{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:18:14Z","timestamp":1788985094131,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007658","name":"Crohn's and Colitis Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013739","name":"Pfizer Canada ULC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019211","name":"AbbVie Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004914","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1053\/j.gastro.2026.06.006","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:25:52Z","timestamp":1782231952000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proactive Fecal Calprotectin Home Monitoring in Ulcerative Colitis: Results of a Prospective Randomized Controlled Trial"],"prefix":"10.1053","author":[{"given":"Gregory","family":"Rosenfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqqas","family":"Afif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid-Jane","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harminder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"McCurdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin E.","family":"Loomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Zezos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ropeleski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ancheta-Schmit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram","family":"Tavakoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Bone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Frederic","family":"Colombel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2026.06.006_bib1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: a review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2026.06.006_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG Clinical Guideline: Ulcerative Colitis in Adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MEG.0b013e32835414b2","article-title":"Mucosal healing restores normal health and quality of life in patients with inflammatory bowel disease","volume":"24","author":"Casellas","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.06.006_bib4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.06.006_bib5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: An update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.06.006_bib6","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ibd.22917","article-title":"Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease","volume":"18","author":"D'Haens","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2136501","article-title":"Systematic review with meta-analysis: fecal calprotectin as a surrogate marker for predicting relapse in adults with ulcerative colitis","volume":"2019","author":"Li","year":"2019","journal-title":"Mediators Inflamm"},{"key":"10.1053\/j.gastro.2026.06.006_bib8","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/MIB.0000000000000057","article-title":"Meta-analysis: fecal calprotectin for assessment of inflammatory bowel disease activity","volume":"20","author":"Lin","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib9","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/ibd.22861","article-title":"Fecal calprotectin in predicting relapse of inflammatory bowel diseases: a meta-analysis of prospective studies","volume":"18","author":"Mao","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib10","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/ajg.2015.120","article-title":"C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis","volume":"110","author":"Mosli","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/j.gastro.2022.12.007","article-title":"AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis","volume":"164","author":"Singh","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.06.006_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/MIB.0000000000001082","article-title":"Clinical utility of fecal calprotectin monitoring in asymptomatic patients with inflammatory bowel disease: a systematic review and practical guide","volume":"23","author":"Heida","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/ibd\/izac095","article-title":"Low fecal calprotectin predicts histological healing in patients with ulcerative colitis with endoscopic remission and leads to prolonged clinical remission","volume":"29","author":"Kawashima","year":"2023","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2098293","article-title":"Fecal calprotectin: a reliable predictor of mucosal healing after treatment for active ulcerative colitis","volume":"2017","author":"Kristensen","year":"2017","journal-title":"Gastroenterol Res Pract"},{"key":"10.1053\/j.gastro.2026.06.006_bib15","first-page":"1021","article-title":"Outcome after discontinuation of TNF\u03b1-blocking therapy in patients with inflammatory bowel disease in deep remission","volume":"20","author":"Molander","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1097\/MIB.0b013e31829b2a37","article-title":"Consecutive fecal calprotectin measurements to predict relapse in patients with ulcerative colitis receiving infliximab maintenance therapy","volume":"19","author":"De Vos","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/2050640614560785","article-title":"Pharmacological intervention based on fecal calprotectin levels in patients with ulcerative colitis at high risk of a relapse: a prospective, randomized, controlled study","volume":"3","author":"Lasson","year":"2015","journal-title":"United European Gastroenterol J"},{"key":"10.1053\/j.gastro.2026.06.006_bib18","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.cgh.2020.08.019","article-title":"Diagnostic accuracy of fecal calprotectin concentration in evaluating therapeutic outcomes of patients with ulcerative