{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:43:40Z","timestamp":1792662220739,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"The Leona M and Harry B Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1053\/j.gastro.2026.05.022","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:18:01Z","timestamp":1782227881000},"page":"885-901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["BIRC3 (Encoding cIAP2) Variants Result in Dysregulated RIPK1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn\u2019s Disease"],"prefix":"10.1053","volume":"171","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Nambu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Yaqiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Argmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Le Voyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Ouahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Collen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bibus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Illig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meino","family":"Rohlfs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig D.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip H.","family":"Comella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayte","family":"Su\u00e1rez-Fari\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed F.","family":"Alosaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremie","family":"Rosain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Fieschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Puel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena W.Y.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Velasco","family":"Rodr\u00edguez-Belv\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Palomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"K\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Snapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raif","family":"Geha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hoffenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P.B.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Schadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kotlarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleixo M.","family":"Muise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2026.05.022_bib1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.05.022_bib2","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1053\/j.gastro.2020.02.023","article-title":"Prevalence and clinical features of inflammatory bowel diseases associated with monogenic variants, identified by whole-exome sequencing in 1000 children at a single center","volume":"158","author":"Crowley","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.05.022_bib3","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1016\/j.cgh.2021.03.021","article-title":"A systematic review of monogenic inflammatory bowel disease","volume":"20","author":"Nambu","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.05.022_bib4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1056\/NEJMoa2405333","article-title":"The genetic architecture of congenital diarrhea and enteropathy","volume":"392","author":"Gaibee","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2026.05.022_bib5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1073\/pnas.1813582116","article-title":"Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases","volume":"116","author":"Li","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2026.05.022_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-019-1830-y","article-title":"A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1","volume":"577","author":"Tao","year":"2020","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.05.022_bib7","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1126\/science.aar2641","article-title":"Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation","volume":"361","author":"Cuchet-Lourenco","year":"2018","journal-title":"Science"},{"key":"10.1053\/j.gastro.2026.05.022_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1053\/j.gastro.2018.09.041","article-title":"Intestinal inflammation and dysregulated immunity in patients with inherited caspase-8 deficiency","volume":"156","author":"Lehle","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.05.022_bib9","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1073\/pnas.1518163113","article-title":"Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-\u03baB activation and autoinflammatory disease","volume":"113","author":"Zilberman-Rudenko","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2026.05.022_bib10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/gutjnl-2013-306520","article-title":"XIAP variants in male Crohn's disease","volume":"64","author":"Zeissig","year":"2015","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.05.022_bib11","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.16439.1","article-title":"Recent advances in understanding inhibitor of apoptosis proteins","volume":"7","author":"Lalaoui","year":"2018","journal-title":"F1000Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2011.163","article-title":"IAPs: guardians of RIPK1","volume":"19","author":"Darding","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1053\/j.gastro.2026.05.022_bib13","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/MCB.26.2.699-708.2006","article-title":"Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival","volume":"26","author":"Conte","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2026.05.022_bib14","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023113614","article-title":"cIAPs control RIPK1 kinase activity-dependent and-independent cell death and tissue inflammation","volume":"42","author":"Schorn","year":"2023","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2026.05.022_bib15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/mi.2015.46","article-title":"A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways","volume":"9","author":"Dagenais","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1053\/j.gastro.2026.05.022_bib16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.immuni.2009.04.011","article-title":"Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2","volume":"30","author":"Bertrand","year":"2009","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2026.05.022_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41575-024-01035-7","article-title":"Understanding the therapeutic toolkit for inflammatory bowel disease","volume":"22","author":"Vieujean","year":"2025","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.05.022_bib18","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2022.02.013","article-title":"Mucus sialylation determines intestinal host-commensal homeostasis","volume":"185","author":"Yao","year":"2022","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2026.05.022_bib19","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41575-023-00838-4","article-title":"Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards","volume":"20","author":"Uhlig","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.05.022_bib20","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1053\/j.gastro.2019.11.019","article-title":"Drug screen identifies leflunomide for treatment of inflammatory bowel disease caused by TTC7A deficiency","volume":"158","author":"Jardine","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.05.022_bib21","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41588-021-00803-4","article-title":"Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice","volume":"53","author":"Wang","year":"2021","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nbt.2661","article-title":"Heritable gene targeting in the