{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:34:28Z","timestamp":1793828068478,"version":"4.6.1"},"reference-count":118,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1053\/j.jvca.2020.11.035","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T11:14:10Z","timestamp":1605957250000},"page":"1176-1188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Brain Protection in Aortic Arch Surgery: An Evolving Field"],"prefix":"10.1053","volume":"35","author":[{"given":"Jason Z.","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Wei","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj H.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Essandoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6054-9650","authenticated-orcid":false,"given":"Adam A.","family":"Dalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2020.11.035_bib0001","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.jacc.2012.06.023","article-title":"Contemporary results for proximal aortic replacement in North America","volume":"60","author":"Williams","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0002","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jacc.2018.10.086","article-title":"Endovascular vs open repair of intact descending thoracic aortic aneurysms","volume":"73","author":"Chiu","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0003","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-5223(94)70334-5","article-title":"Hypothermic circulatory arrest in operations on the thoracic aorta: Determinants of operative mortality and neurologic outcome","volume":"107","author":"Ergin","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0004","first-page":"148","article-title":"A meta-analysis of deep hypothermic circulatory arrest versus moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion","volume":"2","author":"Tian","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0005","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/S0003-4975(99)00432-4","article-title":"Temporary neurological dysfunction after deep hypothermic circulatory arrest: A clinical marker of long-term functional deficit","volume":"67","author":"Ergin","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0006","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1010-7940(01)00728-X","article-title":"Antegrade selective cerebral perfusion during surgery of the thoracic aorta: Risk analysis","volume":"19","author":"Di Bartolomeo","year":"2001","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0007","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.athoracsur.2004.05.002","article-title":"Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery","volume":"78","author":"Bar-Yosef","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0008","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/ALN.0000000000002298","article-title":"Defining an intraoperative hypotension threshold in association with stroke in cardiac surgery","volume":"129","author":"Sun","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2020.11.035_bib0009","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/CIRCULATIONAHA.117.030308","article-title":"High-target versus low-target blood pressure management during cardiopulmonary bypass to prevent cerebral injury in cardiac surgery patients: A randomized controlled trial","volume":"137","author":"Vedel","year":"2018","journal-title":"Circulation"},{"key":"10.1053\/j.jvca.2020.11.035_bib0010","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jtcvs.2017.04.091","article-title":"Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring","volume":"154","author":"Hori","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0011","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jtcvs.2013.07.069","article-title":"Duration and magnitude of blood pressure below cerebral autoregulation threshold during cardiopulmonary bypass is associated with major morbidity and operative mortality","volume":"147","author":"Ono","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0012","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bja\/aeu319","article-title":"Arterial pressure above the upper cerebral autoregulation limit during cardiopulmonary bypass is associated with postoperative delirium","volume":"113","author":"Hori","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0013","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.jvca.2016.01.012","article-title":"Blood pressure deviations from optimal mean arterial pressure during cardiac surgery measured with a novel monitor of cerebral blood flow and risk for perioperative delirium: A pilot study","volume":"30","author":"Hori","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0014","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamasurg.2019.1163","article-title":"Effect of targeting mean arterial pressure during cardiopulmonary bypass by monitoring cerebral autoregulation on postsurgical delirium among older patients: A nested randomized clinical trial","volume":"154","author":"Brown","year":"2019","journal-title":"JAMA Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0015","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.athoracsur.2015.05.032","article-title":"Moderate versus deep hypothermia with unilateral selective antegrade cerebral perfusion for acute type A dissection","volume":"100","author":"Leshnower","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0016","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1213\/01.ane.0000242535.02571.fa","article-title":"Temperature during cardiopulmonary bypass: The discrepancies between monitored sites","volume":"103","author":"Nussmeier","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0017","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-9572(00)00154-4","article-title":"Jugular vein temperature reflects brain temperature during hypothermia","volume":"45","author":"Ao","year":"2000","journal-title":"Resuscitation"},{"key":"10.1053\/j.jvca.2020.11.035_bib0018","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1053\/j.jvca.2015.07.011","article-title":"The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of