{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:40:26Z","timestamp":1790678426066,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/17\/9\/32812"],"award-info":[{"award-number":["RG\/17\/9\/32812"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["AA\/18\/3\/34220"],"award-info":[{"award-number":["AA\/18\/3\/34220"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/12\/1\/29419"],"award-info":[{"award-number":["CH\/12\/1\/29419"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1053\/j.jvca.2020.08.068","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T21:30:51Z","timestamp":1599687051000},"page":"1192-1202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Blood Transfusion Threshold in Patients Receiving Extracorporeal Membrane Oxygenation Support for Cardiac and Respiratory Failure\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.1053","volume":"35","author":[{"given":"Riccardo Giuseppe","family":"Abbasciano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-0983","authenticated-orcid":false,"given":"Hakeem","family":"Yusuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.J.","family":"Vlaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-0624","authenticated-orcid":false,"given":"Florence","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-1482","authenticated-orcid":false,"given":"Gavin James","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2020.08.068_bib0001","unstructured":"Extracorporeal Life Support Organization. ELSO guidelines for cardiopulmonary extracorporeal life support, version 1.4. Available at: https:\/\/www.elso.org\/Resources\/Guidelines.aspx. Accessed on 14\/06\/2020."},{"key":"10.1053\/j.jvca.2020.08.068_bib0002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1537-2995.1996.36196190517.x","article-title":"Blood utilization in adult patients undergoing extracorporeal membrane oxygenated therapy","volume":"36","author":"Butch","year":"1996","journal-title":"Transfusion"},{"key":"10.1053\/j.jvca.2020.08.068_bib0003","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.athoracsur.2015.07.046","article-title":"Bleeding, transfusion, and mortality on extracorporeal life support: ECLS Working Group on Thrombosis and Hemostasis","volume":"101","author":"Mazzeffi","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0004","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.athoracsur.2013.09.008","article-title":"Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: A meta-analysis of 1,866 adult patients","volume":"97","author":"Cheng","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0005","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.21037\/jtd.2018.11.103","article-title":"Clinical complications during veno-arterial extracorporeal membrane oxygenation in post-cardiotomy and non post-cardiotomy shock: Still the Achille's heel","volume":"10","author":"Coco","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1053\/j.jvca.2020.08.068_bib0006","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1423-0410.2008.01110.x","article-title":"Blood transfusion requirements and independent predictors of increased transfusion requirements among adult patients on extracorporeal membrane oxygenation\u2013a single centre experience","volume":"96","author":"Ang","year":"2009","journal-title":"Vox Sang"},{"key":"10.1053\/j.jvca.2020.08.068_bib0007","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/vox.12514","article-title":"Adult extracorporeal membrane oxygenation: An international survey of transfusion and anticoagulation techniques","volume":"112","author":"Esper","year":"2017","journal-title":"Vox Sang"},{"key":"10.1053\/j.jvca.2020.08.068_bib0008","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/jama.2019.0554","article-title":"Patient blood management: Recommendations from the 2018 Frankfurt Consensus Conference","volume":"321","author":"Mueller","year":"2019","journal-title":"JAMA"},{"key":"10.1053\/j.jvca.2020.08.068_bib0009","unstructured":"Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Available at: https:\/\/handbook-5-1.cochrane.org\/. Accessed on 14\/06\/2020."},{"key":"10.1053\/j.jvca.2020.08.068_bib0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0011","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"10","author":"Carson","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.jvca.2020.08.068_bib0012","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1053\/j.jvca.2020.08.068_bib0013","unstructured":"Moga C, Guo B, Schopflocher D, et\u00a0al. Development of a quality appraisal tool for case series studies using a modified Delphi Technique Institute of Health Economics. Available at: https:\/\/www.ihe.ca\/advanced-search\/development-of-a-quality-appraisal-tool-for-case-series-studies-using-a-modified-delphi-technique. Accessed on 14\/06\/2020."},{"key":"10.1053\/j.jvca.2020.08.068_bib0014","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1053\/j.jvca.2020.08.068_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Statistical Software"},{"key":"10.1053\/j.jvca.2020.08.068_bib0016","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: A practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"10.1053\/j.jvca.2020.08.068_bib0017","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1053\/j.jvca.2016.10.015","article-title":"Blood and anticoagulation management in cxtracorporeal membrane oxygenation for surgical and nonsurgical patients: A single-center retrospective review","volume":"31","author":"Buscher","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.08.068_bib0018","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/0267659118814690","article-title":"Prognostic impact of blood product transfusion in VA and VV ECMO","volume":"34","author":"Guimbretiere","year":"2019","journal-title":"Perfusion"},{"key":"10.1053\/j.jvca.2020.08.068_bib0019","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0885066617706339","article-title":"Anticoagulation