colitis","volume":"19","author":"Stevens","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.06.006_bib19","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/S0140-6736(17)32641-7","article-title":"Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial","volume":"390","author":"Colombel","year":"2017","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2026.06.006_bib20","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.cgh.2017.06.007","article-title":"Agreement between home-based measurement of stool calprotectin and ELISA results for monitoring inflammatory bowel disease activity","volume":"15","author":"Heida","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.06.006_bib21","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/ibd\/izy357","article-title":"IBDoc Canadian user performance evaluation","volume":"25","author":"Moore","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib22","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ajg.2009.83","article-title":"Safety and efficacy of a new 3.3 g b.i.d. tablet formulation in patients with mild-to-moderately-active ulcerative colitis: a multicenter, randomized, double-blind, placebo-controlled study","volume":"104","author":"Scherl","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib23","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2026.06.006_bib25","first-page":"1571","article-title":"Canadian Crohn's Relapse Prevention Trial","volume":"91","author":"Irvine","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib26","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual Life Res"},{"key":"10.1053\/j.gastro.2026.06.006_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1053\/j.gastro.2026.06.006_bib28","article-title":"Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis","volume":"8","author":"Murray","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2026.06.006_bib29","doi-asserted-by":"crossref","first-page":"e777","DOI":"10.1097\/MEG.0000000000002248","article-title":"Real-life utility and diagnostic accuracy of a home-performed fecal calprotectin test to predict endoscopic activity in patients with inflammatory bowel disease under maintenance treatment with adalimumab","volume":"33","author":"Orfanoudaki","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.06.006_bib30","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2020.06.043","article-title":"Incremental benefit of achieving endoscopic and histologic remission in patients with ulcerative colitis: a systematic review and meta-analysis","volume":"159","author":"Yoon","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.06.006_bib31","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2025-001336","article-title":"Detection bias and the role of negative control outcomes","volume":"4","author":"Nunez","year":"2025","journal-title":"BMJ Med"},{"key":"10.1053\/j.gastro.2026.06.006_bib32","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.14309\/ajg.0000000000003339","article-title":"Fecal calprotectin correlates with disease extent but remains a reliable marker of mucosal healing in ulcerative colitis","volume":"120","author":"Steinsbo","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib33","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.3748\/wjg.v22.i36.8211","article-title":"FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease","volume":"22","author":"Rosenfeld","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib34","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.cgh.2014.03.035","article-title":"Mesalamine dose escalation reduces fecal calprotectin in patients with quiescent ulcerative colitis","volume":"12","author":"Osterman","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.06.006_bib35","doi-asserted-by":"crossref","first-page":"S385","DOI":"10.1093\/ecco-jcc\/jjx002.723","article-title":"Home testing for faecal calprotectin: follow-up results from the first UK trial [abstract P599]","volume":"11","author":"Raker","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1053\/j.gastro.2026.06.006_bib36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/00365521.2019.1618910","article-title":"Is home monitoring of inflammatory bowel disease feasible? A randomized controlled study","volume":"54","author":"Puolanne","year":"2019","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/ibd\/izz252","article-title":"A noninferiority randomized clinical trial of the use of the smartphone-based health applications IBDsmart and IBDoc in the care of inflammatory bowel disease patients","volume":"26","author":"McCombie","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2026.06.006_bib38","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1093\/ecco-jcc\/jjx180.262","article-title":"Real-world use of faecal calprotectin testing in patients with inflammatory bowel disease","volume":"12","author":"Rubin","year":"2018","journal-title":"J Crohn Colitis"},{"key":"10.1053\/j.gastro.2026.06.006_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/00365521.2020.1854342","article-title":"Self-monitoring with home based fecal calprotectin is associated with increased medical treatment. A randomized controlled trial on patients with inflammatory bowel disease","volume":"56","author":"Ostlund","year":"2021","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.06.006_bib40","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.3748\/wjg.v25.i40.6158","article-title":"Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: a randomized-clinical trial","volume":"25","author":"Ankersen","year":"2019","journal-title":"World J Gastroenterol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:50:48Z","timestamp":1788983448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508526069805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S0016508526069805"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2026.06.006","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proactive Fecal Calprotectin Home Monitoring in Ulcerative Colitis: Results of a Prospective Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2026.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}]}}