Extracorporeal Technology: Clinical practice guidelines for cardiopulmonary bypass\u2014temperature management during cardiopulmonary bypass","volume":"29","author":"Engelman","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0019","first-page":"163","article-title":"Consensus on hypothermia in aortic arch surgery","volume":"2","author":"Yan","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1053\/j.jvca.2008.07.010","article-title":"Neurocognitive function in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass: The effect of two different rewarming strategies","volume":"23","author":"Sahu","year":"2009","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0021","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/j.semtcvs.2019.01.001","article-title":"Optimal cerebral protection strategies in aortic surgery","volume":"31","author":"Lou","year":"2019","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0022","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0022-5223(94)70375-2","article-title":"Evaluation of cerebral metabolism and quantitative electroencephalography after hypothermic circulatory arrest and low-flow cardiopulmonary bypass at different temperatures","volume":"107","author":"Mezrow","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0023","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0003-4975(00)01592-7","article-title":"Deep hypothermic circulatory arrest: I. Effects of cooling on electroencephalogram and evoked potentials","volume":"71","author":"Stecker","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0024","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/ACO.0000000000000819","article-title":"A narrative review of electroencephalogram-based monitoring during cardiovascular surgery","volume":"33","author":"Kaiser","year":"2020","journal-title":"Curr Opin Anesthesiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1213\/ANE.0b013e31823ee030","article-title":"Brain monitoring with electroencephalography and the electroencephalogram-derived bispectral index during cardiac surgery","volume":"114","author":"Kertai","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0026","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4330\/wjc.v8.i7.383","article-title":"Transcranial Doppler ultrasonography: From methodology to major clinical applications","volume":"8","author":"D'Andrea","year":"2016","journal-title":"World J Cardiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0027","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MAT.0b013e318241abd3","article-title":"Real-time continuous neuromonitoring combines transcranial cerebral Doppler with near-infrared spectroscopy cerebral oxygen saturation during total aortic arch replacement procedure: A pilot study","volume":"58","author":"Wang","year":"2012","journal-title":"ASAIO J"},{"key":"10.1053\/j.jvca.2020.11.035_bib0028","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.athoracsur.2015.06.055","article-title":"Transcranial Doppler sonography for optimization of cerebral perfusion in aortic arch operation","volume":"101","author":"Ghazy","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0029","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1053\/j.jvca.2017.02.187","article-title":"Near-infrared spectroscopy in adult cardiac surgery patients: A systematic review and meta-analysis","volume":"31","author":"Chan","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1213\/ANE.0b013e318277a255","article-title":"Cerebral near-infrared spectroscopy monitoring and neurologic outcomes in adult cardiac surgery patients: A systematic review","volume":"116","author":"Zheng","year":"2013","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0031","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1053\/j.jvca.2018.03.032","article-title":"Cerebral neuromonitoring during cardiac surgery: A critical appraisal with an emphasis on near-infrared spectroscopy","volume":"32","author":"Lewis","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0032","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016613","article-title":"Effects of cerebral near-infrared spectroscopy on the outcome of patients undergoing cardiac surgery: A systematic review of randomized trials","volume":"7","author":"Serraino","year":"2017","journal-title":"BMJ Open"},{"key":"10.1053\/j.jvca.2020.11.035_bib0033","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ejcts\/ezs557","article-title":"Near-infrared spectroscopy for neuromonitoring of unilateral cerebral perfusion","volume":"43","author":"Urbanski","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0034","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1213\/ANE.0b013e318297d763","article-title":"Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers","volume":"117","author":"Bickler","year":"2013","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/ALN.0000000000001898","article-title":"Effects of changes in arterial carbon dioxide and oxygen partial pressures on cerebral oximeter performance","volume":"128","author":"Schober","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2020.11.035_bib0036","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/ALN.0000000000001029","article-title":"Cerebral oximetry monitoring to maintain normal cerebral oxygen saturation during high-risk cardiac surgery: A randomized controlled feasibility trial","volume":"124","author":"Deschamps","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2020.11.035_bib0037","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1117\/12.183988","article-title":"Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry","volume":"34","author":"Fantini","year":"1995","journal-title":"Opt Eng"},{"key":"10.1053\/j.jvca.2020.11.035_bib0038","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1364\/JOSAA.14.000192","article-title":"Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation","volume":"14","author":"Boas","year":"1997","journal-title":"J Opt Soc