{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:06:46Z","timestamp":1794366406003,"version":"4.9.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016469","name":"Takeda Pharmaceuticals International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1053\/j.gastro.2021.03.014","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T18:05:46Z","timestamp":1616004346000},"page":"66-80.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":185,"title":["TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.1053","volume":"161","author":[{"given":"Ciar\u00e1n P.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Leffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Getts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Bledsoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glennda","family":"Smithson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Roy","family":"First","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Elhofy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Teh","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Podojil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-0718","authenticated-orcid":false,"given":"Stephen D.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias L.","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Meri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Oliphant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Rizzardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Silvester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2021.03.014_bib1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2015.01.044","article-title":"Celiac disease","volume":"135","author":"Green","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2021.03.014_bib3","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1172\/JCI41344","article-title":"IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis","volume":"120","author":"Malamut","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2021.03.014_bib4","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1053\/j.gastro.2008.01.008","article-title":"Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis","volume":"134","author":"Mazzarella","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2021.03.014_bib5","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1073\/pnas.1311861110","article-title":"Dietary gluten triggers concomitant activation of CD4+ and CD8+ \u03b1\u03b2 T cells and \u03b3\u03b4 T cells in celiac disease","volume":"110","author":"Han","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2021.03.014_bib6","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","article-title":"Clinical practice. Celiac disease","volume":"367","author":"Fasano","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib7","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib8","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/j.gastro.2009.09.008","article-title":"Celiac disease: from pathogenesis to novel therapies","volume":"137","author":"Schuppan","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2021.03.014_bib9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3109\/00365521.2013.792389","article-title":"Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study","volume":"48","author":"Ludvigsson","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2021.03.014_bib10","first-page":"26","article-title":"Even small amounts of gluten cause relapse in children with celiac disease","volume":"34","author":"Laurin","year":"2002","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2021.03.014_bib11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jval.2016.12.016","article-title":"A\u00a0novel patient-derived conceptual model of the impact of celiac disease in adults: implications for patient-reported outcome and health-related quality-of-life instrument development","volume":"20","author":"Leffler","year":"2017","journal-title":"Value Health"},{"key":"10.1053\/j.gastro.2021.03.014_bib12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"ACG clinical guidelines: diagnosis and management of celiac disease","volume":"108","author":"Rubio-Tapia","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2021.03.014_bib13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.it.2015.05.007","article-title":"Harnessing nanoparticles for immune modulation","volume":"36","author":"Getts","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib14","doi-asserted-by":"crossref","first-page":"219ra7","DOI":"10.1126\/scitranslmed.3007563","article-title":"Therapeutic inflammatory monocyte modulation using immune-modifying microparticles","volume":"6","author":"Getts","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib15","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nbt.2434","article-title":"Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis","volume":"30","author":"Getts","year":"2012","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.gastro.2021.03.014_bib16","first-page":"2148","article-title":"Targeted immunomodulation using protein coated nanoparticles","volume":"8","author":"McCarthy","year":"2014","journal-title":"WIRES Nanomed Nanobiotechnol"},{"key":"10.1053\/j.gastro.2021.03.014_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jaut.2017.12.010","article-title":"Tolerogenic Ag-PLG nanoparticles induce Tregs to suppress activated diabetogenic CD4 and CD8 T cells","volume":"89","author":"Prasad","year":"2018","journal-title":"J\u00a0Autoimmun"},{"key":"10.1053\/j.gastro.2021.03.014_bib18","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1053\/j.gastro.2020.01.045","article-title":"Gliadin nanoparticles induce immune tolerance to gliadin in mouse models of celiac disease","volume":"158","author":"Freitag","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2021.03.014_bib19","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1136\/gut.2009.186361","article-title":"Gliadin-primed CD4+CD45RBlowCD25\u2212 T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice","volume":"58","author":"Freitag","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2021.03.014_bib20","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1021\/nn405033r","article-title":"A\u00a0biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease","volume":"8","author":"Hunter","year":"2014","journal-title":"ACS Nano"},{"key":"10.1053\/j.gastro.2021.03.014_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.nano.2016.09.007","article-title":"An antigen-encapsulating nanoparticle platform for TH1\/17 immune tolerance therapy","volume":"13","author":"McCarthy","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1053\/j.gastro.2021.03.014_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4049\/jimmunol.1900127","article-title":"Nanoparticles containing an insulin-ChgA hybrid peptide protect from transfer of autoimmune diabetes by shifting the balance between effector T cells and regulatory T