{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:40Z","timestamp":1787004820877,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jcardioanesthesia.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1053\/j.jvca.2016.06.006","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T08:00:36Z","timestamp":1465632036000},"page":"1485-1493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery"],"prefix":"10.1053","volume":"30","author":[{"given":"Ming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suochun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2016.06.006_bib1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1010-7940(03)00475-5","article-title":"Myocardial protection in adult cardiac surgery: Current options and future challenges","volume":"24","author":"Nicolini","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2016.06.006_bib2","doi-asserted-by":"crossref","first-page":"S661","DOI":"10.1016\/S0003-4975(02)04688-X","article-title":"Mechanisms and alternative methods of achieving cardiac arrest","volume":"75","author":"Chambers","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2016.06.006_bib3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.coph.2008.11.012","article-title":"Targeting for cardioplegia: Arresting agents and their safety","volume":"9","author":"Fallouh","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1053\/j.jvca.2016.06.006_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: From basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2016.06.006_bib5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1124\/pr.107.06002","article-title":"Interaction of cardiovascular risk factors with myocardial ischemia\/reperfusion injury, preconditioning, and postconditioning","volume":"59","author":"Ferdinandy","year":"2007","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.jvca.2016.06.006_bib6","first-page":"2273","article-title":"Injuries of myocardial cells and changes of myocardial enzymes after firearm wound-induced intestinal perforation in porcine abdomen","volume":"8","author":"Xue","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1053\/j.jvca.2016.06.006_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/eurheartj\/eht550","article-title":"The year in cardiology 2013: Coronary intervention","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1053\/j.jvca.2016.06.006_bib8","first-page":"45","article-title":"Myocardial preservation in acute coronary artery occlusion with coronary sinus retroperfusion and carnitine","volume":"41","author":"Katircioglu","year":"2000","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"10.1053\/j.jvca.2016.06.006_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1071-9164(96)80016-9","article-title":"Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure","volume":"2","author":"Kawasaki","year":"1996","journal-title":"J Card Fail"},{"key":"10.1053\/j.jvca.2016.06.006_bib10","first-page":"411","article-title":"Cardioprotective effect of L-carnitine in rats submitted to permanent left coronary artery ligation","volume":"101","author":"Mouhieddine","year":"1993","journal-title":"Arch Int Physiol Biochim Biophys"},{"key":"10.1053\/j.jvca.2016.06.006_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2004.04.013","article-title":"Myocardial ischemia\/reperfusion-injury, a clinical view on a complex pathophysiological process","volume":"100","author":"Moens","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1053\/j.jvca.2016.06.006_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jep.2005.04.031","article-title":"Total flavones from Elsholtzia blanda reduce infarct size during acute myocardial ischemia by inhibiting myocardial apoptosis in rats","volume":"101","author":"Ling","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1053\/j.jvca.2016.06.006_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.febslet.2011.02.029","article-title":"Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore","volume":"585","author":"Chen","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1053\/j.jvca.2016.06.006_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1517\/14728222.2013.733001","article-title":"Targeting the Bcl-2 family for cancer therapy","volume":"17","author":"Thomas","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1053\/j.jvca.2016.06.006_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s003950200053","article-title":"Inhibition of apoptotic responses after ischemic stress in isolated hearts and cardiomyocytes","volume":"97","author":"Hofstaetter","year":"2002","journal-title":"Basic Res Cardiol"},{"key":"10.1053\/j.jvca.2016.06.006_bib16","first-page":"352","article-title":"How does hypothermia protect cardiomyocytes during cardioplegic ischemia?","volume":"40","author":"Drescher","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2016.06.006_bib17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1272\/jnms.80.328","article-title":"Future perspective of cardioplegic protection in cardiac surgery","volume":"80","author":"Maruyama","year":"2013","journal-title":"J Nippon Med Sch"},{"issue":"Suppl","key":"10.1053\/j.jvca.2016.06.006_bib18","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.ymgme.2013.10.007","article-title":"Genetic and cellular modifiers of oxidative stress: What can we learn from fatty acid oxidation defects?","volume":"110","author":"Olsen","year":"2013","journal-title":"Mol Genet Metab"},{"key":"10.1053\/j.jvca.2016.06.006_bib19","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0003-4975(98)00997-7","article-title":"Carnitine supplementation improves myocardial function in hearts from ischemic diabetic and euglycemic rats","volume":"66","author":"Keller","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2016.06.006_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/phrs.1997.0281","article-title":"Effect of L-carnitine on myocardial metabolism: Results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery","volume":"37","author":"Pastoris","year":"1998","journal-title":"Pharmacol Res"},{"key":"10.1053\/j.jvca.2016.06.006_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.regpep.2005.09.015","article-title":"Dendroaspis natriuretic peptide protects the post-ischemic myocardial injury","volume":"133","author":"Ha","year":"2006","journal-title":"Regul Pept"},{"key":"10.1053\/j.jvca.2016.06.006_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/138161211795049651","article-title":"The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: Finding of novel therapeutic opportunities","volume":"17","author":"Silva","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1053\/j.jvca.2016.06.006_bib23","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1038\/cddis.2012.126","article-title":"High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria","volume":"3","author":"Esposito","year":"2012","journal-title":"Cell Death Dis"},{"key":"10.1053\/j.jvca.2016.06.006_bib24","doi-asserted-by":"crossref","first-page":"16105","DOI":"10.1074\/jbc.M611115200","article-title":"Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species","volume":"282","author":"May","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1053\/j.jvca.2016.06.006_bib25","doi-asserted-by":"crossref","first-page":"12825","DOI":"10.1073\/pnas.202474099","article-title":"Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3","volume":"99","author":"Kubasiak","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.jvca.2016.06.006_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biocel.2012.09.022","article-title":"Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x(L): Keep your friends close but your enemies closer","volume":"45","author":"Renault","year":"2013","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077016301781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077016301781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T04:24:02Z","timestamp":1536639842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077016301781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1053077016301781"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2016.06.006","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2016.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}