and transfusions management in veno-venous extracorporeal membrane oxygenation for acute respiratory distress syndrome: Assessment of factors associated with transfusion requirements and mortality","volume":"34","author":"Martucci","year":"2019","journal-title":"J Intensive Care Med"},{"key":"10.1053\/j.jvca.2020.08.068_bib0020","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/aor.12385","article-title":"Restrictive transfusion practice during extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome","volume":"39","author":"Voelker","year":"2015","journal-title":"Artif Organs"},{"key":"10.1053\/j.jvca.2020.08.068_bib0021","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.athoracsur.2014.08.039","article-title":"Blood conservation in extracorporeal membrane oxygenation for acute respiratory distress syndrome","volume":"99","author":"Agerstrand","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0022","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/0267659118772457","article-title":"Hematocrit and impact of transfusion in patients receiving extracorporeal life support","volume":"33","author":"Swol","year":"2018","journal-title":"Perfusion"},{"key":"10.1053\/j.jvca.2020.08.068_bib0023","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1213\/ANE.0000000000002238","article-title":"Implementation of a standardized transfusion protocol for cardiac patients treated with venoarterial extracorporeal membrane oxygenation is associated with decreased blood component utilization and may improve clinical outcome","volume":"126","author":"Cahill","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0024","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1751-2824.2012.01552.x","article-title":"Predictors of increased transfusion requirements and optimizing transfusional support in patients on extracorporeal membrane oxygenation (ECMO)","volume":"7","author":"Ang","year":"2012","journal-title":"ISBT Sci Series"},{"key":"10.1053\/j.jvca.2020.08.068_bib0025","unstructured":"Cahill C, Blumberg N, Schmidt A, et\u00a0al. Implementation of a standardized laboratory testing, clinical evaluation and transfusion protocol for cardiac patients receiving extracorporeal membrane oxygenation (ECMO) is associated with decreased blood transfusions and improved survival. Transfusion 2016;56(Suppl 4):32A."},{"key":"10.1053\/j.jvca.2020.08.068_bib0026","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1053\/j.jvca.2020.08.068_bib0027","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00134-019-05884-8","article-title":"Transfusion strategies in non-bleeding critically ill adults: A clinical practice guideline from the European Society of Intensive Care Medicine","volume":"46","author":"Vlaar","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.jvca.2020.08.068_bib0028","first-page":"B5209","article-title":"Benefits and harms of red blood cell transfusions in patients with septic shock in the intensive care unit","volume":"63","author":"Brokso Holst","year":"2016","journal-title":"Dan Med J"},{"key":"10.1053\/j.jvca.2020.08.068_bib0029","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1711818","article-title":"Restrictive or liberal red-cell transfusion for cardiac surgery","volume":"377","author":"Mazer","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2020.08.068_bib0030","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa1403612","article-title":"Liberal or restrictive transfusion after cardiac surgery","volume":"372","author":"Murphy","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2020.08.068_bib0031","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/01.CCM.0000165566.82925.14","article-title":"Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion","volume":"33","author":"Gong","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1053\/j.jvca.2020.08.068_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-018-2293-5","article-title":"Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: A multicenter retrospective study in Korean patients","volume":"23","author":"Baek","year":"2019","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2020.08.068_bib0033","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.athoracsur.2016.03.005","article-title":"Extracorporeal membrane oxygenation for cardiopulmonary failure during pregnancy and postpartum","volume":"102","author":"Agerstrand","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.08.068_bib0034","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.2015.10890","article-title":"Red blood cell transfusion: Precision vs imprecision medicine","volume":"314","author":"Klein","year":"2015","journal-title":"JAMA"},{"key":"10.1053\/j.jvca.2020.08.068_bib0035","doi-asserted-by":"crossref","unstructured":"Serraino GF, Murphy GJ. Effects of cerebral near-infrared spectroscopy on the outcome of patients undergoing cardiac surgery: A systematic review of randomised trials. BMJ Open7:e016613.","DOI":"10.1136\/bmjopen-2017-016613"},{"key":"10.1053\/j.jvca.2020.08.068_bib0036","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1001\/jama.288.12.1499","article-title":"Anemia and blood transfusion in critically ill patients","volume":"288","author":"Vincent","year":"2002","journal-title":"JAMA"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077020308636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077020308636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:50:40Z","timestamp":1760946640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077020308636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1053077020308636"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2020.08.068","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood Transfusion Threshold in Patients Receiving Extracorporeal Membrane Oxygenation Support for Cardiac and Respiratory Failure\u2014A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2020.08.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}