{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:18:43Z","timestamp":1761005923721,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1053\/j.jvca.2010.12.015","type":"journal-article","created":{"date-parts":[[2011,2,13]],"date-time":"2011-02-13T06:40:32Z","timestamp":1297579232000},"page":"371-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Update in Hematology: Heparin-Induced Thrombocytopenia and Bivalirudin"],"prefix":"10.1053","volume":"25","author":[{"given":"John G.T.","family":"Augoustides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2010.12.015_bib1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1023\/A:1027325002276","article-title":"Heparin-induced thrombocytopenia: patient profiles and clinical manifestations","volume":"10","author":"Spencer","year":"2000","journal-title":"J Thromb Thrombolysis"},{"key":"10.1053\/j.jvca.2010.12.015_bib2","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1023\/A:1027372901367","article-title":"Mechanisms of venous and arterial thrombosis in heparin induced thrombocytopenia","volume":"10","author":"Wallenga","year":"2000","journal-title":"J Thromb Thrombolysis"},{"key":"10.1053\/j.jvca.2010.12.015_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11239-005-0850-7","article-title":"Identification, diagnosis and treatment of heparin-induced thrombocytopenia and thrombosis: A registry of prolonged heparin use and thrombocytopenia among hospitalized patients with and without cardiovascular disease","volume":"10","author":"Ohman","year":"2005","journal-title":"J Thromb Thrombolysis"},{"key":"10.1053\/j.jvca.2010.12.015_bib4","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ahj.2009.01.005","article-title":"Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The Complications after Thrombocytopenia Caused by heparin (CATCH) registry","volume":"157","author":"Crespo","year":"2009","journal-title":"Am Heart J"},{"key":"10.1053\/j.jvca.2010.12.015_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.thromres.2009.01.006","article-title":"Heparin-induced thrombocytopenia and thrombosis in a tertiary care hospital","volume":"124","author":"Ban-Hoefen","year":"2009","journal-title":"Thromb Res"},{"key":"10.1053\/j.jvca.2010.12.015_bib6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.ejcts.2009.12.023","article-title":"Perioperative thrombocytopenia in cardiac surgical patients\u2014Incidence of heparin-induced thrombocytopenia, morbidities and mortality","volume":"37","author":"Thielmann","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1538-7836.2009.03626.x","article-title":"Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive","volume":"8","author":"Selleng","year":"2010","journal-title":"J Thromb Haemaost"},{"key":"10.1053\/j.jvca.2010.12.015_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/j.jvca.2006.05.002","article-title":"Heparin-induced thrombocytopenia following cardiac surgery is associated with poor outcome","volume":"21","author":"Kuitunen","year":"2007","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2010.12.015_bib9","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.athoracsur.2007.05.080","article-title":"Impact of heparin-induced thrombocytopenia on postoperative outcomes after cardiac surgery?","volume":"84","author":"Kerendi","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1055\/s-0030-1250184","article-title":"Heparin-induced thrombocytopenia type II after cardiac surgery: predictors and outcome","volume":"58","author":"Assman","year":"2010","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1213\/01.ane.0000277497.70701.47","article-title":"Reducing thrombotic complications in the perioperative setting: an update on heparin-induced thrombocytopenia","volume":"105","author":"Levy","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2010.12.015_bib12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.athoracsur.2006.09.040","article-title":"Prevalence of heparin\/platelet factor 4 antibodies before and after cardiac surgery","volume":"83","author":"Everett","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1213\/ane.0b013e3181734604","article-title":"The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population","volume":"107","author":"Mullen","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2010.12.015_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1213\/ane.0b013e31817b65c2","article-title":"HIT happens: Diagnosing and evaluating the patient with heparin-induced thrombocytopenia","volume":"107","author":"Greinacher","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2010.12.015_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ahj.2010.05.026","article-title":"Incidence and clinical relevance of anti-platelet factor 4\/heparin antibodies before cardiac surgery","volume":"160","author":"Selleng","year":"2010","journal-title":"Am Heart J"},{"key":"10.1053\/j.jvca.2010.12.015_bib16","doi-asserted-by":"crossref","first-page":"340S","DOI":"10.1378\/chest.08-0677","article-title":"Treatment and prevention of heparin-induced thrombocytopenia","volume":"133","author":"Warkentin","year":"2008","journal-title":"Chest"},{"key":"10.1053\/j.jvca.2010.12.015_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/ACO.0b013e328334dd2f","article-title":"Heparin-induced thrombocytopenia and cardiac surgery","volume":"23","author":"Levy","year":"2010","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1053\/j.jvca.2010.12.015_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1538-7836.2009.03385.x","article-title":"Heparin-induced thrombocytopenia","volume":"7","author":"Greinacher","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.jvca.2010.12.015_bib19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.7326\/0003-4819-127-9-199711010-00005","article-title":"The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytoipenia","volume":"127","author":"Warkentin","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.jvca.2010.12.015_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/archinte.164.1.66","article-title":"Warfarin-induced skin necrosis and venous limb gangrene in the setting of heparin-induced thrombocytopenia","volume":"164","author":"Srinivasan","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.jvca.2010.12.015_bib21","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1378\/chest.127.5.1857","article-title":"Heparin-induced skin lesions and other unusual sequelae of the heparin-induced thrombocytopenia syndrome: A nested cohort