{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:39Z","timestamp":1787004819919,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jrnjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Renal Nutrition"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1053\/j.jrn.2023.10.008","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T22:40:13Z","timestamp":1698792013000},"page":"223-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease"],"prefix":"10.1053","volume":"34","author":[{"given":"Hiroko","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-306X","authenticated-orcid":false,"given":"Shintaro","family":"Mandai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Shikuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuka","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Toshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jrn.2023.10.008_bib1","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1016\/S2468-2667(22)00044-5","article-title":"Projecting prevalence of frailty and dementia and the economic cost of care in Japan from 2016 to 2043: a microsimulation modelling study","volume":"7","author":"Kasajima","year":"2022","journal-title":"Lancet Public Heal"},{"key":"10.1053\/j.jrn.2023.10.008_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ageing\/afy106","article-title":"The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: a systematic review and meta-analyses","volume":"48","author":"Mayhew","year":"2019","journal-title":"Age Ageing"},{"key":"10.1053\/j.jrn.2023.10.008_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s13018-021-02772-0","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"10.1053\/j.jrn.2023.10.008_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bone.2015.04.016","article-title":"Osteoporosis and sarcopenia in older age","volume":"80","author":"Edwards","year":"2015","journal-title":"Bone"},{"key":"10.1053\/j.jrn.2023.10.008_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jcsm.12073","article-title":"Sarcopenia and mortality among a population-based sample of community-dwelling older adults","volume":"7","author":"Brown","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1053\/j.jrn.2023.10.008_bib6","doi-asserted-by":"crossref","first-page":"n1743","DOI":"10.1136\/bmj.n1743","article-title":"Terminal decline in objective and self-reported measures of motor function before death: 10 year follow-up of Whitehall II cohort study","volume":"374","author":"Landr\u00e9","year":"2021","journal-title":"BMJ"},{"key":"10.1053\/j.jrn.2023.10.008_bib7","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/ndt\/gft070","article-title":"Uraemic sarcopenia: aetiology and implications","volume":"29","author":"Fahal","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.jrn.2023.10.008_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jcsm.12705","article-title":"Association of sarcopenia with mortality and end-stage renal disease in those with chronic kidney disease: a UK Biobank study","volume":"12","author":"Wilkinson","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1053\/j.jrn.2023.10.008_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ki.2013.279","article-title":"High rates of death and hospitalization follow bone fracture among hemodialysis patients","volume":"85","author":"Tentori","year":"2014","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2023.10.008_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jcsm.12890","article-title":"Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta-analysis","volume":"13","author":"Shu","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1053\/j.jrn.2023.10.008_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s42358-020-0118-0","article-title":"Mineral bone disorder and osteoporosis in hemodialysis patients","volume":"60","author":"Slouma","year":"2020","journal-title":"Adv Rheumatol"},{"key":"10.1053\/j.jrn.2023.10.008_bib12","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s41598-021-81287-4","article-title":"Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients","volume":"11","author":"Hashimoto","year":"2021","journal-title":"Sci Rep"},{"key":"10.1053\/j.jrn.2023.10.008_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1053\/j.jrn.2023.10.008_bib14","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1053\/j.jrn.2023.10.008_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/jcsm.12567","article-title":"Osteosarcopenia: epidemiology, diagnosis, and treatment\u2014facts and numbers","volume":"11","author":"Kirk","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1053\/j.jrn.2023.10.008_bib16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jcsm.12870","article-title":"Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study","volume":"13","author":"Laskou","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1053\/j.jrn.2023.10.008_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.11005\/jbm.2014.21.1.29","article-title":"Interaction between muscle and bone","volume":"21","author":"Kaji","year":"2014","journal-title":"J Bone Metab"},{"key":"10.1053\/j.jrn.2023.10.008_bib18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jcb.25040","article-title":"Interactions between muscle tissues and bone metabolism","volume":"116","author":"Kawao","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1053\/j.jrn.2023.10.008_bib19","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1007\/s00198-017-4151-8","article-title":"Osteosarcopenia: where bone, muscle, and fat collide","volume":"28","author":"Hirschfeld","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.jrn.2023.10.008_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093286","article-title":"Creatinine index as a surrogate of lean body mass derived from urea Kt\/V, pre-dialysis serum levels and anthropometric characteristics of haemodialysis patients","volume":"9","author":"Canaud","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.jrn.2023.10.008_bib21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.ajkd.2017.01.052","article-title":"Modified creatinine index and the risk of bone fracture in patients undergoing hemodialysis: the Q-cohort study","volume":"70","author":"Yamada","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2023.10.008_bib22","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1053\/j.jrn.2020.08.006","article-title":"Modified creatinine index and clinical outcomes of hemodialysis patients: an indicator of sarcopenia?","volume":"31","author":"Yamamoto","year":"2021","journal-title":"J Ren Nutr"},{"key":"10.1053\/j.jrn.2023.10.008_bib23","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1681\/ASN.2019010008","article-title":"Evaluating Glomerular Filtration rate slope as a surrogate end point for ESKD in clinical trials: an individual participant meta-analysis of observational data","volume":"30","author":"Grams","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2023.10.008_bib24","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1053\/j.jrn.2023.10.008_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-021-00898-1","article-title":"Sarcopenia in chronic kidney disease: a scoping review of prevalence, risk factors, association