{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:37:07Z","timestamp":1792816627572,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcardioanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1053\/j.jvca.2026.09.045","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:03:23Z","timestamp":1790435003000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thromboelastography-Informed Andexanet Alfa Administration for Residual Apixaban Effect During Acute Aortic Dissection With Cardiopulmonary Bypass"],"prefix":"10.1053","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3277-0110","authenticated-orcid":false,"given":"Kohei","family":"Noto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Daitoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Tsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.jvca.2026.09.045_bib0001","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMoa1607887","article-title":"Andexanet alfa for acute major bleeding associated with factor Xa inhibitors","volume":"375","author":"Connolly","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1053\/j.jvca.2026.09.045_bib0002","doi-asserted-by":"crossref","first-page":"ezad100","DOI":"10.1093\/ejcts\/ezad100","article-title":"Andexanet alfa in acute aortic syndrome: First UK experience","volume":"63","author":"Al-Attar","year":"2023","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.jvca.2026.09.045_bib0003","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1161\/ATVBAHA.124.321650","article-title":"Andexanet alfa-associated heparin resistance in cardiac surgery: Mechanism and in vitro perspectives","volume":"45","author":"Chabata","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.jvca.2026.09.045_bib0004","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/j.jvca.2023.12.001","article-title":"Cardiopulmonary bypass circuit obstruction and urgent replacement after the administration of andexanet alfa","volume":"38","author":"Nozumi","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.09.045_bib0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1053\/j.jvca.2020.08.017","article-title":"Intraoperative off-label reversal of apixaban by andexanet alfa while on VA-ECMO immediately after emergent surgery for acute type A aortic dissection","volume":"35","author":"Kainz","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.09.045_bib0006","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.athoracsur.2021.03.033","article-title":"STS\/SCA\/AmSECT\/SABM update to the clinical practice guidelines on patient blood management","volume":"112","author":"Tibi","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.jvca.2026.09.045_bib0007","article-title":"Andexanet alfa for edoxaban reversal and associated thromboelastography changes in surgical pulmonary embolectomy","volume":"16","author":"Fukuda","year":"2024","journal-title":"Cureus"},{"key":"10.1053\/j.jvca.2026.09.045_bib0008","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/rth2.12206","article-title":"Fully automated thromboelastograph TEG 6s to measure anticoagulant effects of direct oral anticoagulants in healthy male volunteers","volume":"3","author":"Artang","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1053\/j.jvca.2026.09.045_bib0009","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1053\/j.jvca.2024.10.006","article-title":"2024 EACTS\/EACTAIC guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP","volume":"39","author":"Casselman","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.09.045_bib0010","unstructured":"European Medicines Agency. Direct healthcare professional communication: Ondexxya (andexanet alfa): Avoid use of andexanet prior to heparinization. Available at: https:\/\/www.ema.europa.eu\/en\/medicines\/dhpc\/ondexxya-0. Published 2020. Accessed August 29, 2026."},{"key":"10.1053\/j.jvca.2026.09.045_bib0011","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/EJA.0000000000001803","article-title":"Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: Second update 2022","volume":"40","author":"Kietaibl","year":"2023","journal-title":"Eur J Anaesthesiol"},{"key":"10.1053\/j.jvca.2026.09.045_bib0012","unstructured":"US Food and Drug Administration. Update on the safety of Andexxa. Available at: https:\/\/www.fda.gov\/vaccines-blood-biologics\/safety-availability-biologics\/update-safety-andexxa. Published 2025. Accessed September 19, 2026."},{"key":"10.1053\/j.jvca.2026.09.045_bib0013","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.jacc.2024.06.013","article-title":"2024 AHA\/ACC\/ACS\/ASNC\/HRS\/SCA\/SCCT\/SCMR\/SVM guideline for perioperative cardiovascular management for noncardiac surgery: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"84","author":"Thompson","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.jvca.2026.09.045_bib0014","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/a-2822-7599","article-title":"Advancing point-of-care analysis: The future of thromboelastographic DOAC-detection: A systematic review","volume":"52","author":"Herpertz","year":"2026","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.jvca.2026.09.045_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.991675","article-title":"The impact of direct oral anticoagulants on viscoelastic testing\u2014A systematic review","volume":"9","author":"Sahli","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1053\/j.jvca.2026.09.045_bib0016","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.jvca.2023.02.015","article-title":"Point-of-care viscoelastic hemostatic assays in cardiac surgery patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra","volume":"37","author":"Demailly","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.09.045_bib0017","first-page":"266","article-title":"Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time","volume":"67","author":"Park","year":"2009","journal-title":"J Trauma"},{"key":"10.1053\/j.jvca.2026.09.045_bib0018","article-title":"Review of thromboelastography (TEG): Medical and surgical applications","volume":"18","author":"Whitton","year":"2023","journal-title":"Ther Adv Pulm Crit Care Med"},{"key":"10.1053\/j.jvca.2026.09.045_bib0019","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/j.ajkd.2022.09.011","article-title":"Pharmacokinetics and pharmacodynamics of apixaban in nephrotic syndrome: Findings from a phase 1a trial","volume":"81","author":"Derebail","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.jvca.2026.09.045_bib0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s40256-024-00664-2","article-title":"Apixaban use in patients with kidney impairment: A review of pharmacokinetic, interventional, and observational study data","volume":"24","author":"Mandt","year":"2024","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1053\/j.jvca.2026.09.045_bib0021","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1540-8191.2009.00840.x","article-title":"Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: A prospective randomized study","volume":"24","author":"Ak","year":"2009","journal-title":"J Card Surg"},{"key":"10.1053\/j.jvca.2026.09.045_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/j.jvca.2019.06.030","article-title":"Viscoelastic blood tests use in adult cardiac surgery: Meta-analysis, meta-regression, and trial sequential analysis","volume":"34","author":"Meco","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.jvca.2026.09.045_bib0023","doi-asserted-by":"crossref","first-page":"7782","DOI":"10.1097\/JS9.0000000000002137","article-title":"Apixaban removal during emergency surgery for type A acute aortic dissection: A prospective cohort study","volume":"110","author":"R\u00f8ed-Undlien","year":"2024","journal-title":"Int J Surg"},{"key":"10.1053\/j.jvca.2026.09.045_bib0024","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/phar.2727","article-title":"Reversal of apixaban and rivaroxaban with andexanet alfa prior to invasive or surgical procedures","volume":"42","author":"Bradshaw","year":"2022","journal-title":"Pharmacotherapy"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026009560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077026009560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:36Z","timestamp":1792813656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077026009560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":24,"alternative-id":["S1053077026009560"],"URL":"https:\/\/doi.org\/10.1053\/j.jvca.2026.09.045","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thromboelastography-Informed Andexanet Alfa Administration for Residual Apixaban Effect During Acute Aortic Dissection With Cardiopulmonary Bypass","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiothoracic and Vascular Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.jvca.2026.09.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}