Am"},{"key":"10.1053\/j.jvca.2020.11.035_bib0039","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1364\/BOE.6.004749","article-title":"Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology","volume":"6","author":"Dehaes","year":"2015","journal-title":"Biomed Opt Express"},{"key":"10.1053\/j.jvca.2020.11.035_bib0040","doi-asserted-by":"crossref","first-page":"44117","DOI":"10.1038\/srep44117","article-title":"Non-invasive assessment of cerebral blood flow and oxygen metabolism in neonates during hypothermic cardiopulmonary bypass: Feasibility and clinical implications","volume":"7","author":"Ferradal","year":"2017","journal-title":"Sci Rep"},{"key":"10.1053\/j.jvca.2020.11.035_bib0041","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0022-5223(19)39653-9","article-title":"Prosthetic replacement of the aortic arch","volume":"70","author":"Griepp","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0042","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0003-4975(99)00441-5","article-title":"Cerebral metabolic suppression during hypothermic circulatory arrest in humans","volume":"67","author":"McCullough","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0043","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtcvs.2010.08.024","article-title":"Internet-based assessment of postoperative neurocognitive function in cardiac and thoracic aortic surgery patients","volume":"141","author":"Uysal","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0044","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.jtcvs.2014.04.014","article-title":"Antegrade versus retrograde cerebral perfusion for hemiarch replacement with deep hypothermic circulatory arrest: Does it matter? A propensity-matched analysis","volume":"148","author":"Ganapathi","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0045","first-page":"553","article-title":"Surgical treatment of aneurysm or dissection involving the ascending aorta and aortic arch, utilizing circulatory arrest and retrograde cerebral perfusion","volume":"31","author":"Ueda","year":"1990","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"10.1053\/j.jvca.2020.11.035_bib0046","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/S0003-4975(01)02718-7","article-title":"Retrograde cerebral perfusion as a method of neuroprotection during thoracic aortic surgery","volume":"72","author":"Reich","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0047","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ejcts.2006.08.024","article-title":"Does retrograde cerebral perfusion via superior vena cava cannulation protect the brain?","volume":"30","author":"K\u00fcnzli","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0048","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.hlc.2019.01.010","article-title":"Unilateral versus bilateral antegrade cerebral perfusion: A meta-analysis of comparative studies","volume":"28","author":"Tian","year":"2019","journal-title":"Heart Lung Circ"},{"key":"10.1053\/j.jvca.2020.11.035_bib0049","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jtcvs.2006.09.045","article-title":"The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: A propensity score analysis","volume":"133","author":"Kamiya","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0050","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.athoracsur.2018.10.008","article-title":"Deep hypothermia with retrograde cerebral perfusion versus moderate hypothermia with antegrade cerebral perfusion for arch surgery","volume":"107","author":"Leshnower","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0051","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.athoracsur.2016.10.024","article-title":"The standardized concept of moderate-to-mild (\u226528\u00b0C) systemic hypothermia during selective antegrade cerebral perfusion for all-comers in aortic arch surgery: Single-center experience in 587 consecutive patients over a 15-year period","volume":"104","author":"El-Sayed Ahmad","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0052","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/ejcts\/ezt103","article-title":"The role of Willis circle variations during unilateral selective cerebral perfusion: A study of 500 circles","volume":"44","author":"Papantchev","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0053","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/s13063-019-3713-9","article-title":"COMMENCE trial (Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry): A randomized controlled trial of mild vs moderate hypothermia on patient outcomes in aortic hemiarch surgery with anterograde cerebral perfusion","volume":"20","author":"Jabagi","year":"2019","journal-title":"Trials"},{"key":"10.1053\/j.jvca.2020.11.035_bib0054","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1749-6632.1959.tb49212.x","article-title":"Lethargic hypothermia in hibernators and nonhibernators","volume":"80","author":"Popovic","year":"1959","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.jvca.2020.11.035_bib0055","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s002469900335","article-title":"Experimental evidence of cerebral injury from profound hypothermia during cardiopulmonary bypass","volume":"19","author":"DeLeon","year":"1998","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0056","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/ejcts\/ezx133","article-title":"Hypothermia and cerebral protection strategies in aortic arch surgery: A comparative effectiveness analysis from the STS Adult Cardiac Surgery Database","volume":"52","author":"Englum","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0057","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.jtcvs.2017.08.015","article-title":"Favorable late survival after aortic surgery under straight deep hypothermic circulatory arrest","volume":"154","author":"Damberg","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0058","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jtcvs.2014.05.027","article-title":"Straight deep hypothermic circulatory arrest for cerebral protection during aortic arch surgery: Safe and