study","volume":"127","author":"Warkentin","year":"2005","journal-title":"Chest"},{"key":"10.1053\/j.jvca.2010.12.015_bib22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1538-7836.2006.01875.x","article-title":"Should vitamin K be administered when HIT is diagnosed after administration of coumarin?","volume":"4","author":"Warkentin","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.jvca.2010.12.015_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.jvca.2006.08.011","article-title":"Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery","volume":"21","author":"Murphy","year":"2007","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2010.12.015_bib24","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM200104263441704","article-title":"Temporal aspects of heparin-induced thrombocytopenia","volume":"344","author":"Warkentin","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2010.12.015_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1378\/chest.122.1.37","article-title":"Heparin-induced thrombocytopenia: Temporal pattern of thrombocytopenia in relation to initial use or reexposure to heparin","volume":"122","author":"Lubenow","year":"2002","journal-title":"Chest"},{"key":"10.1053\/j.jvca.2010.12.015_bib26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ajh.21770","article-title":"Heparin-induced thrombocytopenia: Current status and diagnostic challenges","volume":"85","author":"Otis","year":"2010","journal-title":"Am J Hematol"},{"key":"10.1053\/j.jvca.2010.12.015_bib27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jtcvs.2005.10.049","article-title":"Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: The results of the EVOLUTION-OFF study","volume":"131","author":"Smedira","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1213\/01.ane.0000226098.95698.0f","article-title":"Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: Results of the \u201cEVOLUTION OFF\u201d trial","volume":"103","author":"Koster","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2010.12.015_bib29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jtcvs.2005.09.057","article-title":"A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: The EVOLUTION-ON study","volume":"131","author":"Dyke","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.athoracsur.2006.09.038","article-title":"Bivalirudin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia and heparin antibodies: The CHOOSE-ON trial","volume":"83","author":"Koster","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib31","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.athoracsur.2007.04.007","article-title":"Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor 4\/heparin antibodies","volume":"84","author":"Dyke","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib32","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1586\/erc.10.158","article-title":"Bivalirudin: A review of the pharmacology and clinical application","volume":"8","author":"Van De Car","year":"2010","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1053\/j.jvca.2010.12.015_bib33","article-title":"Bivalirudin utilization in cardiac surgery: Shifting anticoagulation from indirect to direct thrombin inhibition","author":"Anand","year":"2010","journal-title":"Can J Anaesth"},{"key":"10.1053\/j.jvca.2010.12.015_bib34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00000542-200508000-00005","article-title":"Efficacy and safety of heparinase-1 versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass","volume":"103","author":"Stafford-Smith","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2010.12.015_bib35","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1056\/NEJM199509213331204","article-title":"Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina","volume":"333","author":"Bittl","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2010.12.015_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCINTERVENTIONS.109.884478","article-title":"Anticoagulant therapy for percutaneous coronary intervention","volume":"3","author":"Rao","year":"2010","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1053\/j.jvca.2010.12.015_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4244\/EIJV6I2A33","article-title":"The impact of bivalirudin on percutaneous coronary intervention-related bleeding","volume":"6","author":"Lindsey","year":"2010","journal-title":"Eurointervention"},{"key":"10.1053\/j.jvca.2010.12.015_bib38","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.jtcvs.2010.02.038","article-title":"Anticoagulation management during cardiopulmonary bypass: A survey of 54 North American institutions","volume":"139","author":"Lobato","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2010.12.015_bib39","doi-asserted-by":"crossref","DOI":"10.1213\/ANE.0b013e3181c84ba5","article-title":"Multidisciplinary approach to the challenge of hemostasis","volume":"110","author":"Levy","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2010.12.015_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1517\/14740330802648442","article-title":"Aprotinin and renal dysfunction: What does history teach us?","volume":"8","author":"Augoustides","year":"2009","journal-title":"Expert Opin Drug Saf"},{"key":"10.1053\/j.jvca.2010.12.015_bib41","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2165\/00002018-200831070-00001","article-title":"Perioperative safety of aprotinin in coronary artery bypass graft surgery: Is there life after BART?","volume":"31","author":"Augoustides","year":"2008","journal-title":"Drug Saf"},{"key":"10.1053\/j.jvca.2010.12.015_bib42","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa0802395","article-title":"A comparison of aprotinin and lysine analogues in high-risk cardiac surgery","volume":"358","author":"Fergusson","year":"2008","journal-title":"N Engl J Med"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077010005732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077010005732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:37:15Z","timestamp":1760945835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077010005732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1053077010005732"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2010.12.015","relation":{},"ISSN":["1053-0770"],"issn-type":[{"type":"print","value":"1053-0770"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Update in Hematology: Heparin-Induced Thrombocytopenia and Bivalirudin","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2010.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}