{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:23:52Z","timestamp":1793669032863,"version":"4.5.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003194","name":"New York Stem Cell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["P30 DK078392"],"award-info":[{"award-number":["P30 DK078392"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22416"],"award-info":[{"award-number":["19K22416"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H02800"],"award-info":[{"award-number":["JP18H02800"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004398","name":"Mitsubishi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["DP2 DK128799-01"],"award-info":[{"award-number":["DP2 DK128799-01"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20fk0210060h0002"],"award-info":[{"award-number":["20fk0210060h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20gm1210012h0001"],"award-info":[{"award-number":["20gm1210012h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19bm0404045"],"award-info":[{"award-number":["JP19bm0404045"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19bm0704025"],"award-info":[{"award-number":["JP19bm0704025"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk0210037"],"award-info":[{"award-number":["JP19fk0210037"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk0210060"],"award-info":[{"award-number":["JP19fk0210060"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1053\/j.gastro.2020.10.002","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T12:19:14Z","timestamp":1602159554000},"page":"831-846.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":386,"title":["High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell\u2013Derived Organoids"],"prefix":"10.1053","volume":"160","author":[{"given":"Tadahiro","family":"Shinozawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Ouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Maezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran-Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shodai","family":"Togo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy L.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-3041","authenticated-orcid":false,"given":"Takanori","family":"Takebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2020.10.002_bib1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/clpt.2014.110","article-title":"Human iPSC-derived miniature organs: a tool for drug studies","volume":"96","author":"Takebe","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/clpt.2014.158","article-title":"Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity","volume":"96","author":"Yang","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib3","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1124\/jpet.106.119073","article-title":"Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP\/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity","volume":"321","author":"Leslie","year":"2007","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2019.05.007","article-title":"Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids","volume":"30","author":"Ouchi","year":"2019","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2020.10.002_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/embj.201387098","article-title":"iPS cells: a game changer for future medicine","volume":"33","author":"Inoue","year":"2014","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2020.10.002_bib6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.stem.2015.03.004","article-title":"Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation","volume":"16","author":"Takebe","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1053\/j.gastro.2020.10.002_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nprot.2014.020","article-title":"Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"9","author":"Takebe","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2020.10.002_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature09691","article-title":"Directed differentiation of human pluripotent stem cells into intestinal tissue in\u00a0vitro","volume":"470","author":"Spence","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2020.10.002_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.stemcr.2018.01.006","article-title":"Human iPSC-derived posterior gut progenitors are expandable and capable of forming gut and liver organoids","volume":"10","author":"Zhang","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1053\/j.gastro.2020.10.002_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s004410051125","article-title":"The effect of retinoic acid on the re-establishment of differentiated hepatocyte phenotype in primary culture","volume":"293","author":"Falasca","year":"1998","journal-title":"Cell Tissue Res"},{"key":"10.1053\/j.gastro.2020.10.002_bib11","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun"},{"key":"10.1053\/j.gastro.2020.10.002_bib12","first-page":"1106","article-title":"The structure and organization of the bile canalicular cytoskeleton with special reference to actin and actin-binding proteins","volume":"21","author":"Tsukada","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2020.10.002_bib13","doi-asserted-by":"crossref","first-page":"38694","DOI":"10.1038\/srep38694","article-title":"Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: a novel in\u00a0vitro cholestatic model","volume":"6","author":"Ni","year":"2016","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2020.10.002_bib14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/clpt.2012.79","article-title":"A\u00a0perspective on efflux transport proteins in the liver","volume":"92","author":"Kock","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0676.1996.tb00705.x","article-title":"Structural and functional features of bile canaliculi in adult rat hepatocyte spheroids","volume":"16","author":"Yumoto","year":"1996","journal-title":"Liver"},{"key":"10.1053\/j.gastro.2020.10.002_bib16","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/hep.23083","article-title":"De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis","volume":"50","author":"Keitel","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2020.10.002_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jceh.2012.08.002","article-title":"Comparison of culture media for bile acid transport studies in primary human hepatocytes","volume":"2","author":"Mork","year":"2012","journal-title":"J\u00a0Clin Exp Hepatol"},{"key":"10.1053\/j.gastro.2020.10.002_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/toxsci\/kfs326","article-title":"Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans","volume":"132","author":"Khetani","year":"2013","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib19","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in\u00a0vitro cytotoxicity measured in a novel cell-based model using high content screening","volume":"80","author":"O\u2019Brien","year":"2006","journal-title":"Arch Toxicol"},{"key":"10.1053\/j.gastro.2020.10.002_bib20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/toxsci\/kfy058","article-title":"Prediction of drug-induced hepatotoxicity using long-term stable primary hepatic 3D spheroid cultures in chemically defined conditions","volume":"163","author":"Vorrink","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib21","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1007\/s00204-017-2002-1","article-title":"Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury","volume":"91","author":"Proctor","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1053\/j.gastro.2020.10.002_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfn109","article-title":"Cellular imaging predictions of clinical drug-induced liver injury","volume":"105","author":"Xu","year":"2008","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jhep.2012.12.018","article-title":"Drug-induced liver injury in