{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:49:45Z","timestamp":1785250185697,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1053\/j.jvca.2021.01.017","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:53:16Z","timestamp":1610934796000},"page":"2100-2107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung Injury After Neonatal Congenital Cardiac Surgery Is Mild and Modifiable by Corticosteroids"],"prefix":"10.1053","volume":"35","author":[{"given":"Anu K.","family":"Kaskinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Keski-Nisula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Martelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Moilanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rautiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sture","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli M.","family":"Pitk\u00e4nen-Argillander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2021.01.017_bib0001","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1540-8191.2009.00823.x","article-title":"Lung dysfunction following cardiopulmonary bypass","volume":"25","author":"Apostolakis","year":"2010","journal-title":"J Card Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0002","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0003-4975(99)00781-X","article-title":"Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass","volume":"68","author":"Asimakopoulos","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0003","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.jtcvs.2014.01.017","article-title":"Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance","volume":"148","author":"Asija","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0004","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1159\/000495511","article-title":"Acute respiratory distress syndrome following cardiac surgery: Comparison of the American-European Consensus Conference definition versus the Berlin definition","volume":"97","author":"Kogan","year":"2019","journal-title":"Respiration"},{"key":"10.1053\/j.jvca.2021.01.017_bib0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jacc.2019.05.060","article-title":"Corticosteroid therapy in neonates undergoing cardiopulmonary bypass: Randomized controlled trial","volume":"74","author":"Graham","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2021.01.017_bib0006","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.athoracsur.2013.02.013","article-title":"Methylprednisolone in neonatal cardiac surgery: Reduced inflammation without improved clinical outcome","volume":"95","author":"Keski-Nisula","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0007","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/PCC.0000000000000128","article-title":"Perioperative steroids administration in pediatric cardiac surgery: A meta-analysis of randomized controlled trials","volume":"15","author":"Scrascia","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.01.017_bib0008","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.athoracsur.2017.01.111","article-title":"Stress-dose corticosteroid versus placebo in neonatal cardiac operations: A randomized controlled trial","volume":"104","author":"Suominen","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0009","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00246-004-0827-x","article-title":"Administration of steroids in pediatric cardiac surgery: Impact on clinical outcome and systemic inflammatory response","volume":"26","author":"Gessler","year":"2005","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.jvca.2021.01.017_bib0010","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1161\/01.CIR.0000070955.55636.25","article-title":"Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression","volume":"107","author":"Schroeder","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.jvca.2021.01.017_bib0011","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/01.PCC.0000282169.11809.80","article-title":"Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children","volume":"8","author":"Santos","year":"2007","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.01.017_bib0012","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.athoracsur.2016.02.089","article-title":"High-dose methylprednisolone has no benefit over moderate dose for the correction of tetralogy of Fallot","volume":"102","author":"Keski-Nisula","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/PCC.0000000000000568","article-title":"Chronic hypoxemia in children with congenital heart defect impairs airway epithelial sodium transport","volume":"17","author":"Kaskinen","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.01.017_bib0014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jtcvs.2011.12.030","article-title":"Pulmonary reperfusion injury after the unifocalization procedure for tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries","volume":"144","author":"Maskatia","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.resp.2017.12.007","article-title":"Ventilator-derived dynamic respiratory system compliance: Comparison with static compliance in children","volume":"249","author":"Kaskinen","year":"2018","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1053\/j.jvca.2021.01.017_bib0016","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/ejcts\/ezt634","article-title":"Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery","volume":"46","author":"Laurikka","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0017","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S1010-7940(97)00261-3","article-title":"Effects of cardiopulmonary bypass on neonatal and paediatric inflammatory profiles","volume":"12","author":"Ashraf","year":"1997","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0018","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ppul.23531","article-title":"Assessment of extravascular lung water by ultrasound after congenital cardiac surgery","volume":"52","author":"Kaskinen","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"10.1053\/j.jvca.2021.01.017_bib0019","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.athoracsur.2019.06.057","article-title":"Prognostic value of a new lung ultrasound score to predict intensive care unit stay in pediatric cardiac surgery","volume":"109","author":"Cantinotti","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/anae.12479","article-title":"Therapeutic effect of inhaled budesonide (Pulmicort\u00ae Turbuhaler) on the inflammatory response to one-lung ventilation","volume":"69","author":"Ju","year":"2014","journal-title":"Anaesthesia"},{"key":"10.1053\/j.jvca.2021.01.017_bib0021","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0022-5223(99)70331-4","article-title":"Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: Timing of dose is important","volume":"117","author":"Lodge","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0022","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1213\/00000539-199807000-00007","article-title":"Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation","volume":"87","author":"Chaney","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0003-4975(03)00194-2","article-title":"Myocardial and lung injury after cardiopulmonary bypass: Role of interleukin (IL)-10","volume":"76","author":"Giomarelli","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0024","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1097\/PCC.0000000000000434","article-title":"Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: Proceedings from the Pediatric Acute Lung Injury Consensus Conference","volume":"16","author":"Tamburro","year":"2015","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.01.017_bib0025","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1001\/jama.2020.8133","article-title":"Effect of intraoperative dexamethasone on major complications and mortality among infants undergoing cardiac surgery: The decision randomized clinical trial","volume":"323","author":"Lomivorotov","year":"2020","journal-title":"JAMA"},{"key":"10.1053\/j.jvca.2021.01.017_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005550.pub2","article-title":"Prophylactic steroids for pediatric open heart surgery (review)","volume":"4","author":"Robertson-Malt","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.jvca.2021.01.017_bib0027","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/jama.2012.14144","article-title":"Intraoperative high-dose dexamethasone for cardiac surgery: A randomized controlled trial","volume":"308","author":"Dieleman","year":"2012","journal-title":"JAMA"},{"key":"10.1053\/j.jvca.2021.01.017_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1378\/chest.10-2639","article-title":"Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy","volume":"141","author":"Kerr","year":"2012","journal-title":"Chest"},{"key":"10.1053\/j.jvca.2021.01.017_bib0029","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.athoracsur.2014.08.042","article-title":"Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures","volume":"99","author":"Keski-Nisula","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.017_bib0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/01.PCC.0000227755.96700.98","article-title":"Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient","volume":"7","author":"Yates","year":"2006","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.01.017_bib0031","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00246-002-0118-3","article-title":"Systemic inflammatory response related to cardiopulmonary bypass and its modification by methyl prednisolone: High dose versus low dose","volume":"23","author":"Varan","year":"2002","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.jvca.2021.01.017_bib0032","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00003088-200544010-00003","article-title":"Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids","volume":"44","author":"Czock","year":"2005","journal-title":"Clin Pharmacokinet"},{"key":"10.1053\/j.jvca.2021.01.017_bib0033","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ahj.2019.11.016","article-title":"Rationale and design of the steroids to reduce systemic inflammation after infant heart surgery (stress) trial","volume":"220","author":"Hill","year":"2020","journal-title":"Am Heart J"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021000525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021000525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:52:05Z","timestamp":1784818325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077021000525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1053077021000525"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2021.01.017","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung Injury After Neonatal Congenital Cardiac Surgery Is Mild and Modifiable by Corticosteroids","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2021.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}