{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:51:23Z","timestamp":1777366283039,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018870","name":"Swedish Heart and Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["86601"],"award-info":[{"award-number":["86601"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1053\/j.jvca.2021.11.026","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T20:46:29Z","timestamp":1637700389000},"page":"1985-1994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting: A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study"],"prefix":"10.1053","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-8454","authenticated-orcid":false,"given":"Edgars","family":"Grins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Ederoth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Bjursten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Dardashti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Brond\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Metzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6309-242X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Erdling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Nozohoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-7070","authenticated-orcid":false,"given":"Arash","family":"Mokhtari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-0638","authenticated-orcid":false,"given":"Magnus J.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-1826","authenticated-orcid":false,"given":"Eskil","family":"Elm\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Algotsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabin Manandhar","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Jovinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2021.11.026_bib0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1053\/j.jvca.2015.07.013","article-title":"Long-term consequences of acute kidney injury after cardiac surgery: A systematic review and meta-analysis","volume":"30","author":"Corredor","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2021.11.026_bib0002","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1097\/01.ASN.0000130340.93930.DD","article-title":"Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study","volume":"15","author":"Lassnigg","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0003","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jtcvs.2013.07.073","article-title":"Incidence, dynamics, and prognostic value of acute kidney injury for death after cardiac surgery","volume":"147","author":"Dardashti","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2021.11.026_bib0004","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/ALN.0000000000001461","article-title":"Effects of cardiopulmonary bypass on renal perfusion, filtration, and oxygenation in patients undergoing cardiac surgery","volume":"126","author":"Lannemyr","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0005","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/ALN.0b013e318210f86a","article-title":"Cardiopulmonary bypass-associated acute kidney injury","volume":"114","author":"Kumar","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0006","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem J"},{"key":"10.1053\/j.jvca.2021.11.026_bib0007","first-page":"357","article-title":"Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress","volume":"255","author":"Crompton","year":"1988","journal-title":"Biochem J"},{"key":"10.1053\/j.jvca.2021.11.026_bib0008","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tox.2004.09.018","article-title":"Cyclosporine protects against ischemia\/reperfusion injury in rat kidneys","volume":"207","author":"Singh","year":"2005","journal-title":"Toxicology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0009","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1097\/00007890-200112150-00008","article-title":"Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia\/reperfusion injury in rat kidney","volume":"72","author":"Yang","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/j.jvca.2021.11.026_bib0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/ALN.0000000000000331","article-title":"Cyclosporine protects the heart during aortic valve surgery","volume":"121","author":"Chiari","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0011","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/ALN.0000000000002104","article-title":"Cyclosporine before coronary artery bypass grafting does not prevent postoperative decreases in renal function: A randomized clinical trial","volume":"128","author":"Ederoth","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0012","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1681\/ASN.2014080764","article-title":"Plasma IL-6 and IL-10 concentrations predict AKI and long-term mortality in adults after cardiac surgery","volume":"26","author":"Zhang","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0013","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012299","article-title":"Ciclosporin to Protect Renal function In Cardiac Surgery (CiPRICS): A study protocol for a double-blind, randomised, placebo-controlled, proof-of-concept study","volume":"6","author":"Ederoth","year":"2016","journal-title":"BMJ Open"},{"key":"10.1053\/j.jvca.2021.11.026_bib0014","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000368490","article-title":"Renal effects of coronary artery bypass graft surgery in diabetic and non-diabetic patients: A study with urinary neutrophil gelatinase-associated lipocalin and serum cystatin C","volume":"40","author":"Arun","year":"2015","journal-title":"Kidney Blood Press Res"},{"key":"10.1053\/j.jvca.2021.11.026_bib0015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1399-6576.2010.02361.x","article-title":"Evaluation of cystatin C with iohexol clearance in cardiac surgery","volume":"55","author":"Bronden","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1053\/j.jvca.2021.11.026_bib0016","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0162-3109(00)00192-2","article-title":"Mechanisms of action of cyclosporine","volume":"47","author":"Matsuda","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1053\/j.jvca.2021.11.026_bib0017","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s12325-020-01224-1","article-title":"Design and rationale of a scandinavian multicenter randomized study evaluating if once-daily tacrolimus versus twice-daily cyclosporine reduces the 3-year incidence of chronic lung allograft dysfunction after lung transplantation (ScanCLAD Study)","volume":"37","author":"Dellgren","year":"2020","journal-title":"Adv Ther"},{"key":"10.1053\/j.jvca.2021.11.026_bib0018","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/clin.1997.4413","article-title":"Circulating endotoxin and cytokines after cardiopulmonary bypass: Differential correlation with duration of bypass and systemic inflammatory response\/multiple organ dysfunction syndromes","volume":"85","author":"Khabar","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0019","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2249.1998.00682.x","article-title":"Perioperative cytokine release during coronary artery bypass grafting in patients of different ages","volume":"114","author":"Roth-Isigkeit","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2012.11.042","article-title":"Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery","volume":"145","author":"Later","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2021.11.026_bib0021","doi-asserted-by":"crossref","first-page":"R117","DOI":"10.1186\/cc6173","article-title":"Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial","volume":"11","author":"Jimenez","year":"2007","journal-title":"Crit Care"},{"key":"10.1053\/j.jvca.2021.11.026_bib0022","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","article-title":"IL-2, regulatory T cells, and tolerance","volume":"172","author":"Nelson","year":"2004","journal-title":"J Immunol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0023","doi-asserted-by":"crossref","first-page":"41012","DOI":"10.1038\/srep41012","article-title":"Predictive value of serum cystatin C for acute kidney injury in adults: A meta-analysis of prospective cohort trials","volume":"7","author":"Yong","year":"2017","journal-title":"Sci Rep"},{"key":"10.1053\/j.jvca.2021.11.026_bib0024","first-page":"377","article-title":"Serum interleukin 6 levels as an early marker of acute kidney injury on children after cardiac surgery","volume":"22","author":"Miklaszewska","year":"2013","journal-title":"Adv Clin Exp Med"},{"key":"10.1053\/j.jvca.2021.11.026_bib0025","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00467-015-3088-4","article-title":"Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery","volume":"30","author":"Greenberg","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0026","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1007\/s00134-013-2849-4","article-title":"Peri-operative interventions, but not inflammatory mediators, increase risk of acute kidney injury after cardiac surgery: A prospective cohort study","volume":"39","author":"Morgan","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.jvca.2021.11.026_bib0027","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/ard.54.2.137","article-title":"Effect of cyclosporin A on interleukin-6 and soluble interleukin-2 receptor in patients with rheumatoid arthritis","volume":"54","author":"Crilly","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"10.1053\/j.jvca.2021.11.026_bib0028","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1681\/ASN.2007070744","article-title":"IL-6\/IL-6R axis plays a critical role in acute kidney injury","volume":"19","author":"Nechemia-Arbely","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.jvca.2021.11.026_bib0029","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cyto.2012.04.041","article-title":"The role of the kidney in the systemic elimination of interleukin 6, platelet-derived growth factor and transforming growth factor beta","volume":"59","author":"Nowak","year":"2012","journal-title":"Cytokine"},{"key":"10.1053\/j.jvca.2021.11.026_bib0030","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1681\/ASN.2003090757","article-title":"Maladaptive role of IL-6 in ischemic acute renal failure","volume":"16","author":"Kielar","year":"2005","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021010326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077021010326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:10:59Z","timestamp":1762355459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077021010326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1053077021010326"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2021.11.026","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting: A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2021.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}