{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:26:26Z","timestamp":1794353186713,"version":"4.9.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2018118"],"award-info":[{"award-number":["APP2018118"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1053\/j.gastro.2026.07.027","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:38:11Z","timestamp":1786711091000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fiber Supplementation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1053","author":[{"given":"Heidi M.","family":"Staudacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rucco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mancell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Dimidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2026.07.027_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.07.027_bib2","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.07.027_bib3","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(20)31548-8","article-title":"Irritable bowel syndrome","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2026.07.027_bib4","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gutjnl-2021-324598","article-title":"British Society of Gastroenterology guidelines on the management of irritable bowel syndrome","volume":"70","author":"Vasant","year":"2021","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.07.027_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jcag\/gwy071","article-title":"Canadian Association of Gastroenterology Clinical practice guideline for the management of irritable bowel syndrome (IBS)","volume":"2","author":"Moayyedi","year":"2019","journal-title":"J Can Assoc Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00535-020-01746-z","article-title":"Evidence-based clinical practice guidelines for irritable bowel syndrome 2020","volume":"56","author":"Fukudo","year":"2021","journal-title":"J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1053\/j.gastro.2019.10.036","article-title":"Use of treatments for irritable bowel syndrome and patient satisfaction based on the IBS in America Survey","volume":"158","author":"Rangan","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.07.027_bib8","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/ajg.2014.195","article-title":"The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis","volume":"109","author":"Moayyedi","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/MEG.0000000000000425","article-title":"The role of fiber supplementation in the treatment of irritable bowel syndrome: a systematic review and meta-analysis","volume":"27","author":"Nagarajan","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.07.027_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41575-020-00375-4","article-title":"Dietary fibre in gastrointestinal health and disease","volume":"18","author":"Gill","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.07.027_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S2468-1253(19)30324-3","article-title":"Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis","volume":"5","author":"Black","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.07.027_bib12","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1136\/gutjnl-2021-324891","article-title":"Dietary fibres and IBS: translating functional characteristics to clinical value in the era of personalised medicine","volume":"70","author":"So","year":"2021","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.07.027_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003583","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"18","author":"Page","year":"2021","journal-title":"PLoS Med"},{"key":"10.1053\/j.gastro.2026.07.027_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.7326\/M19-0891","article-title":"The accuracy of google translate for abstracting data from non-English-language trials for systematic reviews","volume":"171","author":"Jackson","year":"2019","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2026.07.027_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1053\/j.gastro.2026.07.027_bib17","author":"Huwaldt"},{"key":"10.1053\/j.gastro.2026.07.027_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jclinepi.2016.01.002","article-title":"Extracting data from figures with software was faster, with higher interrater reliability than manual extraction","volume":"74","author":"Kadic","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.gastro.2026.07.027_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2026.07.027_bib20","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2026.07.027_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-16321-w","article-title":"A randomized trial of inulin for bowel symptoms, depression and quality of life in constipation predominant IBS","volume":"15","author":"Ak\u00e7al\u0131","year":"2025","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2026.07.027_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/00365528509091653","article-title":"The effect of coarse wheat bran in the irritable bowel syndrome. A double-blind cross-over study","volume":"20","author":"Arffmann","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12911","article-title":"Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study","volume":"29","author":"Azpiroz","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2026.07.027_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b3154","article-title":"Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial","volume":"339","author":"Bijkerk","year":"2009","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2026.07.027_bib25","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.3390\/nu15163526","article-title":"The effects of agave fructans in a functional food consumed by patients with irritable bowel syndrome with constipation: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Camacho-D\u00edaz","year":"2023","journal-title":"Nutrients"},{"key":"10.1053\/j.gastro.2026.07.027_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0016-5085(90)91292-E","article-title":"Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable bowel syndrome. A controlled, crossover study","volume":"98","author":"Cook","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.07.027_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0022-3999(92)90026-X","article-title":"Irritable bowel syndrome: assessment of psychological disturbance and its influence on the response to fibre supplementation","volume":"36","author":"Fowlie","year":"1992","journal-title":"J Psychosom Res"},{"key":"10.1053\/j.gastro.2026.07.027_bib28","first-page":"353","article-title":"Role of ispaghula husk in the management of irritable bowel syndrome (a randomized double-blind crossover study)","volume":"30","author":"Golechha","year":"1982","journal-title":"J Assoc Physicians India"},{"issue":"Suppl","key":"10.1053\/j.gastro.2026.07.027_bib29","doi-asserted-by":"crossref","first-page":"1451S","DOI":"10.1093\/jn\/129.7.1451S","article-title":"Controlled trial of oligofructose in the management of irritable bowel syndrome. Randomized controlled trial","volume":"129","author":"Hunter","year":"1999","journal-title":"J Nutr"},{"key":"10.1053\/j.gastro.2026.07.027_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13920","article-title":"Human milk oligosaccharide supplementation in irritable bowel syndrome patients: a parallel, randomized, double-blind, placebo-controlled study","volume":"32","author":"Iribarren","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2026.07.027_bib31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1440-1746.1990.tb01432.x","article-title":"Ispaghula