{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:07:58Z","timestamp":1789553278927,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1053\/j.jvca.2026.06.030","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:15:21Z","timestamp":1782573321000},"page":"3287-3294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heparin Dose-Response Curve for Heparin Dose Determination During Cardiopulmonary Bypass for Pediatric Cardiac Surgery: A Prospective Randomized Controlled Study"],"prefix":"10.1053","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4034-6295","authenticated-orcid":false,"given":"Pavana","family":"Gokhale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suruchi","family":"Hasija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushama Gayatri","family":"B","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2026.06.030_bib0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ppedcard.2005.09.003","article-title":"Thrombosis in children with BT shunts, Glenns and Fontans","volume":"21","author":"Monagle","year":"2005","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1053\/j.jvca.2026.06.030_bib0002","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.athoracsur.2007.05.026","article-title":"Elevated risk of thrombosis in neonates undergoing initial palliative cardiac surgery","volume":"84","author":"Cholette","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0003","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0022-5223(19)41482-7","article-title":"Monitoring of intraoperative heparinization and blood loss following cardiopulmonary bypass surgery","volume":"73","author":"Babka","year":"1977","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0004","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00000542-198311000-00022","article-title":"Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin","volume":"59","author":"Lowenstein","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2026.06.030_bib0005","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-5223(19)41500-6","article-title":"Heparin therapy during extracorporeal circulation. II. The use of a dose-response curve to individualize heparin and protamine dosage","volume":"69","author":"Bull","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0006","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00000542-198402000-00007","article-title":"Activated coagulation time method for control of heparin is reliable during cardiopulmonary bypass","volume":"60","author":"Cohen","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1053\/j.jvca.2026.06.030_bib0007","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.jvca.2007.07.011","article-title":"A comparison of activated coagulation time-based techniques for anticoagulation during cardiac surgery with cardiopulmonary bypass","volume":"22","author":"Slight","year":"2008","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.06.030_bib0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1051\/ject\/201042009","article-title":"Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery","volume":"42","author":"Gruenwald","year":"2010","journal-title":"J Extracorporeal Technol"},{"key":"10.1053\/j.jvca.2026.06.030_bib0009","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"Andrew","year":"1992","journal-title":"Blood"},{"key":"10.1053\/j.jvca.2026.06.030_bib0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1191\/0267659104pf755oa","article-title":"Measurement of the activated clotting time during cardiopulmonary bypass: differences between Hemotec\u00ae ACT and Hemochron\u00ae Jr apparatus","volume":"19","author":"Svenmarker","year":"2004","journal-title":"Perfusion"},{"key":"10.1053\/j.jvca.2026.06.030_bib0011","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/0003-4975(93)90073-Q","article-title":"Coagulation defects in neonates during cardiopulmonary bypass","volume":"55","author":"Jobes","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0012","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1213\/00000539-199902000-00006","article-title":"Platelet hyporeactivity in young infants during cardiopulmonary bypass","volume":"88","author":"Ichinose","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0013","series-title":"Pediatric cardiac anesthesia","year":"2005"},{"key":"10.1053\/j.jvca.2026.06.030_bib0014","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-2007-996137","article-title":"Monitoring and management of anticoagulation in children requiring extracorporeal circulation","volume":"23","author":"Malviya","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.jvca.2026.06.030_bib0015","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0038-1655952","article-title":"Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass","volume":"77","author":"Chan","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.jvca.2026.06.030_bib0016","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S0003-4975(98)00330-0","article-title":"Activation of hemostasis during cardiopulmonary bypass and pediatric aprotinin dosage","volume":"65","author":"Mossinger","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0017","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/00365519509075381","article-title":"Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass in children","volume":"55","author":"Saatvedt","year":"1995","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1053\/j.jvca.2026.06.030_bib0018","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archsurg.135.9.1042","article-title":"Anticoagulation of children undergoing cardiopulmonary bypass is overestimated by current monitoring techniques","volume":"135","author":"Owings","year":"2000","journal-title":"Arch Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0019","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1253\/circj.71.948","article-title":"Increased thrombogenesity in patients with cyanotic congenital heart disease","volume":"71","author":"Kajimoto","year":"2007","journal-title":"Circ J"},{"key":"10.1053\/j.jvca.2026.06.030_bib0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/S1047951108002400","article-title":"Disturbances of coagulation in neonates with functionally univentricular physiology prior to the first stage of surgical reconstruction","volume":"18","author":"Hakacova","year":"2008","journal-title":"Cardiol Young"},{"key":"10.1053\/j.jvca.2026.06.030_bib0021","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1053\/j.jvca.2016.08.029","article-title":"The Hepcon HMS should not be used instead of traditional activated clotting time to dose heparin and protamine for cardiac surgery requiring cardiopulmonary bypass","volume":"30","author":"Gilly","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.06.030_bib0022","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0003-4975(00)02586-8","article-title":"Individualized heparin and protamine management in infants and children undergoing cardiac operations","volume":"71","author":"Codispoti","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0023","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0022-5223(05)80008-X","article-title":"The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation","volume":"110","author":"Despotis","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0024","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archsurg.135.9.1042","article-title":"Anticoagulation of children undergoing cardiopulmonary bypass is overestimated by current monitoring techniques","volume":"135","author":"Owings","year":"2000","journal-title":"Arch Surg"},{"key":"10.1053\/j.jvca.2026.06.030_bib0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1051\/ject\/201850005","article-title":"STS\/SCA\/AmSECT Clinical Practice Guidelines: Anticoagulation during cardiopulmonary bypass","volume":"50","author":"Shore-Lesserson","year":"2018","journal-title":"J Extra Corpor Technol"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026005082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026005082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:46:21Z","timestamp":1789551981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077026005082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1053077026005082"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2026.06.030","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heparin Dose-Response Curve for Heparin Dose Determination During Cardiopulmonary Bypass for Pediatric Cardiac Surgery: A Prospective Randomized Controlled Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2026.06.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}