{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:26:37Z","timestamp":1791213997470,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20cm0106206"],"award-info":[{"award-number":["JP20cm0106206"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H06176"],"award-info":[{"award-number":["JP17H06176"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20J12287"],"award-info":[{"award-number":["JP20J12287"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1053\/j.gastro.2020.10.047","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T02:12:26Z","timestamp":1605579146000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer"],"prefix":"10.1053","volume":"160","author":[{"given":"Kazuhiro","family":"Togasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Nanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Matano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirirat","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-8137","authenticated-orcid":false,"given":"Toshiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2020.10.047_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2020.10.047_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification","volume":"64","author":"Lauren","year":"1965","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1053\/j.gastro.2020.10.047_bib3","series-title":"World Health Organization classification of tumours of the digestive system","author":"Bosman","year":"2010"},{"key":"10.1053\/j.gastro.2020.10.047_bib4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/his.13383","article-title":"Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes","volume":"72","author":"Kwon","year":"2018","journal-title":"Histopathology"},{"key":"10.1053\/j.gastro.2020.10.047_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1365-2559.2008.03166.x","article-title":"Intratumoural heterogeneity of intestinal expression reflects environmental induction and progression-related loss of induction in undifferentiated-type gastric carcinomas","volume":"53","author":"Natsagdorj","year":"2008","journal-title":"Histopathology"},{"key":"10.1053\/j.gastro.2020.10.047_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10120-018-00905-9","article-title":"Effect of double-layer structure in intramucosal gastric signet-ring cell carcinoma on lymph node metastasis: a retrospective, single-center study","volume":"22","author":"Murai","year":"2019","journal-title":"Gastric Cancer"},{"key":"10.1053\/j.gastro.2020.10.047_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","article-title":"Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in\u00a0vitro","volume":"6","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1053\/j.gastro.2020.10.047_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In\u00a0Vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.10.047_bib9","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cell.2018.07.027","article-title":"Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis","volume":"174","author":"Nanki","year":"2018","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2020.10.047_bib10","doi-asserted-by":"crossref","first-page":"e11621","DOI":"10.7554\/eLife.11621","article-title":"Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin\/\u03b1-albumin","volume":"5","author":"Mihara","year":"2016","journal-title":"eLife"},{"key":"10.1053\/j.gastro.2020.10.047_bib11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nm.3802","article-title":"Modeling colorectal cancer using CRISPR-Cas9\u2013mediated engineering of human intestinal organoids","volume":"21","author":"Matano","year":"2015","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2020.10.047_bib12","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.3737","article-title":"An in\u00a0vivo model of human small intestine using pluripotent stem cells","volume":"20","author":"Watson","year":"2014","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2020.10.047_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.stem.2017.11.012","article-title":"Reconstruction of the human colon epithelium in\u00a0vivo","volume":"22","author":"Sugimoto","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1053\/j.gastro.2020.10.047_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrc3261","article-title":"Intra-tumour heterogeneity: a looking glass for cancer?","volume":"12","author":"Marusyk","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2020.10.047_bib15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature23642","article-title":"Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis","volume":"548","author":"Sigal","year":"2017","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2020.10.047_bib16","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/bjc.2014.112","article-title":"Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer","volume":"110","author":"Xi","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2020.10.047_bib17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1245\/s10434-007-9660-9","article-title":"Indication for endoscopic mucosal resection in early signet ring cell gastric cancer","volume":"15","author":"Ha","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1053\/j.gastro.2020.10.047_bib18","article-title":"Clinicopathological characteristics and survival outcomes of primary signet ring cell carcinoma in the stomach: retrospective analysis of single center database","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2020.10.047_bib19","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.3748\/wjg.v21.i40.11428","article-title":"Signet-ring cell carcinoma of the stomach: impact on prognosis and specific therapeutic challenge","volume":"21","author":"Pernot","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2020.10.047_bib20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41598-020-57544-3","article-title":"Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing","volume":"10","author":"Nemtsova","year":"2020","journal-title":"Sci Rep"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520354044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520354044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:31:40Z","timestamp":1758036700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508520354044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0016508520354044"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2020.10.047","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.10.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}