therapy in irritable bowel syndrome: improvement in overall well-being is related to reduction in bowel dissatisfaction","volume":"5","author":"Jalihal","year":"1990","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.07.027_bib32","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s00394-024-03398-8","article-title":"Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4- A 4-week randomized double-blinded placebo-controlled intervention trial","volume":"63","author":"JanssenDuijghuijsen","year":"2024","journal-title":"Eur J Nutr"},{"key":"10.1053\/j.gastro.2026.07.027_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7326\/0003-4819-95-1-53","article-title":"Psyllium therapy in the irritable bowel syndrome. A double-blind trial","volume":"95","author":"Longstreth","year":"1981","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2026.07.027_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/gut.28.2.221","article-title":"Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study","volume":"28","author":"Lucey","year":"1987","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.07.027_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/00365528708991878","article-title":"Short-chain fatty acids and the irritable bowel syndrome: the effect of wheat bran","volume":"22","author":"Mortensen","year":"1987","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12986-016-0070-5","article-title":"Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome","volume":"13","author":"Niv","year":"2016","journal-title":"Nutr Metab (Lond)"},{"key":"10.1053\/j.gastro.2026.07.027_bib37","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/ajcn\/72.6.1570","article-title":"Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome","volume":"72","author":"Olesen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2026.07.027_bib38","first-page":"183","article-title":"Glucomannan in treatment of irritable colon. Results of a controlled clinical trial","volume":"3","author":"Piai","year":"1987","journal-title":"Quad Med Chir"},{"key":"10.1053\/j.gastro.2026.07.027_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/gut.28.11.1510","article-title":"Double blind study of ispaghula in irritable bowel syndrome","volume":"28","author":"Prior","year":"1987","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2026.07.027_bib40","doi-asserted-by":"crossref","DOI":"10.1177\/146642400512500112","article-title":"Randomised-controlled trial of a fibre supplement on the symptoms of irritable bowel syndrome","volume":"125","author":"Rees","year":"2005","journal-title":"J R Soc Promot Health"},{"key":"10.1053\/j.gastro.2026.07.027_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13986","article-title":"Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial","volume":"33","author":"Remes-Troche","year":"2021","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2026.07.027_bib42","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/bmj.1.6160.376","article-title":"Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk","volume":"1","author":"Ritchie","year":"1979","journal-title":"Br Med J"},{"key":"10.1053\/j.gastro.2026.07.027_bib43","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2036.2008.03911.x","article-title":"Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome","volume":"29","author":"Silk","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2026.07.027_bib44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2036.1994.tb00323.x","article-title":"Bran supplementation in the treatment of irritable bowel syndrome","volume":"8","author":"Snook","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2026.07.027_bib45","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.cgh.2021.12.016","article-title":"Supplementing dietary fibers with a low FODMAP diet in irritable bowel syndrome: a randomized controlled crossover trial","volume":"20","author":"So","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2026.07.027_bib46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0140-6736(76)91402-1","article-title":"A double-blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome","volume":"1","author":"Soltoft","year":"1976","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2026.07.027_bib47","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1017\/jns.2025.10021","article-title":"Randomised controlled trial: nutritional supplements to relieve irritable bowel syndrome symptoms by targeting the gut microbiota","volume":"14","author":"van den Belt","year":"2025","journal-title":"J Nutr Sci"},{"key":"10.1053\/j.gastro.2026.07.027_bib48","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1039\/D5FO01540E","article-title":"Safety, tolerability, and preliminary effects of cricket chitin for adults with IBS: a double-blind randomized crossover pilot trial","volume":"16","author":"Vita","year":"2025","journal-title":"Food Funct"},{"key":"10.1053\/j.gastro.2026.07.027_bib49","series-title":"Fibre co-administration and impact on symptoms, microbiome and transit time in irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial","author":"Whelan","year":"2025"},{"key":"10.1053\/j.gastro.2026.07.027_bib50","doi-asserted-by":"crossref","first-page":"906","DOI":"10.14309\/ajg.0000000000000641","article-title":"\u03b2-galactooligosaccharide in conjunction with low FODMAP diet improves irritable bowel syndrome symptoms but reduces fecal bifidobacteria","volume":"115","author":"Wilson","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2026.07.027_bib51","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1053\/j.gastro.2010.01.053","article-title":"Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats","volume":"138","author":"Soret","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2026.07.027_bib52","doi-asserted-by":"crossref","DOI":"10.1111\/jhn.70133","article-title":"British Dietetic Association guidelines for the dietary management of chronic constipation in adults","volume":"38","author":"Dimidi","year":"2025","journal-title":"J Hum Nutr Diet"},{"key":"10.1053\/j.gastro.2026.07.027_bib53","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0140-6736(18)31809-9","article-title":"Carbohydrate quality and human health: a series of systematic reviews and meta-analyses","volume":"393","author":"Reynolds","year":"2019","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2026.07.027_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S095442241700004X","article-title":"Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health","volume":"30","author":"Stephen","year":"2017","journal-title":"Nutr Res Rev"},{"key":"10.1053\/j.gastro.2026.07.027_bib55","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S2468-1253(24)00238-3","article-title":"Dietary management of irritable bowel syndrome: considerations, challenges, and solutions","volume":"9","author":"Whelan","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526071477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508526071477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:34:15Z","timestamp":1794350055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508526071477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":54,"alternative-id":["S0016508526071477"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2026.07.027","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fiber Supplementation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2026.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}]}}