{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:27:16Z","timestamp":1778797636714,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,23]],"date-time":"2027-01-23T00:00:00Z","timestamp":1800662400000},"content-version":"am","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 127248"],"award-info":[{"award-number":["DK 127248"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jrnjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Renal Nutrition"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1053\/j.jrn.2025.05.007","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:39:47Z","timestamp":1756946387000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association of Serum Bicarbonate With Psychological and Physical Health-Related Quality of Life in Patients Receiving Maintenance Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial"],"prefix":"10.1053","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-0790","authenticated-orcid":false,"given":"Katherine Scovner","family":"Ravi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enass","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M.","family":"Chertow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finnian R.","family":"Mc Causland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.jrn.2025.05.007_bib1","series-title":"National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases","article-title":"End-stage renal disease (ESRD) in the United States CI, incidence, prevalence, patient characteristics, and treatment modalities","year":"2020"},{"key":"10.1053\/j.jrn.2025.05.007_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2215\/CJN.03890609","article-title":"Temporal trends in health-related quality of life among hemodialysis patients in the United States","volume":"5","author":"Gabbay","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib3","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1046\/j.1523-1755.2003.00289.x","article-title":"Health-related quality of life among dialysis patients on three continents: the dialysis outcomes and practice patterns study","volume":"64","author":"Fukuhara","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1053\/j.ajkd.2012.11.047","article-title":"Effects of 6-times-weekly versus 3-times-weekly hemodialysis on depressive symptoms and self-reported mental health: Frequent Hemodialysis Network (FHN) trials","volume":"61","author":"Unruh","year":"2013","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 13","key":"10.1053\/j.jrn.2025.05.007_bib5","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1093\/joneph\/21.S13.S54","article-title":"Quality of life in patients with end-stage renal disease treated with hemodialysis: survival is not enough!","volume":"21","author":"Kimmel","year":"2008","journal-title":"J Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11136-011-9973-9","article-title":"The psychosocial correlates of quality of life in the dialysis population: a systematic review and meta-regression analysis","volume":"21","author":"Chan","year":"2012","journal-title":"Qual Life Res"},{"key":"10.1053\/j.jrn.2025.05.007_bib7","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/ki.2008.311","article-title":"Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression","volume":"74","author":"Hedayati","year":"2008","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib8","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.ajkd.2005.07.002","article-title":"Physician-diagnosed depression as a correlate of hospitalizations in patients receiving long-term hemodialysis","volume":"46","author":"Hedayati","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2025.05.007_bib9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/039139889201501202","article-title":"Depression as a mortality risk factor in hemodialysis patients","volume":"15","author":"Kimmel","year":"1992","journal-title":"Int J Artif Organs"},{"key":"10.1053\/j.jrn.2025.05.007_bib10","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1046\/j.1523-1755.2000.00059.x","article-title":"Multiple measurements of depression predict mortality in a longitudinal study of chronic hemodialysis outpatients","volume":"57","author":"Kimmel","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib11","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1016\/S0272-6386(00)70240-X","article-title":"Psychosocial factors in adult end-stage renal disease patients treated with hemodialysis: correlates and outcomes","volume":"35","author":"Kimmel","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2025.05.007_bib12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0002-9343(98)00245-9","article-title":"Psychiatric illness in patients with end-stage renal disease","volume":"105","author":"Kimmel","year":"1998","journal-title":"Am J Med"},{"key":"10.1053\/j.jrn.2025.05.007_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1525-139x.2000.00066.x","article-title":"Acidosis and nutritional status in hemodialyzed patients. French Study Group for Nutrition in Dialysis","volume":"13","author":"Chauveau","year":"2000","journal-title":"Semin Dial"},{"key":"10.1053\/j.jrn.2025.05.007_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0272-6386(12)70364-5","article-title":"Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities","volume":"15","author":"Lowrie","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2025.05.007_bib15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0272-6386(04)00936-9","article-title":"Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"44","author":"Bommer","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2025.05.007_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2215\/CJN.00010505","article-title":"Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic?","volume":"1","author":"Wu","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1525-139x.2000.00065.x","article-title":"Acid-base balance in dialysis patients","volume":"13","author":"Gennari","year":"2000","journal-title":"Semin Dial"},{"key":"10.1053\/j.jrn.2025.05.007_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/sj.ki.5002032","article-title":"Kliger AS: Frequent Hemodialysis Network (FHN) randomized trials: study design","volume":"71","author":"Suri","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.5301\/jn.5000160","article-title":"Challenges to enrollment and randomization of the Frequent Hemodialysis Network (FHN) daily trial","volume":"25","author":"Sergeyeva","year":"2012","journal-title":"J Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib21","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1056\/NEJMoa1001593","article-title":"Kliger AS: In-center hemodialysis six times per week versus three times per week","volume":"363","author":"Chertow","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jrn.2025.05.007_bib22","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.kint.2016.10.033","article-title":"Patients receiving frequent