{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:11:42Z","timestamp":1790403102090,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Renal Nutrition"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1053\/j.jrn.2011.04.005","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T04:27:03Z","timestamp":1310531223000},"page":"12-18.e1","source":"Crossref","is-referenced-by-count":6,"title":["Persistent Homocysteine Metabolism Abnormality Accelerates Cardiovascular Disease in Hemodialyzed Patients\u2014the Nishinomiya Study"],"prefix":"10.1053","volume":"22","author":[{"given":"Yukiko","family":"Hasuike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Hama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nonoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahori","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hazeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Nanami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinaga","family":"Otaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kuragano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jrn.2011.04.005_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1525-139X.2003.160271.x","article-title":"Clinical epidemiology of cardiac disease in dialysis patients: left ventricular hypertrophy, ischemic heart disease, cardiac failure","volume":"16","author":"Foley","year":"2003","journal-title":"Semin Dial"},{"key":"10.1053\/j.jrn.2011.04.005_bib2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/sj.ki.5000312","article-title":"Phenotypic and genotypic risk factors for cardiovascular events in an incident dialysis cohort","volume":"69","author":"Pernod","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2011.04.005_bib3","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1016\/S0021-9258(18)61082-8","article-title":"The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells","volume":"262","author":"Heinecke","year":"1987","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.jrn.2011.04.005_bib4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(09)61968-1","article-title":"A \u201cfussy eater\u201d with renal failure","volume":"375","author":"Archer","year":"2010","journal-title":"Lancet"},{"key":"10.1053\/j.jrn.2011.04.005_bib5","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1523-1755.2003.00808.x","article-title":"Free cysteine is increased in plasma from hemodialysis patients","volume":"63","author":"Nakanishi","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2011.04.005_bib6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1681\/ASN.V104891","article-title":"Hyperhomocysteinemia in chronic renal disease","volume":"10","author":"Bostom","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2011.04.005_bib7","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1161\/01.ATV.17.11.2554","article-title":"Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients: a prospective study","volume":"17","author":"Bostom","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6 pt 1","key":"10.1053\/j.jrn.2011.04.005_bib8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1373\/49.6.895","article-title":"Plasma total cysteine, mortality, and cardiovascular disease hospitalizations: the Hordaland Homocysteine Study","volume":"49","author":"El-Khairy","year":"2003","journal-title":"Clin Chem"},{"key":"10.1053\/j.jrn.2011.04.005_bib9","first-page":"88","article-title":"Canada-USA (CANUSA) multicentre study of peritoneal dialysis adequacy: description of the study population and preliminary results","volume":"8","year":"1992","journal-title":"Adv Perit Dial"},{"key":"10.1053\/j.jrn.2011.04.005_bib10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/clinchem\/44.4.825","article-title":"Fully automated assay for total homocysteine, cysteine, cysteinylglycine, glutathione, cysteamine, and 2-mercaptopropionylglycine in plasma and urine","volume":"44","author":"Pastore","year":"1998","journal-title":"Clin Chem"},{"key":"10.1053\/j.jrn.2011.04.005_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0006-2944(76)90049-1","article-title":"A simple fluorometric assay for lipoperoxide in blood plasma","volume":"15","author":"Yagi","year":"1976","journal-title":"Biochem Med"},{"key":"10.1053\/j.jrn.2011.04.005_bib12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.placenta.2009.11.017","article-title":"Expression of folate transporters in human placenta and implications for homocysteine metabolism","volume":"31","author":"Solanky","year":"2010","journal-title":"Placenta"},{"key":"10.1053\/j.jrn.2011.04.005_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0002-9343(02)01075-6","article-title":"Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation","volume":"112","author":"Woo","year":"2002","journal-title":"Am J Med"},{"key":"10.1053\/j.jrn.2011.04.005_bib14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10715760903440153","article-title":"Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance","volume":"44","author":"Li","year":"2010","journal-title":"Free Radic Res"},{"key":"10.1053\/j.jrn.2011.04.005_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1024\/0300-9831.79.2.117","article-title":"Effect of a Klamath algae product (\u201cAFA-B12\u201d) on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study","volume":"79","author":"Baroni","year":"2009","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1053\/j.jrn.2011.04.005_bib16","first-page":"448","article-title":"Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy","volume":"66","author":"Dorszewska","year":"2009","journal-title":"Przegl Lek"},{"key":"10.1053\/j.jrn.2011.04.005_bib17","first-page":"279","article-title":"Influence of folic acid on plasma homocysteine levels and arterial endothelial function in patients with unstable angina","volume":"129","author":"Guo","year":"2009","journal-title":"Indian J Med Res"},{"key":"10.1053\/j.jrn.2011.04.005_bib18","first-page":"235","article-title":"Vitamin treatments that lower homocysteine concentration: can they decrease cerebrovascular disease in primary prevention?","volume":"50","author":"M\u00e9ndez-Gonz\u00e1lez","year":"2010","journal-title":"Rev Neurol"},{"key":"10.1053\/j.jrn.2011.04.005_bib19","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jacc.2005.10.064","article-title":"Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial","volume":"47","author":"Zoungas","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jrn.2011.04.005_bib20","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1053\/j.jrn.2011.04.005_bib21","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.2010.490","article-title":"Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial","volume":"303","author":"House","year":"2010","journal-title":"JAMA"},{"key":"10.1053\/j.jrn.2011.04.005_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1053\/j.jrn.2007.11.007","article-title":"Low total plasma homocysteine level in relation to malnutrition, inflammation, and outcome in hemodialysis patients","volume":"18","author":"Akgul","year":"2008","journal-title":"J Ren Nutr"},{"key":"10.1053\/j.jrn.2011.04.005_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu Rev Nutr"},{"key":"10.1053\/j.jrn.2011.04.005_bib24","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1185\/030079907X218077","article-title":"Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients","volume":"23","author":"Chang","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"10.1053\/j.jrn.2011.04.005_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0021-9150(00)00613-4","article-title":"Chroni renal transplantation: a model for the hyperhomocysteinemia of renal insufficiency","volume":"156","author":"Bostom","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1053\/j.jrn.2011.04.005_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/j.jrn.2005.07.004","article-title":"U-shaped association of body mass index with inflammation and atherosclerosis in hemodialysis patients","volume":"15","author":"Kahraman","year":"2005","journal-title":"J Ren Nutr"},{"key":"10.1053\/j.jrn.2011.04.005_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations: an expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin Chem"}],"container-title":["Journal of Renal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227611000872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227611000872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:21:58Z","timestamp":1638058918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051227611000872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1051227611000872"],"URL":"https:\/\/doi.org\/10.1053\/j.jrn.2011.04.005","relation":{},"ISSN":["1051-2276"],"issn-type":[{"value":"1051-2276","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}