effective","volume":"148","author":"Ziganshin","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0059","first-page":"453","article-title":"Neuroprotection strategies in aortic surgery","volume":"35","author":"Bergeron","year":"2017","journal-title":"Cardiol Clin"},{"key":"10.1053\/j.jvca.2020.11.035_bib0060","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0022-5223(19)37716-5","article-title":"Massive air embolism during cardiopulmonary bypass. Causes, prevention, and management","volume":"80","author":"Mills","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0061","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0003-4975(03)00552-6","article-title":"Determination of cerebral blood flow dynamics during retrograde cerebral perfusion using power M-mode transcranial Doppler","volume":"76","author":"Estrera","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0062","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.athoracsur.2017.07.018","article-title":"Retrograde cerebral perfusion is effective for prolonged circulatory arrest in arch aneurysm repair","volume":"105","author":"Lau","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0063","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1161\/CIRCULATIONAHA.107.757419","article-title":"Ascending and transverse aortic arch repair: The impact of retrograde cerebral perfusion","volume":"118","author":"Estrera","year":"2008","journal-title":"Circulation"},{"key":"10.1053\/j.jvca.2020.11.035_bib0064","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1067\/mtc.2001.115244","article-title":"Retrograde cerebral perfusion provides negligible flow through brain capillaries in the pig","volume":"122","author":"Ehrlich","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0065","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jtcvs.2013.10.036","article-title":"Similar cerebral protective effectiveness of antegrade and retrograde cerebral perfusion combined with deep hypothermia circulatory arrest in aortic arch surgery: A meta-analysis and systematic review of 5060 patients","volume":"148","author":"Hu","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0066","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jtcvs.2019.02.045","article-title":"Cerebral protection strategies in aortic arch surgery: A network meta-analysis","volume":"159","author":"Hameed","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0067","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.athoracsur.2014.12.067","article-title":"Moderate versus deep hypothermic circulatory arrest for elective aortic transverse hemiarch reconstruction","volume":"99","author":"Vallabhajosyula","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0068","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1051\/ject\/201749016","article-title":"Deep hypothermic circulatory arrest vs. antegrade cerebral perfusion in cerebral protection during the surgical treatment of chronic dissection of the ascending and arch aorta","volume":"49","author":"Kamenskaya","year":"2017","journal-title":"J Extra Corpor Technol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0069","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/ejcts\/ezw289","article-title":"Fifteen years of surgery for acute type A aortic dissection in moderate-to-mild systemic hypothermia","volume":"51","author":"Zierer","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0070","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.athoracsur.2012.01.106","article-title":"What is the best strategy for brain protection in patients undergoing aortic arch surgery? A single center experience of 636 patients","volume":"93","author":"Misfeld","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0071","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jtcvs.2007.07.067","article-title":"Hypothermic circulatory arrest with selective antegrade cerebral perfusion in ascending aortic and aortic arch surgery: A risk factor analysis for adverse outcome in 501 patients","volume":"135","author":"Khaladj","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0072","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/ejcts\/ezu284","article-title":"Current trends in cannulation and neuroprotection during surgery of the aortic arch in Europe","volume":"47","author":"De Paulis","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0073","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jtcvs.2019.01.127","article-title":"Aortic arch surgery with hypothermic circulatory arrest and unilateral antegrade cerebral perfusion: Perioperative outcomes","volume":"159","author":"Wang","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0074","first-page":"184","article-title":"Degree of hypothermia in aortic arch surgery - optimal temperature for cerebral and spinal protection: Deep hypothermia remains the gold standard in the absence of randomized data","volume":"2","author":"Englum","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0075","doi-asserted-by":"crossref","first-page":"II231","DOI":"10.1161\/01.CIR.0000138945.78346.9c","article-title":"Selective antegrade cerebral perfusion attenuates brain metabolic deficit in aortic arch surgery: A prospective randomized trial","volume":"110","author":"Harrington","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.jvca.2020.11.035_bib0076","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jtcvs.2011.01.020","article-title":"Branch-first aortic arch replacement with no circulatory arrest or deep hypothermia","volume":"142","author":"Matalanis","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0077","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.jtcvs.2014.07.100","article-title":"Aortic arch replacement without circulatory arrest or deep hypothermia: The \u201cbranch-first\u201d technique","volume":"149","author":"Matalanis","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0078","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/CM9.0000000000000049","article-title":"Application of the \u201cbranch-first technique\u201d in Sun's procedure","volume":"132","author":"Zheng","year":"2019","journal-title":"Chin