mouse and rat using a CRISPR-Cas system","volume":"31","author":"Li","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.gastro.2026.05.022_bib23","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1038\/nprot.2014.171","article-title":"CRISPR\/Cas-mediated genome editing in the rat via direct injection of one-cell embryos","volume":"9","author":"Shao","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2026.05.022_bib24","doi-asserted-by":"crossref","first-page":"W401","DOI":"10.1093\/nar\/gku410","article-title":"CHOPCHOP: a CRISPR\/Cas9 and TALEN web tool for genome editing","volume":"42","author":"Montague","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib25","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2026.05.022_bib26","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib27","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2026.05.022_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/j.gastro.2020.09.029","article-title":"Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2-related disease","volume":"160","author":"Suarez-Farinas","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.05.022_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1053\/j.gastro.2026.05.022_bib30","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2026.05.022_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng.3760","article-title":"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease","volume":"49","author":"de Lange","year":"2017","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib32","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/j.gastro.2021.11.014","article-title":"An integrated taxonomy for monogenic inflammatory bowel disease","volume":"162","author":"Bolton","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.05.022_bib33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nm.4307","article-title":"Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease","volume":"23","author":"West","year":"2017","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2026.05.022_bib34","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/ajg.2011.83","article-title":"Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis","volume":"106","author":"Toedter","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.05.022_bib35","series-title":"ggplot2: Elegant Graphics for Data Analysis. Use R!","author":"Wickham","year":"2016"},{"key":"10.1053\/j.gastro.2026.05.022_bib36","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/ng.3947","article-title":"A functional genomics predictive network model identifies regulators of inflammatory bowel disease","volume":"49","author":"Peters","year":"2017","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib37","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/gutjnl-2021-326451","article-title":"Biopsy and blood-based molecular biomarker of inflammation in IBD","volume":"72","author":"Argmann","year":"2023","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.05.022_bib38","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/ng.167","article-title":"Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks","volume":"40","author":"Zhu","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib39","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.05.022_bib41","doi-asserted-by":"crossref","first-page":"D886","DOI":"10.1093\/nar\/gky1016","article-title":"CADD: predicting the deleteriousness of variants throughout the human genome","volume":"47","author":"Rentzsch","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1053\/j.gastro.2026.05.022_bib43","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/ng.2007.8","article-title":"Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis","volume":"39","author":"Santoro","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib44","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1158\/1078-0432.CCR-12-2518","article-title":"The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells","volume":"19","author":"Krepler","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"10.1053\/j.gastro.2026.05.022_bib46","doi-asserted-by":"crossref","first-page":"W697","DOI":"10.1093\/nar\/gkac328","article-title":"SigCom LINCS: data and metadata search engine for a million gene expression signatures","volume":"50","author":"Evangelista","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2026.05.022_bib47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-5793(95)01116-V","article-title":"An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells","volume":"374","author":"Zhu","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2026.05.022_bib48","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jaci.2019.11.051","article-title":"Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations","volume":"146","author":"Lorenzini","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2026.05.022_bib49","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.20160724","article-title":"Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration","volume":"214","author":"Badran","year":"2017","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2026.05.022_bib50","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20222171","article-title":"Dominant negative OTULIN-related autoinflammatory syndrome","volume":"221","author":"Davidson","year":"2024","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2026.05.022_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ng.3459","article-title":"Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41584-025-01327-5","article-title":"Monogenic disorders of the TNF signalling pathway","volume":"22","author":"Lalaoui","year":"2026","journal-title":"Nat Rev Rheumatol"},{"key":"10.1053\/j.gastro.2026.05.022_bib53","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/ng1429","article-title":"Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise","volume":"36","author":"Mendell","year":"2004","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2026.05.022_bib54","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.celrep.2019.04.111","article-title":"Ubiquitin ligases cIAP1 and cIAP2 limit cell death to prevent inflammation","volume":"27","author":"Zhang","year":"2019","journal-title":"Cell Rep"},{"key":"10.1053\/j.gastro.2026.05.022_bib55","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2021-000680","article-title":"A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis","volume":"8","author":"Weisel","year":"2021","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1053\/j.gastro.2026.05.022_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.365","article-title":"Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers","volume":"5","author":"Weisel","year":"2017","journal-title":"Pharmacol Res Perspect"},{"key":"10.1053\/j.gastro.2026.05.022_bib57","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/acs.jmedchem.6b01751","article-title":"Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases","volume":"60","author":"Harris","year":"2017","journal-title":"J Med Chem"},{"key":"10.1053\/j.gastro.2026.05.022_bib58","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/cts.13607","article-title":"A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers","volume":"16","author":"Jones","year":"2023","journal-title":"Clin Transl Sci"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:32:27Z","timestamp":1792661547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508526069465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0016508526069465"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2026.05.022","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BIRC3 (Encoding cIAP2) Variants Result in Dysregulated RIPK1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2026.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}]}}