{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:04:15Z","timestamp":1793480655919,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1053\/j.jvca.2026.08.151","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:34:26Z","timestamp":1788190466000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dysregulation of Autophagy in Circulating Platelets Is Associated with Platelet Dysfunction During Cardiopulmonary Bypass"],"prefix":"10.1053","author":[{"given":"Xiaoling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongsheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2026.08.151_bib0001","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/0391398819882440","article-title":"Whole blood platelet aggregation kinetics under cardiopulmonary bypass: A pilot study","volume":"43","author":"Petzold","year":"2020","journal-title":"Int J Artif Organs"},{"key":"10.1053\/j.jvca.2026.08.151_bib0002","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1111\/jocs.15943","article-title":"Effects of acute normovolemic hemodilution on post-cardiopulmonary bypass coagulation tests and allogeneic blood transfusion in thoracic aortic repair surgery: An observational cohort study","volume":"36","author":"Mladinov","year":"2021","journal-title":"J Card Surg"},{"key":"10.1053\/j.jvca.2026.08.151_bib0003","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1055\/s-0039-1700517","article-title":"Platelet function changes during neonatal cardiopulmonary bypass surgery: Mechanistic basis and lack of correlation with excessive bleeding","volume":"120","author":"Zwifelhofer","year":"2020","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.jvca.2026.08.151_bib0004","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3233\/CH-180391","article-title":"The combined effects of the microcirculatory status and cardiopulmonary bypass on platelet count and function during cardiac surgery","volume":"70","author":"Di Dedda","year":"2018","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1053\/j.jvca.2026.08.151_bib0005","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0003-4975(98)00749-8","article-title":"The platelet in cardiopulmonary bypass","volume":"66","author":"Weerasinghe","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.08.151_bib0006","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/978-1-4939-8873-0_32","article-title":"Autophagy in platelets","volume":"1880","author":"Banerjee","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1053\/j.jvca.2026.08.151_bib0007","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1002\/jcp.28243","article-title":"Autophagic regulation of platelet biology","volume":"234","author":"Luo","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1053\/j.jvca.2026.08.151_bib0008","doi-asserted-by":"crossref","first-page":"134","DOI":"10.21037\/atm.2019.03.04","article-title":"Enhancing autophagy protects platelets in immune thrombocytopenia patients","volume":"7","author":"Wang","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1053\/j.jvca.2026.08.151_bib0009","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1182\/blood-2014-09-598722","article-title":"Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis","volume":"126","author":"Ouseph","year":"2015","journal-title":"Blood"},{"key":"10.1053\/j.jvca.2026.08.151_bib0010","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1080\/15548627.2021.1990669","article-title":"Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5","volume":"18","author":"Schwertz","year":"2022","journal-title":"Autophagy"},{"key":"10.1053\/j.jvca.2026.08.151_bib0011","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1038\/s41598-025-91181-y","article-title":"Inhibition of autophagy in platelets as a therapeutic strategy preventing hypoxia induced thrombosis","volume":"15","author":"Bandyopadhyay","year":"2025","journal-title":"Sci Rep"},{"key":"10.1053\/j.jvca.2026.08.151_bib0012","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186065","article-title":"TNF-alpha impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation","volume":"135","author":"Rojas-Sanchez","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1053\/j.jvca.2026.08.151_bib0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1182\/blood.2019003851","article-title":"The role of AGK in thrombocytopoiesis and possible therapeutic strategies","volume":"136","author":"Jiang","year":"2020","journal-title":"Blood"},{"key":"10.1053\/j.jvca.2026.08.151_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108065","article-title":"Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5\/AMPK-JNK signaling pathway","volume":"175","author":"Chen","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1053\/j.jvca.2026.08.151_bib0015","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1053\/j.jvca.2023.03.013","article-title":"Platelet function is preserved after moderate cardiopulmonary bypass times but transiently impaired after protamine","volume":"37","author":"Tornudd","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.08.151_bib0016","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1080\/15548627.2021.1904495","article-title":"Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism","volume":"17","author":"Lee","year":"2021","journal-title":"Autophagy"},{"key":"10.1053\/j.jvca.2026.08.151_bib0017","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jclinane.2019.05.012","article-title":"Predicting results of fibrinogen and platelet levels by TEG6s during cardiopulmonary bypass: A pilot study","volume":"58","author":"Tamura","year":"2019","journal-title":"J Clin Anesth"},{"key":"10.1053\/j.jvca.2026.08.151_bib0018","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/cr.2011.152","article-title":"Autophagy: For better or for worse","volume":"22","author":"Wirawan","year":"2012","journal-title":"Cell Res"},{"key":"10.1053\/j.jvca.2026.08.151_bib0019","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1053\/j.jvca.2019.07.129","article-title":"Autologous platelet-rich plasmapheresis in cardiovascular surgery: A narrative review","volume":"34","author":"Bai","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.08.151_bib0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10555-017-9677-x","article-title":"Normal platelet function","volume":"36","author":"Holinstat","year":"2017","journal-title":"Cancer Metastasis Rev"},{"key":"10.1053\/j.jvca.2026.08.151_bib0021","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s12012-025-09971-9","article-title":"Famciclovir ameliorates platelet activation and thrombosis by AhR-regulated autophagy","volume":"25","author":"Ming","year":"2025","journal-title":"Cardiovasc Toxicol"},{"key":"10.1053\/j.jvca.2026.08.151_bib0022","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1007\/s13346-025-01792-1","article-title":"Platelet membrane-modified exosomes targeting plaques to activate autophagy in vascular smooth muscle cells for atherosclerotic therapy","volume":"15","author":"Jiang","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"10.1053\/j.jvca.2026.08.151_bib0023","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.thromres.2022.08.019","article-title":"Autophagy and its consequences for platelet biology","volume":"231","author":"Schwertz","year":"2023","journal-title":"Thromb Res"},{"key":"10.1053\/j.jvca.2026.08.151_bib0024","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet physiology","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin Thromb Hemost"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026008578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026008578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:02:44Z","timestamp":1790539364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077026008578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"alternative-id":["S1053077026008578"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2026.08.151","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of Autophagy in Circulating Platelets Is Associated with Platelet Dysfunction During Cardiopulmonary Bypass","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2026.08.151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}