hemodialysis have better health-related quality of life compared to patients receiving conventional hemodialysis","volume":"91","author":"Garg","year":"2017","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1053\/j.ajkd.2010.08.024","article-title":"Baseline characteristics of participants in the Frequent Hemodialysis Network (FHN) daily and nocturnal trials","volume":"57","author":"Rocco","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jrn.2025.05.007_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1067\/mhl.2002.127940","article-title":"Effect of coronary artery bypass graft surgery on older women's health-related quality of life","volume":"31","author":"Baldassarre","year":"2002","journal-title":"Heart Lung"},{"key":"10.1053\/j.jrn.2025.05.007_bib25","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0895-4356(03)00115-X","article-title":"Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction","volume":"56","author":"Sch\u00fcnemann","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jrn.2025.05.007_bib26","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.2215\/CJN.03951106","article-title":"Screening, diagnosis, and treatment of depression in patients with end-stage renal disease","volume":"2","author":"Cohen","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib27","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2215\/CJN.10601011","article-title":"Effects of six versus three times per week hemodialysis on physical performance, health, and functioning: Frequent Hemodialysis Network (FHN) randomized trials","volume":"7","author":"Hall","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib28","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"10.1053\/j.jrn.2025.05.007_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-064174","article-title":"Prevalence of post-dialysis fatigue: a systematic review and meta-analysis","volume":"13","author":"Dou","year":"2023","journal-title":"BMJ Open"},{"key":"10.1053\/j.jrn.2025.05.007_bib30","first-page":"292","article-title":"Prevalence and risk factors of postdialysis fatigue in patients under maintenance hemodialysis: a systematic review and meta-analysis","volume":"16","author":"You","year":"2022","journal-title":"Asian Nurs Res (Korean Soc Nurs Sci)"},{"key":"10.1053\/j.jrn.2025.05.007_bib31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2215\/CJN.07670618","article-title":"Fostering innovation in symptom management among hemodialysis patients: paths forward for insomnia, muscle cramps, and fatigue","volume":"14","author":"Flythe","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.34067\/KID.0007452020","article-title":"Electrolyte changes in contemporary hemodialysis: a secondary analysis of the monitoring in dialysis (MiD) Study","volume":"2","author":"Correa","year":"2021","journal-title":"Kidney360"},{"key":"10.1053\/j.jrn.2025.05.007_bib33","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1681\/ASN.2016070780","article-title":"Bicarbonate balance and prescription in ESRD","volume":"28","author":"Abramowitz","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/sdi.12573","article-title":"Dialysate composition for hemodialysis: changes and changing risk","volume":"30","author":"McGill","year":"2017","journal-title":"Semin Dial"},{"key":"10.1053\/j.jrn.2025.05.007_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.NME.0000481439.20535.84","article-title":"Alkalosis in brief","volume":"14","author":"Perkins","year":"2016","journal-title":"Nurs Made Incred Easy"},{"key":"10.1053\/j.jrn.2025.05.007_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.semnephrol.2013.04.006","article-title":"Acid-base and potassium homeostasis","volume":"33","author":"Lee Hamm","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib37","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.kint.2016.01.010","article-title":"The choice of dialysate bicarbonate: do different concentrations make a difference?","volume":"89","author":"Basile","year":"2016","journal-title":"Kidney Int"},{"key":"10.1053\/j.jrn.2025.05.007_bib38","first-page":"53","article-title":"pH of soul: how does acid-base balance affect our cognition?","volume":"4","author":"Farnam","year":"2014","journal-title":"Bioimpacts"},{"key":"10.1053\/j.jrn.2025.05.007_bib39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2215\/CJN.07050717","article-title":"Serum bicarbonate concentration and cognitive function in hypertensive adults","volume":"13","author":"Dobre","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.jrn.2025.05.007_bib40","doi-asserted-by":"crossref","first-page":"ii4","DOI":"10.1093\/ndt\/gfab216","article-title":"Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease","volume":"37","author":"Imenez Silva","year":"2021","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.jrn.2025.05.007_bib41","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1046\/j.1523-1755.2003.08802.x","article-title":"Metabolic acidosis in maintenance dialysis patients: clinical considerations","volume":"88","author":"Mehrotra","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.jrn.2025.05.007_bib42","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ndt\/gfn633","article-title":"Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD","volume":"24","author":"Kovesdy","year":"2009","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.jrn.2025.05.007_bib44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/j.jrn.2024.11.001","article-title":"Association between potential renal acid load and 10-year mortality in patients on hemodialysis","volume":"35","author":"Tanaka","year":"2025","journal-title":"J Ren Nutr"},{"key":"10.1053\/j.jrn.2025.05.007_bib45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.1053\/j.jrn.2025.05.007_bib46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1742-6723.2010.01344.x","article-title":"Review article: can venous blood gas analysis replace arterial in emergency medical care","volume":"22","author":"Kelly","year":"2010","journal-title":"Emerg Med Australas"}],"container-title":["Journal of Renal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227625001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051227625001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:01:14Z","timestamp":1778796074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051227625001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1051227625001256"],"URL":"https:\/\/doi.org\/10.1053\/j.jrn.2025.05.007","relation":{},"ISSN":["1051-2276"],"issn-type":[{"value":"1051-2276","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association of Serum Bicarbonate With Psychological and Physical Health-Related Quality of Life in Patients Receiving Maintenance Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Renal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jrn.2025.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the National Kidney Foundation, Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}