Med J (Engl)"},{"key":"10.1053\/j.jvca.2020.11.035_bib0079","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13019-020-1082-9","article-title":"The application of the single branch-first combined with the mid-arch clamping technique and the embedded anastomosis technique for DeBakey type II aortic dissection","volume":"15","author":"Li","year":"2020","journal-title":"J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0080","doi-asserted-by":"crossref","first-page":"236","DOI":"10.21037\/acs-2020-fet-27","article-title":"Mini-access branch-first total arch replacement and frozen elephant trunk procedure","volume":"9","author":"Chakos","year":"2020","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0081","first-page":"303","article-title":"Deep hypothermic circulatory arrest","volume":"2","author":"Ziganshin","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0082","first-page":"43","article-title":"Practice variations in the conduct of hypothermic circulatory arrest for adult aortic arch repair: Focus on an emerging European paradigm","volume":"6","author":"Gutsche","year":"2014","journal-title":"Heart Lung Vessel"},{"key":"10.1053\/j.jvca.2020.11.035_bib0083","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/bja\/57.1.82","article-title":"Barbiturates in brain ischaemia","volume":"57","author":"Shapiro","year":"1985","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0084","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00004311-199603440-00007","article-title":"Anesthetics and cerebroprotection: Experimental aspects","volume":"34","author":"Kirsch","year":"1996","journal-title":"Int Anesthesiol Clin"},{"key":"10.1053\/j.jvca.2020.11.035_bib0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-2007-1013148","article-title":"Protective effect of thiopental against cerebral ischemia during circulatory arrest","volume":"47","author":"Hirotani","year":"1999","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0086","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/icvts\/ivt184","article-title":"Does the use of thiopental provide added cerebral protection during deep hypothermic circulatory arrest?","volume":"17","author":"Al-Hashimi","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0087","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0003-4975(92)90081-E","article-title":"Barbiturates impair cerebral metabolism during hypothermic circulatory arrest","volume":"54","author":"Siegman","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0088","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1046\/j.1365-2044.2002.02787.x","article-title":"Pharmacological agents as cerebral protectants during deep hypothermic circulatory arrest in adult thoracic aortic surgery. A survey of current practice","volume":"57","author":"Dewhurst","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1053\/j.jvca.2020.11.035_bib0089","first-page":"8","article-title":"Pharmacological neuroprotection","volume":"47","author":"Sreedhar","year":"2003","journal-title":"Indian J Anaesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0090","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/17460441.2019.1599356","article-title":"GABA (A) receptor-targeted drug development-new perspectives in perioperative anesthesia","volume":"14","author":"Antkowiak","year":"2019","journal-title":"Expert Opin Drug Discov"},{"key":"10.1053\/j.jvca.2020.11.035_bib0091","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/00000542-200405000-00017","article-title":"Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks","volume":"100","author":"Bayona","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2020.11.035_bib0092","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00000542-199609000-00008","article-title":"Consequences of electroencephalographic-suppressive doses of propofol in conjunction with deep hypothermic circulatory arrest","volume":"85","author":"Stone","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2020.11.035_bib0093","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1053\/j.jvca.2010.02.010","article-title":"Perioperative management of deep hypothermic circulatory arrest","volume":"24","author":"Svyatets","year":"2010","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0094","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(15)00273-1","article-title":"Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): A randomised, double-blind, placebo-controlled trial","volume":"386","author":"Whitlock","year":"2015","journal-title":"Lancet"},{"key":"10.1053\/j.jvca.2020.11.035_bib0095","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1179\/016164101101198398","article-title":"Use of sedative and analgesic agents in neurotrauma patients: Effects on cerebral physiology","volume":"23","author":"Rhoney","year":"2001","journal-title":"Neurol Res"},{"key":"10.1053\/j.jvca.2020.11.035_bib0096","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/bja\/50.10.1047","article-title":"Cerebral blood flow and metabolism during etomidate anaesthesia in man","volume":"50","author":"Renou","year":"1978","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0097","first-page":"17","article-title":"Cerebral protective effects of etomidate: Experimental and clinical aspects","volume":"5","author":"Batjer","year":"1993","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"10.1053\/j.jvca.2020.11.035_bib0098","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3340\/jkns.2011.50.6.497","article-title":"Comparative study of brain protection effect between thiopental and etomidate using bispectral index during temporary arterial occlusion","volume":"50","author":"Kim","year":"2011","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1053\/j.jvca.2020.11.035_bib0099","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1010-7940(00)00533-9","article-title":"Aortic arch repair using hypothermic circulatory arrest technique associated with pharmacological brain protection","volume":"18","author":"Hirotani","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0377-1237(03)80147-8","article-title":"Cerebral