{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:33Z","timestamp":1790777073705,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1053\/j.jvca.2021.01.019","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:53:14Z","timestamp":1610934794000},"page":"2483-2495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Effectiveness of Levosimendan on Veno-Arterial Extracorporeal Membrane Oxygenation Management and Outcome: A Systematic Review and Meta-Analysis"],"prefix":"10.1053","volume":"35","author":[{"given":"Rasha","family":"Kaddoura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr S.","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Izham Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Alkhulaifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar","family":"Elsherbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Caliskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2021.01.019_bib0001","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4414\/smw.2009.12446","article-title":"Presentation and outcome of critically ill medical and cardiac-surgery patients with acute heart failure","volume":"139","author":"Rudiger","year":"2009","journal-title":"Swiss Med Wkly"},{"key":"10.1053\/j.jvca.2021.01.019_bib0002","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00059-011-3434-7","article-title":"Pathophysiology, diagnosis, and treatment of infarction-related cardiogenic shock","volume":"36","author":"Buerke","year":"2011","journal-title":"Herz"},{"key":"10.1053\/j.jvca.2021.01.019_bib0003","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/MAT.0000000000000160","article-title":"Extracorporeal membrane oxygenation use has increased by 433% in adults in the United States from 2006 to 2011","volume":"61","author":"Sauer","year":"2015","journal-title":"ASAIO J"},{"key":"10.1053\/j.jvca.2021.01.019_bib0004","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11936-017-0576-9","article-title":"Temporary mechanical circulatory support for cardiogenic shock","volume":"19","author":"Touchan","year":"2017","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bpa.2015.03.007","article-title":"Pharmacologic approaches to weaning from cardiopulmonary bypass and extracorporeal membrane oxygenation","volume":"29","author":"Cui","year":"2015","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0006","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1053\/j.jvca.2018.05.031","article-title":"Levosimendan for ECLS weaning: A strategy in need of validation","volume":"32","author":"Essandoh","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2021.01.019_bib0007","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0008","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s00134-012-2531-2","article-title":"Adverse cardiac events during catecholamine vasopressor therapy: A prospective observational study","volume":"38","author":"Schmittinger","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0009","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1055\/s-2004-831364","article-title":"Catecholamine therapy in cardiogenic shock: helpful, useless or dangerous? [article in German]","volume":"129","author":"Schwertz","year":"2004","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1053\/j.jvca.2021.01.019_bib0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00000542-200603000-00024","article-title":"Levosimendan, a new inotropic and vasodilator agent","volume":"104","author":"Toller","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2021.01.019_bib0011","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1056\/NEJMoa1616218","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery","volume":"376","author":"Mehta","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0012","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00134-014-3604-1","article-title":"Effects of levosimendan for low cardiac output syndrome in critically ill patients: Systematic review with meta-analysis and trial sequential analysis","volume":"41","author":"Koster","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0013","series-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2019"},{"key":"10.1053\/j.jvca.2021.01.019_bib0014","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1053\/j.jvca.2021.01.019_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1053\/j.jvca.2021.01.019_bib0017","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1053\/j.jvca.2021.01.019_bib0018","unstructured":"Omar A, Kaddoura R, Izham M. The effectiveness of levosimendan in veno-arterial extracorporeal membrane oxygenation weaning and patients\u2019 outcomes: A systematic review and meta-analysis. Available at: https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42019137208. Accessed January 25, 2021."