cells","volume":"203","author":"Jamison","year":"2019","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib23","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2021.03.014_bib24","doi-asserted-by":"crossref","first-page":"41ra51","DOI":"10.1126\/scitranslmed.3001012","article-title":"Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease","volume":"2","author":"Tye-Din","year":"2010","journal-title":"Sci Transl Med"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2021.03.014_bib25","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/bioinformatics\/bti1013","article-title":"A\u00a0systematic approach for comprehensive T-cell epitope discovery using peptide libraries","volume":"21","author":"Beissbarth","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2021.03.014_bib26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S2468-1253(17)30110-3","article-title":"Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies","volume":"2","author":"Goel","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2021.03.014_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/73200","article-title":"In\u00a0vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope","volume":"6","author":"Anderson","year":"2000","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib28","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/gut.2004.059998","article-title":"T\u00a0cells in peripheral blood after gluten challenge in coeliac disease","volume":"54","author":"Anderson","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2021.03.014_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076163","article-title":"Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease","volume":"8","author":"Taavela","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2021.03.014_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cgh.2012.11.005","article-title":"Mild enteropathy celiac disease: a wolf in sheep's clothing?","volume":"11","author":"Leffler","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2021.03.014_bib31","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib32","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri2153","article-title":"Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease","volume":"7","author":"Miller","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nri2527","article-title":"Antiviral immune responses: triggers of or triggered by autoimmunity?","volume":"9","author":"Munz","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac disease","volume":"391","author":"Lebwohl","year":"2018","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2021.03.014_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0016-5085(98)70134-9","article-title":"Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease","volume":"115","author":"Nilsen","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2021.03.014_bib36","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2249.2011.04510.x","article-title":"Up-regulation\u00a0of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes","volume":"167","author":"Lahdenpera","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib37","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4049\/jimmunol.0901919","article-title":"Characterization of IL-17A-producing cells in celiac disease mucosa","volume":"184","author":"Monteleone","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/400_2008_13","article-title":"Prospects for antigen-specific tolerance based therapies for the treatment of multiple sclerosis","volume":"51","author":"Turley","year":"2010","journal-title":"Results and problems in cell differentiation"},{"key":"10.1053\/j.gastro.2021.03.014_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41587-019-0015-4","article-title":"Antigen-specific therapeutic approaches for autoimmunity","volume":"37","author":"Serra","year":"2019","journal-title":"Nature Biotechnol"},{"key":"10.1053\/j.gastro.2021.03.014_bib40","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1073\/pnas.1505782113","article-title":"Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization","volume":"113","author":"Smarr","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2021.03.014_bib41","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.4049\/jimmunol.1601693","article-title":"T\u00a0cells in celiac disease","volume":"198","author":"Jabri","year":"2017","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib42","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1053\/j.gastro.2020.10.040","article-title":"Evaluating responses to gluten challenge: a randomized, double-blind, 2-dose gluten challenge trial","volume":"160","author":"Leonard","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2021.03.014_bib43","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ajg.2017.480","article-title":"Measuring change in small intestinal histology in patients with celiac disease","volume":"113","author":"Adelman","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2021.03.014_bib44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/apt.15435","article-title":"Randomised clinical trial: a placebo-controlled study of subcutaneous or intradermal NEXVAX2, an investigational immunomodulatory peptide therapy for coeliac disease","volume":"50","author":"Truitt","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2021.03.014_bib45","doi-asserted-by":"crossref","first-page":"188ra75","DOI":"10.1126\/scitranslmed.3006168","article-title":"Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis","volume":"5","author":"Lutterotti","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.gastro.2021.03.014_bib46","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.ymthe.2017.03.032","article-title":"Peptide-conjugated nanoparticles reduce positive co-stimulatory expression and T cell activity to induce tolerance","volume":"25","author":"Kuo","year":"2017","journal-title":"Mol Ther"},{"key":"10.1053\/j.gastro.2021.03.014_bib47","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.4049\/jimmunol.1004175","article-title":"Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells","volume":"187","author":"Getts","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2021.03.014_bib48","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1021\/ac901049w","article-title":"Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry","volume":"81","author":"Bandura","year":"2009","journal-title":"Anal Chem"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508521005217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508521005217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:49:15Z","timestamp":1762163355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508521005217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0016508521005217"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2021.03.014","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2021.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the AGA Institute","name":"copyright","label":"Copyright"}]}}