{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:25:14Z","timestamp":1794003914883,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125026"],"award-info":[{"award-number":["82125026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330081"],"award-info":[{"award-number":["82330081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472667"],"award-info":[{"award-number":["82472667"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025QC832"],"award-info":[{"award-number":["ZR2025QC832"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1053\/j.gastro.2026.06.007","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:30:17Z","timestamp":1782178217000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis"],"prefix":"10.1053","author":[{"given":"Ruining","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leina","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Saluja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2026.06.007_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.189065","article-title":"Breaking the stromal barrier in pancreatic cancer: advances and challenges","volume":"1879","author":"Chakkera","year":"2024","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1053\/j.gastro.2026.06.007_bib2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1158\/2159-8290.CD-25-1337","article-title":"Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progression","volume":"16","author":"Nigri","year":"2026","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2026.06.007_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217699","article-title":"Tumor immune microenvironment in pancreatic ductal adenocarcinoma revisited - exploring the \"space\"","volume":"622","author":"Br\u00e4utigam","year":"2025","journal-title":"Cancer Lett"},{"key":"10.1053\/j.gastro.2026.06.007_bib4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature19084","article-title":"Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion","volume":"536","author":"Sousa","year":"2016","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.06.007_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2424051122","article-title":"Nuclear galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells","volume":"122","author":"Vinaixa","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2026.06.007_bib6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/biom11060901","article-title":"Immune cell modulation of the extracellular matrix contributes to the pathogenesis of pancreatic cancer","volume":"11","author":"Ahmad","year":"2021","journal-title":"Biomolecules"},{"key":"10.1053\/j.gastro.2026.06.007_bib7","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ccell.2023.03.001","article-title":"Epithelial cells activate fibroblasts to promote esophageal cancer development","volume":"41","author":"Chen","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2026.06.007_bib8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41586-025-08795-5","article-title":"Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3","volume":"642","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.06.007_bib9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41577-024-00994-x","article-title":"The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases","volume":"24","author":"Sumida","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2026.06.007_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12916-020-01620-y","article-title":"A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma","volume":"18","author":"Houchen","year":"2020","journal-title":"BMC Med"},{"key":"10.1053\/j.gastro.2026.06.007_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41587-019-0392-8","article-title":"Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas","volume":"38","author":"Moncada","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.gastro.2026.06.007_bib12","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41586-024-08225-y","article-title":"Clinical functional proteomics of intercellular signalling in pancreatic cancer","volume":"637","author":"Huang","year":"2025","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2026.06.007_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biomaterials.2016.04.007","article-title":"Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns","volume":"95","author":"Castleberry","year":"2016","journal-title":"Biomaterials"},{"key":"10.1053\/j.gastro.2026.06.007_bib14","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1524-475X.2012.00827.x","article-title":"Adaptation of the dermal collagen structure of human skin and scar tissue in response to stretch: an experimental study","volume":"20","author":"Verhaegen","year":"2012","journal-title":"Wound Repair Regen"},{"key":"10.1053\/j.gastro.2026.06.007_bib15","doi-asserted-by":"crossref","first-page":"8344","DOI":"10.1158\/0008-5472.CAN-06-3304","article-title":"Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer","volume":"67","author":"Hinz","year":"2007","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2026.06.007_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-020-0144-8","article-title":"PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1053\/j.gastro.2026.06.007_bib17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1158\/2159-8290.CD-19-0958","article-title":"Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis","volume":"10","author":"Zhang","year":"2020","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2026.06.007_bib18","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/s41590-023-01579-x","article-title":"Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC","volume":"24","author":"Baer","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2026.06.007_bib19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"\u00d6hlund","year":"2017","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2026.06.007_bib20","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1158\/0008-5472.CAN-13-1558-T","article-title":"Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance","volume":"73","author":"Zhang","year":"2013","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2026.06.007_bib21","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1158\/0008-5472.CAN-08-3717","article-title":"FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2\/histone deacetylase 4 association to the locus","volume":"69","author":"Liu","year":"2009","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2026.06.007_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/BCJ20240769","article-title":"The biology of interleukin-6 family cytokines is regulated by glycosylation","volume":"482","author":"Kohrs","year":"2025","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2026.06.007_bib23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2147\/ITT.S485684","article-title":"IL-6 Signaling in immunopathology: from basic biology to selective therapeutic intervention","volume":"14","author":"Schumertl","year":"2025","journal-title":"Immunotargets Ther"},{"key":"10.1053\/j.gastro.2026.06.007_bib24","doi-asserted-by":"crossref","first-page":"25638","DOI":"10.1021\/acs.jafc.4c06475","article-title":"Fasting-mimicking diet prevents pancreatic carcinogenesis via gut microbiota and metabolites","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"key":"10.1053\/j.gastro.2026.06.007_bib25","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1158\/0008-5472.CAN-07-5714","article-title":"Cancer-associated stromal fibroblasts promote pancreatic tumor progression","volume":"68","author":"Hwang","year":"2008","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2026.06.007_bib26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2026.06.007_bib27","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2026.06.007_bib28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2026.06.007_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1053\/j.gastro.2026.06.007_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217620","article-title":"Irreversible electroporation combined with PD-L1\/IL-6 dual blockade promotes anti-tumor immunity via cDC2\/CD4(+)T cell axis in MHC-I deficient pancreatic cancer","volume":"617","author":"Wu","year":"2025","journal-title":"Cancer Lett"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526069817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:01:14Z","timestamp":1794002474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508526069817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":30,"alternative-id":["S0016508526069817"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2026.06.007","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2026.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}]}}