},{"key":"10.1053\/j.jvca.2021.01.019_bib0019","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jclinepi.2010.09.012","article-title":"GRADE guidelines: 2. Framing the question and deciding on important outcomes","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0021","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. Rating the quality of evidence","volume":"64","author":"Balshem","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0022","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence\u2013study limitations (risk of bias)","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0023","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jclinepi.2011.01.011","article-title":"GRADE guidelines: 5. Rating the quality of evidence\u2013publication bias","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0024","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jclinepi.2011.01.012","article-title":"GRADE guidelines 6. Rating the quality of evidence\u2013imprecision","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0025","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines: 7. Rating the quality of evidence\u2013inconsistency","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0026","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jclinepi.2011.04.014","article-title":"GRADE guidelines: 8. Rating the quality of evidence\u2013indirectness","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0027","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1053\/j.jvca.2021.01.019_bib0028","unstructured":"Sterne JAC, Higgins JPT, Elbers RG, et\u00a0al. and the development group for ROBINS-I. Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I): detailed guidance, updated 12 October 2016. Available from. Risk of bias tools - ROBINS-I detailed guidance (2016) Accessed May 2019."},{"key":"10.1053\/j.jvca.2021.01.019_bib0029","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: The kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1053\/j.jvca.2021.01.019_bib0030","unstructured":"Ryan R. Cochrane consumers and communication. Available at: http:\/\/cccrg.cochrane.org. Microsoft Word - Meta-analysis.docx (cochrane.org). Accessed May 2020."},{"key":"10.1053\/j.jvca.2021.01.019_bib0031","unstructured":"Higgins JPT, Green S, eds. Identifying and measuring heterogeneity. Available at: https:\/\/handbook-5-1.cochrane.org\/chapter_9\/9_5_2_identifying_and_measuring_heterogeneity.htm. Accessed May 2019."},{"key":"10.1053\/j.jvca.2021.01.019_bib0032","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jrsm.1240","article-title":"Power analysis for random-effects meta-analysis","volume":"8","author":"Jackson","year":"2017","journal-title":"Res Synth Methods"},{"key":"10.1053\/j.jvca.2021.01.019_bib0033","doi-asserted-by":"crossref","first-page":"e59202","DOI":"10.1371\/journal.pone.0059202","article-title":"The impact of study size on meta-analyses: Examination of underpowered studies in Cochrane reviews","volume":"8","author":"Turner","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.jvca.2021.01.019_bib0034","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/MAT.0b013e3182a4b32e","article-title":"Levosimendan may improve weaning outcomes in venoarterial ECMO patients","volume":"59","author":"Affronti","year":"2013","journal-title":"ASAIO J"},{"key":"10.1053\/j.jvca.2021.01.019_bib0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/bja\/aew151","article-title":"Beneficial effects of levosimendan on survival in patients undergoing extracorporeal membrane oxygenation after cardiovascular surgery","volume":"117","author":"Distelmaier","year":"2016","journal-title":"Br J Anaesth"},{"issue":"Suppl 1","key":"10.1053\/j.jvca.2021.01.019_bib0036","first-page":"P128","article-title":"Levosimendan for weaning veno-arterial ECMO (VA ECMO)","volume":"22","author":"Haffner","year":"2018","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2021.01.019_bib0037","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1053\/j.jvca.2018.04.019","article-title":"Comparison of levosimendan and milrinone for ECLS weaning in patients after cardiac surgery\u2014A retrospective before-and-after study","volume":"32","author":"Jacky","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2021.01.019_bib0038","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1053\/j.jvca.2016.03.139","article-title":"Effects of levosimendan on endothelial function and hemodynamics during weaning from veno-arterial extracorporeal life support","volume":"30","author":"Sangalli","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2021.01.019_bib0039","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13613-019-0503-1","article-title":"Impact of levosimendan on weaning from peripheral venoarterial extracorporeal membrane oxygenation in intensive care unit","volume":"9","author":"Vally","year":"2019","journal-title":"Ann Intensive Care"},{"issue":"Suppl 1","key":"10.1053\/j.jvca.2021.01.019_bib0040","doi-asserted-by":"crossref","first-page":"S383","DOI":"10.1016\/j.healun.2018.01.986","article-title":"Levosimendan effects benefit weaning from veno-arterial extracorporeal life support","volume":"37","author":"Zipfel","year":"2018","journal-title":"J Heart Lung Transpl"},{"key":"10.1053\/j.jvca.2021.01.019_bib0041","first-page":"92","article-title":"Levosimendan in lung transplant recipients with difficult weaning from ECMO","volume":"81","author":"Feltracco","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0042","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1053\/j.jvca.2014.12.011","article-title":"Timing and strategy for weaning from venoarterial ECMO are complex issues","volume":"29","author":"Pappalardo","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2021.01.019_bib0043","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0003-4975(00)02340-7","article-title":"When to discontinue extracorporeal membrane oxygenation for postcardiotomy support","volume":"71","author":"Fiser","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.019_bib0044","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s00134-018-5220-y","article-title":"Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No","volume":"44","author":"Vincent","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13054-016-1261-1","article-title":"In-hospital