{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T19:07:29Z","timestamp":1794251249073,"version":"4.9.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304130"],"award-info":[{"award-number":["82304130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1053\/j.gastro.2025.04.021","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T18:32:32Z","timestamp":1747247552000},"page":"705-714.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies"],"prefix":"10.1053","volume":"169","author":[{"given":"Hongliang","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianjianyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun On","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-1457","authenticated-orcid":false,"given":"Chao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2025.04.021_bib1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib2","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2012.04.004","article-title":"EASL clinical practical guidelines: management of alcoholic liver disease","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1465-3362.2009.00153.x","article-title":"Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis","volume":"29","author":"Rehm","year":"2010","journal-title":"Drug Alcohol Rev"},{"key":"10.1053\/j.gastro.2025.04.021_bib5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2025.04.021_bib6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","author":"Kozlitina","year":"2014","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2025.04.021_bib7","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2025.04.021_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001324","article-title":"Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits","volume":"7","author":"Speliotes","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2025.04.021_bib9","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","article-title":"A protein-truncating HSD17B13 variant and protection from chronic liver disease","volume":"378","author":"Abul-Husn","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2025.04.021_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jhep.2020.11.024","article-title":"Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores","volume":"74","author":"Bianco","year":"2021","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib11","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cgh.2021.05.056","article-title":"A polygenic risk score to refine risk stratification and prediction for severe liver disease by clinical fibrosis scores","volume":"20","author":"De Vincentis","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1053\/j.gastro.2025.04.021_bib13","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/hep.30083","article-title":"Diabetes, plasma glucose, and incidence of fatty liver, cirrhosis, and liver cancer: a prospective study of 0.5 million people","volume":"68","author":"Pang","year":"2018","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib14","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/s41591-023-02383-8","article-title":"Alcohol consumption and risks of more than 200 diseases in Chinese men","volume":"29","author":"Im","year":"2023","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2025.04.021_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/hep.32123","article-title":"Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity","volume":"75","author":"Innes","year":"2022","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2025.04.021_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jhep.2013.09.027","article-title":"1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998-2009: a large population study","volume":"60","author":"Ratib","year":"2014","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2307\/590279","article-title":"Health and deprivation: inequality and the north","volume":"40","author":"Blane","year":"1987","journal-title":"Br J Sociol"},{"key":"10.1053\/j.gastro.2025.04.021_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCULATIONAHA.115.018585","article-title":"Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2025.04.021_bib21","article-title":"Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants","volume":"363","author":"Rutten-Jacobs","year":"2018","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2025.04.021_bib22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg2813","article-title":"New approaches to population stratification in genome-wide association studies","volume":"11","author":"Price","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1053\/j.gastro.2025.04.021_bib23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/hep.31238","article-title":"Combined effect of PNPLA3, TM6SF2, and HSD17B13 variants on risk of cirrhosis and hepatocellular carcinoma in the general population","volume":"72","author":"Gellert-Kristensen","year":"2020","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jhep.2024.06.030","article-title":"Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer","volume":"81","author":"Ahmed","year":"2024","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib25","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.14309\/ajg.0000000000000340","article-title":"Alcohol consumption and risk of liver cirrhosis: a systematic review and meta-analysis","volume":"114","author":"Roerecke","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2025.04.021_bib26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/apt.17388","article-title":"Meta-analysis: the impact of light-to-moderate alcohol consumption on progressive non-alcoholic fatty liver disease","volume":"57","author":"Magherman","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2025.04.021_bib27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jhep.2014.12.005","article-title":"Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study","volume":"62","author":"Askgaard","year":"2015","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2025.04.021_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.08.023","article-title":"Sex and gender-related differences in alcohol use and its consequences: contemporary knowledge and future research considerations","volume":"156","author":"Erol","year":"2015","journal-title":"Drug Alcohol Depend"},{"key":"10.1053\/j.gastro.2025.04.021_bib29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/joim.12719","article-title":"Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver","volume":"283","author":"Dongiovanni","year":"2018","journal-title":"J Intern Med"},{"key":"10.1053\/j.gastro.2025.04.021_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008955","article-title":"Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease","volume":"16","author":"Li","year":"2020","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2025.04.021_bib31","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/liv.15716","article-title":"Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio)","volume":"43","author":"Shihana","year":"2023","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2025.04.021_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16211","article-title":"PNPLA3 in alcohol-related liver disease","volume":"45","author":"Galvanin","year":"2025","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2025.04.021_bib33","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/hep.29041","article-title":"The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells","volume":"65","author":"Bruschi","year":"2017","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib34","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/hep.30350","article-title":"17-Beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease","volume":"69","author":"Ma","year":"2019","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/hep.30996","article-title":"Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers","volume":"72","author":"Stickel","year":"2020","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib36","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/hep.22292","article-title":"Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease","volume":"47","author":"Dunn","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib37","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41395-018-0133-5","article-title":"Type and pattern of alcohol consumption is associated with liver fibrosis in patients with non-alcoholic fatty liver disease","volume":"113","author":"Mitchell","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2025.04.021_bib38","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1053\/jhep.2002.32101","article-title":"Lower risk for alcohol-induced cirrhosis in wine drinkers","volume":"35","author":"Becker","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2025.04.021_bib39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.gastro.2019.08.024","article-title":"Red wine consumption associated with increased gut microbiota alpha-diversity in 3 independent cohorts","volume":"158","author":"Le Roy","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2025.04.021_bib40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/sj.ejcn.1602107","article-title":"Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease","volume":"59","author":"Hansen","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"10.1053\/j.gastro.2025.04.021_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3945\/ajcn.2009.27814","article-title":"Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects","volume":"90","author":"Qin","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2025.04.021_bib42","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.fct.2008.05.014","article-title":"Contribution of anthocyanin fraction to the antioxidant properties of wine","volume":"46","author":"Rivero-Perez","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/j.gastro.2025.04.021_bibe1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/ije\/dyr120","article-title":"China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up","volume":"40","author":"Chen","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1053\/j.gastro.2025.04.021_bibe2","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1016\/S2214-109X(20)30069-3","article-title":"Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0.5 million Chinese adults","volume":"8","author":"Chen","year":"2020","journal-title":"Lancet Glob Health"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508525007127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508525007127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:07:10Z","timestamp":1778746030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508525007127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0016508525007127"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2025.04.021","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2025.04.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the AGA Institute.","name":"copyright","label":"Copyright"}]}}