{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:50:48Z","timestamp":1794361848847,"version":"4.9.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012688","name":"North American Society for Pediatric Gastroenterology, Hepatology and Nutrition","doi-asserted-by":"publisher","award":["F32DK132810"],"award-info":[{"award-number":["F32DK132810"]}],"id":[{"id":"10.13039\/100012688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH119510"],"award-info":[{"award-number":["R01MH119510"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["NIDDK-DD56338"],"award-info":[{"award-number":["NIDDK-DD56338"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK130517"],"award-info":[{"award-number":["R01DK130517"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK111667"],"award-info":[{"award-number":["DK111667"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK130518"],"award-info":[{"award-number":["R01DK130518"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01NS015547"],"award-info":[{"award-number":["R01NS015547"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK126644"],"award-info":[{"award-number":["R01DK126644"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F32DK132810"],"award-info":[{"award-number":["F32DK132810"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019274","name":"National Institute of Mental Health and Neurosciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["P01-AI152999"],"award-info":[{"award-number":["P01-AI152999"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["R01-DK130517"],"award-info":[{"award-number":["R01-DK130517"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["R01DK126644"],"award-info":[{"award-number":["R01DK126644"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["DoD PR160365"],"award-info":[{"award-number":["DoD PR160365"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["R01DK130518"],"award-info":[{"award-number":["R01DK130518"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W911NF-21-S-0008"],"award-info":[{"award-number":["W911NF-21-S-0008"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1053\/j.gastro.2024.11.012","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:16:51Z","timestamp":1733937411000},"page":"754-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood"],"prefix":"10.1053","volume":"168","author":[{"given":"Lin Y.","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno D.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Del Colle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardesheer","family":"Talati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsteen N.","family":"Browning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Juarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Posner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Tonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narek","family":"Israelyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roey","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam W.","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Ying","family":"Sze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Savidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Gingrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Gershon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Ouellet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Takser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Ansorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara Gross","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2024.11.012_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110209","article-title":"Psychological comorbidity in gastrointestinal diseases: update on the brain-gut-microbiome axis","volume":"107","author":"Person","year":"2021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14297","article-title":"Role of psychological questionnaires in clinical practice and research within functional gastrointestinal disorders","volume":"33","author":"Luo","year":"2021","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2024.11.012_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2024.11.012_bib4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.5498\/wjp.v5.i4.366","article-title":"Treating comorbid anxiety and depression: psychosocial and pharmacological approaches","volume":"5","author":"Coplan","year":"2015","journal-title":"World J Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1517\/13543784.2013.761205","article-title":"The use of psychotropic drugs in irritable bowel syndrome","volume":"22","author":"Dekel","year":"2013","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1053\/j.gastro.2024.11.012_bib6","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/j.gastro.2017.11.279","article-title":"Neuromodulators for functional gastrointestinal disorders (disorders of gut-brain interaction): a Rome Foundation working team report","volume":"154","author":"Drossman","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2024.11.012_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ajg.2017.57","article-title":"Central neuromodulators for treating functional GI disorders: a primer","volume":"112","author":"Sobin","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2024.11.012_bib8","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1176\/ajp.156.7.1000","article-title":"Recurrence after recovery from major depressive disorder during 15 years of observational follow-up","volume":"156","author":"Mueller","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1017\/S0033291700033146","article-title":"Residual symptoms after partial remission: an important outcome in depression","volume":"25","author":"Paykel","year":"1995","journal-title":"Psychol Med"},{"key":"10.1053\/j.gastro.2024.11.012_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2982.2000.00193.x","article-title":"Motions and emotions: the treatment of depression causes constipation","volume":"12","author":"Bassotti","year":"2000","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2024.11.012_bib11","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1038\/s41380-018-0227-x","article-title":"5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy","volume":"25","author":"Demireva","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib12","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41386-022-01523-x","article-title":"Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study","volume":"48","author":"Langley","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2024.11.012_bib13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1176\/appi.ajp.160.5.993","article-title":"Placental passage of antidepressant medications","volume":"160","author":"Hendrick","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s40262-014-0233-3","article-title":"Placental transfer of antidepressant medications: implications for postnatal adaptation syndrome","volume":"54","author":"Ewing","year":"2015","journal-title":"Clin Pharmacokinet"},{"key":"10.1053\/j.gastro.2024.11.012_bib15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/GRF.0b013e3181b52bd6","article-title":"Antidepressant