{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:28:44Z","timestamp":1760956124481,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1053\/j.jvca.2021.08.019","type":"journal-article","created":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T01:58:33Z","timestamp":1628992713000},"page":"195-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dosing of Opioid Medications During and After Pediatric Cardiac Surgery for Children With Down Syndrome"],"prefix":"10.1053","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-5098","authenticated-orcid":false,"given":"Elizabeth R.","family":"Vogel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-7596","authenticated-orcid":false,"given":"Steven J.","family":"Staffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"DiNardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-3145","authenticated-orcid":false,"given":"Morgan L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2021.08.019_bib0001","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/dmcn.12845","article-title":"Reduced pain threshold documented in children with Down syndrome","volume":"57","author":"Barney","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/j.jvca.2021.08.019_bib0002","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fnbeh.2015.00194","article-title":"Pain perception in people with Down syndrome: A synthesis of clinical and experimental research","volume":"9","author":"McGuire","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"10.1053\/j.jvca.2021.08.019_bib0003","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/PCC.0b013e3182a54dd3","article-title":"Defining adequate pain control in the child with Down syndrome: Are we treating perception or reality?","volume":"14","author":"Tsang","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.08.019_bib0004","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/PCC.0000000000001537","article-title":"Morphine pharmacokinetics in children with Down syndrome following cardiac surgery","volume":"19","author":"Goot","year":"2018","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.08.019_bib0005","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/PCC.0000000000000904","article-title":"Pharmacodynamics and pharmacokinetics of morphine after cardiac surgery in children with and without Down syndrome","volume":"17","author":"Valkenburg","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.08.019_bib0006","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/PCC.0000000000002580","article-title":"Sedation with midazolam after cardiac surgery in children with and without Down syndrome: A pharmacokinetic-pharmacodynamic study","volume":"22","author":"Valkenburg","year":"2021","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.08.019_bib0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5055\/jom.2006.0015","article-title":"Opioids and Down's syndrome","volume":"2","author":"Mafrica","year":"2006","journal-title":"J Opioid Manag"},{"key":"10.1053\/j.jvca.2021.08.019_bib0008","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/bja\/aer421","article-title":"Anaesthesia and postoperative analgesia in surgical neonates with or without Down's syndrome: Is it really different?","volume":"108","author":"Valkenburg","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1053\/j.jvca.2021.08.019_bib0009","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/pds.3945","article-title":"A synthesis of oral morphine equivalents (OME) for opioid utilisation studies","volume":"25","author":"Nielsen","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1053\/j.jvca.2021.08.019_bib0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1460-9592.1998.00764.x","article-title":"Comparison of morphine requirements for sedation in Down's syndrome and non-Down's patients following paediatric cardiac surgery","volume":"8","author":"Gakhal","year":"1998","journal-title":"Paediatr Anaesth"},{"key":"10.1053\/j.jvca.2021.08.019_bib0011","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/PCC.0b013e31829f5d9d","article-title":"Opioid use after cardiac surgery in children with Down syndrome","volume":"14","author":"Van Driest","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.jvca.2021.08.019_bib0012","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/S0140-6736(00)03259-1","article-title":"Pain expression and stimulus localisation in individuals with Down's syndrome","volume":"356","author":"Hennequin","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/j.jvca.2021.08.019_bib0013","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/dmcn.12823","article-title":"Pain sensitivity of children with Down syndrome and their siblings: Quantitative sensory testing versus parental reports","volume":"57","author":"Valkenburg","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/j.jvca.2021.08.019_bib0014","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pmn.2014.08.001","article-title":"Evaluation of pain in healthy newborns and in newborns with developmental problems (Down syndrome)","volume":"16","author":"Aguilar Cordero","year":"2015","journal-title":"Pain Manag Nurs"},{"key":"10.1053\/j.jvca.2021.08.019_bib0015","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1460-9592.2005.01773.x","article-title":"The revised FLACC observational pain tool: Improved reliability and validity for pain assessment in children with cognitive impairment","volume":"16","author":"Malviya","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"10.1053\/j.jvca.2021.08.019_bib0016","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.pain.2011.05.001","article-title":"The COMFORT-behavior scale is useful to assess pain and distress in 0- to 3-year-old children with Down syndrome","volume":"152","author":"Valkenburg","year":"2011","journal-title":"Pain"},{"key":"10.1053\/j.jvca.2021.08.019_bib0017","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/archpedi.1990.02150340066025","article-title":"Atrioventricular canal in Down syndrome. Prevalence of associated cardiac malformations compared with patients without Down syndrome","volume":"144","author":"Marino","year":"1990","journal-title":"Am J Dis Child"},{"key":"10.1053\/j.jvca.2021.08.019_bib0018","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/CIRCOUTCOMES.113.000764","article-title":"Association between Down syndrome and in-hospital death among children undergoing surgery for congenital heart disease: A US population-based study","volume":"7","author":"Evans","year":"2014","journal-title":"Circ Cardiovasc Qual Outcomes"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021006911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021006911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:57:28Z","timestamp":1760947048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077021006911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1053077021006911"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2021.08.019","relation":{},"ISSN":["1053-0770"],"issn-type":[{"type":"print","value":"1053-0770"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dosing of Opioid Medications During and After Pediatric Cardiac Surgery for Children With Down Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2021.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}