mortality and successful weaning from venoarterial extracorporeal membrane oxygenation: Analysis of 5,263 patients using a national inpatient database in Japan","volume":"20","author":"Aso","year":"2016","journal-title":"Crit Care"},{"issue":"Suppl","key":"10.1053\/j.jvca.2021.01.019_bib0046","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1016\/j.cardfail.2019.07.487","article-title":"Use of levosimendan as a strategy to wean off veno-arterial ECMO in cardiogenic shock; A systematic review and metanalysis","volume":"25","author":"Silvestri","year":"2019","journal-title":"J Card Fail"},{"key":"10.1053\/j.jvca.2021.01.019_bib0047","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1177\/0267659120918473","article-title":"Effects of levosimendan on weaning and survival in adult cardiogenic shock patients with veno-arterial extracorporeal membrane oxygenation: Systematic review and meta-analysis","volume":"35","author":"Burgos","year":"2020","journal-title":"Perfusion"},{"key":"10.1053\/j.jvca.2021.01.019_bib0048","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1590\/S0066-782X2010005000072","article-title":"Levosimendan in acute decompensated heart failure: Systematic review and meta-analysis","volume":"95","author":"Ribeiro","year":"2010","journal-title":"Arq Bras Cardiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0049","first-page":"142","article-title":"Perioperative use of levosimendan in patients undergoing cardiac surgery: Systematic review and meta-analysis","volume":"47","author":"Oliveros","year":"2019","journal-title":"Rev Col Anest"},{"key":"10.1053\/j.jvca.2021.01.019_bib0050","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/icvts\/ivy133","article-title":"Levosimendan versus placebo in cardiac surgery: A systematic review and meta-analysis","volume":"27","author":"Tena","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1053\/j.jvca.2021.01.019_bib0051","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jocs.12562","article-title":"Levosimendan reduces mortality in adults with left ventricular dysfunction undergoing cardiac surgery: A systematic review and meta-analysis","volume":"30","author":"Lim","year":"2015","journal-title":"J Card Surg"},{"key":"10.1053\/j.jvca.2021.01.019_bib0052","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.medin.2017.08.009","article-title":"Levosimendan in patients with cardiogenic shock complicating myocardial infarction: A meta-analysis","volume":"42","author":"Fang","year":"2018","journal-title":"Med Intensiva"},{"key":"10.1053\/j.jvca.2021.01.019_bib0053","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/cc10263","article-title":"Levosimendan and mortality after coronary revascularisation: A meta-analysis of randomised controlled trials","volume":"15","author":"Maharaj","year":"2011","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2021.01.019_bib0054","unstructured":"Wells GA, Shea B, O'Connell D, et\u00a0al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis. Available at: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed May 2019."},{"key":"10.1053\/j.jvca.2021.01.019_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jclinepi.2018.05.021","article-title":"Three risk of bias tools lead to opposite conclusions in observational research synthesis","volume":"101","author":"Losilla","year":"2018","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0056","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13104-015-1181-1","article-title":"Failure of a numerical quality assessment scale to identify potential risk of bias in a systematic review: A comparison study","volume":"8","author":"O'Connor","year":"2015","journal-title":"BMC Res Notes"},{"key":"10.1053\/j.jvca.2021.01.019_bib0057","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"What is \u201cquality of evidence\u201d and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1053\/j.jvca.2021.01.019_bib0058","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jamainternmed.2015.2147","article-title":"Reporting of limitations of observational research","volume":"175","author":"Wang","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1053\/j.jvca.2021.01.019_bib0059","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0895-4356(00)00242-0","article-title":"Publication and related bias in meta-analysis: Power of statistical tests and prevalence in the literature","volume":"53","author":"Sterne","year":"2000","journal-title":"J Clin Epidemiol"},{"key":"10.1053\/j.jvca.2021.01.019_bib0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13054-017-1633-1","article-title":"Duration of veno-arterial extracorporeal life support (VA ECMO) and outcome: An analysis of the Extracorporeal Life Support Organization (ELSO) registry","volume":"21","author":"Smith","year":"2017","journal-title":"Crit Care"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021000549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021000549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:55:23Z","timestamp":1760946923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077021000549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1053077021000549"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2021.01.019","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effectiveness of Levosimendan on Veno-Arterial Extracorporeal Membrane Oxygenation Management and Outcome: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2021.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}