medication use during breastfeeding","volume":"52","author":"Lanza di Scalea","year":"2009","journal-title":"Clin Obstet Gynecol"},{"key":"10.1053\/j.gastro.2024.11.012_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fncel.2013.00047","article-title":"Placental serotonin: implications for the developmental effects of SSRIs and maternal depression","volume":"7","author":"Velasquez","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nrn1256","article-title":"The developmental role of serotonin: news from mouse molecular genetics","volume":"4","author":"Gaspar","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1523\/JNEUROSCI.3973-07.2008","article-title":"Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice","volume":"28","author":"Ansorge","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.gastro.2024.11.012_bib20","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1172\/JCI84877","article-title":"Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function","volume":"126","author":"Margolis","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2024.11.012_bib21","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1523\/JNEUROSCI.1020-13.2014","article-title":"Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function","volume":"34","author":"Rebello","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.celrep.2014.12.033","article-title":"Disruption of transient serotonin accumulation by non-serotonin-producing neurons impairs cortical map development","volume":"10","author":"Chen","year":"2015","journal-title":"Cell Rep"},{"key":"10.1053\/j.gastro.2024.11.012_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A\u00a0robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ Res"},{"key":"10.1053\/j.gastro.2024.11.012_bib25","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/npp.2015.85","article-title":"Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors","volume":"40","author":"Hill","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2024.11.012_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/10253890.2015.1105211","article-title":"SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system","volume":"19","author":"Santarelli","year":"2016","journal-title":"Stress"},{"key":"10.1053\/j.gastro.2024.11.012_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2019.04.022","article-title":"Effects of serotonin and slow-release 5-hydroxytryptophan on gastrointestinal motility in a mouse model of depression","volume":"157","author":"Israelyan","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2024.11.012_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jaac.2016.02.013","article-title":"Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: a national register-based study","volume":"55","author":"Malm","year":"2016","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/jamapediatrics.2017.5227","article-title":"Associations between brain structure and connectivity in infants and exposure to selective serotonin reuptake inhibitors during pregnancy","volume":"172","author":"Lugo-Candelas","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1053\/j.gastro.2024.11.012_bib30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1601-1848.2003.00050.x","article-title":"Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background","volume":"2","author":"Holmes","year":"2003","journal-title":"Genes Brain Behav"},{"key":"10.1053\/j.gastro.2024.11.012_bib31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2007.12.032","article-title":"A\u00a0study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders","volume":"152","author":"Olivier","year":"2008","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2024.11.012_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.earlhumdev.2020.105075","article-title":"Intra-uterine exposure to selective serotonin reuptake inhibitors (SSRIs), maternal psychopathology, and neurodevelopment at age 2.5years - Results from the prospective cohort SMOK study","volume":"147","author":"van der Veere","year":"2020","journal-title":"Early Hum Dev"},{"key":"10.1053\/j.gastro.2024.11.012_bib33","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41598-021-81327-z","article-title":"Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats","volume":"11","author":"Van der Knaap","year":"2021","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2024.11.012_bib34","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-1157","article-title":"In utero antidepressants and neurodevelopmental outcomes in kindergarteners","volume":"145","author":"Singal","year":"2020","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2024.11.012_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.npp.1300823","article-title":"Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry","volume":"31","author":"Maciag","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2024.11.012_bib36","doi-asserted-by":"crossref","first-page":"18465","DOI":"10.1073\/pnas.1109353108","article-title":"Perinatal antidepressant exposure alters cortical network function in rodents","volume":"108","author":"Simpson","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2024.11.012_bib37","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0006-3223(03)00696-6","article-title":"Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice","volume":"54","author":"Lira","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib38","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1021\/acschemneuro.8b00655","article-title":"Fluoxetine induces morphological rearrangements of serotonergic fibers in the hippocampus","volume":"10","author":"Nazzi","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib39","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0376-16.2017","article-title":"Perturbation of serotonin homeostasis during adulthood affects serotonergic neuronal circuitry","volume":"4","author":"Pratelli","year":"2017","journal-title":"eneuro"},{"key":"10.1053\/j.gastro.2024.11.012_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0306-4522(90)90301-J","article-title":"Quantified distribution of the serotonin innervation in adult rat hippocampus","volume":"34","author":"Oleskevich","year":"1990","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2024.11.012_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12035-011-8214-0","article-title":"Serotonin and prefrontal cortex function: neurons, networks, and circuits","volume":"44","author":"Puig","year":"2011","journal-title":"Mol Neurobiol"},{"key":"10.1053\/j.gastro.2024.11.012_bib42","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1523\/JNEUROSCI.21-16-06348.2001","article-title":"Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: abnormal intestinal motility and the expression of cation transporters","volume":"21","author":"Chen","year":"2001","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib43","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1523\/JNEUROSCI.6684-10.2011","article-title":"Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development\/survival