{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:40Z","timestamp":1787004820838,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jcardioanesthesia.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1053\/j.jvca.2017.08.035","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T14:21:20Z","timestamp":1503670880000},"page":"684-690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Disturbances in Oxygen Balance During Cardiopulmonary Bypass: A Risk Factor for Postoperative Delirium"],"prefix":"10.1053","volume":"32","author":[{"given":"Nina","family":"Smulter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Claesson","family":"Lingehall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngve","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micael","family":"Appelblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Svenmarker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2017.08.035_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2147\/vhrm.2006.2.4.477","article-title":"Outcomes of coronary artery bypass graft surgery","volume":"2","author":"Hawkes","year":"2006","journal-title":"Vasc Health Risk Manag"},{"key":"10.1053\/j.jvca.2017.08.035_bib2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/icvts\/ivt304","article-title":"Pre-existing cerebral infarcts as a risk factor for delirium after coronary artery bypass graft surgery","volume":"17","author":"Otomo","year":"2013","journal-title":"Interact Cardio Vasc Thorac Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1540-8191.2005.00134.x","article-title":"Delirium in the postoperative cardiac patient: A review","volume":"20","author":"Sockalingam","year":"2005","journal-title":"J Card Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ana.21899","article-title":"Delirium after coronary artery bypass graft surgery and late mortality","volume":"67","author":"Gottesman","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1053\/j.jvca.2017.08.035_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.athoracsur.2011.07.006","article-title":"Consequences of delirium after cardiac operations","volume":"93","author":"Koster","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/CCM.0000000000002483","article-title":"Preoperative cognitive performance and postoperative delirium are independently associated with future dementia in older people who have undergone cardiac surgery: A longitudinal cohort study","volume":"45","author":"Lingehall","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1053\/j.jvca.2017.08.035_bib7","series-title":"Diagnostic and statistical manual of mental disorders","author":"DSM-IV-TR","year":"2000"},{"key":"10.1053\/j.jvca.2017.08.035_bib8","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1053\/j.jvca.2014.08.021","article-title":"Postoperative delirium in cardiac surgery: An unavoidable menace?","volume":"29","author":"Hollinger","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib9","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1053\/j.jvca.2015.06.018","article-title":"Incidence of and risk factors for delirium after cardiac surgery at a quaternary care center: A retrospective cohort study","volume":"29","author":"Tse","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib10","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1053\/j.jvca.2014.03.017","article-title":"Postoperative delirium: Risk factors, prevention, and treatment","volume":"28","author":"Trabold","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib11","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/icvts\/ivt323","article-title":"Delirium after cardiac surgery: Incidence and risk factors","volume":"17","author":"Smulter","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state.\" A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1053\/j.jvca.2017.08.035_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/gps.930080305","article-title":"A comparison between three psychogeriatric rating scales","volume":"8","author":"Jensen","year":"1993","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1053\/j.jvca.2017.08.035_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/gps.1449","article-title":"The Organic Brain Syndrome (OBS) scale: A systematic review","volume":"21","author":"Bjorkelund","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1053\/j.jvca.2017.08.035_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejcts.2009.05.019","article-title":"Static blood-flow control during cardiopulmonary bypass is a compromise of oxygen delivery","volume":"37","author":"Svenmarker","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13054-016-1288-3","article-title":"Early goal-directed therapy in severe sepsis and septic shock: Insights and comparisons to ProCESS, ProMISe, and ARISE","volume":"20","author":"Nguyen","year":"2016","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2017.08.035_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/bja\/aer166","article-title":"Mixed venous oxygen saturation predicts short- and long-term outcome after coronary artery bypass grafting surgery: A retrospective cohort analysis","volume":"107","author":"Holm","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib18","doi-asserted-by":"crossref","first-page":"R218","DOI":"10.1186\/cc10454","article-title":"Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: A prospective observational trial","volume":"15","author":"Schoen","year":"2011","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2017.08.035_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2016.12.039","article-title":"Intraoperative cerebral oxygenation, oxidative injury, and delirium following cardiac surgery","volume":"103","author":"Lopez","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/j.jvca.2017.08.035_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/bja\/aes375","article-title":"Relation between mixed venous