edema and its management","volume":"59","author":"Jha","year":"2003","journal-title":"Med J Armed Forces India"},{"key":"10.1053\/j.jvca.2020.11.035_bib0101","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/ejcts\/ezt182","article-title":"Intraoperative neuroprotective drugs without beneficial effects? Results of the German Registry for Acute Aortic Dissection Type A (GERAADA)","volume":"44","author":"Kruger","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0102","doi-asserted-by":"crossref","first-page":"S508","DOI":"10.21037\/jtd.2017.04.67","article-title":"Intraoperative care for aortic surgery using circulatory arrest","volume":"9","author":"Fern\u00e1ndez Su\u00e1rez","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1053\/j.jvca.2020.11.035_bib0103","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/j.jvca.2011.12.002","article-title":"Pro: Topical hypothermia should be used during deep hypothermic circulatory arrest","volume":"26","author":"Zhurav","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0104","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/0003-4975(91)91010-S","article-title":"Brain protection during circulatory arrest","volume":"51","author":"Crittenden","year":"1991","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0003-4975(93)90473-U","article-title":"Cerebral metabolism and circulatory arrest: Effects of duration and strategies for protection","volume":"55","author":"Mault","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0106","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0003-4975(03)00038-9","article-title":"Topical head cooling during rewarming after experimental hypothermic circulatory arrest","volume":"75","author":"Pokela","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0107","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/j.jvca.2011.12.001","article-title":"Con: Topical head cooling should not be used during deep hypothermic circulatory arrest","volume":"26","author":"Grocott","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0108","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/jappl.1999.86.1.265","article-title":"A mathematical model for human brain cooling during cold-water near- drowning","volume":"86","author":"Xu","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1053\/j.jvca.2020.11.035_bib0109","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1067\/mtc.2000.107344","article-title":"An improved method for topical cerebral cooling during deep hypothermic circulatory arrest","volume":"120","author":"Lighthall","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0110","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0003-4975(03)00828-2","article-title":"Pulmonary endarterectomy: Experience and lessons learned in 1.500 cases","volume":"76","author":"Jamieson","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jtcvs.2003.08.033","article-title":"The influence of pH strategy on cerebral and collateral circulation during hypothermic cardiopulmonary bypass in cyanotic patients with heart disease: Results of a randomized trial and real-time monitoring","volume":"127","author":"Sakamoto","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0112","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-5223(97)70013-8","article-title":"Perioperative effects of alpha-stat vs pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants","volume":"114","author":"du Plessis","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0113","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/mtc.2001.111206","article-title":"Developmental and neurologic effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants","volume":"121","author":"Bellinger","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0114","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0022-5223(96)70230-1","article-title":"Alpha-stat acid-base regulation during cardiopulmonary bypass improves neuropsychologic outcome in patients undergoing coronary artery bypass grafting","volume":"111","author":"Patel","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0115","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1525-1594.2004.47353.x","article-title":"Comparison of pH-stat versus alpha-stat during hypothermic cardiopulmonary bypass in the prevention and control of acidosis in cardiac surgery","volume":"28","author":"Piccioni","year":"2004","journal-title":"Artif Organs"},{"key":"10.1053\/j.jvca.2020.11.035_bib0116","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.athoracsur.2007.04.107","article-title":"Straight deep hypothermic arrest: Experience in 394 patients supports its effectiveness as a sole means of brain preservation","volume":"84","author":"Gega","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2020.11.035_bib0117","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bja.2019.09.012","article-title":"2019 EACTS\/EACTA\/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery","volume":"123","author":"Kunst","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2020.11.035_bib0118","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1053\/j.jvca.2016.03.128","article-title":"Comparison of two different red blood cell transfusion thresholds on short-term clinical outcomes of patients undergoing aortic surgery with deep hypothermic circulatory arrest","volume":"30","author":"Wang","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077020312702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077020312702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:50:32Z","timestamp":1760946632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077020312702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":118,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1053077020312702"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2020.11.035","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Protection in Aortic Arch Surgery: An Evolving Field","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2020.11.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}