of enteric dopaminergic neurons","volume":"31","author":"Li","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib44","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1136\/gutjnl-2013-304901","article-title":"Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine","volume":"63","author":"Margolis","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2024.11.012_bib45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2024.11.012_bib46","doi-asserted-by":"crossref","first-page":"G342","DOI":"10.1152\/ajpgi.00095.2017","article-title":"Validation and characterization of a novel method for selective vagal deafferentation of the gut","volume":"313","author":"Diepenbroek","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2024.11.012_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100474","article-title":"Dissection and surgical approaches to the mouse jugular-nodose ganglia","volume":"2","author":"Han","year":"2021","journal-title":"STAR Protoc"},{"key":"10.1053\/j.gastro.2024.11.012_bib48","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1126\/science.1094987","article-title":"Cognitive inflexibility after prefrontal serotonin depletion","volume":"304","author":"Clarke","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.gastro.2024.11.012_bib49","article-title":"Medial prefrontal cortex serotonin input regulates cognitive flexibility in mice","author":"Morgan","year":"2023","journal-title":"bioRxiv"},{"key":"10.1053\/j.gastro.2024.11.012_bib50","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuron.2018.04.030","article-title":"Hippocampal 5-HT input regulates memory formation and schaffer collateral excitation","volume":"98","author":"Teixeira","year":"2018","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2024.11.012_bib51","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1523\/JNEUROSCI.2238-16.2016","article-title":"Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate cotransmission","volume":"37","author":"Sengupta","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib52","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/mp.2017.165","article-title":"Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT(1A) receptor-dependent manner","volume":"23","author":"Garcia-Garcia","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib53","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1038\/s41380-020-0763-z","article-title":"Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission","volume":"26","author":"Cunha","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-018-0416-4","article-title":"5-HT release in nucleus accumbens rescues social deficits in mouse autism model","volume":"560","author":"Walsh","year":"2018","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2024.11.012_bib55","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41380-018-0260-9","article-title":"SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior","volume":"24","author":"Soiza-Reilly","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib56","first-page":"54","article-title":"Vagus nerve stimulation (VNS) and treatment of depression: to the brainstem and beyond","volume":"3","author":"O'Reardon","year":"2006","journal-title":"Psychiatry (Edgmont)"},{"key":"10.1053\/j.gastro.2024.11.012_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50807-8","article-title":"Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling","volume":"9","author":"McVey Neufeld","year":"2019","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2024.11.012_bib58","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1002\/j.2040-4603.2023.tb00272.x","article-title":"Serotonergic control of gastrointestinal development, motility, and inflammation","volume":"13","author":"Najjar","year":"2023","journal-title":"Compr Physiol"},{"key":"10.1053\/j.gastro.2024.11.012_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003301","article-title":"Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants","volume":"3","author":"Savelieva","year":"2008","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2024.11.012_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/49097405-57c1-4923-875a-9216de91d230","article-title":"Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities","volume":"8","author":"Suidan","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2024.11.012_bib61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-023-05829-8","article-title":"Gut enterochromaffin cells drive visceral pain and anxiety","volume":"616","author":"Bayrer","year":"2023","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2024.11.012_bib62","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1523\/JNEUROSCI.2316-16.2016","article-title":"Activity of tachykinin1-expressing Pet1 raphe neurons modulates the respiratory chemoreflex","volume":"37","author":"Hennessy","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2024.11.012_bib63","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.celrep.2015.10.061","article-title":"Activity of raphe serotonergic neurons controls emotional behaviors","volume":"13","author":"Teissier","year":"2015","journal-title":"Cell Rep"},{"key":"10.1053\/j.gastro.2024.11.012_bib64","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpeds.2017.12.012","article-title":"Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria","volume":"195","author":"Robin","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2024.11.012_bib65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/09540261.2017.1314952","article-title":"Coeliac disease and psychiatric comorbidity: epidemiology, pathophysiological mechanisms, quality-of-life, and gluten-free diet effects","volume":"29","author":"Cossu","year":"2017","journal-title":"Int Rev Psychiatry"},{"key":"10.1053\/j.gastro.2024.11.012_bib66","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","article-title":"Depression and anxiety in patients with inflammatory bowel disease: a systematic review","volume":"87","author":"Neuendorf","year":"2016","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1053\/j.gastro.2024.11.012_bib67","doi-asserted-by":"crossref","first-page":"853","DOI":"10.14309\/ajg.0000000000000597","article-title":"Psychiatric comorbidities and psychiatric medication use are highly prevalent in patients with eosinophilic esophagitis and associate with clinical presentation","volume":"115","author":"Reed","year":"2020","journal-title":"Am J Gastroenterol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508524057512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508524057512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:54:03Z","timestamp":1762163643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508524057512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0016508524057512"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2024.11.012","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2024.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the AGA Institute.","name":"copyright","label":"Copyright"}]}}