{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:34:48Z","timestamp":1790778888600,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018952","name":"Birmingham Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1053\/j.gastro.2020.12.024","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T16:18:48Z","timestamp":1612628328000},"page":"1558-1569.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["An International Multicenter Real-Life Prospective Study of Electronic Chromoendoscopy Score PICaSSO in Ulcerative Colitis"],"prefix":"10.1053","volume":"160","author":[{"given":"Marietta","family":"Iacucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel C.L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Bazarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday N.","family":"Shivaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Cannatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Daperno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyong","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu","family":"Hayee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"De Hertogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lazarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga M.","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Parra-Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pastorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Panaccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Occhipinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Eugenio","family":"Tontini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Zardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Bisschops","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Kiesslich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2020.12.024_bib1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): determining therapeutic goals for treat-to-target","volume":"110","author":"Peyrin-Biroulet","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2020.12.024_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/apt.13475","article-title":"Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn\u2019s disease","volume":"43","author":"Shah","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2020.12.024_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.crohns.2008.03.004","article-title":"Long-term outcome after infliximab for refractory ulcerative colitis","volume":"2","author":"Ferrante","year":"2008","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1053\/j.gastro.2011.06.054","article-title":"Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis","volume":"141","author":"Colombel","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.12.024_bib5","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2020.12.024_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ecco-jcc\/jjv180","article-title":"Mucosal healing in ulcerative colitis--when zero is better","volume":"10","author":"Boal Carvalho","year":"2016","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ecco-jcc\/jjv158","article-title":"Evaluation of the risk of relapse in ulcerative colitis according to the degree of mucosal healing (Mayo 0 vs 1): a longitudinal cohort study","volume":"10","author":"Barreiro-de Acosta","year":"2016","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib8","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2020.06.043","article-title":"Incremental benefit of achieving endoscopic and histologic remission in patients with ulcerative colitis: a systematic review and meta-analysis","volume":"159","author":"Yoon","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.12.024_bib9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1055\/s-0034-1391863","article-title":"Complete mucosal healing defined by endoscopic Mayo subscore still demonstrates abnormalities by novel high definition colonoscopy and refined histological gradings","volume":"47","author":"Iacucci","year":"2015","journal-title":"Endoscopy"},{"key":"10.1053\/j.gastro.2020.12.024_bib10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/ecco-jcc\/jjaa056","article-title":"Assessment of endoscopic healing by using advanced technologies reflects histologic healing in ulcerative colitis","volume":"14","author":"Iacucci","year":"2020","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib11","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.gie.2017.03.012","article-title":"Development and reliability of the new endoscopic virtual chromoendoscopy score: the PICaSSO (Paddington International Virtual ChromoendoScopy ScOre) in ulcerative colitis","volume":"86","author":"Iacucci","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2020.12.024_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/gutjnl-2011-300486","article-title":"Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS)","volume":"61","author":"Travis","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/gutjnl-2015-310393","article-title":"Development and validation of a histological index for UC","volume":"66","author":"Mosli","year":"2017","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2015-310187","article-title":"Development and validation of the Nancy histological index for UC","volume":"66","author":"Marchal-Bressenot","year":"2017","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib15","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1038\/s41598-017-07338-x","article-title":"Usefulness of different pathological scores to assess healing of the mucosa in inflammatory bowel diseases: a real life study","volume":"7","author":"Villanacci","year":"2017","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2020.12.024_bib16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"A\u00a0reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gie.2018.02.044","article-title":"The Paddington International Virtual Chromoendoscopy Score in ulcerative colitis exhibits very good inter-rater agreement after computerized module training: a multicenter study across academic and community practice (with video)","volume":"88","author":"Trivedi","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2020.12.024_bib18","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.gie.2010.06.068","article-title":"Comprehensive validation of the Boston Bowel Preparation Scale","volume":"72","author":"Calderwood","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2020.12.024_bib19","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1136\/gutjnl-2018-317547","article-title":"Definitions of response and remission for the Robarts Histopathology Index","volume":"68","author":"Pai","year":"2019","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121945","article-title":"cocor: a comprehensive solution for the statistical comparison of correlations","volume":"10","author":"Diedenhofen","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2020.12.024_bib21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1053\/j.gastro.2020.12.024_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2020.12.024_bib23","series-title":"Modern applied statistics with S","author":"Venables","year":"2002"},{"key":"10.1053\/j.gastro.2020.12.024_bib24","doi-asserted-by":"crossref","first-page":"E568","DOI":"10.1055\/a-0869-7619","article-title":"Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis: a retrospective study","volume":"7","author":"Kanazawa","year":"2019","journal-title":"Endosc Int Open"},{"key":"10.1053\/j.gastro.2020.12.024_bib25","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.crohns.2014.08.011","article-title":"Systematic review: histological remission in inflammatory bowel disease. Is \u2018complete\u2019 remission the new treatment paradigm? An IOIBD initiative","volume":"8","author":"Bryant","year":"2014","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib26","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/ajg.2012.301","article-title":"Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing","volume":"107","author":"Bessissow","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2020.12.024_bib27","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.cgh.2017.02.016","article-title":"Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes","volume":"15","author":"Christensen","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2020.12.024_bib28","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.dld.2017.08.041","article-title":"Acute histological inflammatory activity is associated with clinical relapse in patients with ulcerative colitis in clinical and endoscopic remission","volume":"49","author":"Calafat","year":"2017","journal-title":"Dig Liver Dis"},{"key":"10.1053\/j.gastro.2020.12.024_bib29","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/ajg.2016.418","article-title":"Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: systematic review and meta-analysis","volume":"111","author":"Park","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2020.12.024_bib30","author":"Cannatelli"},{"key":"10.1053\/j.gastro.2020.12.024_bib31","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/gutjnl-2017-315235","article-title":"Advanced endoscopic techniques in the assessment of inflammatory bowel disease: new technology, new era","volume":"68","author":"Iacucci","year":"2019","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2020.12.024_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.gie.2019.11.032","article-title":"A\u00a0review of endoscopic scoring systems and their importance in a treat-to-target approach in inflammatory bowel disease (with videos)","volume":"91","author":"Limdi","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2020.12.024_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0042-124363","article-title":"Beyond white light: optical enhancement in conjunction with magnification colonoscopy for the assessment of mucosal healing in ulcerative colitis","volume":"49","author":"Iacucci","year":"2017","journal-title":"Endoscopy"},{"key":"10.1053\/j.gastro.2020.12.024_bib34","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2013.07.024","article-title":"Reliability and initial validation of the ulcerative colitis endoscopic index of severity","volume":"145","author":"Travis","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.12.024_bib35","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/ecco-jcc\/jjy081","article-title":"Correlation between endoscopic and histological activity in ulcerative colitis using validated indices","volume":"12","author":"Irani","year":"2018","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1053\/j.gastro.2020.12.024_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/j.gastro.2013.03.025","article-title":"The role of centralized reading of endoscopy in a randomized controlled trial of mesalamine for ulcerative colitis","volume":"145","author":"Feagan","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2020.12.024_bib37","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/gutjnl-2015-309598","article-title":"Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up","volume":"65","author":"Bryant","year":"2016","journal-title":"Gut"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520355633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508520355633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:31:39Z","timestamp":1758036699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508520355633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0016508520355633"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2020.12.024","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An International Multicenter Real-Life Prospective Study of Electronic Chromoendoscopy Score PICaSSO in Ulcerative Colitis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2020.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the AGA Institute","name":"copyright","label":"Copyright"}]}}