with outcomes, and treatment","volume":"110","author":"Chatzipetrou","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"10.1053\/j.jrn.2023.10.008_bib26","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/jamainternmed.2016.7701","article-title":"Association of \u03b2-blockers with functional outcomes, death, and Rehospitalization in older Nursing Home Residents after acute myocardial infarction","volume":"177","author":"Steinman","year":"2017","journal-title":"JAMA Intern Med"},{"key":"10.1053\/j.jrn.2023.10.008_bib27","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/HJH.0000000000003130","article-title":"Can \u03b2-blockers influence regular daily physical activity?","volume":"40","author":"Alimento","year":"2022","journal-title":"J Hypertens"},{"key":"10.1053\/j.jrn.2023.10.008_bib28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1152\/physrev.00028.2007","article-title":"Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease","volume":"88","author":"Lynch","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1053\/j.jrn.2023.10.008_bib29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/sj.bjp.0706670","article-title":"Cardiac implications for the use of beta2-adrenoceptor agonists for the management of muscle wasting","volume":"147","author":"Molenaar","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.jrn.2023.10.008_bib30","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/0002-9378(82)90235-6","article-title":"The effect of estrogen and progesterone on beta-adrenergic receptor activity in rabbit lung tissue","volume":"144","author":"Moawad","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/j.jrn.2023.10.008_bib31","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1096\/fj.11-194779","article-title":"Selective estrogen receptor-\u03b2 activation stimulates skeletal muscle growth and regeneration","volume":"26","author":"Velders","year":"2012","journal-title":"FASEB J"},{"key":"10.1053\/j.jrn.2023.10.008_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fphys.2012.00260","article-title":"Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review","volume":"3","author":"Mitchell","year":"2012","journal-title":"Front Physiol"},{"key":"10.1053\/j.jrn.2023.10.008_bib33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/med.21343","article-title":"Renin-angiotensin system: an old player with novel functions in skeletal muscle","volume":"35","author":"Cabello-Verrugio","year":"2015","journal-title":"Med Res Rev"},{"key":"10.1053\/j.jrn.2023.10.008_bib34","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1111\/jcmm.14412","article-title":"Muscle wasting: a review of exercise, classical and non-classical RAS axes","volume":"23","author":"Winslow","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1053\/j.jrn.2023.10.008_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.coph.2012.12.002","article-title":"Beta blockers, nitric oxide, and cardiovascular disease","volume":"13","author":"Vanhoutte","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1053\/j.jrn.2023.10.008_bib36","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/sms.13544","article-title":"Effect of beta 2 -adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men","volume":"29","author":"Lemminger","year":"2019","journal-title":"Scand J Med Sci Sports"},{"key":"10.1053\/j.jrn.2023.10.008_bib37","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002584","article-title":"Prognostic benefits of carvedilol, bisoprolol, and metoprolol controlled release\/extended release in hemodialysis patients with heart failure: a 10-year cohort","volume":"5","author":"Tang","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1053\/j.jrn.2023.10.008_bib38","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/ckj\/sfaa249","article-title":"\u03b2-blockers in hemodialysis: simple questions, complicated answers","volume":"14","author":"Hundemer","year":"2021","journal-title":"Clin Kidney J"},{"key":"10.1053\/j.jrn.2023.10.008_bib39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.ajkd.2020.07.023","article-title":"\u03b2-Blocker Use and risk of mortality in heart failure patients initiating maintenance dialysis","volume":"77","author":"Zhou","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2023.10.008_bib40","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2215\/CJN.14180920","article-title":"Management of heart failure patient with CKD","volume":"16","author":"Banerjee","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2023.10.008_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12020-014-0167-4","article-title":"Antihypertensive medications, bone mineral density, and fractures: a review of old cardiac drugs that provides new insights into osteoporosis","volume":"46","author":"Ghosh","year":"2014","journal-title":"Endocrine"},{"key":"10.1053\/j.jrn.2023.10.008_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00774-010-0252-6","article-title":"L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking","volume":"29","author":"Li","year":"2011","journal-title":"J Bone Miner Metab"},{"key":"10.1053\/j.jrn.2023.10.008_bib43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev-physiol-031620-091043","article-title":"Voltage-gated calcium channels in Nonexcitable tissues","volume":"83","author":"Pitt","year":"2021","journal-title":"Annu Rev Physiol"},{"key":"10.1053\/j.jrn.2023.10.008_bib44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/jbmr.1474","article-title":"Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow","volume":"27","author":"Lu","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.jrn.2023.10.008_bib45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s11914-020-00647-7","article-title":"Skeletal functions of voltage Sensitive calcium channels","volume":"19","author":"Wright","year":"2021","journal-title":"Curr Osteoporos Rep"},{"key":"10.1053\/j.jrn.2023.10.008_bib46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4009\/jsdt.55.665","article-title":"2021 annual dialysis data report, JSDT renal data Registry","volume":"55","author":"Hanafusa","year":"2022","journal-title":"Nihon Toseki Igakkai Zasshi"},{"key":"10.1053\/j.jrn.2023.10.008_bib47","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.clnu.2016.10.016","article-title":"The diagnosis of sarcopenia is mainly driven by muscle mass in hemodialysis patients","volume":"36","author":"Bataille","year":"2017","journal-title":"Clin Nutri"}],"container-title":["Journal of Renal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227623001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227623001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T10:58:56Z","timestamp":1718449136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051227623001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1051227623001917"],"URL":"https:\/\/doi.org\/10.1053\/j.jrn.2023.10.008","relation":{},"ISSN":["1051-2276"],"issn-type":[{"value":"1051-2276","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Renal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jrn.2023.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the National Kidney Foundation, Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}