{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:34:03Z","timestamp":1764858843431},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jcardioanesthesia.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1053\/j.jvca.2015.12.003","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T08:02:40Z","timestamp":1449216160000},"page":"917-923","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality After Liver Transplantation"],"prefix":"10.1053","volume":"30","author":[{"given":"Ramona","family":"Nicolau-Raducu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Ganier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Koveleskie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"William J.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Fish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor W.","family":"Reichman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto E.","family":"Bohorquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian C.","family":"Carmody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Loss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Gitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby D.","family":"Nossaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2015.12.003_bib1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/00000542-198706000-00010","article-title":"Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation","volume":"66","author":"Kang","year":"1987","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2015.12.003_bib2","first-page":"2001","article-title":"Coagulation and liver transplantation","volume":"25","author":"Kang","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1053\/j.jvca.2015.12.003_bib3","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1572-0241.2001.03781.x","article-title":"Hyperfibrinolytic activity in hospitalized cirrhotic patients in a referral liver unit","volume":"96","author":"Hu","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.jvca.2015.12.003_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-6143.2006.01591.x","article-title":"Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis","volume":"7","author":"Molenaar","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1053\/j.jvca.2015.12.003_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1538-7836.2008.02831.x","article-title":"Intraoperative pulmonary embolism and intracardiac thrombosis complicating liver transplantation: A systematic review. J Thrombosis","volume":"6","author":"Warnaar","year":"2008","journal-title":"Haemostasis"},{"key":"10.1053\/j.jvca.2015.12.003_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/lt.20275","article-title":"Antifibrinolytics in orthotopic liver transplantation: Current status and controversies","volume":"11","author":"Xia","year":"2005","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib7","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa0802395","article-title":"A comparison of aprotinin and lysine analogues in high-risk cardiac surgery","volume":"358","author":"Fergusson","year":"2008","journal-title":"New Engl J Med"},{"key":"10.1053\/j.jvca.2015.12.003_bib8","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1056\/NEJMe0803514","article-title":"The aprotinin story\u2014is BART the final chapter?","volume":"358","author":"Ray","year":"2008","journal-title":"New Engl J Med"},{"key":"10.1053\/j.jvca.2015.12.003_bib9","unstructured":"Food and Drug Administration: 2007 Safety Alerts for Human Medical Products: Trasylol. Available at: \u3008http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm095103.htm\u3009. Accessed December 13, 2015."},{"key":"10.1053\/j.jvca.2015.12.003_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: The concept of a donor risk index","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1053\/j.jvca.2015.12.003_bib11","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/lt.23723","article-title":"Cardiac arrest during adult liver transplantation: A single institution\u2019s experience with 1238 deceased donor transplants","volume":"19","author":"Matsusaki","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib12","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1478-3231.2009.01977.x","article-title":"Heparin-like effect contributes to the coagulopathy in patients with acute liver failure undergoing liver transplantation","volume":"29","author":"Senzolo","year":"2009","journal-title":"Liver Int"},{"key":"10.1053\/j.jvca.2015.12.003_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/lt.21437","article-title":"The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantation","volume":"14","author":"Agarwal","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: A KDIGO summary (Part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2015.12.003_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/lt.23997","article-title":"Adverse cardiac events after orthotopic liver transplantation: A cross-sectional study in 389 consecutive patients","volume":"21","author":"Nicolau-Raducu","year":"2015","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1053\/jlts.2001.26928","article-title":"Intracardiac thrombus formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation","volume":"7","author":"Gologorsky","year":"2001","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib17","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1213\/01.ane.0000242643.50670.3e","article-title":"Prevention of intracardiac\/pulmonary thrombosis during liver transplantation","volume":"103","author":"Planinsic","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2015.12.003_bib18","first-page":"A44","article-title":"A double-blind, placebo-controlled trial of epsilon-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery","author":"Kikura","year":"2006","journal-title":"J Am Coll Surg 202:216-222; quiz"},{"key":"10.1053\/j.jvca.2015.12.003_bib19","first-page":"211","article-title":"Antifibrinolytic therapy in cardiac surgery","volume":"22","author":"Chen","year":"1995","journal-title":"Texas Heart Inst J"},{"key":"10.1053\/j.jvca.2015.12.003_bib20","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.transproceed.2014.04.006","article-title":"Aminocaproic acid (Amicar) as an alternative to aprotinin (trasylol) in liver transplantation","volume":"46","author":"Mangus","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1053\/j.jvca.2015.12.003_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1213\/00000539-200007000-00006","article-title":"Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation","volume":"91","author":"Dalmau","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2015.12.003_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00268-013-2282-4","article-title":"Epsilon-aminocaproic acid improves postrecirculation hemodynamics by reducing intraliver activated protein C consumption in orthotopic liver transplantation","volume":"38","author":"Kong","year":"2014","journal-title":"World J Surg"},{"key":"10.1053\/j.jvca.2015.12.003_bib23","doi-asserted-by":"crossref","first-page":"c3365","DOI":"10.1136\/bmj.c3365","article-title":"Perioperative acute kidney injury: Risk factors, recognition, management, and outcomes","volume":"341","author":"Borthwick","year":"2010","journal-title":"Br Med J"},{"key":"10.1053\/j.jvca.2015.12.003_bib24","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/01.TP.0000137176.95730.5B","article-title":"Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation","volume":"78","author":"Sanchez","year":"2004","journal-title":"Transplantation"},{"key":"10.1053\/j.jvca.2015.12.003_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2369-14-43","article-title":"Impact of acute kidney injury exposure period among liver transplantation patients","volume":"14","author":"Narciso","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1053\/j.jvca.2015.12.003_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/lt.23384","article-title":"Impact of the etiology of acute kidney injury on outcomes following liver transplantation: Acute tubular necrosis versus hepatorenal syndrome","volume":"18","author":"Nadim","year":"2012","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.transproceed.2012.06.060","article-title":"Frequency and predictors of venous thromboembolism in orthotopic liver transplant recipients: A single-center retrospective review","volume":"45","author":"Salami","year":"2013","journal-title":"Transplant Proc"},{"key":"10.1053\/j.jvca.2015.12.003_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/lt.20077","article-title":"Antifibrinolytics in liver transplantation: They are effective, but what about the risk-benefit ratio?","volume":"10","author":"Porte","year":"2004","journal-title":"Liver Transpl"},{"key":"10.1053\/j.jvca.2015.12.003_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/bja\/aer392","article-title":"Pulmonary thromboembolism during adult liver transplantation: Incidence, clinical presentation, outcome, risk factors, and diagnostic predictors","volume":"108","author":"Sakai","year":"2012","journal-title":"Br J Anaesth"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077015009647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077015009647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T02:21:48Z","timestamp":1537150908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077015009647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1053077015009647"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2015.12.003","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality After Liver Transplantation","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2015.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}