0016-5085"],"issn-type":[{"type":"print","value":"0016-5085"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploiting Alternative Brush Border Trafficking Routes to Treat Microvillous Inclusion Disease","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.06.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the AGA Institute","name":"copyright","label":"Copyright"}]}}