{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:58:19Z","timestamp":1772107099178,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"USDA ARS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","gastrojournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1053\/j.gastro.2023.12.011","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T04:12:43Z","timestamp":1702959163000},"page":"645-657.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex-Dependent Efficacy of Dietary Fiber in Pediatric Functional Abdominal Pain"],"prefix":"10.1053","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-0084","authenticated-orcid":false,"given":"Sik Yu","family":"So","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Badu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazli","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Mirabile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Castaneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Musaad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Heitkemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor C.","family":"Savidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41572-020-00222-5","article-title":"Paediatric functional abdominal pain disorders","volume":"6","author":"Thapar","year":"2020","journal-title":"Nat Rev Dis Prim"},{"key":"10.1053\/j.gastro.2023.12.011_bib2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/sj.ejcn.1602386","article-title":"Low-dietary fiber intake as a risk factor for recurrent abdominal pain in children","volume":"60","author":"Paulo","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"10.1053\/j.gastro.2023.12.011_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1440-1754.2000.00513.x","article-title":"Prevalence and pattern of childhood abdominal pain in an Australian general practice","volume":"36","author":"Huang","year":"2000","journal-title":"J\u00a0Paediatr Child Health"},{"key":"10.1053\/j.gastro.2023.12.011_bib4","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/MEG.0000000000000425","article-title":"The role of fiber supplementation in the treatment of irritable bowel syndrome: a systematic review and meta-analysis","volume":"27","author":"Nagarajan","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2023.12.011_bib5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2016.03.045","article-title":"Psyllium fiber reduces abdominal pain in children with irritable bowel syndrome in a randomized, double-blind trial","volume":"15","author":"Shulman","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2023.12.011_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","article-title":"Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2023.12.011_bib7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/gutjnl-2015-310683","article-title":"The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS","volume":"66","author":"Tack","year":"2017","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2023.12.011_bib8","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1046\/j.1365-2036.1999.00610.x","article-title":"Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist","volume":"13","author":"Camilleri","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2023.12.011_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2036.2000.00684.x","article-title":"A\u00a0double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome","volume":"14","author":"Bardhan","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2023.12.011_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cgh.2007.12.015","article-title":"Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"6","author":"Andresen","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1297053","article-title":"Dietary intake of fibers: differential effects in men and women on perceived general health and immune functioning","volume":"61","author":"Fernstrand","year":"2017","journal-title":"Food Nutr Res"},{"issue":"7","key":"10.1053\/j.gastro.2023.12.011_bib12","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.3390\/nu12072088","article-title":"Sex-specific differences in the gut microbiome in response to dietary fiber supplementation in IL-10-deficient mice","volume":"12","author":"Zhang","year":"2020","journal-title":"Nutrients"},{"key":"10.1053\/j.gastro.2023.12.011_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2019-0124OC","article-title":"Sex differences in the impact of dietary fiber on pulmonary responses to ozone","volume":"62","author":"Tashiro","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1053\/j.gastro.2023.12.011_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jmoldx.2019.01.006","article-title":"Leveraging human microbiome features to diagnose and stratify children with irritable bowel syndrome","volume":"21","author":"Hollister","year":"2019","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1053\/j.gastro.2023.12.011_bib15","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1053\/j.gastro.2011.06.072","article-title":"Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome","volume":"141","author":"Saulnier","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2023.12.011_bib16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.cgh.2020.09.034","article-title":"Activation of the innate immune system in children with irritable bowel syndrome evidenced by increased fecal human \u03b2-defensin-2","volume":"19","author":"Shulman","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2023.12.011_bib17","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2023.12.011_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2036.2010.04535.x","article-title":"The interpretation of Rome III criteria and method of assessment affect the irritable bowel syndrome classification of children","volume":"33","author":"Czyzewski","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2023.12.011_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pain.2009.03.002","article-title":"Three new datasets supporting use of the Numerical Rating Scale (NRS-11) for children\u2019s self-reports of pain intensity","volume":"143","author":"von Baeyer","year":"2009","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2023.12.011_bib20","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","author":"Lewis","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2023.12.011_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1542\/peds.2014-0793","article-title":"Validity of self-assessment of pubertal maturation","volume":"135","author":"Rasmussen","year":"2015","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2023.12.011_bib22","series-title":"BASC-2: Behavior Assessment System for Children, Second Edition Manual","author":"Reynolds","year":"2004"},{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41522-023-00421-4","article-title":"Donor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms","volume":"9","author":"Wu","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1053\/j.gastro.2023.12.011_bib24","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1053\/j.gastro.2023.12.011_bib25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nmeth.2066","article-title":"Metagenomic microbial community profiling using unique clade-specific marker genes","volume":"9","author":"Segata","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.100","article-title":"QIIME 2 enables comprehensive end-to-end analysis of diverse