obesity","volume":"58","author":"Fromenty","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2020.10.002_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.taap.2015.12.020","article-title":"A\u00a0cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen","volume":"292","author":"Michaut","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1053\/j.gastro.2020.10.002_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/hep.27206","article-title":"Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump","volume":"60","author":"Aleo","year":"2014","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2020.10.002_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tiv.2016.03.008","article-title":"Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes","volume":"34","author":"Oorts","year":"2016","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1053\/j.gastro.2020.10.002_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-3565(24)37925-X","article-title":"Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity","volume":"288","author":"Bort","year":"1999","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib28","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/mds.10342","article-title":"Entacapone-induced hepatotoxicity and hepatic dysfunction","volume":"17","author":"Fisher","year":"2002","journal-title":"Mov Disord"},{"key":"10.1053\/j.gastro.2020.10.002_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2020.10.002_bib30","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0006-3002(63)90799-6","article-title":"Induction of swelling of liver mitochondria by fatty acids of various chain length","volume":"70","author":"Zborowski","year":"1963","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2020.10.002_bib31","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.gastro.2009.06.006","article-title":"Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure","volume":"137","author":"Lee","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.10.002_bib32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.taap.2009.07.021","article-title":"Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes","volume":"240","author":"Rachek","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1053\/j.gastro.2020.10.002_bib33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/clpt.2013.143","article-title":"Association of CYP2C9\u22172 with bosentan-induced liver injury","volume":"94","author":"Markova","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.gastro.2020.10.002_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2020.10.002_bib35","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-term expansion of functional mouse and human hepatocytes as 3D organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2020.10.002_bib36","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1074\/jbc.R114.635995","article-title":"Human enteroids\/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology","volume":"291","author":"Zachos","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2020.10.002_bib37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1053\/j.gastro.2015.12.042","article-title":"Organoid models of human gastrointestinal development and disease","volume":"150","author":"Dedhia","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.10.002_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0031-3955(16)32665-7","article-title":"Drug metabolism in the human fetus and newborn infant","volume":"19","author":"Rane","year":"1972","journal-title":"Pediatr Clin North Am"},{"key":"10.1053\/j.gastro.2020.10.002_bib39","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.20101","article-title":"Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress","volume":"39","author":"Serviddio","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2020.10.002_bib40","first-page":"471","article-title":"Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria","volume":"19","author":"Krahenbuhl","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2020.10.002_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0005-2728(96)00041-2","article-title":"The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death","volume":"1275","author":"Bernardi","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2020.10.002_bib42","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41591-020-1023-0","article-title":"Polygenic architecture informs potential vulnerability to drug-induced liver injury","volume":"26","author":"Koido","year":"2020","journal-title":"Nature Medicine"},{"key":"10.1053\/j.gastro.2020.10.002_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/03602532.2011.604086","article-title":"Central role of mitochondria in drug-induced liver injury","volume":"44","author":"Pessayre","year":"2012","journal-title":"Drug Metab Rev"},{"key":"10.1053\/j.gastro.2020.10.002_bib44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/toxsci\/kfu176","article-title":"A\u00a0systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells","volume":"142","author":"Li","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tiv.2016.03.008","article-title":"Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes","volume":"34","author":"Oorts","year":"2016","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1053\/j.gastro.2020.10.002_bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/toxsci\/kfz229","article-title":"High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice","volume":"173","author":"Kohara","year":"2020","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/toxsci\/kfv159","article-title":"Quantification of drug-induced inhibition of canalicular cholyl-L-lysyl-fluorescein excretion from hepatocytes by high content cell imaging","volume":"148","author":"Barber","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib48","doi-asserted-by":"crossref","first-page":"38694","DOI":"10.1038\/srep38694","article-title":"Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: a novel in\u00a0vitro cholestatic model","volume":"6","author":"Ni","year":"2016","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2020.10.002_bib49","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.tiv.2013.07.003","article-title":"Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells","volume":"27","author":"Le Vee","year":"2013","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1053\/j.gastro.2020.10.002_bib50","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1073\/pnas.1413481111","article-title":"Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes","volume":"111","author":"Takayama","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2020.10.002_bib51","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/toxsci\/kfv048","article-title":"Prediction of drug-induced liver injury in micropatterned co-cultures containing iPSC-derived human hepatocytes","volume":"145","author":"Ware","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1053\/j.gastro.2020.10.002_bib52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jhep.2018.12.028","article-title":"Generation of hepatobiliary organoids from human induced pluripotent stem cells","volume":"70","author":"Wu","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2020.10.002_bib53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2019.05.007","article-title":"Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids","volume":"30","author":"Ouchi","year":"2019","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2020.10.002_bib54","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in\u00a0vitro cytotoxicity measured in a novel cell-based model using high content screening","volume":"80","author":"O\u2019Brien","year":"2006","journal-title":"Arch Toxicol"},{"key":"10.1053\/j.gastro.2020.10.002_bib55","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1007\/s00204-017-2002-1","article-title":"Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury","volume":"91","author":"Proctor","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1053\/j.gastro.2020.10.002_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax5516","article-title":"Reproducing human and cross-species drug toxicities using a liver-chip","volume":"11","author":"Jang","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.gastro.2020.10.002_bib57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.stem.2017.08.016","article-title":"Synergistic engineering: organoids meet organs-on-a-chip","volume":"21","author":"Takebe","year":"2017","journal-title":"Cell Stem Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520352288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520352288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:48:40Z","timestamp":1762163320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508520352288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0016508520352288"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2020.10.002","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell\u2013Derived Organoids","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}