{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:18:59Z","timestamp":1784693939530,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jcardioanesthesia.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1053\/j.jvca.2019.01.021","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T11:40:35Z","timestamp":1547034035000},"page":"1601-1606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The HAS-BLED Score is Associated With Major Bleeding in Patients After Cardiac Surgery"],"prefix":"10.1053","volume":"33","author":[{"given":"Gianluca","family":"Santise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-2022","authenticated-orcid":false,"given":"Saverio","family":"Nardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Migliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Maselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2019.01.021_bib0001","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.athoracsur.2013.03.015","article-title":"Surgical and Clinical Outcome Research (SCORE) Group. Major bleeding, transfusions, and anemia: The deadly triad of cardiac surgery","volume":"96","author":"Ranucci","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2019.01.021_bib0002","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jtcvs.2013.10.070","article-title":"Universal definition of perioperative bleeding in adult cardiac surgery","volume":"147","author":"Aronson","year":"2014","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2019.01.021_bib0003","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ahj.2011.11.016","article-title":"Impact of major bleeding and blood transfusions after cardiac surgery: Analysis from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial","volume":"163","author":"Stone","year":"2012","journal-title":"Am Heart J"},{"key":"10.1053\/j.jvca.2019.01.021_bib0004","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2019.01.021_bib0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/ejcts\/ezs455","article-title":"Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Vahanian","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2019.01.021_bib0006","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ejcts\/ezu366","volume":"46","author":"Kolh","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2019.01.021_bib0007","doi-asserted-by":"crossref","unstructured":"Pisters R, Lane DA, Nieuwlaat R, et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey Chest 2010;138:1093-100.","DOI":"10.1378\/chest.10-0134"},{"key":"10.1053\/j.jvca.2019.01.021_bib0008","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2013.08.1623","article-title":"The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation","volume":"62","author":"Rold\u00e1n","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2019.01.021_bib0009","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1160\/TH11-10-0690","article-title":"Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis","volume":"106","author":"Lip","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.jvca.2019.01.021_bib0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cjca.2012.01.021","article-title":"Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: Recommendations for stroke prevention and rate\/rhythm control","volume":"28","author":"Skanes","year":"2012","journal-title":"Can J Cardiol"},{"key":"10.1053\/j.jvca.2019.01.021_bib0011","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur Heart J"},{"issue":"123","key":"10.1053\/j.jvca.2019.01.021_bib0012","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium","volume":"14","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1053\/j.jvca.2019.01.021_bib0013","series-title":"Applied logistic regression","first-page":"143","author":"Hosmer","year":"2000"},{"key":"10.1053\/j.jvca.2019.01.021_bib0014","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0895-4356(01)00341-9","article-title":"Internal validation of predictive models: efficiency of some procedures for logistic regression analysis","volume":"54","author":"Steyerberg","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2019.01.021_bib0015","series-title":"Monographs on statistics and applied probability","first-page":"60","article-title":"An introduction to the bootstrap","author":"Efron","year":"1993"},{"key":"10.1053\/j.jvca.2019.01.021_bib0016","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1538-7836.2011.04378.x","article-title":"Bleeding risk in \u2018real world\u2019 patients with atrial fibrillation: Comparison of two established bleeding prediction schemes in a nationwide cohort","volume":"9","author":"Olesen","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.jvca.2019.01.021_bib0017","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/qjmed\/hcm076","volume":"100","author":"Hughes","year":"2007","journal-title":"QJM"},{"key":"10.1053\/j.jvca.2019.01.021_bib0018","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCEP.111.967000","article-title":"Relation of the HASBLED bleeding risk score to major bleeding, cardiovascular events and mortality in anticoagulated patients with atrial fibrillation","volume":"5","author":"Gallego","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1053\/j.jvca.2019.01.021_bib0019","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1160\/TH11-12-0827","article-title":"The HAS-BLED score predicts bleeding during bridging of chronic oral anticoagulation. Results from the national multicentre BNK Online bRiDgingREgistRy (BORDER)","volume":"108","author":"Omran","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.jvca.2019.01.021_bib0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.4244\/EIJV8I6A105","article-title":"Triple antithrombotic therapy following an acute coronary syndrome: Prevalence, outcomes and prognostic utility of the HAS-BLED score","volume":"8","author":"Smith","year":"2012","journal-title":"EuroIntervention"},{"key":"10.1053\/j.jvca.2019.01.021_bib0021","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCINTERVENTIONS.112.968792","article-title":"Should we recommend oral anticoagulation therapy in patients with atrial fibrillation undergoing coronary artery stenting with a high HAS-BLED bleeding risk score?","volume":"5","author":"Ruiz-Nodar","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1053\/j.jvca.2019.01.021_bib0022","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/hrt.2006.109967","article-title":"Enoxaparin as bridging anticoagulant treatment in cardiac surgery","volume":"94","author":"Rivas-G\u00e1ndara","year":"2008","journal-title":"Heart"},{"key":"10.1053\/j.jvca.2019.01.021_bib0023","doi-asserted-by":"crossref","first-page":"e576S","DOI":"10.1378\/chest.11-2305","article-title":"Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Whitlock","year":"2012","journal-title":"Chest"},{"key":"10.1053\/j.jvca.2019.01.021_bib0024","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(09)60780-7","article-title":"Antithrombotic management of patients with prosthetic heart valves: Current evidence and future trends","volume":"374","author":"Sun","year":"2009","journal-title":"Lancet"},{"key":"10.1053\/j.jvca.2019.01.021_bib0025","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/ejcts\/ezx015","article-title":"Outcome after procedures for retained blood syndrome in coronary surgery","volume":"51","author":"Tauriainen","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2019.01.021_bib0026","doi-asserted-by":"crossref","first-page":"e4710","DOI":"10.1097\/MD.0000000000004710","article-title":"The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study","volume":"95","author":"Guan","year":"2016","journal-title":"Medicine"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077019300497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077019300497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T11:21:09Z","timestamp":1557573669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077019300497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S1053077019300497"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2019.01.021","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The HAS-BLED Score is Associated With Major Bleeding in Patients After Cardiac Surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2019.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}