microbiome data and comparative studies with publicly available data","volume":"70","author":"Estaki","year":"2020","journal-title":"Curr Protoc Bioinforma"},{"key":"10.1053\/j.gastro.2023.12.011_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2023.12.011_bib28","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.gastro.2023.12.011_bib29","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41592-018-0176-y","article-title":"Species-level functional profiling of metagenomes and metatranscriptomes","volume":"15","author":"Franzosa","year":"2018","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2023.12.011_bib30","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1542\/peds.96.5.985","article-title":"A\u00a0new recommendation for dietary fiber in childhood","volume":"96","author":"Williams","year":"1995","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2023.12.011_bib31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2147\/IJGM.S291964","article-title":"Sex-gender differences in the effectiveness of treatment of irritable bowel syndrome: a systematic review","volume":"14","author":"Kessel","year":"2021","journal-title":"Int J Gen Med"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2023.12.011_bib32","first-page":"S20","article-title":"Dietary fiber and risk of irritable bowel syndrome: a case-control study","volume":"11","author":"Hosseini Oskouie","year":"2018","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"10.1053\/j.gastro.2023.12.011_bib33","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.cgh.2021.12.016","article-title":"Supplementing dietary fibers with a low FODMAP diet in irritable bowel syndrome: a randomized controlled crossover trial","volume":"20","author":"So","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2023.12.011_bib34","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/ajg.2014.195","article-title":"The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis","volume":"109","author":"Moayyedi","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2023.12.011_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MPG.0000000000003622","article-title":"Efficacy of oral psyllium in pediatric irritable bowel syndrome: a double-blind randomized control trial","volume":"76","author":"Menon","year":"2023","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2023.12.011_bib36","first-page":"714","article-title":"[Do bulk preparations help in cases of recurrent abdominal pain in children? A controlled study]","volume":"144","author":"Christensen","year":"1982","journal-title":"Ugeskr Laeger"},{"key":"10.1053\/j.gastro.2023.12.011_bib37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/aje\/kwi187","article-title":"When is baseline adjustment useful in analyses of change? An example with education and cognitive change","volume":"162","author":"Glymour","year":"2005","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2023.12.011_bib38","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1002\/sim.3639","article-title":"Should baseline be a covariate or dependent variable in analyses of change from baseline in clinical trials?","volume":"28","author":"Liu","year":"2009","journal-title":"Stat Med"},{"key":"10.1053\/j.gastro.2023.12.011_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s43587-020-00014-2","article-title":"Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities","volume":"1","author":"Zhang","year":"2021","journal-title":"Nat Aging"},{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02375-z","article-title":"Gut microbiota develop towards an adult profile in a sex-specific manner during puberty","volume":"11","author":"Korpela","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1053\/j.gastro.2023.12.011_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13293-023-00490-2","article-title":"Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases","volume":"14","author":"Santos-Marcos","year":"2023","journal-title":"Biol Sex Differ"},{"key":"10.1053\/j.gastro.2023.12.011_bib42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The impact of dietary fiber on gut microbiota in host health and disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1053\/j.gastro.2023.12.011_bib43","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/ajcn\/nqy041","article-title":"Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis","volume":"107","author":"So","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2023.12.011_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1158\/2767-9764.CRC-22-0154","article-title":"Grain, gluten, and dietary fiber intake influence gut microbial diversity: data from the Food and Microbiome Longitudinal Investigation","volume":"3","author":"Um","year":"2023","journal-title":"Cancer Res Commun"},{"key":"10.1053\/j.gastro.2023.12.011_bib45","doi-asserted-by":"crossref","first-page":"15366","DOI":"10.18632\/aging.203095","article-title":"The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis","volume":"13","author":"Yang","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1053\/j.gastro.2023.12.011_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/ijms20020433","article-title":"The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls","volume":"20","author":"Jalanka","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1053\/j.gastro.2023.12.011_bib47","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/brain\/awab408","article-title":"Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain","volume":"145","author":"Dedek","year":"2022","journal-title":"Brain"},{"key":"10.1053\/j.gastro.2023.12.011_bib48","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/gbb.12183","article-title":"NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities","volume":"13","author":"Milenkovic","year":"2014","journal-title":"Genes Brain Behav"},{"key":"10.1053\/j.gastro.2023.12.011_bib49","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.3748\/wjg.v20.i10.2433","article-title":"Sex hormones in the modulation of irritable bowel syndrome","volume":"20","author":"Mulak","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2023.12.011_bib50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/MPG.0b013e31824cf08a","article-title":"Accuracy of pain recall in children","volume":"55","author":"Chogle","year":"2012","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2023.12.011_bib51","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/nmo.12590","article-title":"Agreement between prospective diary data and retrospective questionnaire report of abdominal pain and stooling symptoms in children with irritable bowel syndrome","volume":"27","author":"Self","year":"2015","journal-title":"Neurogastroenterol Motil"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650852305607X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650852305607X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T21:30:26Z","timestamp":1738013426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650852305607X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S001650852305607X"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2023.12.011","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-Dependent Efficacy of Dietary Fiber in Pediatric Functional Abdominal Pain","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2023.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the AGA Institute.","name":"copyright","label":"Copyright"}]}}