oxygen saturation and cerebral oxygen saturation measured by absolute and relative near-infrared spectroscopy during off-pump coronary artery bypass grafting","volume":"110","author":"Moerman","year":"2013","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-2044.2001.01707.x","article-title":"Jugular bulb oximetry during cardiac surgery","volume":"56","author":"Shaaban Ali","year":"2001","journal-title":"Anaesthesia"},{"key":"10.1053\/j.jvca.2017.08.035_bib22","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1213\/ane.0b013e3181875e2e","article-title":"Optimal perfusion during cardiopulmonary bypass: An evidence-based approach","volume":"108","author":"Murphy","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2017.08.035_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.athoracsur.2015.02.034","article-title":"Acute kidney injury and hemodilution during cardiopulmonary bypass: A changing scenario","volume":"100","author":"Ranucci","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0022-5223(19)39061-0","article-title":"Complement and the damaging effects of cardiopulmonary bypass","volume":"86","author":"Kirklin","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1017\/S1041610213002378","article-title":"Raised IL-2 and TNF-alpha concentrations are associated with postoperative delirium in patients undergoing coronary-artery bypass graft surgery","volume":"26","author":"Kazmierski","year":"2014","journal-title":"Int Psychogeriatr"},{"key":"10.1053\/j.jvca.2017.08.035_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbi.2004.01.004","article-title":"The influence of systemic inflammation on inflammation in the brain: Implications for chronic neurodegenerative disease","volume":"18","author":"Perry","year":"2004","journal-title":"Brain Behav Immun"},{"key":"10.1053\/j.jvca.2017.08.035_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1089253214532375","article-title":"Pathophysiology of cardiopulmonary bypass: Current strategies for the prevention and treatment of anemia, coagulopathy, and organ dysfunction","volume":"18","author":"Esper","year":"2014","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib28","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S1053-0770(99)90123-4","article-title":"Increased extracellular brain water after coronary artery bypass grafting is avoided by off-pump surgery","volume":"13","author":"Anderson","year":"1999","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib29","doi-asserted-by":"crossref","first-page":"R238","DOI":"10.1186\/cc9393","article-title":"High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: A prospective cohort study","volume":"14","author":"Mu","year":"2010","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2017.08.035_bib30","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1210\/jc.2005-0354","article-title":"Cortisol response in relation to the severity of stress and illness","volume":"90","author":"Widmer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.jvca.2017.08.035_bib31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/eurheartj\/ehp178","article-title":"Protecting the brain from gaseous and solid micro-emboli during coronary artery bypass grafting: A randomized controlled trial","volume":"31","author":"Gerriets","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1053\/j.jvca.2017.08.035_bib32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1067\/mtc.2002.122303","article-title":"Fat contamination of pericardial suction blood and its influence on in vitro capillary-pore flow properties in patients undergoing routine coronary artery bypass grafting","volume":"124","author":"Appelblad","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2017.08.035_bib33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/01.STR.31.3.707","article-title":"Longer duration of cardiopulmonary bypass is associated with greater numbers of cerebral microemboli","volume":"31","author":"Brown","year":"2000","journal-title":"Stroke"},{"key":"10.1053\/j.jvca.2017.08.035_bib34","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S0020-1383(11)70005-5","article-title":"Cerebral fat emboli: A trigger of post-operative delirium","volume":"42","author":"Cox","year":"2011","journal-title":"Injury"},{"key":"10.1053\/j.jvca.2017.08.035_bib35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1089253215626728","article-title":"Intraoperative embolization and cognitive decline after cardiac surgery: A systematic review","volume":"20","author":"Patel","year":"2016","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2017.08.035_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/1358863X13502699","article-title":"Single aortic clamping in coronary artery bypass surgery reduces cerebral embolism and improves neurocognitive outcomes","volume":"18","author":"Gasparovic","year":"2013","journal-title":"Vasc Med"},{"key":"10.1053\/j.jvca.2017.08.035_bib37","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bja\/aeu319","article-title":"Arterial pressure above the upper cerebral autoregulation limit during cardiopulmonary bypass is associated with postoperative delirium","volume":"113","author":"Hori","year":"2014","journal-title":"Br J Anaesth"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077017307176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077017307176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:10:28Z","timestamp":1750806628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077017307176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1053077017307176"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2017.08.035","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disturbances in Oxygen Balance During Cardiopulmonary Bypass: A Risk Factor for Postoperative Delirium","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2017.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}